{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:09:16Z","timestamp":1759205356988},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s00406-014-0518-4","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T12:18:28Z","timestamp":1407154708000},"page":"117-126","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia"],"prefix":"10.1007","volume":"265","author":[{"given":"Marta","family":"Krzy\u017canowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Brisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mawrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Busse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Jankowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Gert","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Bogerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Gos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"518_CR1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0074-7742(06)78005-9","volume":"78","author":"A Abi-Dargham","year":"2007","unstructured":"Abi-Dargham A (2007) Alterations of serotonin transmission in schizophrenia. Int Rev Neurobiol 78:133\u2013164","journal-title":"Int Rev Neurobiol"},{"key":"518_CR2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0893-133X(01)00310-4","volume":"25","author":"V Arango","year":"2001","unstructured":"Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Hsiung S, Chenn JJ, Mann JJ (2001) Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 25:892\u2013903","journal-title":"Neuropsychopharmacology"},{"key":"518_CR3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1192\/pb.21.4.224","volume":"21","author":"M Atkins","year":"1997","unstructured":"Atkins M, Burgess A, Bottomley C, Riccio M (1997) Chlorpromazine equivalents: a consensus of opinion for both clinical and research applications. Psych Bull 21:224\u2013226","journal-title":"Psych Bull"},{"key":"518_CR4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/sj.mp.4001250","volume":"8","author":"MC Austin","year":"2003","unstructured":"Austin MC, Janosky JE, Murphy HA (2003) Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men. Mol Psychiatry 8:324\u2013332","journal-title":"Mol Psychiatry"},{"key":"518_CR5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1201\/b12215-3","volume-title":"The neurobiological basis of suicide","author":"H Bach","year":"2012","unstructured":"Bach H, Arango V (2012) Neuroanatomy of serotonergic abnormalities in suicide. In: Dwivedi Y (ed) The neurobiological basis of suicide. Taylor and Francis, New York, pp 11\u201327"},{"key":"518_CR6","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/sj.npp.1300897","volume":"31","author":"H Bach-Mizrachi","year":"2006","unstructured":"Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V (2006) Neuronal tryptophan hydroxylase mRNA expression in human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 31:814\u2013824","journal-title":"Neuropsychopharmacology"},{"key":"518_CR7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/sj.mp.4002143","volume":"13","author":"H Bach-Mizrachi","year":"2008","unstructured":"Bach-Mizrachi H, Underwood MD, Tin A, Ellis SP, Mann JJ, Arango V (2008) Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Mol Psychiatry 13:507\u2013513","journal-title":"Mol Psychiatry"},{"key":"518_CR8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/cne.903010202","volume":"301","author":"KG Baker","year":"1990","unstructured":"Baker KG, Halliday GM, T\u00f6rk I (1990) Cytoarchitecture of the human dorsal raphe nucleus. J Comp Neurol 301:147\u2013161","journal-title":"J Comp Neurol"},{"key":"518_CR9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0033291701004822","volume":"32","author":"B Baumann","year":"2002","unstructured":"Baumann B, Bielau H, Krell D, Agelink MW, Diekmann S, Wurthmann C, Tr\u00fcbner K, Bernstein HG, Danos P, Bogerts B (2002) Circumscribed numerical deficit of dorsal raphe neurons in mood disorders. Psychol Med 32:93\u2013103","journal-title":"Psychol Med"},{"key":"518_CR10","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1002\/cne.23080","volume":"520","author":"R Bernard","year":"2012","unstructured":"Bernard R, Veh RW (2012) Individual neurons in the rat lateral habenular complex project mostly to the dopaminergic ventral tegmental area or to the serotonergic