{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:09:51Z","timestamp":1789052991906,"version":"build-2803163510"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Max Planck Institute of Psychiatry"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Postmortem findings, neuroimaging data, and in-vitro models suggest a decrease in number and density of oligodendrocytes is driving cognitive deficits in schizophrenia (SCZ). Second-generation antipsychotics are discussed to improve oligodendrocyte dysfunction with most conclusive evidence available for quetiapine (QET). We postulate that sustained QET treatment leads to cognitive improvement in SCZ, particularly, in tests with high demands for working memory function. We further hypothesize that these effects are moderated by polygenic factors associated with hippocampus-related brain volumes, general white matter integrity, and\/or oligodendroglia-related SCZ risk. Using data of the prospective PsyCourse study, we identified 166 patients with SCZ spectrum disorder receiving QET at one or two consecutive visits plus 166 matched patients without QET. Polygenic scores were calculated for subcortical brain volumes, measures of white matter integrity, and for cell type-specific genetic SCZ risks. QET treatment was consistently associated with improved cognitive function independent of time, specifically, in tests with high, but not with low to medium working memory load. Polygenic analyses did not reveal significant moderation effects. In contrary, low genetic SCZ risk specific for genes related to human oligodendrocyte function was associated with higher cognitive performance independent from QET. While we observed improved cognitive performance under QET in high working memory tests, we did not find evidence that polygenic factors associated with hippocampus-related brain volumes, white matter integrity, or oligodendroglia-related SCZ risk moderate this association. Thus, our tentative findings do not provide evidence for the hypothesis that polygenic estimates of hippocampal remyelination capacities influence the association between QET and cognitive performance in SCZ.<\/jats:p>","DOI":"10.1007\/s00406-026-02309-8","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:09:28Z","timestamp":1783148968000},"page":"3493-3507","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of quetiapine on cognitive functioning in schizophrenia: evidence for the remyelination 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E.C.S. is supported through the Munich Clinician Scientist Program (MCSP). T.G.S. and P.F. are supported by the Deutsche Forschungsgemeinschaft (DFG) within the framework of the projects www.kfo241.de and www.PsyCourse.de (SCHU 1603\/4-1, 5-1, 7-1; FA241\/16-1). T.G.S. is further supported by the Dr. Lisa Oehler Foundation (Kassel, Germany), IntegraMent (01ZX1614K), BipoLife (01EE1404H), e:Med Program (01ZX1614K), GEPI-BIOPSY (01EW2005), and Muliobio (01EW2009). The study was endorsed by the Ministry of Research, Technology and Space (BMFTR) (Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt) within the setup phase of the German Center for Mental Health (DZPG) (01EE2503A, 01EE2503F to P.F., T.G.S., and 01EE2306B to A.J.F.). U.H. was supported by European Union\u2019s Horizon 2020 Research and Innovation Programme (PSY-PGx, grant agreement No 945151) and DFG (514201724). S.P. was supported by European Union\u2019s Horizon 2020 Research and Innovation Programme (Psych-STRATA, GA N\u00b0 101057454) and by BMFTR under the frame of the European Partnership for Personalised Medicine, EP PerMed, (omiCSFit, GA N\u00b0 101137129 of the EU Horizon Europe Research and Innovation Programme). The other authors have no conflicts of interest to be disclosed.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}