{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T21:27:09Z","timestamp":1784669229727,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T00:00:00Z","timestamp":1500076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01GV0615"],"award-info":[{"award-number":["01GV0615"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00406-017-0823-9","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T16:19:18Z","timestamp":1500135558000},"page":"161-170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Does prior traumatization affect the treatment outcome of CBT for panic disorder? The potential role of the MAOA gene and depression symptoms"],"prefix":"10.1007","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-3244","authenticated-orcid":false,"given":"Sebastian","family":"Trautmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Muehlhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"H\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"Wittchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Domschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Str\u00f6hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfons O.","family":"Hamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Kircher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Arolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander L.","family":"Gerlach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg W.","family":"Alpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fydrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,15]]},"reference":[{"issue":"3","key":"823_CR1","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/mpr.1439","volume":"23","author":"F Jacobi","year":"2014","unstructured":"Jacobi F, H\u00f6fler M, Siegert J et al (2014) Twelve-month prevalence, comorbidity and correlates of mental disorders in Germany: the Mental Health Module of the German Health Interview and Examination Survey for Adults (DEGS1-MH). Int J Methods Psychiatr Res 23(3):304\u2013319","journal-title":"Int J Methods Psychiatr Res"},{"issue":"6","key":"823_CR2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","volume":"62","author":"RC Kessler","year":"2005","unstructured":"Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62(6):617\u2013627","journal-title":"Arch Gen Psychiatry"},{"issue":"9","key":"823_CR3","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","volume":"21","author":"HU Wittchen","year":"2011","unstructured":"Wittchen HU, Jacobi F, Rehm J et al (2011) The size and burden of mental disorders and other disorders of the brain in Europe. Eur Neuropsychopharmacol 21(9):655\u2013679","journal-title":"Eur Neuropsychopharmacol"},{"issue":"Suppl 1","key":"823_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1468-1331.2005.01196.x","volume":"12","author":"P Andlin-Sobocki","year":"2005","unstructured":"Andlin-Sobocki P, Wittchen H-U (2005) Cost of anxiety disorders in Europe. Eur J Neurol 12(Suppl 1):39\u201344","journal-title":"Eur J Neurol"},{"issue":"4","key":"823_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.4088\/JCP.v69n0415","volume":"69","author":"SG Hofmann","year":"2008","unstructured":"Hofmann SG, Smits JAJ (2008) Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry 69(4):621\u2013632","journal-title":"J Clin Psychiatry"},{"key":"823_CR6","doi-asserted-by":"publisher","unstructured":"James AC, James G, Cowdrey FA, Soler A, Choke A (2013) Cognitive behavioural therapy for anxiety disorders in children and adolescents. Cochrane Database Syst Rev. doi: 10.1002\/14651858.CD004690.pub4","DOI":"10.1002\/14651858.CD004690.pub4"},{"key":"823_CR7","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.cpr.2015.08.004","volume":"42","author":"AG Loerinc","year":"2015","unstructured":"Loerinc AG, Meuret AE, Twohig MP, Rosenfield D, Bluett EJ, Craske MG (2015) Response rates for CBT for anxiety disorders: need for standardized criteria. Clin Psychol Rev 42:72\u201382","journal-title":"Clin Psychol Rev"},{"issue":"3","key":"823_CR8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.psc.2009.05.001","volume":"32","author":"JJ Arch","year":"2009","unstructured":"Arch JJ, Craske MG (2009) First-line treatment: a critical appraisal of cognitive behavioral therapy developments and alternatives. Psychiatr Clin North Am 32(3):525\u2013547","journal-title":"Psychiatr Clin North