raphe nuclei. J Comp Neurol 520:2545\u20132558","journal-title":"J Comp Neurol"},{"key":"518_CR11","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1242\/dev.121.8.2327","volume":"121","author":"B Berninger","year":"1995","unstructured":"Berninger B, Marty S, Zafra F, Berzaghi M, Thoenen H, Lindholm D (1995) GABAergic stimulation switches from enhancing to repressing BDNF expression in rat hippocampal neurons during maturation in vitro. Development 121:2327\u20132335","journal-title":"Development"},{"key":"518_CR12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainres.2005.01.055","volume":"1039","author":"H Bielau","year":"2005","unstructured":"Bielau H, Mawrin C, Krell D, Agelink MW, Tr\u00fcbner K, Davis R, Gos T, Bogerts B, Bernstein HG, Baumann B (2005) Differences in activation of the dorsal raphe nucleus depending on performance of suicide. Brain Res 1039:43\u201352","journal-title":"Brain Res"},{"key":"518_CR13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0006-3223(99)00313-3","volume":"47","author":"W Bligh-Glover","year":"2000","unstructured":"Bligh-Glover W, Kolli TN, Shapiro-Kulnane L, Dilley GE, Friedman L, Balraj E, Rajkowska G, Stockmeier CA (2000) The serotonin transporter in the midbrain of suicide victims with major depression. Biol Psychiatry 47:1015\u20131024","journal-title":"Biol Psychiatry"},{"key":"518_CR14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2005.01.083","volume":"1041","author":"M Boldrini","year":"2005","unstructured":"Boldrini M, Underwood MD, Mann JJ, Arango V (2005) More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res 1041:19\u201328","journal-title":"Brain Res"},{"key":"518_CR15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jpsychires.2007.05.004","volume":"42","author":"M Boldrini","year":"2008","unstructured":"Boldrini M, Underwood MD, Mann JJ, Arango V (2008) Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res 42:433\u2013442","journal-title":"J Psychiatr Res"},{"key":"518_CR16","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1046\/j.1471-4159.2003.02225.x","volume":"88","author":"WL Bonkale","year":"2004","unstructured":"Bonkale WL, Murdock S, Janosky JE, Austin MC (2004) Normal levels of tryptophan hydroxylase immunoreactivity in the dorsal raphe of depressed suicide victims. J Neurochem 88:958\u2013964","journal-title":"J Neurochem"},{"key":"518_CR17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/syn.20278","volume":"60","author":"WL Bonkale","year":"2006","unstructured":"Bonkale WL, Turecki G, Austin MC (2006) Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse 60:81\u201385","journal-title":"Synapse"},{"key":"518_CR18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s004010100392","volume":"102","author":"C Bouras","year":"2001","unstructured":"Bouras C, K\u00f6vari E, Hof PR, Riederer BM, Giannakopoulos P (2001) Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathol 102:373\u2013379","journal-title":"Acta Neuropathol"},{"key":"518_CR19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0920-9964(02)00201-3","volume":"58","author":"K Broadbelt","year":"2002","unstructured":"Broadbelt K, Byne W, Jones LB (2002) Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex. Schizophr Res 58:75\u201381","journal-title":"Schizophr Res"},{"key":"518_CR20","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S0006-3223(03)00114-8","volume":"53","author":"G Chana","year":"2003","unstructured":"Chana G, Landau S, Beasley C, Everall IP, Cotter D (2003) Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol Psychiatry 53:1086\u20131098","journal-title":"Biol Psychiatry"},{"key":"518_CR21","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1523\/JNEUROSCI.21-24-09917.2001","volume":"21","author":"P Celada","year":"2001","unstructured":"Celada P, Puig MV, Casanovas JM, Guillazo G, Artigas F (2001) Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: involvement of serotonin-1A, GABAA, and glutamate receptors. J Neurosci 21:9917\u20139929","journal-title":"J Neurosci"},{"key":"518_CR22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2990.2005.00598.x","volume":"31","author":"RM Craven","year":"2005","unstructured":"Craven RM, Priddle TH, Cooper SJ, Crow TJ, Esiri MM (2005) The dorsal raphe nucleus in schizophrenia: a post mortem study of 5-hydroxytryptamine