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Often IPCBs are stigmatized being unwilling or unable to accept help. Separated physical and mental healthcare systems hamper integrated acute care for IPCBs. This pilot aimed to substantiate the physical, psychiatric, and social health needs of IPCBs visiting the emergency room (ER) during a 3-month period. All ER visits were screened. After triage by the ER physician, indicated IPCBs were additionally assessed by the consultation\u2013liaison\u2013psychiatry physician. If needed, IPCBs were admitted to a complexity intervention unit for further examinations to provide integrated treatments and appropriate follow-up care. The INTERMED and Health of the Nation Outcome Scale (HoNOS) questionnaires were used to substantiate the complexity and needs. Field-relevant stakeholders were interviewed about this approach for acute integrated care. Alongside substance abuse, almost half of identified IPCBs suffered from comorbid psychiatric disturbances and one third showed substantial physical conditions requiring immediate medical intervention. Almost all IPCBs (96%) accepted the acute medical care voluntarily. IPCBs showed high mean initial scores of INTERMED (27.8\u2009\u00b1\u200910.0) and HoNOS (20.8\u2009\u00b1\u20096.9). At discharge from the complexity intervention unit, the mean HoNOS score decreased significantly (13.4\u2009\u00b1\u20098.6;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Field-relevant stakeholders strongly supported the interdisciplinary approach and ER-facility for IPCBs and acknowledged their unmet health needs. A biopsychosocial assessment at the ER, followed by a short admission if necessary, is effective in IPCBs. This approach helps to merge separated healthcare systems and may reduce stigmatization of IPCBs needing help.\n                  <\/jats:p>","DOI":"10.1007\/s00406-020-01162-7","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T08:02:22Z","timestamp":1594540942000},"page":"903-913","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intoxicated persons showing challenging behavior demand complexity interventions: a pilot study at the interface of the ER and the complexity intervention unit"],"prefix":"10.1007","volume":"271","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-8216","authenticated-orcid":false,"given":"Stefan M. 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Therefore, in accordance with Dutch law, informed consent and consultation with a medical ethical committee was not needed. This was confirmed by a formal letter from the local Medical Research Ethics Committee (CMO region Arnhem-Nijmegen, NL).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Statistical analyses were performed in R version 3.4.1 (R Core Team, 2017; https:\/\/www.R-project.org\/). Data regarding the qualitative research were analyzed using ATLAS.ti version 8.2.4 (Scientific Software Development GmbH, Berlin, DE).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}