{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:35:03Z","timestamp":1786988103786,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Liaoning Provincial Science and Technology Plan Project","award":["No. 2023JH2\/101600030"],"award-info":[{"award-number":["No. 2023JH2\/101600030"]}]},{"name":"Liaoning Provincial Doctoral Research Start-up Fund Program","award":["No. 2025-BS-0710"],"award-info":[{"award-number":["No. 2025-BS-0710"]}]},{"name":"Liaoning Provincial Department of Science and Technology Joint Fund Doctoral Research Start-up Project","award":["No. 2023-BSBA-214"],"award-info":[{"award-number":["No. 2023-BSBA-214"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.82505715"],"award-info":[{"award-number":["No.82505715"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 82274494"],"award-info":[{"award-number":["No. 82274494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00406-026-02241-x","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:44:55Z","timestamp":1776653095000},"page":"2611-2627","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The neutrophil-to-lymphocyte ratio: a psychoneuroimmunological nexus linking depression and cardiovascular comorbidity"],"prefix":"10.1007","volume":"276","author":[{"given":"Chengyu","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"6","key":"2241_CR1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.pcad.2013.03.010","volume":"55","author":"L Elderon","year":"2013","unstructured":"Elderon L, Whooley MA (2013) Depression and cardiovascular disease. Prog Cardiovasc Dis 55(6):511\u2013523","journal-title":"Prog Cardiovasc Dis"},{"issue":"21","key":"2241_CR2","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","volume":"35","author":"DL Hare","year":"2014","unstructured":"Hare DL, Toukhsati SR, Johansson P, Jaarsma T (2014) Depression and cardiovascular disease: a clinical review. Eur Heart J 35(21):1365\u20131372","journal-title":"Eur Heart J"},{"issue":"2","key":"2241_CR3","doi-asserted-by":"publisher","first-page":"e1921043","DOI":"10.1001\/jamanetworkopen.2019.21043","volume":"3","author":"R Meng","year":"2020","unstructured":"Meng R, Yu C, Liu N, He M, Lv J, Guo Y, Bian Z, Yang L, Chen Y, Zhang X et al (2020) Association of depression with all-cause and cardiovascular disease mortality among adults in China. JAMA Netw Open 3(2):e1921043","journal-title":"JAMA Netw Open"},{"issue":"14","key":"2241_CR4","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/j.jacc.2019.01.041","volume":"73","author":"MK Jha","year":"2019","unstructured":"Jha MK, Qamar A, Vaduganathan M, Charney DS, Murrough JW (2019) Screening and management of depression in patients with cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol 73(14):1827\u20131845","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"2241_CR5","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.amjmed.2023.04.036","volume":"136","author":"C Krittanawong","year":"2023","unstructured":"Krittanawong C, Maitra NS, Qadeer YK, Wang Z, Fogg S, Storch EA, Celano CM, Huffman JC, Jha M, Charney DS et al (2023) Association of depression and cardiovascular disease. Am J Med 136(9):881\u2013895","journal-title":"Am J Med"},{"issue":"23","key":"2241_CR6","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1001\/jama.2020.23068","volume":"324","author":"EL Harshfield","year":"2020","unstructured":"Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S et al (2020) Association between depressive symptoms and incident cardiovascular diseases. JAMA 324(23):2396\u20132405","journal-title":"JAMA"},{"key":"2241_CR7","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neubiorev.2020.06.031","volume":"116","author":"BS Pope","year":"2020","unstructured":"Pope BS, Wood SK (2020) Advances in understanding mechanisms and therapeutic targets to treat comorbid depression and cardiovascular disease. Neurosci Biobehav Rev 