neurones. Neuropathol Appl Neurobiol 31:258\u2013269","journal-title":"Neuropathol Appl Neurobiol"},{"key":"518_CR23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.schres.2008.06.011","volume":"104","author":"B Dean","year":"2008","unstructured":"Dean B, Crossland N, Boer S, Scarr E (2008) Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia. Schizophr Res 104:185\u2013197","journal-title":"Schizophr Res"},{"key":"518_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-012-2921-8","volume":"225","author":"A Bartolomeis de","year":"2013","unstructured":"de Bartolomeis A, Buonaguro EF, Iasevoli F (2013) Serotonin\u2013glutamate and serotonin\u2013dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins. Psychopharmacology 225:1\u201319","journal-title":"Psychopharmacology"},{"key":"518_CR25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0968-4328(99)00067-0","volume":"31","author":"M Derenzini","year":"2000","unstructured":"Derenzini M (2000) The AgNORs. Micron 31:117\u2013120","journal-title":"Micron"},{"key":"518_CR26","doi-asserted-by":"crossref","first-page":"9171","DOI":"10.1523\/JNEUROSCI.3040-05.2005","volume":"25","author":"Q Ding","year":"2005","unstructured":"Ding Q, Markesbery WR, Chen Q, Li F, Keller JN (2005) Ribosome dysfunction is an early event in Alzheimer\u2019s disease. J Neurosci 25:9171\u20139175","journal-title":"J Neurosci"},{"key":"518_CR27","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11064-006-9071-5","volume":"31","author":"Q Ding","year":"2006","unstructured":"Ding Q, Markesbery WR, Cecarini V, Keller JN (2006) Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer\u2019s disease. Neurochem Res 31:705\u2013710","journal-title":"Neurochem Res"},{"key":"518_CR28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1080\/10673220701679812","volume":"15","author":"WG Frankle","year":"2007","unstructured":"Frankle WG (2007) Neuroreceptor imaging studies in schizophrenia. Harv Rev Psychiatry 15:212\u2013232","journal-title":"Harv Rev Psychiatry"},{"key":"518_CR29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0047-6374(97)00054-7","volume":"97","author":"LM Garcia-Moreno","year":"1997","unstructured":"Garcia-Moreno LM, Cimadevilla JM, Gonzalez-Pardo H, Zahonero MC, Arias JL (1997) NOR activity in hippocampal areas during the postnatal development and ageing. Mech Ageing Dev 97:173\u2013181","journal-title":"Mech Ageing Dev"},{"key":"518_CR30","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1074\/jbc.M110.170134","volume":"286","author":"C Gomes","year":"2011","unstructured":"Gomes C, Smith SC, Youssef MN, Zheng JJ, Hagg T, Hetman M (2011) RNA polymerase 1-driven transcription as a mediator of BDNF-induced neurite outgrowth. J Biol Chem 286:4357\u20134363","journal-title":"J Biol Chem"},{"key":"518_CR31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainresbull.2008.11.012","volume":"78","author":"L Gon\u00e7alves","year":"2009","unstructured":"Gon\u00e7alves L, Nogueira MI, Shammah-Lognado SJ, Metzger M (2009) Prefrontal afferents to the dorsal raphe nucleus in the rat. Brain Res Bull 78:240\u2013247","journal-title":"Brain Res Bull"},{"key":"518_CR32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/15622970601169758","volume":"8","author":"T Gos","year":"2007","unstructured":"Gos T, Krell D, Brisch R, Bielau H, Tr\u00fcbner K, Bernstein HG, Bogerts B (2007) The changes of AgNOR parameters of anterior cingulate pyramidal neurons are region-specific in suicidal and non-suicidal depressive patients. World J Biol Psychiatry 8:245\u2013255","journal-title":"World J Biol Psychiatry"},{"key":"518_CR33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jad.2008.03.002","volume":"111","author":"T Gos","year":"2008","unstructured":"Gos T, Krell D, Brisch R, Bielau H, Tr\u00fcbner K, Steiner J, Bernstein HG, Bogerts B (2008) Demonstration of decreased activity of dorsal raphe nucleus neurons in depressed suicidal patients by the AgNOR staining method. J Affect Disord 111:251\u2013260","journal-title":"J Affect Disord"},{"key":"518_CR34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jad.2009.02.012","volume":"118","author":"T Gos","year":"2009","unstructured":"Gos T, Krell D, Bielau H, Steiner J, Mawrin C, Tr\u00fcbner K, Brisch R, Bernstein HG, Jankowski Z, Bogerts B (2009) Demonstration of disturbed