{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:01:28Z","timestamp":1783548088895,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00406-014-0495-7","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T18:58:50Z","timestamp":1393873130000},"page":"567-575","source":"Crossref","is-referenced-by-count":35,"title":["Three-Year long-term outcome of 458 naturalistically treated inpatients with major depressive episode: severe relapse rates and risk factors"],"prefix":"10.1007","volume":"264","author":[{"given":"Florian","family":"Seem\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Obermeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Musil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Adli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kronm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Holsboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Brieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Laux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Heuser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Zeiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Gaebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Falkai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,4]]},"reference":[{"key":"495_CR1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0140-6736(03)12599-8","volume":"361","author":"JR Geddes","year":"2003","unstructured":"Geddes JR, Carney SM, Davies C et al (2003) Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review. Lancet 361:653\u2013661. doi: 10.1016\/S0140-6736(03)12599-8","journal-title":"Lancet"},{"key":"495_CR2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1176\/appi.ajp.159.2.191","volume":"159","author":"MA Posternak","year":"2002","unstructured":"Posternak MA, Zimmerman M, Keitner GI, Miller IW (2002) A reevaluation of the exclusion criteria used in antidepressant efficacy trials. Am J Psychiatry 159:191\u2013200","journal-title":"Am J Psychiatry"},{"key":"495_CR3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.comppsych.2004.07.002","volume":"45","author":"DA Solomon","year":"2004","unstructured":"Solomon DA, Leon AC, Endicott J et al (2004) Psychosocial impairment and recurrence of major depression. Compr Psychiatry 45:423\u2013430. doi: 10.1016\/j.comppsych.2004.07.002","journal-title":"Compr Psychiatry"},{"key":"495_CR4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jad.2009.01.027","volume":"118","author":"S Hughes","year":"2009","unstructured":"Hughes S, Cohen D (2009) A systematic review of long-term studies of drug treated and non-drug treated depression. J Affect Disord 118:9\u201318. doi: 10.1016\/j.jad.2009.01.027","journal-title":"J Affect Disord"},{"key":"495_CR5","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.clinbiochem.2007.06.001","volume":"40","author":"AO Akanji","year":"2007","unstructured":"Akanji AO, Ohaeri JU, Al-Shammri SA, Fatania HR (2007) Associations of blood homocysteine concentrations in Arab schizophrenic patients. Clin Biochem 40:1026\u20131031","journal-title":"Clin Biochem"},{"key":"495_CR6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.psychres.2009.12.003","volume":"180","author":"C-H Lin","year":"2010","unstructured":"Lin C-H, Chen M-C, Chou L-S et al (2010) Time to rehospitalization in patients with major depression vs. those with schizophrenia or bipolar I disorder in a public psychiatric hospital. Psychiatry Res 180:74\u201379. doi: 10.1016\/j.psychres.2009.12.003","journal-title":"Psychiatry Res"},{"key":"495_CR7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1440-1819.2007.01662.x","volume":"61","author":"C-H Lin","year":"2007","unstructured":"Lin C-H, Chen Y-S, Lin C-H, Lin K-S (2007) Factors affecting time to rehospitalization for patients with major depressive disorder. Psychiatry Clin Neurosci 61:249\u2013254. doi: 10.1111\/j.1440-1819.2007.01662.x","journal-title":"Psychiatry Clin Neurosci"},{"key":"495_CR8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4088\/JCP.v69n0108","volume":"69","author":"C-H Lin","year":"2008","unstructured":"Lin C-H, Lin K-S, Lin C-Y et al (2008) Time to rehospitalization in patients with major depressive disorder taking venlafaxine or fluoxetine. J Clin Psychiatry 69:54\u201359","journal-title":"J Clin Psychiatry"},{"key":"495_CR9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/archfami.7.5.443","volume":"7","author":"EH Lin","year":"1998","unstructured":"Lin EH, Katon WJ, VonKorff M et al (1998) Relapse of depression in primary