{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:09:01Z","timestamp":1784891341641,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s00406-021-01267-7","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T10:03:22Z","timestamp":1619690602000},"page":"541-556","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016\u20132020) systematic review of preclinical and human studies"],"prefix":"10.1007","volume":"272","author":[{"given":"Lucas Silva","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordano Novak","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Mendes","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via","family":"L Os\u00f3rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Bouso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E. Cec\u00edlio","family":"Hallak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-4745","authenticated-orcid":false,"given":"Rafael G.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"1267_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev.clinpsy.3.022806.091455","volume":"3","author":"TH Brandon","year":"2007","unstructured":"Brandon TH, Vidrine JI, Litvin EB (2007) Relapse and relapse prevention. Annu Rev Clin Psychol 3:257\u2013284. https:\/\/doi.org\/10.1146\/annurev.clinpsy.3.022806.091455","journal-title":"Annu Rev Clin Psychol"},{"key":"1267_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev.psych.59.103006.093548","volume":"59","author":"GF Koob","year":"2008","unstructured":"Koob GF, Le Moal M (2008) Addiction and the brain antireward system. Annu Rev Psychol 59:29\u201353. https:\/\/doi.org\/10.1146\/annurev.psych.59.103006.093548","journal-title":"Annu Rev Psychol"},{"key":"1267_CR3","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/S2215-0366(18)30337-7","volume":"5","author":"BD 2016 Alcohol and Drug Use Collaborators","year":"2018","unstructured":"BD 2016 Alcohol and Drug Use Collaborators (2018) The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Psychiatry 5:987\u20131012. https:\/\/doi.org\/10.1016\/S2215-0366(18)30337-7","journal-title":"Lancet Psychiatry"},{"key":"1267_CR4","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.3390\/ijerph17072610","volume":"17","author":"TW Lo","year":"2020","unstructured":"Lo TW, Yeung JWK, Tam CHL (2020) Substance abuse and public health: a multilevel perspective and multiple responses. Int J Environ Res Public Health 17:2610. https:\/\/doi.org\/10.3390\/ijerph17072610","journal-title":"Int J Environ Res Public Health"},{"key":"1267_CR5","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1177\/0269881115581980","volume":"29","author":"J van Amsterdam","year":"2015","unstructured":"van Amsterdam J, Nutt D, Phillips L, van den Brink W (2015) European rating of drug harms. J Psychopharmacol 29:655\u2013660. https:\/\/doi.org\/10.1177\/0269881115581980","journal-title":"J Psychopharmacol"},{"key":"1267_CR6","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.euroneuro.2016.05.001","volume":"26","author":"A Rickli","year":"2016","unstructured":"Rickli A, Moning OD, Hoener MC, Liechti ME (2016) Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens. Eur Neuropsychopharmacol 26:1327\u20131337","journal-title":"Eur Neuropsychopharmacol"},{"key":"1267_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.04.053","author":"RG Dos Santos","year":"2019","unstructured":"Dos Santos RG, Hallak JEC (2019) Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience. Epilepsy Behav. https:\/\/doi.org\/10.1016\/j.yebeh.2019.04.053","journal-title":"Epilepsy Behav"},{"key":"1267_CR8","doi-asserted-by":"publisher","first-page":"e0118143","DOI":"10.1371\/journal.pone.0118143","volume":"10","author":"F Palhano-Fontes","year":"2015","unstructured":"Palhano-Fontes F, Andrade KC, Tofoli LF, Santos AC, Crippa