activity of orbitofrontal pyramidal neurons in depressed patients by the AgNOR staining method. J Affect Disord 118:131\u2013138","journal-title":"J Affect Disord"},{"key":"518_CR35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jad.2009.03.010","volume":"119","author":"T Gos","year":"2009","unstructured":"Gos T, Krell D, Bielau H, Steiner J, Tr\u00fcbner K, Brisch R, Bernstein HG, Jankowski Z, Bogerts B (2009) Demonstration of disturbed activity of external globus pallidus projecting neurons in depressed patients by the AgNOR staining method. J Affect Disord 119:149\u2013155","journal-title":"J Affect Disord"},{"key":"518_CR36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jad.2010.04.006","volume":"126","author":"T Gos","year":"2010","unstructured":"Gos T, Krell D, Bielau H, Steiner J, Mawrin C, Tr\u00fcbner K, Brisch R, Bernstein HG, Jankowski Z, Bogerts B (2010) Demonstration of disturbed activity of the lateral amygdaloid nucleus projection neurons in depressed patients by the AgNOR staining method. J Affect Disord 126:402\u2013410","journal-title":"J Affect Disord"},{"key":"518_CR37","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.psychres.2013.02.017","volume":"210","author":"T Gos","year":"2013","unstructured":"Gos T, Steiner J, Krell D, Bielau H, Mawrin C, Krzy\u017canowski M, Brisch R, Pie\u015bniak D, Bernstein HG, Jankowski Z, Braun K, Bogerts B (2013) Ribosomal DNA transcription in the anterior cingulate cortex is decreased in unipolar but not bipolar depression. Psychiatry Res 210:338\u2013345","journal-title":"Psychiatry Res"},{"key":"518_CR38","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","volume":"96","author":"HJG Gundersen","year":"1988","unstructured":"Gundersen HJG, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, M\u00f8ller A, Nielsen K, Nyengaard JR, Pakkenberg B et al (1988) The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857\u2013881","journal-title":"APMIS"},{"key":"518_CR39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/brain\/122.4.593","volume":"122","author":"PJ Harrison","year":"1999","unstructured":"Harrison PJ (1999) The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain 122:593\u2013624","journal-title":"Brain"},{"key":"518_CR40","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.pnpbp.2009.02.013","volume":"33","author":"M Hayashida","year":"2009","unstructured":"Hayashida M, Miyaoka T, Tsuchie K, Yasuda H, Wake R, Nishida A, Inagaki T, Toga T, Nagami H, Oda T, Horiguchi J (2009) Hyperbilirubinemia-related behavioral and neuropathological changes in rats: a possible schizophrenia animal model. Prog Neuropsychopharmacol Biol Psychiatry 33:581\u2013588","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"518_CR41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/1359786810385490","volume":"24","author":"K Hor","year":"2010","unstructured":"Hor K, Taylor M (2010) Suicide and schizophrenia: a systematic review of rates and risk factors. J Psychopharmacol 24:81\u201390","journal-title":"J Psychopharmacol"},{"key":"518_CR42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","volume":"72","author":"BL Jacobs","year":"1992","unstructured":"Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72:165\u2013229","journal-title":"Physiol Rev"},{"key":"518_CR43","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1073\/pnas.95.2.735","volume":"95","author":"RL Jakab","year":"1998","unstructured":"Jakab RL, Goldman-Rakic PS (1998) 5-Hydroxytryptamine2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc Natl Acad Sci USA 95:735\u2013740","journal-title":"Proc Natl Acad Sci USA"},{"key":"518_CR44","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/cne.10976","volume":"468","author":"MP Jankowski","year":"2004","unstructured":"Jankowski MP, Sesack SR (2004) Prefrontal cortical projections to the rat dorsal raphe nucleus: ultrastructural features and associations with serotonin and \u03b3-aminobutyric acid neurons. J Comp Neurol 468:518\u2013529","journal-title":"J Comp Neurol"},{"key":"518_CR45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0006-8993(02)03841-6","volume":"963","author":"HS Lee","year":"2003","unstructured":"Lee HS, Kim MA, Valentino RJ, Waterhouse BD (2003) Glutamatergic afferent projections to the dorsal raphe nucleus of the rat. Brain Res 