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In this study protocol, we propose to examine the synergistic effects of a self-administered home-treatment, encompassing transcranial direct current stimulation (tDCS) along with a video game based training of attentional control. The study is designed as a two-arm, double-blind, randomized and placebo-controlled multi-center trial (ClinicalTrials.gov: NCT04953208). At three study sites (Israel, Latvia, and Germany), 114 patients with a primary diagnosis of MDD undergo 6 weeks of intervention (30\u2009\u00d7\u200930\u00a0min sessions). Patients assigned to the intervention group receive active tDCS (anode F3 and cathode F4; 2\u00a0mA intensity) and an action-like video game, while those assigned to the control group receive sham tDCS along with a control video game. An electrode-positioning algorithm is used to standardize tDCS electrode positioning. Participants perform their designated treatment at the clinical center (sessions 1\u20135) and continue treatment at home under remote supervision (sessions 6\u201330). The endpoints are\n                    <jats:italic>feasibility<\/jats:italic>\n                    (primary) and\n                    <jats:italic>safety<\/jats:italic>\n                    ,\n                    <jats:italic>treatment efficacy<\/jats:italic>\n                    (secondary, i.e., change of Montgomery-\u00c5sberg Depression Rating Scale (MADRS) scores at week six from baseline, clinical response and remission, measures of social, occupational, and psychological functioning, quality of life, and cognitive control (tertiary). Demonstrating the feasibility, safety, and efficacy of this novel combined intervention could expand the range of available treatments for MDD to neuromodulation enhanced interventions providing cost-effective, easily accessible, and low-risk treatment options.\n                  <\/jats:p>\n                  <jats:p>ClinicalTrials.gov: NCT04953208.<\/jats:p>","DOI":"10.1007\/s00406-022-01464-y","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T10:12:38Z","timestamp":1666433558000},"page":"85-98","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Examining the synergistic effects of a cognitive control video game and a home-based, self-administered non-invasive brain stimulation on alleviating depression: the DiSCoVeR trial 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He has received speaker's honoraria from Mag&More GmbH, Brainsway Inc., Jerusalem, Israel, and the neuroCare Group. His lab has received support with equipment from neuroConn GmbH, Ilmenau, Germany, and Mag&More GmbH and Brainsway Inc., Jerusalem, Israel. F.C.H. is on the scientific advisory board of the Novartis Foundation. D.B. is a founding member and scientific advisor to Akili Interactive, Boston, MA, USA. A.P., M.N., Z.M., and D.B. are among the inventors who filed a patent application which protects some of the mechanics of the video game Legends of Hoa'Manu. All other authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}