116:337\u2013349","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"2241_CR8","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/s41380-019-0615-x","volume":"25","author":"RB Price","year":"2020","unstructured":"Price RB, Duman R (2020) Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model. Mol Psychiatry 25(3):530\u2013543","journal-title":"Mol Psychiatry"},{"issue":"9","key":"2241_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/nri3042","volume":"11","author":"MR Irwin","year":"2011","unstructured":"Irwin MR, Cole SW (2011) Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11(9):625\u2013632","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2241_CR10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s41467-021-27604-x","volume":"13","author":"L Dion-Albert","year":"2022","unstructured":"Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Daigle B, Parise LF, Cathomas F, Samba N, Hudson N et al (2022) Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nat Commun 13(1):164","journal-title":"Nat Commun"},{"issue":"21","key":"2241_CR11","doi-asserted-by":"publisher","first-page":"eadt6632","DOI":"10.1126\/sciadv.adt6632","volume":"11","author":"H Yao","year":"2025","unstructured":"Yao H, Jiang SY, Jiao YY, Zhou ZY, Zhu Z, Wang C, Zhang KZ, Ma TF, Hu G, Du RH et al (2025) Astrocyte-derived CCL5-mediated CCR5(+) neutrophil infiltration drives depression pathogenesis. Sci Adv 11(21):eadt6632","journal-title":"Sci Adv"},{"issue":"3","key":"2241_CR12","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ccell.2024.01.013","volume":"42","author":"XY He","year":"2024","unstructured":"He XY, Gao Y, Ng D, Michalopoulou E, George S, Adrover JM, Sun L, Albrengues J, Da\u00dfler-Plenker J, Han X et al (2024) Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment. Cancer Cell 42(3):474\u2013486e412","journal-title":"Cancer Cell"},{"issue":"43","key":"2241_CR13","doi-asserted-by":"publisher","first-page":"e2404096","DOI":"10.1002\/advs.202404096","volume":"11","author":"H Huang","year":"2024","unstructured":"Huang H, Deng X, Wang Y, Shen S, Wang S, Hu M, Liu S, Su X, Li C, Li T et al (2024) Chronic stress exacerbates cerebral amyloid angiopathy through promoting neutrophil extracellular traps formation. Adv Sci (Weinh) 11(43):e2404096","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"2241_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1053\/euhj.2001.2611","volume":"23","author":"A Steptoe","year":"2002","unstructured":"Steptoe A, Marmot M (2002) The role of psychobiological pathways in socio-economic inequalities in cardiovascular disease risk. Eur Heart J 23(1):13\u201325","journal-title":"Eur Heart J"},{"issue":"1","key":"2241_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12933-024-02191-5","volume":"23","author":"X Zhang","year":"2024","unstructured":"Zhang X, Wei R, Wang X, Zhang W, Li M, Ni T, Weng W, Li Q (2024) The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension. Cardiovasc Diabetol 23(1):117","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"2241_CR16","doi-asserted-by":"publisher","first-page":"26692","DOI":"10.1038\/s41598-024-76836-6","volume":"14","author":"X Li","year":"2024","unstructured":"Li X, Liu M, Wang G (2024) The neutrophil-lymphocyte ratio is associated with all-cause and cardiovascular mortality in cardiovascular patients. Sci Rep 14(1):26692","journal-title":"Sci Rep"},{"issue":"5","key":"2241_CR17","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.jchf.2024.11.003","volume":"13","author":"A Cannata","year":"2025","unstructured":"Cannata A, Segev A, Madaudo C, Bobbio E, Baggio C, Sch\u00fctze J, Gentile P, Sanguineti M, Monzo L, Schettino M et al (2025) Elevated neutrophil-to-lymphocyte ratio predicts prognosis in acute myocarditis. JACC Heart Fail 13(5):770\u2013780","journal-title":"JACC Heart Fail"},{"key":"2241_CR18","doi-asserted-by":"crossref","unstructured":"Del Turco S, Bastiani L, Minichilli F, Landi P, Basta G, Pingitore A, Vassalle C (2022) Interaction of uric acid and neutrophil-to-lymphocyte ratio for cardiometabolic risk stratification and prognosis in coronary artery disease patients. Antioxid (Basel) 11(11)","DOI":"10.3390\/antiox11112163"},{"issue":"1","key":"2241_CR19","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1192\/j.eurpsy.2019.20","volume":"63","author":"\u00c1 Velasco","year":"2020","unstructured":"Velasco \u00c1, Rodr\u00edguez-Revuelta J, Oli\u00e9 E, Abad I, Fern\u00e1ndez-Pel\u00e1ez A, Cazals A, Guillaume S, de la Fuente-Tom\u00e1s L, Jim\u00e9nez-Trevi\u00f1o L, Guti\u00e9rrez L et al (2020) Neutrophil-to-lymphocyte ratio: a potential new peripheral biomarker of suicidal behavior. Eur Psychiatry 63(1):e14","journal-title":"Eur Psychiatry"},{"key":"2241_CR20","doi-asserted-by":"publisher","first-page":"911779","DOI":"10.3389\/fimmu.2022.911779","volume":"13","author":"Z Liu","year":"2022","unstructured":"Liu Z, Li Y, Wang Y, Zhang H, Lian Y, Cheng X (2022) The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with the severity of autoimmune encephalitis. Front Immunol 13:911779","journal-title":"Front Immunol"},{"key":"2241_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.pediatrneurol.2023.03.009","volume":"143","author":"L Devlin","year":"2023","unstructured":"Devlin L, Gombolay G (2023) The neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio predict expanded disability status scale score at one year in pediatric neuromyelitis optica spectrum disorder but not in multiple sclerosis. Pediatr Neurol 143:84\u201388","journal-title":"Pediatr Neurol"},{"key":"2241_CR22","doi-asserted-by":"publisher","first-page":"104570","DOI":"10.1016\/j.msard.2023.104570","volume":"71","author":"L Lin","year":"2023","unstructured":"Lin L, Ji M, Wu Y, Hang H, Lu J (2023) Neutrophil to lymphocyte ratio may be a useful marker in distinguishing MOGAD and MS and platelet to lymphocyte ratio associated with MOGAD activity. Mult Scler Relat Disord 71:104570","journal-title":"Mult Scler Relat Disord"},{"key":"2241_CR23","doi-asserted-by":"publisher","first-page":"12869","DOI":"10.2147\/JIR.S548421","volume":"18","author":"A Han","year":"2025","unstructured":"Han A, Xie Y, Sun W, Zhou X, Zhang S, Xie Y, Yang N, Xie N (2025) The associations of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index with the severity and prognosis of autoimmune glial fibrillary acidic protein astrocytopathy. J Inflamm Res 18:12869\u201312882","journal-title":"J Inflamm Res"},{"key":"2241_CR24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jad.2022.08.004","volume":"315","author":"F Meng","year":"2022","unstructured":"Meng F, Yan X, Qi J, He F (2022) Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio with depression: a cross-sectional analysis of the NHANES data. J Affect Disord 315:168\u2013173","journal-title":"J Affect Disord"},{"issue":"1","key":"2241_CR25","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12933-023-01998-y","volume":"22","author":"G Dong","year":"2023","unstructured":"Dong G, Gan M, Xu S, Xie Y, Zhou M, Wu L (2023) The neutrophil-lymphocyte ratio as a risk factor for all-cause and cardiovascular mortality among individuals with diabetes: evidence from the NHANES 2003\u20132016. Cardiovasc Diabetol 22(1):267","journal-title":"Cardiovasc Diabetol"},{"key":"2241_CR26","doi-asserted-by":"publisher","first-page":"103470","DOI":"10.1016\/j.redox.2024.103470","volume":"79","author":"X Qi","year":"2025","unstructured":"Qi X, Wang S, Fang C, Jia J, Lin L, Yuan T (2025) Machine learning and SHAP value interpretation for predicting comorbidity of cardiovascular disease and cancer with dietary antioxidants. Redox Biol 79:103470","journal-title":"Redox Biol"},{"issue":"1","key":"2241_CR27","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1186\/s12916-025-04248-y","volume":"23","author":"Y Cui","year":"2025","unstructured":"Cui Y, Du H (2025) A population-based observational study using statistical