care. Rate and clinical predictors. Arch Fam Med 7:443\u2013449","journal-title":"Arch Fam Med"},{"key":"495_CR10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1099-176X(200003)3:1<3::AID-MHP68>3.0.CO;2-H","volume":"3","author":"P Berto","year":"2000","unstructured":"Berto P, D\u2019Ilario D, Ruffo P et al (2000) Depression: cost-of-illness studies in the international literature, a review. J Ment Health Policy Econ 3:3\u201310","journal-title":"J Ment Health Policy Econ"},{"key":"495_CR11","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.euroneuro.2009.11.011","volume":"20","author":"F Seem\u00fcller","year":"2010","unstructured":"Seem\u00fcller F, Riedel M, Obermeier M et al (2010) Outcomes of 1014 naturalistically treated inpatients with major depressive episode. Eur Neuropsychopharmacol 20:346\u2013355. doi: 10.1016\/j.euroneuro.2009.11.011","journal-title":"Eur Neuropsychopharmacol"},{"key":"495_CR12","volume-title":"Strukturiertes Klinisches Interview f\u00fcr DSM-IV","author":"HU Wittchen","year":"1997","unstructured":"Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M (1997) Strukturiertes Klinisches Interview f\u00fcr DSM-IV. Hogrefe, G\u00f6ttingen"},{"key":"495_CR13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.2044-8260.1967.tb00530.x","volume":"6","author":"M Hamilton","year":"1967","unstructured":"Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278\u2013296","journal-title":"Br J Soc Clin Psychol"},{"key":"495_CR14","first-page":"3","volume":"24","author":"C Cording","year":"1995","unstructured":"Cording C, Gaebel W, Spengler A (1995) Die neue psychiatrische Basisdokumentation. Eine Empfehlung der DGPPN zur Qualit\u201etssicherung im (teil-) station\u201eren Bereich. [The new psychiatric basic documentation. A recommendation by the DGPPN for quality assurance in inpatient treatment]. Spektrum Psychiatr Nervenheilkd 24:3\u201341","journal-title":"Spektrum Psychiatr Nervenheilkd"},{"key":"495_CR15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/15622970701227829","volume":"8","author":"M Bauer","year":"2007","unstructured":"Bauer M, Bschor T, Pfennig A et al (2007) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders in primary care. World J Biol Psychiatry 8:67\u2013104","journal-title":"World J Biol Psychiatry"},{"key":"495_CR16","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jpsychires.2010.03.006","volume":"44","author":"M Riedel","year":"2010","unstructured":"Riedel M, Moller HJ, Obermeier M et al (2010) Response and remission criteria in major depression\u2014a validation of current practice. J Psychiatr Res 44:1063\u20131068","journal-title":"J Psychiatr Res"},{"key":"495_CR17","volume-title":"R: a language and environment for statistical computing","author":"R Foundation for Statistical Computing","year":"2012","unstructured":"R Foundation for Statistical Computing (2012) R: a language and environment for statistical computing. Austria, Vienna"},{"key":"495_CR18","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/archpsyc.1991.01810330075011","volume":"48","author":"E Frank","year":"1991","unstructured":"Frank E, Prien RF, Jarrett RB et al (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48:851\u2013855","journal-title":"Arch Gen Psychiatry"},{"key":"495_CR19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.yic.0000199452.16682.b8","volume":"21","author":"A-C Akerblad","year":"2006","unstructured":"Akerblad A-C, Bengtsson F, von Knorring L, Ekselius L (2006) Response, remission and relapse in relation to adherence in primary care treatment of depression: a 2-year outcome study. Int Clin Psychopharmacol 21:117\u2013124","journal-title":"Int Clin Psychopharmacol"},{"key":"495_CR20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/00048679809062740","volume":"32","author":"BA Daniels","year":"1998","unstructured":"Daniels BA, Kirkby KC, Hay DA et al (1998) Predictability of rehospitalisation over 5 years for schizophrenia, bipolar disorder and depression. Aust N Z J Psychiatry 32:281\u2013286","journal-title":"Aust N Z J Psychiatry"},{"key":"495_CR21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1176\/appi.ajp.160.4.727","volume":"160","author":"AC Leon","year":"2003","unstructured":"Leon AC, Solomon DA, Mueller TI et al (2003) A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness. Am J Psychiatry 160:727\u2013733","journal-title":"Am J Psychiatry"},{"key":"495_CR22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S003329170005100X","volume":"13","author":"JR