{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:16:46Z","timestamp":1790299006278,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973759"],"award-info":[{"award-number":["81973759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Health Research Project","award":["TJWJ2025MS023"],"award-info":[{"award-number":["TJWJ2025MS023"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00406-025-02106-9","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:05:42Z","timestamp":1757415942000},"page":"1253-1261","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperhomocysteinemia in chronic schizophrenia: prevalence, clinical correlates, and paradoxical associations with symptom severity"],"prefix":"10.1007","volume":"276","author":[{"given":"Jianyan","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-4369","authenticated-orcid":false,"given":"Guoshuai","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"issue":"12","key":"2106_CR1","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1038\/s41380-023-02138-4","volume":"28","author":"M Solmi","year":"2023","unstructured":"Solmi M et al (2023) Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the global burden of disease (GBD) 2019. Mol Psychiatry 28(12):5319\u20135327","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2106_CR2","first-page":"59","volume":"9","author":"MH Zhu","year":"2022","unstructured":"Zhu MH et al (2022) Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial. Mil Med Res 9(1):59","journal-title":"Mil Med Res"},{"key":"2106_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jpsychires.2025.05.052","volume":"189","author":"J Li","year":"2025","unstructured":"Li J et al (2025) Effects of varied rTMS frequencies on cognitive function in individuals with chronic schizophrenia: A double-blind randomized controlled trial. J Psychiatr Res 189:33\u201341","journal-title":"J Psychiatr Res"},{"key":"2106_CR4","doi-asserted-by":"publisher","first-page":"1620700","DOI":"10.3389\/fpsyt.2025.1620700","volume":"16","author":"M Yang","year":"2025","unstructured":"Yang M, Li Z, Feng D (2025) Editorial: brain pathology and rehabilitation mechanisms of neuromodulation in psychiatric disorders. Front Psychiatry 16:1620700","journal-title":"Front Psychiatry"},{"key":"2106_CR5","doi-asserted-by":"crossref","unstructured":"Hermann A, Sitdikova G (2021) Homocysteine: biochemistry, molecular biology and role in disease. Biomolecules 11(5):737","DOI":"10.3390\/biom11050737"},{"key":"2106_CR6","doi-asserted-by":"publisher","first-page":"1380900","DOI":"10.3389\/fpsyt.2024.1380900","volume":"15","author":"N Fan","year":"2024","unstructured":"Fan N et al (2024) Homocysteine levels in first-episode patients with psychiatric disorders. Front Psychiatry 15:1380900","journal-title":"Front Psychiatry"},{"key":"2106_CR7","doi-asserted-by":"crossref","unstructured":"Cordaro M et al (2021) Involvements of hyperhomocysteinemia in neurological disorders. Metabolites 11(1):37","DOI":"10.3390\/metabo11010037"},{"issue":"1","key":"2106_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41537-024-00458-0","volume":"10","author":"K Tabata","year":"2024","unstructured":"Tabata K et al (2024) Association of homocysteine with white matter dysconnectivity in schizophrenia. Schizophrenia (Heidelb) 10(1):39","journal-title":"Schizophrenia (Heidelb)"},{"issue":"3","key":"2106_CR9","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s11011-014-9534-3","volume":"29","author":"B Misiak","year":"2014","unstructured":"Misiak B et al (2014) Elevated homocysteine level in first-episode schizophrenia patients\u2013the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse. Metab Brain Dis 29(3):661\u2013670","journal-title":"Metab Brain Dis"},{"issue":"11","key":"2106_CR10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1093\/ijnp\/pyad051","volume":"26","author":"M Hidalgo-Figueroa","year":"2023","unstructured":"Hidalgo-Figueroa M et al (2023) Association of prolactin, oxytocin, and homocysteine with the clinical and cognitive features of a first episode of psychosis over a 1-Year Follow-Up. Int J Neuropsychopharmacol 26(11):796\u2013807","journal-title":"Int J Neuropsychopharmacol"},{"issue":"4","key":"2106_CR11","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00406-020-01150-x","volume":"271","author":"Y Yang","year":"2021","unstructured":"Yang Y et al (2021) Prevalence and clinical demography of hyperhomocysteinemia in Han Chinese patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci 271(4):759\u2013765","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2106_CR12","doi-asserted-by":"publisher","first-page":"p7721760","DOI":"10.1155\/2021\/7721760","volume":"2021","author":"TV Zhilyaeva","year":"2021","unstructured":"Zhilyaeva TV et al (2021) Homocysteine in schizophrenia: independent pathogenetic factor with prooxidant activity or integral marker of other biochemical disturbances?? Schizophr Res Treat 