Am"},{"issue":"1","key":"823_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/YCO.0b013e3283345dc5","volume":"23","author":"J Laugharne","year":"2010","unstructured":"Laugharne J, Lillee A, Janca A (2010) Role of psychological trauma in the cause and treatment of anxiety and depressive disorders. Curr Opin Psychiatry 23(1):25\u201329","journal-title":"Curr Opin Psychiatry"},{"issue":"2","key":"823_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/da.20786","volume":"28","author":"RA Bryant","year":"2011","unstructured":"Bryant RA (2011) Mental disorders and traumatic injury. Depress Anxiety 28(2):99\u2013102","journal-title":"Depress Anxiety"},{"issue":"12","key":"823_CR11","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1097\/NMD.0000000000000049","volume":"201","author":"CP Carr","year":"2013","unstructured":"Carr CP, Martins CMS, Stingel AM, Lemgruber VB, Juruena MF (2013) The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J Nerv Ment Dis 201(12):1007\u20131020","journal-title":"J Nerv Ment Dis"},{"issue":"6","key":"823_CR12","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.eurpsy.2015.06.004","volume":"30","author":"V Fernandes","year":"2015","unstructured":"Fernandes V, Os\u00f3rio FL (2015) Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis. Eur Psychiatry 30(6):756\u2013764","journal-title":"Eur Psychiatry"},{"issue":"10","key":"823_CR13","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1176\/appi.ajp.2013.12070957","volume":"170","author":"MH Teicher","year":"2013","unstructured":"Teicher MH, Samson JA (2013) Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. Am J Psychiatry 170(10):1114\u20131133","journal-title":"Am J Psychiatry"},{"issue":"5","key":"823_CR14","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.neuron.2016.01.019","volume":"89","author":"CB Nemeroff","year":"2016","unstructured":"Nemeroff CB (2016) Paradise lost: the neurobiological and clinical consequences of child abuse and neglect. Neuron 89(5):892\u2013909","journal-title":"Neuron"},{"issue":"2","key":"823_CR15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.chc.2014.01.002","volume":"23","author":"MD Bellis De","year":"2014","unstructured":"De Bellis MD, Zisk A (2014) The biological effects of childhood trauma. Child Adolesc Psychiatr Clin N Am 23(2):185\u2013222","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"1","key":"823_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/j.2051-5545.2010.tb00254.x","volume":"9","author":"AC McFarlane","year":"2010","unstructured":"McFarlane AC (2010) The long-term costs of traumatic stress: intertwined physical and psychological consequences. World Psychiatry 9(1):3\u201310","journal-title":"World Psychiatry"},{"issue":"2","key":"823_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1176\/appi.ajp.2011.11020335","volume":"169","author":"V Nanni","year":"2012","unstructured":"Nanni V, Uher R, Danese A (2012) Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 169(2):141\u2013151","journal-title":"Am J Psychiatry"},{"issue":"6","key":"823_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1080\/10503307.2013.874053","volume":"24","author":"MI Berman","year":"2014","unstructured":"Berman MI, Hegel MT (2014) Predicting depression outcome in mental health treatment: a recursive partitioning analysis. Psychother Res J Soc Psychother Res 24(6):675\u2013686","journal-title":"Psychother Res J Soc Psychother Res"},{"issue":"24","key":"823_CR19","doi-asserted-by":"publisher","first-page":"14293","DOI":"10.1073\/pnas.2336126100","volume":"100","author":"CB Nemeroff","year":"2003","unstructured":"Nemeroff CB, Heim CM, Thase ME et al (2003) Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proc Natl Acad Sci 100(24):14293\u201314296","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"823_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1891\/jcop.20.1.7","volume":"20","author":"LE Alden","year":"2006","unstructured":"Alden LE, Taylor CT, Laposa JM, Mellings TMB (2006) Impact of social developmental experiences on cognitive-behavioral therapy for generalized social phobia. J Cogn Psychother 20(1):7\u201316","journal-title":"J Cogn Psychother"},{"issue":"7","key":"823_CR21","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1002\/da.22112","volume":"30","author":"LC Bruce","year":"2013","unstructured":"Bruce LC, Heimberg RG, Goldin PR, Gross JJ (2013) Childhood maltreatment and response to cognitive behavioral therapy among individuals with social anxiety disorder. Depress Anxiety 30(7):662\u2013669","journal-title":"Depress Anxiety"},{"issue":"2","key":"823_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/da.20909","volume":"29","author":"LC Bruce","year":"2012","unstructured":"Bruce LC, Heimberg RG, Blanco C, Schneier FR, Liebowitz MR (2012) Childhood maltreatment and social anxiety disorder: implications for symptom severity and response to pharmacotherapy. Depress Anxiety 29(2):131\u2013138","journal-title":"Depress Anxiety"},{"issue":"2","key":"823_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.eurpsy.2006.09.009","volume":"22","author":"L Kipper","year":"2007","unstructured":"Kipper L, Blaya C, Wachleski C et al (2007) Trauma and defense style as response predictors of pharmacological treatment in panic patients. Eur Psychiatry 22(2):87\u201391","journal-title":"Eur Psychiatry"},{"issue":"2","key":"823_CR24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s10862-012-9327-0","volume":"35","author":"J Bomyea","year":"2013","unstructured":"Bomyea J, Lang AJ, Golinelli D et al (2013) Trauma exposure in anxious primary care patients. J Psychopathol Behav Assess 35(2):254\u2013263","journal-title":"J Psychopathol Behav Assess"},{"issue":"7","key":"823_CR25","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1017\/S0033291713002286","volume":"44","author":"EJ Wolf","year":"2014","unstructured":"Wolf EJ, Mitchell KS, Koenen KC, Miller MW (2014) Combat exposure severity as a moderator of genetic and environmental liability to post-traumatic stress disorder. Psychol Med 44(7):1499\u20131509","journal-title":"Psychol Med"},{"issue":"3","key":"823_CR26","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.drugalcdep.2010.10.024","volume":"115","author":"WE Copeland","year":"2011","unstructured":"Copeland WE, Magnusson A, Goransson M, Heilig MA (2011) Genetic moderators and psychiatric mediators of the link between sexual abuse and alcohol dependence. Drug Alcohol Depend 115(3):183\u2013189","journal-title":"Drug Alcohol Depend"},{"issue":"5","key":"823_CR27","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.biopsych.2006.10.017","volume":"62","author":"J Savitz","year":"2007","unstructured":"Savitz J, van der Merwe L, Stein DJ, Solms M, Ramesar R (2007) Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variants. Biol Psychiatry 62(5):391\u2013399","journal-title":"Biol Psychiatry"},{"issue":"3","key":"823_CR28","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1601-183X.2007.00354.x","volume":"7","author":"N Perroud","year":"2008","unstructured":"Perroud N, Courtet P, Vincze I et al (2008) Interaction between BDNF Val66Met and childhood trauma on adult\u2019s violent suicide attempt. Genes Brain Behav 7(3):314\u2013322","journal-title":"Genes Brain Behav"},{"issue":"4","key":"823_CR29","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1001\/2013.jamapsychiatry.188","volume":"70","author":"I Wald","year":"2013","unstructured":"Wald I, Degnan KA, Gorodetsky E et al (2013) Attention to threats and combat-related posttraumatic stress symptoms: prospective associations and moderation by the serotonin transporter gene. JAMA Psychiatry 70(4):401\u2013408","journal-title":"JAMA Psychiatry"},{"issue":"7","key":"823_CR30","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1002\/ajmg.b.32085","volume":"159B","author":"A Reif","year":"2012","unstructured":"Reif A, Weber H, Domschke K et al (2012) Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations. Am J Med Genet B Neuropsychiatr Genet 159B(7):786\u2013793","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"11","key":"823_CR31","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1001\/archpsyc.63.11.1209","volume":"63","author":"JH Meyer","year":"2006","unstructured":"Meyer JH, Ginovart N, Boovariwala A et al (2006) Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry 63(11):1209\u20131216","journal-title":"Arch Gen Psychiatry"},{"issue":"4","key":"823_CR32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/hmg\/8.4.621","volume":"8","author":"J Deckert","year":"1999","unstructured":"Deckert J, Catalano M, Syagailo YV et al (1999) Excess of high activity monoamine oxidase A gene promoter alleles in female patients with panic disorder. Hum Mol Genet 8(4):621\u2013624","journal-title":"Hum Mol Genet"},{"issue":"2","key":"823_CR33","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1017\/S1461145704004985","volume":"8","author":"E Maron","year":"2005","unstructured":"Maron E, Lang A, Tasa G et al (2005) Associations between serotonin-related gene polymorphisms and panic disorder. Int J Neuropsychopharmaco. 