{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:32:02Z","timestamp":1787671922295,"version":"build-2736575974"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Otorhinolaryngol"],"DOI":"10.1007\/s00405-026-10569-2","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:27:29Z","timestamp":1787624849000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory markers as determinants of glue-type effusion and recurrent ventilation tube placement"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-8339","authenticated-orcid":false,"given":"Kadir Sinasi","family":"Bulut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-7373","authenticated-orcid":false,"given":"Serkan","family":"Serifler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4641-6698","authenticated-orcid":false,"given":"Selman","family":"Seckin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0186-289X","authenticated-orcid":false,"given":"Esra Zeynep","family":"Karakus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-6493","authenticated-orcid":false,"given":"Mehmet Ali","family":"Babademez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"2","key":"10569_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.joto.2019.01.005","volume":"14","author":"P Vanneste","year":"2019","unstructured":"Vanneste P, Page C (2019) Otitis media with effusion in children: pathophysiology, diagnosis, and treatment. A review. J Otol 14(2):33\u201339. https:\/\/doi.org\/10.1016\/j.joto.2019.01.005","journal-title":"J Otol"},{"key":"10569_CR2","doi-asserted-by":"publisher","unstructured":"Rosenfeld RM, Shin JJ, Schwartz SR et al (2016) Clinical practice guideline: otitis media with effusion (update). Otolaryngol Head Neck Surg 154(1_suppl):S1\u2013S41. https:\/\/doi.org\/10.1177\/0194599815623467","DOI":"10.1177\/0194599815623467"},{"key":"10569_CR3","doi-asserted-by":"publisher","unstructured":"MacKeith S, Mulvaney CA, Galbraith K et al (2023) Ventilation tubes (grommets) for otitis media with effusion (OME) in children. Cochrane Database Syst Rev 11:CD015215. https:\/\/doi.org\/10.1002\/14651858.CD015215.pub2","DOI":"10.1002\/14651858.CD015215.pub2"},{"issue":"5","key":"10569_CR4","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1017\/S0022215116000943","volume":"130","author":"R Mills","year":"2016","unstructured":"Mills R, Hathorn I (2016) Aetiology and pathology of otitis media with effusion in adult life. J Laryngol Otol 130(5):418\u2013424. https:\/\/doi.org\/10.1017\/S0022215116000943","journal-title":"J Laryngol Otol"},{"key":"10569_CR5","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.2.70","author":"CM Song","year":"2010","unstructured":"Song CM, Park MH, Kim YH, Lee JH (2010) Factors affecting the extrusion rate of ventilation tubes. Clin Exp Otorhinolaryngol 3(2):70\u201375. https:\/\/doi.org\/10.3342\/ceo.2010.3.2.70","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"7","key":"10569_CR6","doi-asserted-by":"publisher","first-page":"474","DOI":"10.4149\/BLL_2021_078","volume":"122","author":"R Zahorec","year":"2021","unstructured":"Zahorec R (2021) Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratisl Lek Listy 122(7):474\u2013488. https:\/\/doi.org\/10.4149\/BLL_2021_078","journal-title":"Bratisl Lek Listy"},{"key":"10569_CR7","doi-asserted-by":"publisher","unstructured":"Vitiello R, Smimmo A, Matteini E et al (2024) Systemic inflammation response index (SIRI) and monocyte-to-lymphocyte ratio (MLR) are predictors of good outcomes in surgical treatment of periprosthetic joint infections of lower limbs: a single-center retrospective analysis. Healthcare (Basel) 12(9):867. https:\/\/doi.org\/10.3390\/healthcare12090867","DOI":"10.3390\/healthcare12090867"},{"issue":"1","key":"10569_CR8","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00405-025-09766-2","volume":"283","author":"B Celik","year":"2026","unstructured":"Celik B, Gul F, Serifler S, Bulut KS, Babademez MA (2026) Inflammatory indices as early predictors of mortality in mucormycosis. Eur Arch Otorhinolaryngol 283(1):263\u2013271. https:\/\/doi.org\/10.1007\/s00405-025-09766-2","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"12","key":"10569_CR9","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1016\/j.ijporl.2015.10.043","volume":"79","author":"OF Boztepe","year":"2015","unstructured":"Boztepe OF, Demir M, G\u00fcn T, Bilal N, Ensari NA, Do\u011fru H (2015) A novel predictive marker for the viscosity of otitis media with effusion. Int J Pediatr Otorhinolaryngol 79(12):2355\u20132358. https:\/\/doi.org\/10.1016\/j.ijporl.2015.10.043","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10569_CR10","doi-asserted-by":"publisher","unstructured":"Almutairi AA, Aljabr IK, Alsindi ZS et al (2025) Blood inflammatory markers as predictors of effusion characteristics and postoperative hearing outcomes in children with otitis media with effusion: a retrospective study. Medicina (Kaunas) 61(9):1520. https:\/\/doi.org\/10.3390\/medicina61091520","DOI":"10.3390\/medicina61091520"},{"issue":"12","key":"10569_CR11","doi-asserted-by":"publisher","first-page":"6239","DOI":"10.1007\/s00405-025-09591-7","volume":"282","author":"A Yeniceri","year":"2025","unstructured":"Yeniceri A, Sahutoglu C, Sevim I, Cayonu M (2025) Evaluation of inflammatory markers in pediatric patients with otitis media with effusion: a retrospective analysis. Eur Arch Otorhinolaryngol 282(12):6239\u20136245. https:\/\/doi.org\/10.1007\/s00405-025-09591-7","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"2","key":"10569_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/medicina61091520","volume":"13","author":"MG Smirnova","year":"2004","unstructured":"Smirnova MG, Birchall JP, Pearson JP (2004) The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediators Inflamm 13(2):75\u201388. https:\/\/doi.org\/10.3390\/medicina61091520","journal-title":"Mediators Inflamm"},{"issue":"18","key":"10569_CR13","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1182\/blood-2013-11-462432","volume":"123","author":"CN Morrell","year":"2014","unstructured":"Morrell CN, Aggrey AA, Chapman LM, Modjeski KL (2014) Emerging roles for platelets as immune and inflammatory cells. Blood 123(18):2759\u20132767. https:\/\/doi.org\/10.1182\/blood-2013-11-462432","journal-title":"Blood"},{"issue":"3","key":"10569_CR14","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3342\/ceo.2008.1.3.117","volume":"1","author":"SK Juhn","year":"2008","unstructured":"Juhn SK, Jung MK, Hoffman MD et al (2008) The role of inflammatory mediators in the pathogenesis of otitis media and sequelae. Clin Exp Otorhinolaryngol 1(3):117\u2013138. https:\/\/doi.org\/10.3342\/ceo.2008.1.3.117","journal-title":"Clin Exp Otorhinolaryngol"}],"container-title":["European Archives of Oto-Rhino-Laryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-026-10569-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00405-026-10569-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00405-026-10569-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:07:45Z","timestamp":1787670465000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00405-026-10569-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":14,"alternative-id":["10569"],"URL":"https:\/\/doi.org\/10.1007\/s00405-026-10569-2","relation":{},"ISSN":["0937-4477","1434-4726"],"issn-type":[{"value":"0937-4477","type":"print"},{"value":"1434-4726","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"11 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in accordance with the ethical standards of the institution\u2019s research committee and the principles of the Declaration of Helsinki and its subsequent amendments. Ethical approval was obtained from our hospital\u2019s Medical Research Scientific and Ethical Evaluation Committee (approval number: 1-26-2437). Due to the retrospective nature of the study, the requirement for informed consent was waived by the ethics committee.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. No identifiable personal or clinical data are included in this article.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}