2021:p7721760","journal-title":"Schizophr Res Treat"},{"key":"2106_CR13","doi-asserted-by":"publisher","first-page":"109679","DOI":"10.1016\/j.pnpbp.2019.109679","volume":"95","author":"B Trze\u015bniowska-Druka\u0142a","year":"2019","unstructured":"Trze\u015bniowska-Druka\u0142a B et al (2019) Evaluation of hyperhomocysteinemia prevalence and its influence on the selected cognitive functions in patients with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 95:109679","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2106_CR14","doi-asserted-by":"publisher","first-page":"103214","DOI":"10.1016\/j.ajp.2022.103214","volume":"75","author":"S Zhou","year":"2022","unstructured":"Zhou S et al (2022) Gender differences in associations of cognitive impairments with homocysteine in schizophrenia. Asian J Psychiatr 75:103214","journal-title":"Asian J Psychiatr"},{"issue":"1","key":"2106_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/ajmg.b.30179","volume":"135b","author":"JW Muntjewerff","year":"2005","unstructured":"Muntjewerff JW et al (2005) Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control study. Am J Med Genet B Neuropsychiatr Genet 135b(1):69\u201372","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1","key":"2106_CR16","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1186\/s12888-022-04246-x","volume":"22","author":"N Shahini","year":"2022","unstructured":"Shahini N et al (2022) Relationship of serum homocysteine and vitamin D with positive, negative, and extrapyramidal symptoms in schizophrenia: a case-control study in Iran. BMC Psychiatry 22(1):681","journal-title":"BMC Psychiatry"},{"issue":"6","key":"2106_CR17","doi-asserted-by":"publisher","first-page":"e5366","DOI":"10.1002\/bmc.5366","volume":"36","author":"Z Li","year":"2022","unstructured":"Li Z et al (2022) Simultaneous determination of serum homocysteine, cysteine, and methionine in patients with schizophrenia by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr 36(6):e5366","journal-title":"Biomed Chromatogr"},{"issue":"1","key":"2106_CR18","doi-asserted-by":"publisher","first-page":"e14376","DOI":"10.1002\/alz.14376","volume":"21","author":"WZ Lin","year":"2025","unstructured":"Lin WZ et al (2025) Homocysteine, neurodegenerative biomarkers, and APOE \u03b54 in neurodegenerative diseases. Alzheimers Dement 21(1):e14376","journal-title":"Alzheimers Dement"},{"key":"2106_CR19","doi-asserted-by":"crossref","unstructured":"Kaplan P et al (2020) Homocysteine and mitochondria in cardiovascular and cerebrovascular systems. Int J Mol Sci 21(20):7698","DOI":"10.3390\/ijms21207698"},{"key":"2106_CR20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.psychres.2016.01.077","volume":"238","author":"B Misiak","year":"2016","unstructured":"Misiak B et al (2016) Metabolic dysregulation in first-episode schizophrenia patients with respect to genetic variation in one-carbon metabolism. Psychiatry Res 238:60\u201367","journal-title":"Psychiatry Res"},{"issue":"1\u20132","key":"2106_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.psychres.2009.01.013","volume":"175","author":"A Kale","year":"2010","unstructured":"Kale A et al (2010) Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Res 175(1\u20132):47\u201353","journal-title":"Psychiatry Res"},{"issue":"7","key":"2106_CR22","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.pnpbp.2005.06.028","volume":"29","author":"AS Brown","year":"2005","unstructured":"Brown AS, Susser ES (2005) Homocysteine and schizophrenia: from prenatal to adult life. Prog Neuropsychopharmacol Biol Psychiatry 29(7):1175\u20131180","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2106_CR23","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neulet.2017.04.025","volume":"650","author":"N Fan","year":"2017","unstructured":"Fan N et al (2017) Effect of Risperidone on serum homocysteine levels in first-episode, drug-na\u00efve patients with schizophrenia. Neurosci Lett 650:168\u2013173","journal-title":"Neurosci Lett"},{"issue":"1","key":"2106_CR24","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1186\/s12888-022-04416-x","volume":"22","author":"X Yang","year":"2022","unstructured":"Yang X et al (2022) Increased serum homocysteine in first episode and drug-na\u00efve individuals with schizophrenia: sex differences and correlations with clinical symptoms. BMC Psychiatry 22(1):759","journal-title":"BMC Psychiatry"},{"key":"2106_CR25","doi-asserted-by":"publisher","first-page":"136826","DOI":"10.1016\/j.neulet.2022.136826","volume":"788","author":"C Lin","year":"2022","unstructured":"Lin C et al (2022) Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: moderated by brain cortical thickness. Neurosci Lett 788:136826","journal-title":"Neurosci Lett"},{"issue":"5","key":"2106_CR26","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s00406-023-01706-7","volume":"274","author":"P Peng","year":"2024","unstructured":"Peng P et al (2024) Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study. Eur Arch Psychiatry Clin Neurosci 274(5):1105\u20131113","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"1","key":"2106_CR27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41398-018-0294-4","volume":"8","author":"J Lefort-Besnard","year":"2018","unstructured":"Lefort-Besnard J et al (2018) Patterns of schizophrenia symptoms: hidden structure in the PANSS questionnaire. Transl Psychiatry 8(1):237","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2106_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jad.2011.10.014","volume":"140","author":"IM Lako","year":"2012","unstructured":"Lako IM et al (2012) A systematic review of instruments to measure depressive symptoms in patients with schizophrenia. J Affect Disord 140(1):38\u201347","journal-title":"J Affect Disord"},{"key":"2106_CR29","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jpsychires.2023.05.011","volume":"163","author":"M Wang","year":"2023","unstructured":"Wang M et al (2023) Regulatory T cells mediate insomnia-related psychotic symptoms and cognitive impairment in chronic schizophrenia patients. J Psychiatr Res 163:102\u2013108","journal-title":"J Psychiatr Res"},{"issue":"3","key":"2106_CR30","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3109\/00048670903446882","volume":"44","author":"A Gogos","year":"2010","unstructured":"Gogos A, Joshua N, Rossell SL (2010) Use of the repeatable battery for the assessment of neuropsychological status (RBANS) to investigate group and gender differences in schizophrenia and bipolar disorder. Aust N Z J Psychiatry 44(3):220\u2013229","journal-title":"Aust N Z J Psychiatry"},{"issue":"1","key":"2106_CR31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12915-025-02202-1","volume":"23","author":"H Lai","year":"2025","unstructured":"Lai H et al (2025) PBertKla: a protein large Language model for predicting human lysine lactylation sites. BMC Biol 23(1):95","journal-title":"BMC Biol"},{"issue":"1","key":"2106_CR32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12915-025-02243-6","volume":"23","author":"H Zhang","year":"2025","unstructured":"Zhang H et al (2025) NeuroScale: evolutional scale-based protein Language models enable prediction of neuropeptides. BMC Biol 23(1):142","journal-title":"BMC Biol"},{"key":"2106_CR33","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Lamu\u00f1o D et al (2023) Hyperhomocysteinemia in adult patients: A treatable metabolic condition. Nutrients 16(1):135","DOI":"10.3390\/nu16010135"},{"key":"2106_CR34","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1476-511X-13-134","volume":"13","author":"S Zhou","year":"2014","unstructured":"Zhou S, Zhang Z, Xu G (2014) Notable epigenetic role of hyperhomocysteinemia in atherogenesis. Lipids Health Dis 13:134","journal-title":"Lipids Health Dis"},{"key":"2106_CR35","doi-asserted-by":"publisher","first-page":"841429","DOI":"10.3389\/fpsyt.2022.841429","volume":"13","author":"J Yu","year":"2022","unstructured":"Yu J et al (2022) The effects of plasma homocysteine level on the risk of three major psychiatric disorders: A Mendelian randomization study. Front Psychiatry 13:841429","journal-title":"Front Psychiatry"},{"issue":"1","key":"2106_CR36","doi-asserted-by":"publisher","first-page":"e704","DOI":"10.1038\/tp.2015.204","volume":"6","author":"S Hoirisch-Clapauch","year":"2016","unstructured":"Hoirisch-Clapauch S et al (2016) Dysfunction in the coagulation system and schizophrenia. Transl Psychiatry 6(1):e704","journal-title":"Transl Psychiatry"},{"key":"2106_CR37","doi-asserted-by":"publisher","first-page":"1353308","DOI":"10.3389\/fpsyt.2024.1353308","volume":"15","author":"CC Huang","year":"2024","unstructured":"Huang CC (2024) Case report: rare variants in the MTRR gene, 66GG and 524TT cause hyperhomocysteinemia and folic acid deficiency linked to schizophrenia. Front Psychiatry 15:1353308","journal-title":"Front Psychiatry"},{"issue":"6","key":"2106_CR38","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1530\/eje.1.02303","volume":"155","author":"HR Nakhai Pour","year":"2006","unstructured":"Nakhai Pour HR et al (2006) Serum sex hormone and plasma homocysteine levels in middle-aged and elderly men. Eur J Endocrinol 155(6):887\u2013893","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2106_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1515\/CCLM.2003.045","volume":"41","author":"M Bic\u00edkov\u00e1","year":"2003","unstructured":"Bic\u00edkov\u00e1 M et al (2003) Steroids, sex hormone-binding globulin, homocysteine, selected hormones and markers of lipid and carbohydrate metabolism in patients with severe hypothyroidism and their changes following thyroid hormone supplementation. Clin Chem Lab Med 41(3):284\u2013292","journal-title":"Clin Chem Lab Med"},{"issue":"5","key":"2106_CR40","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/schbul\/sbn023","volume":"35","author":"MV