963:57\u201371","journal-title":"Brain Res"},{"key":"518_CR46","first-page":"387","volume":"11","author":"KG Lloyd","year":"1974","unstructured":"Lloyd KG, Farley IJ, Deck JHN, Horynkiewicz O (1974) Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv Biochem Psychopharmacol 11:387\u2013397","journal-title":"Adv Biochem Psychopharmacol"},{"key":"518_CR47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jad.2011.10.043","volume":"137","author":"PR Matthews","year":"2012","unstructured":"Matthews PR, Harrison PJ (2012) A morphometric, immunohistochemical, and in situ hybridization study of the dorsal raphe nucleus in major depression, bipolar disorder, schizophrenia, and suicide. J Affect Disord 137:125\u2013134","journal-title":"J Affect Disord"},{"key":"518_CR48","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2009.12.026","volume":"39","author":"PO McGowan","year":"2010","unstructured":"McGowan PO, Szyf M (2010) The epigenetics of social adversity in early life: implications for mental health outcomes. Neurobiol Dis 39:66\u201372","journal-title":"Neurobiol Dis"},{"key":"518_CR49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-3-642-25761-2_4","volume":"212","author":"HY Meltzer","year":"2012","unstructured":"Meltzer HY (2012) Serotonergic mechanisms as targets for existing and novel antipsychotics. Handb Exp Pharmacol 212:87\u2013124","journal-title":"Handb Exp Pharmacol"},{"key":"518_CR50","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0940-2993(11)80069-2","volume":"46","author":"HD Mennel","year":"1994","unstructured":"Mennel HD, M\u00fcller I (1994) Morphometric investigation on nuclear and nucleolar arrangement and AgNOR content in the rat hippocampus under normal and ischemic conditions. Exp Toxicol Pathol 46:491\u2013501","journal-title":"Exp Toxicol Pathol"},{"key":"518_CR51","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.euroneuro.2012.10.006","volume":"23","author":"C Muguruza","year":"2013","unstructured":"Muguruza C, Moreno JL, Umali A, Callado LF, Meana JJ, Gonz\u00e1lez-Maeso J (2013) Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects. Eur Neuropsychopharmacol 23:852\u2013864","journal-title":"Eur Neuropsychopharmacol"},{"key":"518_CR52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4522(97)00268-6","volume":"82","author":"C Peyron","year":"1998","unstructured":"Peyron C, Petit JM, Rampon C, Jouvet M, Luppi PH (1998) Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods. Neuroscience 82:443\u2013468","journal-title":"Neuroscience"},{"key":"518_CR53","doi-asserted-by":"crossref","first-page":"e22585","DOI":"10.1371\/journal.pone.0022585","volume":"6","author":"M Pietrzak","year":"2011","unstructured":"Pietrzak M, Rempala G, Nelson PT, Zheng JJ, Hetman M (2011) Epigenetic silencing of nucleolar rRNA genes in Alzheimer\u2019s disease. PLoS One 6:e22585","journal-title":"PLoS One"},{"key":"518_CR54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF01676192","volume":"18","author":"D Ploton","year":"1986","unstructured":"Ploton D, Menager M, Jeannesson P, Himber G, Pigeon F, Adnet JJ (1986) Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organiser region at the optical level. Histochem J 18:5\u201314","journal-title":"Histochem J"},{"key":"518_CR55","first-page":"14","volume":"14","author":"D Ploton","year":"1992","unstructured":"Ploton D, Visseaux-Coletto B, Canellas JC, Bourzat C, Adnet JJ, Lechki C, Bonnet N (1992) Semiautomatic quantification of silver-stained nucleolar organiser regions in tissue sections and cellular smears. Anal Quant Cytol Histol 14:14\u201323","journal-title":"Anal Quant Cytol Histol"},{"key":"518_CR56","first-page":"3","volume":"140","author":"D Ploton","year":"1994","unstructured":"Ploton D (1994) Structure and molecular organization of the nucleolus. Zentralbl Pathol 140:3\u20136","journal-title":"Zentralbl Pathol"},{"key":"518_CR57","first-page":"363","volume-title":"Histology and histopathology of nervous system","author":"M Polak","year":"1982","unstructured":"Polak M, Haymaker W, Johnson JE, D\u2019Amelio F (1982) Neuroglia and their reactions. In: Haymaker W, Adams RD (eds) Histology and histopathology of nervous system. Charles C. Thomas Publishing, Springfield, pp 363\u2013480"},{"key":"518_CR58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pscychresns.2010.05.008","volume":"183","author":"UW