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Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dialectical behavioral therapy (DBT) and repetitive transcranial magnetic stimulation (rTMS) are both effective in borderline personality disorder (BPD). We hypothesized that intermittent theta burst stimulation (iTBS), a modified rTMS protocol that provides unilateral stimulation to the left dorsolateral prefrontal cortex, would enhance the effects of DBT and reduce BPD-specific symptoms more than sham stimulation. We performed a single-blind, randomized, sham-controlled pilot study to evaluate iTBS as an add-on to 8-week DBT for BPD in routine inpatient treatment. A total of 53 BPD patients were randomly assigned to either iTBS (n\u2009=\u200925) or sham stimulation (n\u2009=\u200928) in weeks 4\u20138 of DBT; 40 patients were eligible for inclusion in the analyses according to pre-specified criteria (\u2265\u200916 of 20 iTBS sessions). The primary endpoint was change on the 23-item Borderline Symptom List; secondary endpoints were changes in depressive symptoms and general level of functioning. A mixed model repeated measures analysis with a 2\u2009\u00d7\u20092 factorial between-subjects design showed no significant effect of add-on iTBS treatment, but a distinct trend was observed in favor of iTBS (Cohen\u2019s d\u2009=\u20090.23 for group difference). We found a main effect of DBT with and without iTBS over time, indicating efficacy of 8\u00a0weeks\u2019 DBT (d\u2009=\u20090.89\u20131.12). iTBS may be beneficial as an add-on to DBT in the long term and warrants further evaluation in larger studies.\n                    <jats:italic>Trial registration<\/jats:italic>\n                    Registered at drks.de (no. DRKS00020413) on January 13, 2020.\n                  <\/jats:p>","DOI":"10.1007\/s00406-024-01901-0","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T10:21:10Z","timestamp":1726741270000},"page":"2301-2314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: results of a randomized, sham-controlled pilot trial"],"prefix":"10.1007","volume":"275","clinical-trial-number":[{"clinical-trial-number":"drks00020413","registry":"10.18810\/drks"}],"author":[{"given":"Milenko","family":"Kujovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Riesbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Benz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Wingerter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Dei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia","family":"Margittai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Reinermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Plewnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meisenzahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"9759","key":"1901_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/s0140-6736(10)61422-5","volume":"377","author":"F Leichsenring","year":"2011","unstructured":"Leichsenring F, Leibing E, Kruse J, New AS, Leweke F (2011) Borderline Personality disorder. 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