Seeman","year":"2009","unstructured":"Seeman MV (2009) Secondary effects of antipsychotics: women at greater risk than men. Schizophr Bull 35(5):937\u2013948","journal-title":"Schizophr Bull"},{"issue":"6","key":"2106_CR41","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/phar.2689","volume":"42","author":"KJ Burghardt","year":"2022","unstructured":"Burghardt KJ et al (2022) The effect of antipsychotic treatment on hormonal, inflammatory, and metabolic biomarkers in healthy volunteers: A systematic review and meta-analysis. Pharmacotherapy 42(6):504\u2013513","journal-title":"Pharmacotherapy"},{"key":"2106_CR42","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.psychres.2017.08.063","volume":"259","author":"SJ Zhou","year":"2018","unstructured":"Zhou SJ et al (2018) Prevalence and clinical-demographic correlates of hyperhomocysteinemia in inpatients with bipolar disorder in a Han Chinese population. Psychiatry Res 259:364\u2013369","journal-title":"Psychiatry Res"},{"issue":"9","key":"2106_CR43","doi-asserted-by":"publisher","first-page":"e30193","DOI":"10.1016\/j.heliyon.2024.e30193","volume":"10","author":"Y Isomura","year":"2024","unstructured":"Isomura Y et al (2024) Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia. Heliyon 10(9):e30193","journal-title":"Heliyon"},{"issue":"11","key":"2106_CR44","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s11920-023-01457-1","volume":"25","author":"A Stein","year":"2023","unstructured":"Stein A et al (2023) Magnetic resonance spectroscopy studies of brain energy metabolism in schizophrenia: progression from prodrome to chronic psychosis. Curr Psychiatry Rep 25(11):659\u2013669","journal-title":"Curr Psychiatry Rep"},{"issue":"3","key":"2106_CR45","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/wps.20252","volume":"14","author":"D Vancampfort","year":"2015","unstructured":"Vancampfort D et al (2015) Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry 14(3):339\u2013347","journal-title":"World Psychiatry"},{"key":"2106_CR46","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1745-0179-2-14","volume":"2","author":"M De Hert","year":"2006","unstructured":"De Hert M et al (2006) Prevalence of diabetes, metabolic syndrome and metabolic abnormalities in schizophrenia over the course of the illness: a cross-sectional study. Clin Pract Epidemiol Ment Health 2:14","journal-title":"Clin Pract Epidemiol Ment Health"},{"key":"2106_CR47","unstructured":"Bo\u012dchuk Ia A, Kopanytsia MV, Lozova NO (1999) Adaptation of synaptic transmission to high concentrations of homocysteinic acid. Ukr Biokhim Zh 2001. 73(5):114-118"},{"issue":"1\u20132","key":"2106_CR48","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jns.2003.11.009","volume":"218","author":"P G\u00f6rtz","year":"2004","unstructured":"G\u00f6rtz P et al (2004) Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J Neurol Sci 218(1\u20132):109\u2013114","journal-title":"J Neurol Sci"},{"key":"2106_CR49","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.schres.2023.10.016","volume":"262","author":"X Wu","year":"2023","unstructured":"Wu X et al (2023) Sulfur-containing amino acids and risk of schizophrenia. Schizophr Res 262:8\u201317","journal-title":"Schizophr Res"},{"issue":"13","key":"2106_CR50","doi-asserted-by":"publisher","first-page":"5331","DOI":"10.1021\/acs.analchem.4c00395","volume":"96","author":"B Zhang","year":"2024","unstructured":"Zhang B et al (2024) Simultaneous SERS sensing of cysteine and homocysteine in blood based on the CBT-Cys click reaction: toward precisive diagnosis of schizophrenia. Anal Chem 96(13):5331\u20135339","journal-title":"Anal Chem"},{"issue":"2","key":"2106_CR51","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/sj.mp.4001746","volume":"11","author":"JW Muntjewerff","year":"2006","unstructured":"Muntjewerff JW et al (2006) Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry 11(2):143\u2013149","journal-title":"Mol Psychiatry"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-025-02106-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00406-025-02106-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-025-02106-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:02:37Z","timestamp":1773925357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00406-025-02106-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2106"],"URL":"https:\/\/doi.org\/10.1007\/s00406-025-02106-9","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"18 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The protocol for the research project had been approved by the Institutional Review Board (IRB) of the Institute of Psychology, Chinese Academy of Sciences (approval number: H18031), and had therefore been performed following the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Patients\u2019 informed consent forms were obtained, and their anonymity was protected.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}