{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:02:24Z","timestamp":1793678544512,"version":"4.5.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/2\/June 2021\/PG Thesis HRD (17)]"],"award-info":[{"award-number":["3\/2\/June 2021\/PG Thesis HRD (17)]"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00406-026-02319-6","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:49:03Z","timestamp":1785818943000},"page":"3623-3633","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of add-on topiramate vs. metformin on cardiometabolic profile in patients of schizophrenia on atypical antipsychotics with metabolic syndrome: an active-controlled, rater-blinded, parallel-design randomized controlled trial"],"prefix":"10.1007","volume":"276","author":[{"given":"Radhika","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debadatta","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tathagata","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathan Kumar","family":"Ramasubbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituparna","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-9454","authenticated-orcid":false,"given":"Biswa Ranjan","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"10","key":"2319_CR1","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1001\/archpsyc.64.10.1123","volume":"64","author":"S Saha","year":"2007","unstructured":"Saha S, Chant D, McGrath J (2007) A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry 64(10):1123\u20131131","journal-title":"Arch Gen Psychiatry"},{"issue":"2\u20133","key":"2319_CR2","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.schres.2010.07.012","volume":"123","author":"C Rummel-Kluge","year":"2010","unstructured":"Rummel-Kluge C, Komossa K, Schwarz S, Hunger H, Schmid F, Lobos CA et al (2010) Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res 123(2\u20133):225\u2013233","journal-title":"Schizophr Res"},{"issue":"6","key":"2319_CR3","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/hup.514","volume":"18","author":"M Atmaca","year":"2003","unstructured":"Atmaca M, Kuloglu M, Tezcan E, Ustundag B (2003) Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight gain. Hum Psychopharmacol 18(6):457\u2013461","journal-title":"Hum Psychopharmacol"},{"issue":"1","key":"2319_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1177\/0300060517716783","volume":"46","author":"X-J Gu","year":"2018","unstructured":"Gu X-J, Chen R, Sun C-H, Zheng W, Yang X-H, Wang S-B et al (2018) Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials. J Int Med Res 46(1):22\u201332","journal-title":"J Int Med Res"},{"issue":"7","key":"2319_CR5","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/npp.2010.21","volume":"35","author":"L Maayan","year":"2010","unstructured":"Maayan L, Vakhrusheva J, Correll CU (2010) Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology 35(7):1520\u20131530","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"2319_CR6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.euroneuro.2003.10.004","volume":"14","author":"M Poyurovsky","year":"2004","unstructured":"Poyurovsky M, Tal V, Maayan R, Gil-Ad I, Fuchs C, Weizman A (2004) The effect of famotidine addition on olanzapine-induced weight gain in first-episode schizophrenia patients: a double-blind placebo-controlled pilot study. Eur Neuropsychopharmacol 14(4):332\u2013336","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"2319_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1097\/JCP.0000000000000598","volume":"37","author":"W Zheng","year":"2017","unstructured":"Zheng W, Wang S, Ungvari GS, Ng CH, Yang X-H, Gu Y-H et al (2017) Amantadine for Antipsychotic-Related Weight Gain: Meta-Analysis of Randomized Placebo-Controlled Trials. J Clin Psychopharmacol 37(3):341\u2013346","journal-title":"J Clin Psychopharmacol"},{"issue":"5","key":"2319_CR8","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1093\/schbul\/sbae205","volume":"51","author":"A Carolan","year":"2025","unstructured":"Carolan A, Hynes-Ryan