modeling to assess the association between depressive symptom severity and sleep disorders in postmenopausal women. BMC Med 23(1):424","journal-title":"BMC Med"},{"issue":"8","key":"2241_CR28","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jacc.2021.12.017","volume":"79","author":"L Liberale","year":"2022","unstructured":"Liberale L, Badimon L, Montecucco F, L\u00fcscher TF, Libby P, Camici GG (2022) Inflammation, aging, and cardiovascular disease: JACC review topic of the week. J Am Coll Cardiol 79(8):837\u2013847","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2241_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","volume":"17","author":"C Silvestre-Roig","year":"2020","unstructured":"Silvestre-Roig C, Braster Q, Ortega-Gomez A, Soehnlein O (2020) Neutrophils as regulators of cardiovascular inflammation. Nat Rev Cardiol 17(6):327\u2013340","journal-title":"Nat Rev Cardiol"},{"key":"2241_CR30","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.psyneuen.2019.01.007","volume":"103","author":"G Meng","year":"2019","unstructured":"Meng G, Wang L, Wang X, Chi VTQ, Zhang Q, Liu L, Yao Z, Wu H, Bao X, Gu Y et al (2019) Association between neutrophil to lymphocyte ratio and depressive symptoms among Chinese adults: a population study from the TCLSIH cohort study. Psychoneuroendocrinology 103:76\u201382","journal-title":"Psychoneuroendocrinology"},{"key":"2241_CR31","doi-asserted-by":"publisher","first-page":"110786","DOI":"10.1016\/j.pnpbp.2023.110786","volume":"126","author":"J Yin","year":"2023","unstructured":"Yin J, Gong R, Zhang M, Ding L, Shen T, Cai Y, He S, Peng D (2023) Associations between sleep disturbance, inflammatory markers and depressive symptoms: mediation analyses in a large NHANES community sample. Prog Neuropsychopharmacol Biol Psychiatry 126:110786","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2241_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.psychres.2018.02.043","volume":"263","author":"J Arabska","year":"2018","unstructured":"Arabska J, \u0141ucka A, Magierski R, Sob\u00f3w T, Wysoki\u0144ski A (2018) Neutrophil-lymphocyte ratio is increased in elderly patients with first episode depression, but not in recurrent depression. Psychiatry Res 263:35\u201340","journal-title":"Psychiatry Res"},{"key":"2241_CR33","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3389\/fimmu.2019.00546","volume":"10","author":"H Bonnekoh","year":"2019","unstructured":"Bonnekoh H, Scheffel J, Wu J, Hoffmann S, Maurer M, Krause K (2019) Skin and systemic inflammation in Schnitzler\u2019s syndrome are associated with neutrophil extracellular trap formation. Front Immunol 10:546","journal-title":"Front Immunol"},{"issue":"1","key":"2241_CR34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41420-025-02350-x","volume":"11","author":"XB Zheng","year":"2025","unstructured":"Zheng XB, Wang X, Gao SQ, Gao CC, Li T, Han YL, Zhao R, Sun Y, Miao SH, Qiu JY et al (2025) NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury. Cell Death Discov 11(1):69","journal-title":"Cell Death Discov"},{"issue":"1","key":"2241_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12974-025-03395-6","volume":"22","author":"J Yue","year":"2025","unstructured":"Yue J, Mo L, Zeng G, Ma P, Zhang X, Peng Y, Zhang X, Zhou Y, Jiang Y, Huang N et al (2025) Inhibition of neutrophil extracellular traps alleviates blood-brain barrier disruption and cognitive dysfunction via Wnt3\/\u03b2-catenin\/TCF4 signaling in sepsis-associated encephalopathy. J Neuroinflammation 22(1):87","journal-title":"J Neuroinflammation"},{"key":"2241_CR36","doi-asserted-by":"crossref","unstructured":"Ma Y, Zhang J, Qi Y, Lu Y, Dong Y, Hu D (2025) Neutrophil extracellular traps in cardiovascular diseases: pathological roles and therapeutic implications. Biomolecules 15(9)","DOI":"10.3390\/biom15091263"},{"key":"2241_CR37","doi-asserted-by":"publisher","first-page":"117476","DOI":"10.1016\/j.biopha.2024.117476","volume":"180","author":"Y