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Current suicidal symptom severity was classified as none, mild, or strong if an individual has scores of 0, 2\u20133, and \u2265\u20094, respectively, on item 10 of the Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS). The presence of a lifetime history of suicide attempts was also determined. All participants had CRP levels measured and underwent the Wisconsin Card Sorting Test (WCST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Generalized linear models (GLM) with adjustments for demographic characteristics, diagnoses, and non-suicidal depressive symptoms indicated that patients presenting strong suicidal symptoms had the highest CRP levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and percentage of nonperseverative errors on the WCST (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), whereas those with mild suicidal symptoms were more likely to have intermediate CRP levels relative to non-suicidal young people. Only young people with a history of suicide attempts exhibited an increased percentage of perseverative errors on the WCST (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) compared with the healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings suggest that CRP levels and the percentage of nonperseverative errors on the WCST served as concurrent markers of suicidality, whereas the percentage of perseverative errors served as a trait marker of suicidality among young people with major affective disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00406-026-02293-z","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:10:20Z","timestamp":1782119420000},"page":"2751-2758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct effects of current suicidal symptoms and lifetime suicide attempts on C-reactive protein levels and executive function in young people with major affective disorders"],"prefix":"10.1007","volume":"276","author":[{"given":"Ju-Wei","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Mei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1073","authenticated-orcid":false,"given":"Mu-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"2293_CR1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1177\/00048674221108640","volume":"57","author":"YH Chang","year":"2023","unstructured":"Chang YH, Lin CY, Liao SC, Chen YY, Shaw FF, Hsu CY, Gunnell D, Chang SS (2023) Societal factors and psychological distress indicators associated with the recent rise in youth suicide in Taiwan: A time trend analysis. 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