JA, Hallak JE, Ribeiro S, de Araujo DB (2015) The psychedelic state induced by ayahuasca modulates the activity and connectivity of the default mode network. PLoS One 10:e0118143. https:\/\/doi.org\/10.1371\/journal.pone.0118143","journal-title":"PLoS One"},{"key":"1267_CR9","doi-asserted-by":"publisher","first-page":"204512531984577","DOI":"10.1177\/2045125319845774","volume":"9","author":"JM Rocha","year":"2019","unstructured":"Rocha JM, Os\u00f3rio FL, Crippa JAS, Bouso JC, Rossi GN, Hallak JEC, Dos Santos RG (2019) Serotonergic hallucinogens and recognition of facial emotion expressions: a systematic review of the literature. Ther Adv Psychopharmacol 9:2045125319845774. https:\/\/doi.org\/10.1177\/2045125319845774","journal-title":"Ther Adv Psychopharmacol"},{"key":"1267_CR10","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1177\/0022167816673493","volume":"57","author":"MP Bogenschutz","year":"2017","unstructured":"Bogenschutz MP, Forcehimes AA (2017) Development of a psychotherapeutic model for psilocybin-assisted treatment of alcoholism. J Humanistic Psychol 57:389\u2013414. https:\/\/doi.org\/10.1177\/0022167816673493","journal-title":"J Humanistic Psychol"},{"key":"1267_CR11","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1177\/0269881112439253","volume":"26","author":"TS Krebs","year":"2012","unstructured":"Krebs TS, Johansen P\u00d8 (2012) Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials. J Psychopharmacol 26:994\u20131002. https:\/\/doi.org\/10.1177\/0269881112439253","journal-title":"J Psychopharmacol"},{"key":"1267_CR12","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1177\/0269881114548296","volume":"28","author":"MW Johnson","year":"2014","unstructured":"Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR (2014) Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction. J Psychopharmacol 28:983\u2013992. https:\/\/doi.org\/10.1177\/0269881114548296","journal-title":"J Psychopharmacol"},{"key":"1267_CR13","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1177\/0269881118780612","volume":"32","author":"T Noorani","year":"2018","unstructured":"Noorani T, Garcia-Romeu A, Swift TC, Griffiths RR, Johnson MW (2018) Psychedelic therapy for smoking cessation: qualitative analysis of participant accounts. J Psychopharmacol 32:756\u2013769. https:\/\/doi.org\/10.1177\/0269881118780612","journal-title":"J Psychopharmacol"},{"key":"1267_CR14","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1177\/0269881114565144","volume":"29","author":"MP Bogenschutz","year":"2015","unstructured":"Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ (2015) Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol 29:289\u2013299. https:\/\/doi.org\/10.1177\/0269881114565144","journal-title":"J Psychopharmacol"},{"key":"1267_CR15","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fphar.2018.00100","volume":"9","author":"MP Bogenschutz","year":"2018","unstructured":"Bogenschutz MP, Podrebarac SK, Duane JH, Amegadzie SS, Malone TC, Owens LT, Ross S, Mennenga SE (2018) Clinical interpretations of patient experience in a trial of psilocybin-assisted psychotherapy for alcohol use disorder. Front Pharmacol 9:100. https:\/\/doi.org\/10.3389\/fphar.2018.00100","journal-title":"Front Pharmacol"},{"key":"1267_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1874473708666150107121331","volume":"7","author":"A Garcia-Romeu","year":"2014","unstructured":"Garcia-Romeu A, Griffiths RR, Johnson MW (2014) Psilocybin-occasioned mystical experiences in the treatment of tobacco addiction. Curr Drug Abuse Rev 7:157\u2013164. https:\/\/doi.org\/10.2174\/1874473708666150107121331","journal-title":"Curr Drug Abuse Rev"},{"key":"1267_CR17","doi-asserted-by":"publisher","first-page":"955","DOI":"10.3389\/fpsyt.2019.00955","volume":"10","author":"A