8(2):261\u2013266","journal-title":"Int J Neuropsychopharmaco."},{"issue":"1","key":"823_CR34","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.psychres.2004.05.012","volume":"128","author":"J Samochowiec","year":"2004","unstructured":"Samochowiec J, Hajduk A, Samochowiec A et al (2004) Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum. Psychiatry Res 128(1):21\u201326","journal-title":"Psychiatry Res"},{"key":"823_CR35","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/mp.2015.138","volume":"21","author":"AS Howe","year":"2015","unstructured":"Howe AS, Buttensch\u00f8n HN, Bani-Fatemi A et al. (2015) Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. Mol Psychiatry 21:665\u2013679","journal-title":"Mol Psychiatry"},{"issue":"5","key":"823_CR36","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/sj.mp.4000772","volume":"5","author":"SP Hamilton","year":"2000","unstructured":"Hamilton SP, Slager SL, Heiman GA et al (2000) No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase-A gene and panic disorder. Mol Psychiatry 5(5):465\u2013466","journal-title":"Mol Psychiatry"},{"issue":"1","key":"823_CR37","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/mp.2012.172","volume":"19","author":"A Reif","year":"2014","unstructured":"Reif A, Richter J, Straube B et al (2014) MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy. Mol Psychiatry 19(1):122\u2013128","journal-title":"Mol Psychiatry"},{"issue":"7","key":"823_CR38","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1017\/S1461145713000102","volume":"16","author":"PA Melas","year":"2013","unstructured":"Melas PA, Wei Y, Wong CCY et al (2013) Genetic and epigenetic associations of MAOA and NR3C1 with depression and childhood adversities. Int J Neuropsychopharmacol 16(7):1513\u20131528","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"823_CR39","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/sj.mp.4002034","volume":"13","author":"F Ducci","year":"2008","unstructured":"Ducci F, Enoch M-A, Hodgkinson C et al (2008) Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13(3):334\u2013347","journal-title":"Mol Psychiatry"},{"issue":"3","key":"823_CR40","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1037\/a0023584","volume":"79","author":"AT Gloster","year":"2011","unstructured":"Gloster AT, Wittchen H-U, Einsle F et al (2011) Psychological treatment for panic disorder with agoraphobia: a randomized controlled trial to examine the role of therapist-guided exposure in situ in CBT. J Consult Clin Psychol 79(3):406\u2013420","journal-title":"J Consult Clin Psychol"},{"issue":"Suppl 2","key":"823_CR41","doi-asserted-by":"publisher","first-page":"S155","DOI":"10.1007\/s00406-009-0065-6","volume":"259","author":"AT Gloster","year":"2009","unstructured":"Gloster AT, Wittchen HU, Einsle F et al (2009) Mechanism of action in CBT (MAC): methods of a multi-center randomized controlled trial in 369 patients with panic disorder and agoraphobia. Eur Arch Psychiatry Clin Neurosc. 259(Suppl 2):S155\u2013S166","journal-title":"Eur Arch Psychiatry Clin Neurosc."},{"key":"823_CR42","unstructured":"Wittchen H-U, Pfister H (1997) DIA-X-Interviews: Manual F\u00fcr Screening-Verfahren Und Interview; Interviewheft L\u00e4ngsschnittuntersuchung (DIA-X-Lifetime); Erg\u00e4nzungsheft (DIA-X-Lifetime); Interviewheft Querschnittuntersuchung (DIA-X-Monate); Erg\u00e4nzungsheft (DIA-X-Monate); PC-Programm Zur Durchf\u00fchrung Des Interviews (L\u00e4ngs- Und Querschnittuntersuchung); Auswertungsprogramm. Swets and Zeitlinger, Frankfurt"},{"issue":"4","key":"823_CR43","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/da.1033","volume":"13","author":"MK Shear","year":"2001","unstructured":"Shear MK, Vander Bilt J, Rucci P et al (2001) Reliability and validity of a structured interview guide for the Hamilton Anxiety Rating Scale (SIGH-A). Depress Anxiety 13(4):166\u2013178","journal-title":"Depress Anxiety"},{"key":"823_CR44","first-page":"218","volume":"338","author":"W Guy","year":"1976","unstructured":"Guy W (1976) Clinical global impression scale. ECDEU Assess Man Psychopharmacol 338:218\u2013222","journal-title":"ECDEU Assess Man Psychopharmacol"},{"key":"823_CR45","volume-title":"Panic and Agoraphobia Scale (PAS)","author":"B Bandelow","year":"1999","unstructured":"Bandelow B (1999) Panic and Agoraphobia Scale (PAS), vol iii. Hogrefe & Huber, Ashland"},{"issue":"1","key":"823_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0005-7967(85)90140-8","volume":"23","author":"DL Chambless","year":"1985","unstructured":"Chambless DL, Caputo GC, Jasin SE, Gracely EJ, Williams C (1985) The mobility inventory for agoraphobia. Behav Res Ther 23(1):35\u201344","journal-title":"Behav Res Ther"},{"key":"823_CR47","unstructured":"Hautzinger M, Keller F, K\u00fchner C (2006) BDI-II Beck-depressions-inventar. Franfurt Am Main: Harcourt Test Services"},{"issue":"6","key":"823_CR48","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.biopsych.2012.03.035","volume":"72","author":"J Richter","year":"2012","unstructured":"Richter J, Hamm AO, Pan\u00e9-Farr\u00e9 CA et al (2012) Dynamics of defensive reactivity in patients with panic disorder and agoraphobia: implications for the etiology of panic disorder. Biol Psychiatry 72(6):512\u2013520","journal-title":"Biol Psychiatry"},{"issue":"3","key":"823_CR49","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/psyp.12553","volume":"53","author":"AO Hamm","year":"2016","unstructured":"Hamm AO, Richter J, Pan\u00e9-Farr\u00e9 C et al (2016) Panic disorder with agoraphobia from a behavioral neuroscience perspective: applying the research principles formulated by the Research Domain Criteria (RDoC) initiative. Psychophysiology 53(3):312\u2013322","journal-title":"Psychophysiology"},{"issue":"2","key":"823_CR50","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2307\/1403146","volume":"54","author":"R Royall","year":"1986","unstructured":"Royall R (1986) Model robust confidence-intervals using maximum-likelihood estimators. Int Stat Rev 54(2):221\u2013226","journal-title":"Int Stat Rev"},{"key":"823_CR51","unstructured":"Stata Corp (2012) Stata Statistical Software: Release 12.1. Stata Corporation"},{"issue":"2","key":"823_CR52","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3109\/08039480903426929","volume":"64","author":"A Eskildsen","year":"2010","unstructured":"Eskildsen A, Hougaard E, Rosenberg NK (2010) Pre-treatment patient variables as predictors of drop-out and treatment outcome in cognitive behavioural therapy for social phobia: a systematic review. Nord J Psychiatry 64(2):94\u2013105","journal-title":"Nord J Psychiatry"},{"issue":"3","key":"823_CR53","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000335246","volume":"81","author":"A Emmrich","year":"2012","unstructured":"Emmrich A, Beesdo-Baum K, Gloster AT et al (2012) Depression does not affect the treatment outcome of CBT for panic and agoraphobia: results from a multicenter randomized trial. Psychother Psychosom 81(3):161\u2013172","journal-title":"Psychother Psychosom"},{"issue":"1","key":"823_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2009.11.025","volume":"208","author":"D Mueller","year":"2010","unstructured":"Mueller D, Cahill SP (2010) Noradrenergic modulation of extinction learning and exposure therapy. Behav Brain Res 208(1):1\u201311","journal-title":"Behav Brain Res"},{"key":"823_CR55","doi-asserted-by":"publisher","unstructured":"Homberg JR (2012) Serotonergic modulation of conditioned fear. Scientifica. doi: 10.6064\/2012\/821549","DOI":"10.6064\/2012\/821549"},{"issue":"1","key":"823_CR56","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0091-3057(95)02135-3","volume":"54","author":"FG Graeff","year":"1996","unstructured":"Graeff FG, Guimar\u00e3es FS, De Andrade TG, Deakin JF (1996) Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 54(1):129\u2013141","journal-title":"Pharmacol Biochem Behav"},{"issue":"1","key":"823_CR57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2201\/nonlin.003.01.002","volume":"3","author":"E Baldi","year":"2005","unstructured":"Baldi E, Bucherelli C (2005) The inverted \u201cU-Shaped\u201d dose-effect relationships in learning and memory: modulation of arousal and consolidation. Nonlinearity Biol Toxicol Med 3(1):9\u201321","journal-title":"Nonlinearity Biol Toxicol Med"},{"issue":"3","key":"823_CR58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.31887\/DCNS.2011.13.2\/jsherin","volume":"13","author":"JE