Copeland","year":"1983","unstructured":"Copeland JR (1983) Psychotic and neurotic depression: discriminant function analysis and five-year outcome. Psychol Med 13:373\u2013383","journal-title":"Psychol Med"},{"issue":"Suppl 1","key":"495_CR23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4088\/JCP.9104su1c.01","volume":"71","author":"L Culpepper","year":"2010","unstructured":"Culpepper L (2010) Why do you need to move beyond first-line therapy for major depression? J Clin Psychiatry 71(Suppl 1):4\u20139. doi: 10.4088\/JCP.9104su1c.01","journal-title":"J Clin Psychiatry"},{"key":"495_CR24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1176\/appi.ajp.161.1.169","volume":"161","author":"CA Zarate Jr","year":"2004","unstructured":"Zarate CA Jr, Tohen M (2004) Double-blind comparison of the continued use of antipsychotic treatment versus its discontinuation in remitted manic patients. Am J Psychiatry 161:169\u2013171","journal-title":"Am J Psychiatry"},{"key":"495_CR25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.euroneuro.2009.04.003","volume":"19","author":"G Goodwin","year":"2009","unstructured":"Goodwin G, Fleischhacker W, Arango C et al (2009) Advantages and disadvantages of combination treatment with antipsychotics ECNP consensus meeting, March 2008, Nice. Eur Neuropsychopharmacol 19:520\u2013532. doi: 10.1016\/j.euroneuro.2009.04.003","journal-title":"Eur Neuropsychopharmacol"},{"key":"495_CR26","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1176\/appi.ps.52.8.1100","volume":"52","author":"AC Bernardo","year":"2001","unstructured":"Bernardo AC, Forchuk C (2001) Factors associated with readmission to a psychiatric facility. Psychiatr Serv 52:1100\u20131102","journal-title":"Psychiatr Serv"},{"key":"495_CR27","first-page":"820","volume":"40","author":"BE Havassy","year":"1989","unstructured":"Havassy BE, Hopkin JT (1989) Factors predicting utilization of acute psychiatric inpatient services by frequently hospitalized patients. Hosp Community Psychiatry 40:820\u2013823","journal-title":"Hosp Community Psychiatry"},{"key":"495_CR28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000289125","volume":"66","author":"LA Labbate","year":"1997","unstructured":"Labbate LA, Doyle ME (1997) Recidivism in major depressive disorder. Psychother Psychosom 66:145\u2013149","journal-title":"Psychother Psychosom"},{"key":"495_CR29","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4088\/JCP.v66n0302","volume":"66","author":"DA Solomon","year":"2005","unstructured":"Solomon DA, Leon AC, Mueller TI et al (2005) Tachyphylaxis in unipolar major depressive disorder. J Clin Psychiatry 66:283\u2013290","journal-title":"J Clin Psychiatry"},{"key":"495_CR30","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1017\/S0033291707001249","volume":"38","author":"OJ Robinson","year":"2008","unstructured":"Robinson OJ, Sahakian BJ (2008) Recurrence in major depressive disorder: a neurocognitive perspective. Psychol Med 38:315\u2013318. doi: 10.1017\/S0033291707001249","journal-title":"Psychol Med"},{"key":"495_CR31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1017\/S1092852900010622","volume":"11","author":"ME Thase","year":"2006","unstructured":"Thase ME (2006) Preventing relapse and recurrence of depression: a brief review of therapeutic options. CNS Spectr 11:12\u201321","journal-title":"CNS Spectr"},{"key":"495_CR32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","volume":"163","author":"MH Trivedi","year":"2006","unstructured":"Trivedi MH, Rush AJ, Wisniewski SR et al (2006) Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 163:28\u201340","journal-title":"Am J Psychiatry"},{"key":"495_CR33","first-page":"1","volume":"40","author":"AA Nierenberg","year":"2009","unstructured":"Nierenberg AA, Husain MM, Trivedi MH et al (2009) Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report. Psychol Med 40:1\u201310","journal-title":"Psychol Med"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-014-0495-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00406-014-0495-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-014-0495-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:22:53Z","timestamp":1559053373000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00406-014-0495-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,4]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["495"],"URL":"https:\/\/doi.org\/10.1007\/s00406-014-0495-7","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,4]]}}}