C, Agarwal SM, Bourke R, Cullen W, Gaughran F et al (2025) Metformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation. Schizophr Bull 51(5):1193\u20131205","journal-title":"Schizophr Bull"},{"issue":"5","key":"2319_CR9","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/JCP.0000000000000392","volume":"35","author":"W Zheng","year":"2015","unstructured":"Zheng W, Li X-B, Tang Y-L, Xiang Y-Q, Wang C-Y, de Leon J (2015) Metformin for Weight Gain and Metabolic Abnormalities Associated With Antipsychotic Treatment: Meta-Analysis of Randomized Placebo-Controlled Trials. J Clin Psychopharmacol 35(5):499\u2013509","journal-title":"J Clin Psychopharmacol"},{"issue":"19","key":"2319_CR10","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1001\/jama.2019.3805","volume":"321","author":"J Flory","year":"2019","unstructured":"Flory J, Lipska K (2019) Metformin in 2019. JAMA 321(19):1926\u20131927","journal-title":"JAMA"},{"issue":"6","key":"2319_CR11","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1345\/aph.1K656","volume":"42","author":"AR Desilets","year":"2008","unstructured":"Desilets AR, Dhakal-Karki S, Dunican KC (2008) Role of metformin for weight management in patients without type 2 diabetes. Ann Pharmacother 42(6):817\u2013826","journal-title":"Ann Pharmacother"},{"issue":"1","key":"2319_CR12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/13651501.2018.1449864","volume":"23","author":"KK Goh","year":"2019","unstructured":"Goh KK, Chen C-H, Lu M-L (2019) Topiramate mitigates weight gain in antipsychotic-treated patients with schizophrenia: meta-analysis of randomised controlled trials. Int J Psychiatry Clin Pract 23(1):14\u201332","journal-title":"Int J Psychiatry Clin Pract"},{"key":"2319_CR13","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.genhosppsych.2024.06.003","volume":"90","author":"NC Hegde","year":"2024","unstructured":"Hegde NC, Mishra A, Maiti R, Mishra BR, Mohapatra D, Srinivasan A (2024) Pharmacological interventions for antipsychotic-induced weight gain in schizophrenia: A network meta-analysis. Gen Hosp Psychiatry 90:12\u201321","journal-title":"Gen Hosp Psychiatry"},{"issue":"9","key":"2319_CR14","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1177\/02698811211035391","volume":"35","author":"Y Wang","year":"2021","unstructured":"Wang Y, Wang D, Cheng J, Fang X, Chen Y, Yu L et al (2021) Efficacy and tolerability of pharmacological interventions on metabolic disturbance induced by atypical antipsychotics in adults: A systematic review and network meta-analysis. J Psychopharmacol 35(9):1111\u20131119","journal-title":"J Psychopharmacol"},{"issue":"6","key":"2319_CR15","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/WNF.0000000000000188","volume":"39","author":"P-J Peng","year":"2016","unstructured":"Peng P-J, Ho P-S, Tsai C-K, Huang S-Y, Liang C-S (2016) A Pilot Study of Randomized, Head-to-Head of Metformin Versus Topiramate in Obese People With Schizophrenia. Clin Neuropharmacol 39(6):306\u2013310","journal-title":"Clin Neuropharmacol"},{"issue":"1","key":"2319_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12991-020-00319-x","volume":"19","author":"C Wang","year":"2020","unstructured":"Wang C, Shi W, Xu J, Huang C, Zhu J (2020) Outcomes and safety of concomitant topiramate or metformin for antipsychotics-induced obesity: a randomized-controlled trial. Ann Gen Psychiatry 19(1):68","journal-title":"Ann Gen Psychiatry"},{"issue":"22","key":"2319_CR17","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1136\/heartjnl-2022-321231","volume":"109","author":"RE Parsons","year":"2023","unstructured":"Parsons RE, Liu X, Collister JA, Clifton DA, Cairns BJ, Clifton L (2023) Independent external validation of the QRISK3 cardiovascular disease risk prediction model using UK Biobank. Heart 109(22):1690\u20131697","journal-title":"Heart"},{"issue":"7","key":"2319_CR18","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412\u2013419","journal-title":"Diabetologia"},{"issue":"4","key":"2319_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4274\/Jcrpe.1127","volume":"5","author":"Y