Sherin","year":"2011","unstructured":"Sherin JE, Nemeroff CB (2011) Post-traumatic stress disorder: the neurobiological impact of psychological trauma. Dialogues Clin Neurosci 13(3):263\u2013278","journal-title":"Dialogues Clin Neurosci"},{"issue":"1","key":"823_CR59","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","volume":"42","author":"CW Berridge","year":"2003","unstructured":"Berridge CW, Waterhouse BD (2003) The locus coeruleus\u2013noradrenergic system: modulation of behavioral state and state-dependent cognitive processes. Brain Res Rev 42(1):33\u201384","journal-title":"Brain Res Rev"},{"issue":"5","key":"823_CR60","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.brat.2004.04.004","volume":"43","author":"BP Marx","year":"2005","unstructured":"Marx BP, Sloan DM (2005) Peritraumatic dissociation and experiential avoidance as predictors of posttraumatic stress symptomatology. Behav Res Ther 43(5):569\u2013583","journal-title":"Behav Res Ther"},{"issue":"5","key":"823_CR61","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10608-008-9225-7","volume":"33","author":"RM Merwin","year":"2008","unstructured":"Merwin RM, Rosenthal MZ, Coffey KA (2008) Experiential avoidance mediates the relationship between sexual victimization and psychological symptoms: replicating findings with an ethnically diverse sample. Cogn Ther Res 33(5):537\u2013542","journal-title":"Cogn Ther Res"},{"key":"823_CR62","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3389\/fnbeh.2014.00279","volume":"8","author":"M Costanzi","year":"2014","unstructured":"Costanzi M, Saraulli D, Cannas S et al (2014) Fear but not fright: re-evaluating traumatic experience attenuates anxiety-like behaviors after fear conditioning. Front Behav Neurosci 8:279","journal-title":"Front Behav Neurosci"},{"issue":"4","key":"823_CR63","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/da.21891","volume":"29","author":"LM McTeague","year":"2012","unstructured":"McTeague LM, Lang PJ (2012) The anxiety sprectrum and the reflex physiology of defense: from circumscribed fear to broad distress. Depress Anxiety 29(4):264\u2013281","journal-title":"Depress Anxiety"},{"issue":"3","key":"823_CR64","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/psyp.12462","volume":"53","author":"PJ Lang","year":"2016","unstructured":"Lang PJ, McTeague LM, Bradley MM (2016) RDoC, DSM, and the reflex physiology of fear: a biodimensional analysis of the anxiety disorders spectrum. Psychophysiology 53(3):336\u2013347","journal-title":"Psychophysiology"},{"issue":"3","key":"823_CR65","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1375\/bech.23.3.165","volume":"23","author":"G Cribb","year":"2006","unstructured":"Cribb G, Moulds ML, Carter S (2006) Rumination and experiential avoidance in depression. Behav Change 23(3):165\u2013176","journal-title":"Behav Change"},{"issue":"3","key":"823_CR66","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.paid.2012.03.018","volume":"53","author":"T Brockmeyer","year":"2012","unstructured":"Brockmeyer T, Holtforth MG, Pfeiffer N, Backenstrass M, Friederich H-C, Bents H (2012) Mood regulation expectancies and emotion avoidance in depression vulnerability. Personal Individ Differ 53(3):351\u2013354","journal-title":"Personal Individ Differ"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-017-0823-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00406-017-0823-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-017-0823-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T01:19:03Z","timestamp":1659230343000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00406-017-0823-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,15]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["823"],"URL":"https:\/\/doi.org\/10.1007\/s00406-017-0823-9","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,15]]},"assertion":[{"value":"1 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All participants provided informed consent. The study protocol was approved by the Ethics Committee of the Medical Faculty of the Technische Universit\u00e4t Dresden (EK164082006).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"HUW has served as a general consultant (non-product related) for Lundbeck.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}