Tang","year":"2024","unstructured":"Tang Y, Jiao Y, An X, Tu Q, Jiang Q (2024) Neutrophil extracellular traps and cardiovascular disease: associations and potential therapeutic approaches. Biomed Pharmacother 180:117476","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2241_CR38","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41590-024-01836-7","volume":"25","author":"AD Jerome","year":"2024","unstructured":"Jerome AD, Sas AR, Wang Y, Hammond LA, Wen J, Atkinson JR, Webb A, Liu T, Segal BM (2024) Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration. Nat Immunol 25(6):957\u2013968","journal-title":"Nat Immunol"},{"issue":"12","key":"2241_CR39","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1038\/s41590-020-00813-0","volume":"21","author":"AR Sas","year":"2020","unstructured":"Sas AR, Carbajal KS, Jerome AD, Menon R, Yoon C, Kalinski AL, Giger RJ, Segal BM (2020) A new neutrophil subset promotes CNS neuron survival and axon regeneration. Nat Immunol 21(12):1496\u20131505","journal-title":"Nat Immunol"},{"issue":"1","key":"2241_CR40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/imr.13123","volume":"311","author":"AP Coulibaly","year":"2022","unstructured":"Coulibaly AP (2022) Neutrophil modulation of behavior and cognition in health and disease: the unexplored role of an innate immune cell. Immunol Rev 311(1):177\u2013186","journal-title":"Immunol Rev"},{"issue":"1","key":"2241_CR41","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1586\/erc.12.159","volume":"11","author":"T Bhat","year":"2013","unstructured":"Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, Meghani M, Akhtar M, Costantino T (2013) Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 11(1):55\u201359","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2241_CR42","doi-asserted-by":"crossref","unstructured":"Trtica Majnari\u0107 L, Gulja\u0161 S, Bosni\u0107 Z, \u0160eri\u0107 V, Wittlinger T (2021) Neutrophil-to-lymphocyte ratio as a cardiovascular risk marker may be less efficient in women than in men. Biomolecules 11(4)","DOI":"10.3390\/biom11040528"},{"key":"2241_CR43","doi-asserted-by":"publisher","first-page":"1309835","DOI":"10.3389\/fimmu.2023.1309835","volume":"14","author":"E Zhou","year":"2023","unstructured":"Zhou E, Wu J, Zhou X, Yin Y (2023) The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among U.S. adults with rheumatoid arthritis: results from NHANES 1999\u20132020. Front Immunol 14:1309835","journal-title":"Front Immunol"},{"issue":"1","key":"2241_CR44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1161\/CIRCULATIONAHA.121.056171","volume":"145","author":"SG Deftereos","year":"2022","unstructured":"Deftereos SG, Beerkens FJ, Shah B, Giannopoulos G, Vrachatis DA, Giotaki SG, Siasos G, Nicolas J, Arnott C, Patel S et al (2022) Colchicine in cardiovascular disease: in-depth review. Circulation 145(1):61\u201378","journal-title":"Circulation"},{"issue":"10235","key":"2241_CR45","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1016\/S0140-6736(20)30564-X","volume":"395","author":"IB McInnes","year":"2020","unstructured":"McInnes IB, Behrens F, Mease PJ, Kavanaugh A, Ritchlin C, Nash P, Masmitja JG, Goupille P, Korotaeva T, Gottlieb AB et al (2020) Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial. Lancet 395(10235):1496\u20131505","journal-title":"Lancet"},{"key":"2241_CR46","doi-asserted-by":"crossref","unstructured":"Fede MS, Daziani G, Tavoletta F, Montana A, Compagnucci P, Goteri G, Neri M, Busard\u00f2 FP (2025) Myocardial ischemia\/reperfusion injury: molecular insights, forensic perspectives, and therapeutic horizons. Cells 14(19)","DOI":"10.3390\/cells14191509"},{"issue":"1","key":"2241_CR47","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13020-023-00732-w","volume":"18","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, Chen F, Wan J, Liu X (2023) Potential traditional Chinese medicines