Garcia-Romeu","year":"2020","unstructured":"Garcia-Romeu A, Davis AK, Erowid E, Erowid F, Griffiths RR, Johnson MW (2020) Persisting reductions in cannabis, opioid, and stimulant misuse after naturalistic psychedelic use: an online survey. Front Psychiatry 10:955. https:\/\/doi.org\/10.3389\/fpsyt.2019.00955","journal-title":"Front Psychiatry"},{"key":"1267_CR18","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s00213-020-05477-0","volume":"237","author":"T Lea","year":"2020","unstructured":"Lea T, Amada N, Jungaberle H et al (2020) Perceived outcomes of psychedelic microdosing as self-managed therapies for mental and substance use disorders. Psychopharmacology 237:1521\u20131532. https:\/\/doi.org\/10.1007\/s00213-020-05477-0","journal-title":"Psychopharmacology"},{"key":"1267_CR19","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1177\/0269881116684335","volume":"31","author":"MW Johnson","year":"2017","unstructured":"Johnson MW, Garcia-Romeu A, Johnson PS, Griffiths RR (2017) An online survey of tobacco smoking cessation associated with naturalistic psychedelic use. J Psychopharmacol 31:841\u2013850. https:\/\/doi.org\/10.1177\/0269881116684335","journal-title":"J Psychopharmacol"},{"key":"1267_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drugalcdep.2015.05.031","volume":"154","author":"HM Lai","year":"2015","unstructured":"Lai HM, Cleary M, Sitharthan T, Hunt GE (2015) Prevalence of comorbid substance use, anxiety and mood disorders in epidemiological surveys, 1990\u20132014: a systematic review and meta-analysis. Drug Alcohol Depend 154:1\u201313. https:\/\/doi.org\/10.1016\/j.drugalcdep.2015.05.031","journal-title":"Drug Alcohol Depend"},{"key":"1267_CR21","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1177\/0269881116675513","volume":"30","author":"RR Griffiths","year":"2016","unstructured":"Griffiths RR, Johnson MW, Carducci MA, Umbricht A, Richards WA, Richards BD, Cosimano MP, Klinedinst MA (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial. J Psychopharmacol 30:1181\u20131197. https:\/\/doi.org\/10.1177\/0269881116675513","journal-title":"J Psychopharmacol"},{"key":"1267_CR22","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1177\/0269881116675512","volume":"30","author":"S Ross","year":"2016","unstructured":"Ross S, Bossis A, Guss J, Agin-Liebes G, Malone T, Cohen B, Mennenga SE, Belser A, Kalliontzi K, Babb J, Su Z, Corby P, Schmidt BL (2016) Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. J Psychopharmacol 30:1165\u20131180. https:\/\/doi.org\/10.1177\/0269881116675512","journal-title":"J Psychopharmacol"},{"key":"1267_CR23","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S2215-0366(16)30065-7","volume":"3","author":"RL Carhart-Harris","year":"2016","unstructured":"Carhart-Harris RL, Bolstridge M, Rucker J, Day CM, Erritzoe D, Kaelen M, Bloomfield M, Rickard JA, Forbes B, Feilding A, Taylor D, Pilling S, Curran VH, Nutt DJ (2016) Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry 3:619\u2013627. https:\/\/doi.org\/10.1016\/S2215-0366(16)30065-7","journal-title":"Lancet Psychiatry"},{"key":"1267_CR24","doi-asserted-by":"publisher","unstructured":"Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, Finan PH, Griffiths RR (2020) Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial. JAMA Psychiatry e203285. https:\/\/doi.org\/10.1001\/jamapsychiatry.2020.3285.","DOI":"10.1001\/jamapsychiatry.2020.3285"},{"key":"1267_CR25","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1177\/0269881116652578","volume":"30","author":"RG Dos Santos","year":"2016","unstructured":"Dos Santos RG, Balthazar FM, Bouso JC, Hallak JE (2016) The current state of research on ayahuasca: a systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging. J Psychopharmacol 