Preuss","year":"2010","unstructured":"Preuss UW, Zetzsche T, Pogarell O, Mulert C, Frodl T, M\u00fcller D, Schmidt G, Born C, Reiser M, M\u00f6ller HJ, Hegerl U, Meisenzahl EM (2010) Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms. Psychiatry Res 183:133\u2013139","journal-title":"Psychiatry Res"},{"key":"518_CR59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0074-7696(06)55004-1","volume":"255","author":"I Raska","year":"2006","unstructured":"Raska I, Shaw PJ, Cmarko D (2006) New insights into nucleolar architecture and activity. Int Rev Cytol 255:177\u2013235","journal-title":"Int Rev Cytol"},{"key":"518_CR60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1001\/archgenpsychiatry.2009.176","volume":"67","author":"H Rasmussen","year":"2010","unstructured":"Rasmussen H, Erritzoe D, Andersen R, Ebdrup BH, Aggernaes B, Oranje B, Kalbitzer J, Madsen J, Pinborg LH, Baar\u00e9 W, Svarer C, Lublin H, Knudsen GM, Glenthoj B (2010) Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia. Arch Gen Psychiatry 67:9\u201316","journal-title":"Arch Gen Psychiatry"},{"key":"518_CR61","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00004850-198904000-00001","volume":"4","author":"M-J Rey","year":"1989","unstructured":"Rey M-J, Schulz P, Costa C, Dick P, Tissot R (1989) Guidelines for the dosage of neuroleptics. I: chlorpromazine equivalents of orally administrated neuroleptics. Int Clin Psychopharmacol 4:95\u2013104","journal-title":"Int Clin Psychopharmacol"},{"key":"518_CR62","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00006676-199508000-00007","volume":"11","author":"J R\u00fcschoff","year":"1995","unstructured":"R\u00fcschoff J, Els\u00e4sser HP, Adler G (1995) Correlation of nucleolar organiser regions with secretory and regenerative process in experimental cerulein-induced pancreatitis in the rat. Pancreas 11:154\u2013159","journal-title":"Pancreas"},{"key":"518_CR63","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/archpsyc.57.5.471","volume":"57","author":"M Sanfilipo","year":"2000","unstructured":"Sanfilipo M, Lafargue T, Rusinek H, Arena L, Loneragan C, Lautin A, Feiner D, Rotrosen J, Wolkin A (2000) Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms. Arch Gen Psychiatry 57:471\u2013480","journal-title":"Arch Gen Psychiatry"},{"key":"518_CR64","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.tips.2007.10.009","volume":"28","author":"T Sharp","year":"2007","unstructured":"Sharp T, Boothman L, Raley J, Qu\u00e9r\u00e9e P (2007) Important messages in the \u2018post\u2019: recent discoveries in 5-HT neurone feedback control. Trends Pharmacol Sci 28:629\u2013636","journal-title":"Trends Pharmacol Sci"},{"key":"518_CR65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00418-007-0359-6","volume":"129","author":"V Sirri","year":"2008","unstructured":"Sirri V, Urcuqui-Inchima S, Roussel P, Hernandez-Verdun D (2008) Nucleolus: the fascinating nuclear body. Histochem Cell Biol 129:13\u201331","journal-title":"Histochem Cell Biol"},{"key":"518_CR66","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jchemneu.2011.04.004","volume":"41","author":"M Soiza-Reilly","year":"2011","unstructured":"Soiza-Reilly M, Commons KG (2011) Glutamatergic drive of the dorsal raphe nucleus. J Chem Neuroanat 41:247\u2013255","journal-title":"J Chem Neuroanat"},{"key":"518_CR67","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jpsychires.2007.10.001","volume":"42","author":"J Steiner","year":"2008","unstructured":"Steiner J, Bernstein HG, Bielau H, Farkas N, Winter J, Dobrowolny H, Brisch R, Gos T, Mawrin C, Myint AM, Bogerts B (2008) S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: a morphometric study. J Psychiatr Res 42:868\u2013876","journal-title":"J Psychiatr Res"},{"key":"518_CR68","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00406-014-0490-z","volume":"264","author":"J Steiner","year":"2014","unstructured":"Steiner J, Schmitt A, Schroeter ML, Bogerts B, Falkai P, Turck CW, Martins-de-Souza D (2014) S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum. Eur Arch Psychiatry Clin Neurosci 264:311\u2013316","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"518_CR69","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1523\/JNEUROSCI.18-18-07394.1998","volume":"18","author":"CA