with anti-inflammation in the prevention of heart failure following myocardial infarction. Chin Med 18(1):28","journal-title":"Chin Med"},{"key":"2241_CR48","doi-asserted-by":"publisher","first-page":"114133","DOI":"10.1016\/j.jconrel.2025.114133","volume":"386","author":"B Hu","year":"2025","unstructured":"Hu B, Zhu D, Chan L, Tuohan M, Wang W, Lu Y, Wang Y (2025) Oral ruthenium-based PAD4 inhibitor modulates immunogenic cell death and neutrophil extracellular traps in triple-negative breast cancer. J Control Release 386:114133","journal-title":"J Control Release"},{"issue":"5","key":"2241_CR49","doi-asserted-by":"publisher","first-page":"e1132","DOI":"10.1038\/tp.2017.76","volume":"7","author":"F Euteneuer","year":"2017","unstructured":"Euteneuer F, Dannehl K, Del Rey A, Engler H, Schedlowski M, Rief W (2017) Immunological effects of behavioral activation with exercise in major depression: an exploratory randomized controlled trial. Transl Psychiatry 7(5):e1132","journal-title":"Transl Psychiatry"},{"key":"2241_CR50","doi-asserted-by":"crossref","unstructured":"Huang J, Chen B, Wang H, Hu S, Yu X, Reilly J, He Z, You Y, Shu X (2022) Dihydromyricetin attenuates depressive-like behaviors in mice by inhibiting the AGE-RAGE signaling pathway. Cells 11(23)","DOI":"10.3390\/cells11233730"},{"issue":"1","key":"2241_CR51","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1093\/cvr\/cvad158","volume":"120","author":"F Rolski","year":"2024","unstructured":"Rolski F, Tkacz K, W\u0119glarczyk K, Kwiatkowski G, Pelczar P, Ja\u017awa-Kusior A, Bar A, Kuster GM, Ch\u0142opicki S, Siedlar M et al (2024) TNF-\u03b1 protects from exacerbated myocarditis and cardiac death by suppressing expansion of activated heart-reactive CD4\u2009+\u2009T cells. Cardiovasc Res 120(1):82\u201394","journal-title":"Cardiovasc Res"},{"key":"2241_CR52","doi-asserted-by":"crossref","unstructured":"Pinzi M, Fagiolini A, Koukouna D, Gualtieri G, Rescalli MB, Pierini C, Pardossi S, Patrizio B, Cuomo A (2025) Inflammatory and immune biomarkers in mood disorders: from mechanistic pathways to clinical translation. Cells 14(19)","DOI":"10.3390\/cells14191558"},{"key":"2241_CR53","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.toxlet.2025.07.1414","volume":"411","author":"G Li","year":"2025","unstructured":"Li G, Zhang T, He K, Zhang M, Hu J, Ge T, Wang M, Zou R, Fan X (2025) Deciphering the influence of heavy metals on adverse cardiovascular events using machine learning. Toxicol Lett 411:101\u2013110","journal-title":"Toxicol Lett"},{"issue":"1","key":"2241_CR54","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s13098-025-01753-1","volume":"17","author":"G Li","year":"2025","unstructured":"Li G, Luo C, Ge T, He K, Zhang M, Hu J, Zheng B, Zou R, Fan X (2025) Evaluating the impact of metabolic indicators and scores on cardiovascular events using machine learning. Diabetol Metab Syndr 17(1):180","journal-title":"Diabetol Metab Syndr"},{"key":"2241_CR55","doi-asserted-by":"crossref","unstructured":"Li G, Lin D, Fan X, Peng B (2024) Exploring hypertrophic cardiomyopathy biomarkers through integrated bioinformatics analysis: uncovering novel diagnostic candidates. Cardiol Res Pract 2024:4639334","DOI":"10.1155\/2024\/4639334"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02241-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00406-026-02241-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02241-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:01:12Z","timestamp":1786986072000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00406-026-02241-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["2241"],"URL":"https:\/\/doi.org\/10.1007\/s00406-026-02241-x","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"assertion":[{"value":"10 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised due missing of funding note. Now, it has been updated.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}