30:1230\u20131247. https:\/\/doi.org\/10.1177\/0269881116652578","journal-title":"J Psychopharmacol"},{"key":"1267_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1590\/1516-4446-2015-1701","volume":"38","author":"RG Dos Santos","year":"2016","unstructured":"Dos Santos RG, Os\u00f3rio FL, Crippa JA, Hallak JE (2016) Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies. Braz J Psychiatry 38:65\u201372. https:\/\/doi.org\/10.1590\/1516-4446-2015-1701","journal-title":"Braz J Psychiatry"},{"key":"1267_CR27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1097\/00005053-199602000-00004","volume":"184","author":"CS Grob","year":"1996","unstructured":"Grob CS, McKenna DJ, Callaway JC, Brito GS, Neves ES, Oberlaender G, Saide OL, Labigalini E, Tacla C, Miranda CT, Strassman RJ, Boone KB (1996) Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. J Nerv Ment Dis 184:86\u201394. https:\/\/doi.org\/10.1097\/00005053-199602000-00004","journal-title":"J Nerv Ment Dis"},{"key":"1267_CR28","first-page":"205","volume-title":"Ayahuasca, ritual and religion in Brazil","author":"B Labate","year":"2010","unstructured":"Labate B, dos Santos RG, Anderson B, Mercante M, Barbosa PCR (2010) The treatment and handling of substance dependence with ayahuasca: reflections on current and future research. In: Labate BC, MacRae E (eds) Ayahuasca, ritual and religion in Brazil. Equinox, London and Oakville, pp 205\u2013227"},{"key":"1267_CR29","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1080\/02791072.2013.873157","volume":"46","author":"A Loizaga-Velder","year":"2014","unstructured":"Loizaga-Velder A, Verres R (2014) Therapeutic effects of ritual ayahuasca use in the treatment of substance dependence\u2013qualitative results. J Psychoactive Drugs 46:63\u201372. https:\/\/doi.org\/10.1080\/02791072.2013.873157","journal-title":"J Psychoactive Drugs"},{"key":"1267_CR30","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.drugpo.2016.07.011","volume":"39","author":"I Apud","year":"2017","unstructured":"Apud I, Roman\u00ed O (2017) Medicine, religion and ayahuasca in Catalonia. Considering ayahuasca networks from a medical anthropology perspective. Int J Drug Policy 39:28\u201336. https:\/\/doi.org\/10.1016\/j.drugpo.2016.07.011","journal-title":"Int J Drug Policy"},{"key":"1267_CR31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.drugpo.2017.02.017","volume":"44","author":"P Talin","year":"2017","unstructured":"Talin P, Sanabria E (2017) Ayahuasca\u2019s entwined efficacy: An ethnographic study of ritual healing from \u201caddiction.\u201d Int J Drug Policy 44:23\u201330. https:\/\/doi.org\/10.1016\/j.drugpo.2017.02.017","journal-title":"Int J Drug Policy"},{"key":"1267_CR32","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/02791072.2016.1188225","volume":"48","author":"AA Nunes","year":"2016","unstructured":"Nunes AA, Dos Santos RG, Os\u00f3rio FL, Sanches RF, Crippa JA, Hallak JE (2016) Effects of ayahuasca and its alkaloids on drug dependence: a systematic literature review of quantitative studies in animals and humans. J Psychoactive Drugs 48:195\u2013205. https:\/\/doi.org\/10.1080\/02791072.2016.1188225","journal-title":"J Psychoactive Drugs"},{"key":"1267_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/0006-8993(94)90948-2","volume":"657","author":"SD Glick","year":"1994","unstructured":"Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (1994) Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Brain Res 657:14\u201322. https:\/\/doi.org\/10.1016\/0006-8993(94)90948-2","journal-title":"Brain Res"},{"key":"1267_CR34","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1016\/s0024-3205(03)00647-7","volume":"73","author":"F Aricioglu-Kartal","year":"2003","unstructured":"Aricioglu-Kartal F, Kayir H, Tayfun Uzbay I (2003) Effects of harman and harmine on naloxone-precipitated withdrawal syndrome in morphine-dependent rats. Life Sci 73:2363\u20132371. https:\/\/doi.org\/10.1016\/s0024-3205(03)00647-7","journal-title":"Life Sci"},{"key":"1267_CR35","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/0269881112463125","volume":"27","author":"DI Brierley","year":"2013","unstructured":"Brierley DI, Davidson C (2013) Harmine augments electrically evoked dopamine efflux in the nucleus accumbens shell. J Psychopharmacol 27:98\u2013108. https:\/\/doi.org\/10.1177\/0269881112463125","journal-title":"J Psychopharmacol"},{"key":"1267_CR36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neulet.2012.07.052","volume":"525","author":"S Owaisat","year":"2012","unstructured":"Owaisat S, Raffa RB, Rawls SM (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525:12\u201316. https:\/\/doi.org\/10.1016\/j.neulet.2012.07.052","journal-title":"Neurosci Lett"},{"key":"1267_CR37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.physbeh.2015.01.032","volume":"142","author":"AJ Oliveira-Lima","year":"2015","unstructured":"Oliveira-Lima AJ, Santos R, Hollais AW, Gerardi-Junior CA, Baldaia MA, Wuo-Silva R, Yokoyama TS, Costa JL, Malpezzi-Marinho EL, Ribeiro-Barbosa PC, Berro LF, Frussa-Filho R, Marinho EA (2015) Effects of ayahuasca on the development of alcohol-induced behavioral sensitization and on a post-sensitization treatment in mice. Physiol Behav 142:28\u201336. https:\/\/doi.org\/10.1016\/j.physbeh.2015.01.032","journal-title":"Physiol Behav"},{"key":"1267_CR38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/02791072.2005.10399792","volume":"37","author":"DX Da Silveira","year":"2005","unstructured":"Da Silveira DX, Grob CS, de Rios MD, Lopez E, Alonso LK, Tacla C, Doering-Silveira E (2005) Ayahuasca in adolescence: a preliminary psychiatric assessment. J Psychoactive Drugs 37:129\u2013133. https:\/\/doi.org\/10.1080\/02791072.2005.10399792","journal-title":"J Psychoactive Drugs"},{"key":"1267_CR39","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/02791072.2005.10399794","volume":"37","author":"E Doering-Silveira","year":"2005","unstructured":"Doering-Silveira E, Grob CS, de Rios MD, Lopez E, Alonso LK, Tacla C, Da Silveira DX (2005) Report on psychoactive drug use among adolescents using ayahuasca within a religious context. J Psychoactive Drugs 37:141\u2013144. https:\/\/doi.org\/10.1080\/02791072.2005.10399794","journal-title":"J Psychoactive Drugs"},{"key":"1267_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.drugalcdep.2010.03.024","volume":"111","author":"JM F\u00e1bregas","year":"2010","unstructured":"F\u00e1bregas JM, Gonz\u00e1lez D, Fondevila S, Cutchet M, Fern\u00e1ndez X, Barbosa PC, Alc\u00e1zar-C\u00f3rcoles M\u00c1, Barbanoj MJ, Riba J, Bouso JC (2010) Assessment of addiction severity among ritual users of ayahuasca. Drug Alcohol Depend 111:257\u2013261. https:\/\/doi.org\/10.1016\/j.drugalcdep.2010.03.024","journal-title":"Drug Alcohol Depend"},{"key":"1267_CR41","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2174\/15733998113099990003","volume":"6","author":"G Thomas","year":"2013","unstructured":"Thomas G, Lucas P, Capler NR, Tupper KW, Martin G (2013) Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada. Curr Drug Abuse Rev 6:30\u201342. https:\/\/doi.org\/10.2174\/15733998113099990003","journal-title":"Curr Drug Abuse Rev"},{"key":"1267_CR42","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-40426-9_11","author":"X Fern\u00e1ndez","year":"2014","unstructured":"Fern\u00e1ndez X, dos Santos RG, Cutchet M, Fondevila S, Gonz\u00e1lez D, Alc\u00e1zar M\u00c1, Mar\u00eda F\u00e1bregas J (2014) Assessment of the psychotherapeutic effects of ritual ayahuasca use on drug dependency: a pilot study. Therap Use