Singh","year":"2013","unstructured":"Singh Y, Garg MK, Tandon N, Marwaha RK (2013) A study of insulin resistance by HOMA-IR and its cut-off value to identify metabolic syndrome in urban Indian adolescents. J Clin Res Pediatr Endocrinol 5(4):245\u2013251","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"7","key":"2319_CR20","first-page":"28","volume":"4","author":"J Busner","year":"2007","unstructured":"Busner J, Targum SD (2007) The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont) 4(7):28\u201337","journal-title":"Psychiatry (Edgmont)"},{"issue":"9","key":"2319_CR21","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1093\/occmed\/kqv078","volume":"65","author":"J Hobson","year":"2015","unstructured":"Hobson J (2015) The Montreal Cognitive Assessment (MoCA). Occup Med (Lond) 65(9):764\u2013765","journal-title":"Occup Med (Lond)"},{"issue":"1","key":"2319_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1001\/archpsyc.1973.04200010072013","volume":"29","author":"L Kayton","year":"1973","unstructured":"Kayton L (1973) Good outcome in young adult schizophrenia. Arch Gen Psychiatry 29(1):103\u2013110","journal-title":"Arch Gen Psychiatry"},{"key":"2319_CR23","doi-asserted-by":"publisher","first-page":"j2099","DOI":"10.1136\/bmj.j2099","volume":"357","author":"J Hippisley-Cox","year":"2017","unstructured":"Hippisley-Cox J, Coupland C, Brindle P (2017) Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ 357:j2099","journal-title":"BMJ"},{"issue":"22","key":"2319_CR24","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1001\/archinte.161.22.2685","volume":"161","author":"I Lemieux","year":"2001","unstructured":"Lemieux I, Lamarche B, Couillard C, Pascot A, Cantin B, Bergeron J et al (2001) Total cholesterol\/HDL cholesterol ratio vs LDL cholesterol\/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch Intern Med 161(22):2685\u20132692","journal-title":"Arch Intern Med"},{"key":"2319_CR25","unstructured":"(NICE) NIfHaCE Cardiovascular disease: risk assessment and reduction, including lipid modification London 2023 https:\/\/www.nice.org.uk\/guidance\/cg181"},{"issue":"4","key":"2319_CR26","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/jpm.12809","volume":"29","author":"S Meepring","year":"2022","unstructured":"Meepring S, Gray R, Li Y, Ho G, Chien WT, Bressington D (2022) Cardiometabolic health risks, lifestyle behaviours and quality of life in people diagnosed with early psychosis - A cross-sectional study. J Psychiatr Ment Health Nurs 29(4):578\u2013591","journal-title":"J Psychiatr Ment Health Nurs"},{"issue":"1\u20133","key":"2319_CR27","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.schres.2010.02.001","volume":"118","author":"PK Narula","year":"2010","unstructured":"Narula PK, Rehan HS, Unni KES, Gupta N (2010) Topiramate for prevention of olanzapine associated weight gain and metabolic dysfunction in schizophrenia: a double-blind, placebo-controlled trial. Schizophr Res 118(1\u20133):218\u2013223","journal-title":"Schizophr Res"},{"issue":"4","key":"2319_CR28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/01.wnf.0000172994.56028.c3","volume":"28","author":"Y-H Ko","year":"2005","unstructured":"Ko Y-H, Joe S-H, Jung I-K, Kim S-H (2005) Topiramate as an adjuvant treatment with atypical antipsychotics in schizophrenic patients experiencing weight gain. Clin Neuropharmacol 28(4):169\u2013175","journal-title":"Clin Neuropharmacol"},{"issue":"4","key":"2319_CR29","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1093\/schbul\/sbac027","volume":"48","author":"BR Mishra","year":"2022","unstructured":"Mishra BR, Agrawal K, Biswas T, Mohapatra D, Nath S, Maiti R (2022) Comparison of Acute Followed by Maintenance ECT vs Clozapine on Psychopathology and Regional Cerebral Blood Flow in Treatment-Resistant Schizophrenia: A Randomized Controlled Trial. Schizophr Bull 48(4):814\u2013825","journal-title":"Schizophr