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Acute rehabilitation (AR) is an interdisciplinary rehabilitation intervention applied early while still in a hospital setting. The goal of AR is to improve functional limitations and to increase functional independence at discharge. It is established in the treatment of patients with other severe diseases such as sepsis, polytrauma, or stroke. Data concerning AR in COVID-19 are sparse.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>To evaluate the changes in physical function during AR in patients after severe COVID-19.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This monocentric, retrospective observational study examined the functional outcomes of a sample of COVID-19-patients who received interdisciplinary AR at a university hospital. Inclusion criteria were a positive SARS-CoV-2 test in 05\/2020\u201301\/2022 and transfer to AR after intensive care treatment. 87 patients were elegible for evaluation, 3 of whom were excluded because of death during AR. Data were extracted from the hospital information system. In a pre-post analysis, mobility (Charit\u00e9 Mobility Index), ADL (Barthel Index), and oxygen demand were assessed. In addition, discharge location after AR, factors associated with AR unit length of stay, and functional improvements were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Data of 84 patients were analyzed. Mobility increased significantly from a median of 4 [1.25-6] CHARMI points at admission to a median of 9 [8.25-9] at discharge (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). ADL increased significantly from a median of 52.5 [35.0-68.75] Barthel Index points at admission to a median of 92.5 [85\u201395] at discharge (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Oxygen demand decreased from 80.7 to 30.5% of patients. The majority (55.9%) of patients were discharged home, while 36.9% received direct follow-up rehabilitation. Older age correlated significantly with lower scores on the discharge assessment for mobility (Spearman\u2019s \u03f1 = -0.285, <jats:italic>p<\/jats:italic>\u2009=\u20090.009) and ADL (Spearman\u2019s \u03f1 = -0.297, <jats:italic>p<\/jats:italic>\u2009=\u20090.006).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Acute rehabilitation is a viable option for COVID-19 patients with severe functional deficits after ICU treatment to achieve functional progress in mobility and ADL, reduce oxygen requirements and enable follow-up rehabilitation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration number and date of registration for prospectively registered trials<\/jats:title>\n                <jats:p>Trial registration number: DRKS00025239. Date of registration: 08 Sep 2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00406-024-01862-4","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T04:01:49Z","timestamp":1721102509000},"page":"1993-2001","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional outcome after interdisciplinary, acute rehabilitation in COVID-19 patients: a retrospective study"],"prefix":"10.1007","volume":"274","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5488-8592","authenticated-orcid":false,"given":"Nancy","family":"Elmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9437-4858","authenticated-orcid":false,"given":"Anett","family":"Rei\u00dfhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Brehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-2872","authenticated-orcid":false,"given":"Daniel","family":"Drebinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-9584","authenticated-orcid":false,"given":"Stefan J.","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Schwedtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-4281","authenticated-orcid":false,"given":"Max E.","family":"Liebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"1862_CR1","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/vaccines10070985","volume":"10","author":"AA Rabaan","year":"2022","unstructured":"Rabaan AA, Bakhrebah MA, Mutair AA et al (2022) Systematic review on pathophysiological complications in severe COVID-19 among the non-vaccinated and vaccinated population. 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AR declares no conflicts of interest directly or indirectly related to this study. KB declares no conflicts of interest directly or indirectly related to this study. DD declares no conflicts of interest directly or indirectly related to this study. SJS received grants and non-financial support from Reactive Robotics GmbH (Munich, Germany), ASP GmbH (Attendorn, Germany), STIMIT AG (Biel, Switzerland), ESICM (Geneva, Switzerland), grants, personal fees and non-financial support from Fresenius Kabi Deutschland GmbH (Bad Homburg, Germany), grants from the Innovationsfond of The Federal Joint Committee (G-BA), personal fees from Springer Verlag GmbH (Vienna, Austria) for educational purposes and Advanz Pharma GmbH (Bielefeld, Germany), non-financial support from national and international societies (and their congress organizers) in the field of anesthesiology and intensive care medicine, outside the submitted work. Dr. Schaller holds stocks in small amounts from Alphabeth Inc., Bayer AG and Siemens AG; these holdings have not affected any decisions regarding his research or this study. CS declares no conflicts of interest directly or indirectly related to this study. ML declares no conflicts of interest directly or indirectly related to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}