Ayahuasca. https:\/\/doi.org\/10.1007\/978-3-642-40426-9_11","journal-title":"Therap Use Ayahuasca"},{"key":"1267_CR43","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1038\/s41598-020-61169-x","volume":"10","author":"DF Jim\u00e9nez-Garrido","year":"2020","unstructured":"Jim\u00e9nez-Garrido DF, G\u00f3mez-Sousa M, Ona G, Dos Santos RG, Hallak JEC, Alc\u00e1zar-C\u00f3rcoles M\u00c1, Bouso JC (2020) Effects of ayahuasca on mental health and quality of life in na\u00efve users: a longitudinal and cross-sectional study combination. Sci Rep 10:4075. https:\/\/doi.org\/10.1038\/s41598-020-61169-x","journal-title":"Sci Rep"},{"key":"1267_CR44","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/JCP.0000000000000436","volume":"36","author":"RF Sanches","year":"2016","unstructured":"Sanches RF, de Lima Os\u00f3rio F, Dos Santos RG, Macedo LR, Maia-de-Oliveira JP, Wichert-Ana L, de Araujo DB, Riba J, Crippa JA, Hallak JE (2016) Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a SPECT study. J Clin Psychopharmacol 36:77\u201381. https:\/\/doi.org\/10.1097\/JCP.0000000000000436","journal-title":"J Clin Psychopharmacol"},{"key":"1267_CR45","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1017\/S0033291718001356","volume":"49","author":"F Palhano-Fontes","year":"2019","unstructured":"Palhano-Fontes F, Barreto D, Onias H, Andrade KC, Novaes MM, Pessoa JA, Mota-Rolim SA, Os\u00f3rio FL, Sanches R, Dos Santos RG, T\u00f3foli LF, de Oliveira SG, Yonamine M, Riba J, Santos FR, Silva-Junior AA, Alchieri JC, Galv\u00e3o-Coelho NL, Lob\u00e3o-Soares B, Hallak JEC, Arcoverde E, Maia-de-Oliveira JP, Ara\u00fajo DB (2019) Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial. Psychol Med 49:655\u2013663. https:\/\/doi.org\/10.1017\/S0033291718001356","journal-title":"Psychol Med"},{"key":"1267_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4:1. https:\/\/doi.org\/10.1186\/2046-4053-4-1","journal-title":"Syst Rev"},{"key":"1267_CR47","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"14","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW (2014) SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol 14:43. https:\/\/doi.org\/10.1186\/1471-2288-14-43","journal-title":"BMC Med Res Methodol"},{"key":"1267_CR48","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.comppsych.2016.09.003","volume":"71","author":"PC Barbosa","year":"2016","unstructured":"Barbosa PC, Strassman RJ, da Silveira DX, Areco K, Hoy R, Pommy J, Thoma R, Bogenschutz M (2016) Psychological and neuropsychological assessment of regular hoasca users. Compr Psychiatry 71:95\u2013105. https:\/\/doi.org\/10.1016\/j.comppsych.2016.09.003","journal-title":"Compr Psychiatry"},{"key":"1267_CR49","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3389\/fpsyt.2018.00136","volume":"9","author":"PCR Barbosa","year":"2018","unstructured":"Barbosa PCR, T\u00f3foli LF, Bogenschutz MP, Hoy R, Berro LF, Marinho EAV, Areco KN, Winkelman MJ (2018) Assessment of alcohol and tobacco use disorders among religious users of ayahuasca. Front Psychiatry 9:136. https:\/\/doi.org\/10.3389\/fpsyt.2018.00136","journal-title":"Front Psychiatry"},{"key":"1267_CR50","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1080\/02791072.2019.1607956","volume":"51","author":"I Berlowitz","year":"2019","unstructured":"Berlowitz I, Walt H, Ghasarian C, Mendive F, Martin-Soelch C (2019) Short-term treatment effects of a substance use disorder therapy involving traditional amazonian medicine. J Psychoactive Drugs 51:323\u2013334. https:\/\/doi.org\/10.1080\/02791072.2019.1607956","journal-title":"J Psychoactive Drugs"},{"key":"1267_CR51","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3389\/fphar.2018.00561","volume":"9","author":"EG Cata-Preta","year":"2018","unstructured":"Cata-Preta EG, Serra