Stockmeier","year":"1998","unstructured":"Stockmeier CA, Shapiro LA, Dilley GE, Kolli TN, Friedman L, Rajkowska G (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18:7394\u20137401","journal-title":"J Neurosci"},{"key":"518_CR70","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.schres.2013.07.036","volume":"150","author":"M Takayanagi","year":"2013","unstructured":"Takayanagi M, Wentz J, Takayanagi Y, Schretlen DJ, Ceyhan E, Wang L, Suzuki M, Sawa A, Barta PE, Ratnanather JT, Cascella NG (2013) Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia. Schizophr Res 150:484\u2013490","journal-title":"Schizophr Res"},{"key":"518_CR71","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0006-3223(99)00043-8","volume":"46","author":"MD Underwood","year":"1999","unstructured":"Underwood MD, Khaibulina AA, Ellis SP, Moran A, Rice PM, Mann JJ, Arango V (1999) Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. Biol Psychiatry 46:473\u2013483","journal-title":"Biol Psychiatry"},{"key":"518_CR72","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0006-8993(93)90077-Z","volume":"624","author":"EJ Bockstaele Van","year":"1993","unstructured":"Van Bockstaele EJ, Biswas A, Pickel VM (1993) Topography of serotonin neurons in the dorsal raphe nucleus that send axon collaterals to the rat prefrontal cortex and nucleus accumbens. Brain Res 624:188\u2013198","journal-title":"Brain Res"},{"key":"518_CR73","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0306-4522(01)00294-9","volume":"106","author":"V Varga","year":"2001","unstructured":"Varga V, Sz\u00e9kely AD, Csillag A, Sharp T, Haj\u00f3s M (2001) Evidence for a role of GABA interneurons in the cortical modulation of midbrain 5-hydroxytryptamine neurones. Neuroscience 106:783\u2013792","journal-title":"Neuroscience"},{"key":"518_CR74","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1460-9568.2003.02465.x","volume":"17","author":"V Varga","year":"2003","unstructured":"Varga V, Kocsis B, Sharp T (2003) Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus. Eur J Neurosci 17:280\u2013286","journal-title":"Eur J Neurosci"},{"key":"518_CR75","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jchemneu.2011.05.008","volume":"41","author":"RK Vasudeva","year":"2011","unstructured":"Vasudeva RK, Lin RC, Simpson KL, Waterhouse BD (2011) Functional organization of the dorsal raphe efferent system with special consideration of nitrergic cell groups. J Chem Neuroanat 41:281\u2013293","journal-title":"J Chem Neuroanat"},{"key":"518_CR76","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/cercor\/bhn204","volume":"19","author":"P V\u00e1zquez-Borsetti","year":"2009","unstructured":"V\u00e1zquez-Borsetti P, Cort\u00e9s R, Artigas F (2009) Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors. Cereb Cortex 19:1678\u20131686","journal-title":"Cereb Cortex"},{"key":"518_CR77","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A","volume":"27","author":"DL Willins","year":"1997","unstructured":"Willins DL, Deutch AY, Roth BL (1997) Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse 27:79\u201382","journal-title":"Synapse"},{"key":"518_CR78","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0306-4522(91)90077-2","volume":"44","author":"MA Wilson","year":"1991","unstructured":"Wilson MA, Molliver ME (1991) The organization of serotonergic projections to cerebral cortex in primates: retrograde transport studies. Neuroscience 44:555\u2013570","journal-title":"Neuroscience"},{"key":"518_CR79","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.88.22.10037","volume":"88","author":"F Zafra","year":"1991","unstructured":"Zafra F, Castrene E, Thoenen H, Lindholm D (1991) Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons. Proc Natl Acad Sci USA 88:10037\u201310041","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00406-014-0518-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-014-0518-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-014-0518-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T15:21:35Z","timestamp":1649863295000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00406-014-0518-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["518"],"URL":"https:\/\/doi.org\/10.1007\/s00406-014-0518-4","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]}}}