Bull"},{"issue":"10","key":"2319_CR30","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S0899-9007(00)00452-4","volume":"16","author":"D Richard","year":"2000","unstructured":"Richard D, Ferland J, Lalonde J, Samson P, Deshaies Y (2000) Influence of topiramate in the regulation of energy balance. Nutrition 16(10):961\u2013966","journal-title":"Nutrition"},{"key":"2319_CR31","doi-asserted-by":"crossref","unstructured":"Mu X, Wu A, Hu H, Zhou H, Yang M (2022) Assessment of QRISK3 as a predictor of cardiovascular disease events in type 2 diabetes mellitus. Front Endocrinol 13","DOI":"10.3389\/fendo.2022.1077632"},{"issue":"1","key":"2319_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2174\/157340012798994867","volume":"8","author":"JG Fiedorowicz","year":"2012","unstructured":"Fiedorowicz JG, Miller DD, Bishop JR, Calarge CA, Ellingrod VL, Haynes WG (2012) Systematic Review and Meta-analysis of Pharmacological Interventions for Weight Gain from Antipsychotics and Mood Stabilizers. Curr Psychiatry Rev 8(1):25\u201336","journal-title":"Curr Psychiatry Rev"},{"key":"2319_CR33","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.3389\/fphar.2018.01393","volume":"9","author":"C Zhuo","year":"2018","unstructured":"Zhuo C, Xu Y, Liu S, Li J, Zheng Q, Gao X et al (2018) Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis. Front Pharmacol 9:1393","journal-title":"Front Pharmacol"},{"issue":"4","key":"2319_CR34","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s11154-014-9298-4","volume":"15","author":"S Lim","year":"2014","unstructured":"Lim S, Eckel RH (2014) Pharmacological treatment and therapeutic perspectives of metabolic syndrome. Rev Endocr Metab Disord 15(4):329\u2013341","journal-title":"Rev Endocr Metab Disord"},{"key":"2319_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pmip.2019.02.001","volume":"15\u201316","author":"N Zhand","year":"2019","unstructured":"Zhand N, Attwood DG, Harvey PD (2019) Glutamate modulators for treatment of schizophrenia. Personalized Med Psychiatry 15\u201316:1\u201312","journal-title":"Personalized Med Psychiatry"},{"issue":"1","key":"2319_CR36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1744-859X-4-5","volume":"4","author":"D Arnone","year":"2005","unstructured":"Arnone D (2005) Review of the use of Topiramate for treatment of psychiatric disorders. Ann Gen Psychiatry 4(1):5","journal-title":"Ann Gen Psychiatry"},{"issue":"6","key":"2319_CR37","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1177\/2042098612455357","volume":"3","author":"M Mula","year":"2012","unstructured":"Mula M (2012) Topiramate and cognitive impairment: evidence and clinical implications. Ther Adv Drug Saf 3(6):279\u2013289","journal-title":"Ther Adv Drug Saf"},{"issue":"5","key":"2319_CR38","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.5114\/aoms\/152921","volume":"18","author":"P Dobrowolski","year":"2022","unstructured":"Dobrowolski P, Prejbisz A, Kury\u0142owicz A, Baska A, Burchardt P, Chlebus K et al (2022) Metabolic syndrome - a new definition and management guidelines: A joint position paper by the Polish Society of Hypertension, Polish Society for the Treatment of Obesity, Polish Lipid Association, Polish Association for Study of Liver, Polish Society of Family Medicine, Polish Society of Lifestyle Medicine, Division of Prevention and Epidemiology Polish Cardiac Society, Club 30 Polish Cardiac Society, and Division of Metabolic and Bariatric Surgery Society of Polish Surgeons. Arch Med Sci 18(5):1133\u20131156","journal-title":"Arch Med Sci"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02319-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00406-026-02319-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02319-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:49:46Z","timestamp":1789051786000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00406-026-02319-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2319"],"URL":"https:\/\/doi.org\/10.1007\/s00406-026-02319-6","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}