YA, Moreira-Junior EDC, Reis HS, Kisaki ND, Libarino-Santos M, Silva RRR, Barros-Santos T, Santos LC, Barbosa PCR, Costa JL, Oliveira-Lima AJ, Berro LF, Marinho EAV (2018) Ayahuasca and Its DMT- and \u03b2-carbolines\u2014containing ingredients block the expression of alcohol-induced conditioned place preference in mice: role of the treatment environment. Front Pharmacol 9:561. https:\/\/doi.org\/10.3389\/fphar.2018.00561","journal-title":"Front Pharmacol"},{"key":"1267_CR52","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2020.1789247","author":"C Giovannetti","year":"2020","unstructured":"Giovannetti C, Garcia Arce S, Rush B, Mendive F (2020) Pilot evaluation of a residential drug addiction treatment combining traditional amazonian medicine, ayahuasca and psychotherapy on depression and anxiety. J Psychoactive Drugs. https:\/\/doi.org\/10.1080\/02791072.2020.1789247","journal-title":"J Psychoactive Drugs"},{"key":"1267_CR53","doi-asserted-by":"publisher","first-page":"15201","DOI":"10.1038\/s41598-017-14700-6","volume":"7","author":"W Lawn","year":"2017","unstructured":"Lawn W, Hallak JE, Crippa JA, Dos Santos R, Porffy L, Barratt MJ, Ferris JA, Winstock AR, Morgan CJA (2017) Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey. Sci Rep 7:15201. https:\/\/doi.org\/10.1038\/s41598-017-14700-6","journal-title":"Sci Rep"},{"key":"1267_CR54","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.alcohol.2019.10.005","volume":"84","author":"LM Nolli","year":"2019","unstructured":"Nolli LM, de Oliveira DGR, Alves SS, von Zuben MV, Pic-Taylor A, Mortari MR, Caldas ED (2019) Effects of the hallucinogenic beverage ayahuasca on voluntary alcohol intake by rats and on cFos expression in brain areas relevant to drug addiction. Alcohol 84:67\u201375. https:\/\/doi.org\/10.1016\/j.alcohol.2019.10.005","journal-title":"Alcohol"},{"key":"1267_CR55","doi-asserted-by":"publisher","first-page":"3269","DOI":"10.1007\/s00213-020-05609-6","volume":"237","author":"HS Reis","year":"2020","unstructured":"Reis HS, Rodrigues IRS, Anjos-Santos A, Libarino-Santos M, Serra YA, Cata-Preta EG, Oliveira-Campos D, Kisaki ND, Barros-Santos T, Yokoyama TS, Cruz FC, Oliveira-Lima AJ, Barbosa PCR, Berro LF, Marinho EAV (2020) Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations. Psychopharmacology 237:3269\u20133281. https:\/\/doi.org\/10.1007\/s00213-020-05609-6","journal-title":"Psychopharmacology"},{"key":"1267_CR56","first-page":"2","volume":"13","author":"AF Godinho","year":"2017","unstructured":"Godinho AF, Silva MC, Kawashima JD et al (2017) Ayahuasca modifies amphetamine self ingestion and modifies anxiety and locomotor activity in adolescent rats. Electron J Biol 13:2","journal-title":"Electron J Biol"},{"key":"1267_CR57","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00213-013-3167-9","volume":"230","author":"JC Bouso","year":"2013","unstructured":"Bouso JC, F\u00e1bregas JM, Antonijoan RM, Rodr\u00edguez-Fornells A, Riba J (2013) Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users. Psychopharmacology 230:415\u2013424. https:\/\/doi.org\/10.1007\/s00213-013-3167-9","journal-title":"Psychopharmacology"},{"key":"1267_CR58","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1124\/pr.114.009514","volume":"67","author":"LL Howell","year":"2015","unstructured":"Howell LL, Cunningham KA (2015) Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder. Pharmacol Rev 67:176\u2013197. https:\/\/doi.org\/10.1124\/pr.114.009514","journal-title":"Pharmacol Rev"},{"key":"1267_CR59","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neubiorev.2018.02.004","volume":"87","author":"JC Bouso","year":"2018","unstructured":"Bouso JC, Dos Santos RG, Alc\u00e1zar-C\u00f3rcoles M\u00c1, Hallak JEC (2018) Serotonergic psychedelics and personality: a systematic