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This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)\u2014both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system\u2014for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14\u201345\u00a0years were randomised to 10-week add-on intervention of either BLT (10,000\u00a0lx; daily 30-min sessions) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200970), EI (aerobic and muscle-strengthening activities 3\u00a0days\/ week) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200969), or treatment-as-usual (TAU) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200968), of whom 165 (80%) were retained (BLT:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954; EI:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952; TAU:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200959). Intervention adherence (i.e.\u2009\u2265 80% completed sessions) was very low for both BLT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913, 22%) and EI (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: \u22120.124 [95% CI: \u22122.219, 1.971], EI: \u22122.646 [95% CI: \u22124.777, \u22120.515], TAU: \u22121.428 [95% CI: \u22123.381, 0.526]) with no group differences [\n                      <jats:italic>F<\/jats:italic>\n                      (2,153)\u2009=\u20091.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.2384]. These findings suggest that the m-health approach did not achieve feasibility of EI and BLT in young people with ADHD. Prior to designing efficacy studies, strategies how to achieve high intervention adherence should be specifically investigated in this patient group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov, NCT03371810, 13 December 2017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00406-024-01784-1","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T17:01:21Z","timestamp":1713286881000},"page":"653-665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit\/hyperactivity disorder: a multicentre, three-arm, randomised controlled, pilot phase-IIa trial"],"prefix":"10.1007","volume":"275","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5328-5893","authenticated-orcid":false,"given":"Jutta S.","family":"Mayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kohlhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Stermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Medda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geva A.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Pawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Asherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit Palacio","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Richarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douwe","family":"Bergsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena D.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e0","family":"Muntaner-Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich W.","family":"Ebner-Priemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meinhard","family":"Kieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Retz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco B.","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Colla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K.","family":"Buitelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna","family":"Kuntsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep A.","family":"Ramos-Quiroga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Freitag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"10","key":"1784_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.euroneuro.2018.08.001","volume":"28","author":"B Franke","year":"2018","unstructured":"Franke B, Michelini G, Asherson P, Banaschewski T, Bilbow A, Buitelaar JK, Cormand B, Faraone SV, Ginsberg Y, Haavik J, Kuntsi J, Larsson H, Lesch K-P, Ramos-Quiroga JA, R\u00e9thelyi JM, Ribases M, Reif A (2018) Live fast, die young? 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