review of contemporary research. Neurosci Biobehav Rev 87:118\u2013132. https:\/\/doi.org\/10.1016\/j.neubiorev.2018.02.004","journal-title":"Neurosci Biobehav Rev"},{"key":"1267_CR60","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3389\/fphar.2018.00994","volume":"9","author":"K Alper","year":"2018","unstructured":"Alper K, Dong B, Shah R, Sershen H, Vinod KY (2018) LSD Administered as a single dose reduces alcohol consumption in C57BL\/6J mice. Front Pharmacol 9:994. https:\/\/doi.org\/10.3389\/fphar.2018.00994","journal-title":"Front Pharmacol"},{"key":"1267_CR61","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/s41386-020-0694-z","volume":"45","author":"MW Meinhardt","year":"2020","unstructured":"Meinhardt MW, G\u00fcng\u00f6r C, Skorodumov I, Mertens LJ, Spanagel R (2020) Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse. Neuropsychopharmacology 45:1316\u20131322. https:\/\/doi.org\/10.1038\/s41386-020-0694-z","journal-title":"Neuropsychopharmacology"},{"key":"1267_CR62","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/s0014-2999(99)00125-9","volume":"370","author":"S Maurel","year":"1999","unstructured":"Maurel S, De Vry J, Schreiber R (1999) 5-HT receptor ligands differentially affect operant oral self-administration of alcohol in the rat. Eur J Pharmacol 370:217\u2013223. https:\/\/doi.org\/10.1016\/s0014-2999(99)00125-9","journal-title":"Eur J Pharmacol"},{"key":"1267_CR63","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1111\/ejn.13572","volume":"45","author":"H Vargas-Perez","year":"2017","unstructured":"Vargas-Perez H, Grieder TE, Ting-A-Kee R, Maal-Bared G, Chwalek M, van der Kooy D (2017) A single administration of the hallucinogen, 4-acetoxy-dimethyltryptamine, prevents the shift to a drug-dependent state and the expression of withdrawal aversions in rodents. Eur J Neurosci 45:1410\u20131417. https:\/\/doi.org\/10.1111\/ejn.13572","journal-title":"Eur J Neurosci"},{"key":"1267_CR64","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1007\/s00213-019-05328-7","volume":"236","author":"A Oppong-Damoah","year":"2019","unstructured":"Oppong-Damoah A, Curry KE, Blough BE, Rice KC, Murnane KS (2019) Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on alcohol consumption and place conditioning in male mice. Psychopharmacology 236:3567\u20133578. https:\/\/doi.org\/10.1007\/s00213-019-05328-7","journal-title":"Psychopharmacology"},{"key":"1267_CR65","doi-asserted-by":"publisher","unstructured":"Martin DA, Gyawali U, Calu DJ (2020) Effects of 5-HT2A receptor stimulation on economic demand for fentanyl after intermittent and continuous access self-administration in male rats. Addict Biol e12926. https:\/\/doi.org\/10.1111\/adb.12926.","DOI":"10.1111\/adb.12926"},{"key":"1267_CR66","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/02791072.2019.1567961","volume":"51","author":"G Ona","year":"2019","unstructured":"Ona G, Kohek M, Massaguer T, Gomariz A, Jim\u00e9nez DF, Dos Santos RG et al (2019) Ayahuasca and public health: health status, psychosocial well-being, lifestyle, and coping strategies in a large sample of ritual ayahuasca users. J Psychoactive Drugs 51:135\u2013145","journal-title":"J Psychoactive Drugs"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-021-01267-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00406-021-01267-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-021-01267-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T04:04:03Z","timestamp":1652241843000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00406-021-01267-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["1267"],"URL":"https:\/\/doi.org\/10.1007\/s00406-021-01267-7","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"18 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}