{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:09:55Z","timestamp":1789052995687,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"he National Science and Technology Innovation 2030-Major program of \u201cBrain Science and Brain-Like Research\u201d","award":["2021ZD0200701"],"award-info":[{"award-number":["2021ZD0200701"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82373660"],"award-info":[{"award-number":["82373660"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00406-026-02326-7","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:28:43Z","timestamp":1785385723000},"page":"3665-3676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stressful life events and lifestyle factors are associated with elevated peripheral TNF-\u03b1 levels in adults with depression without physical diseases"],"prefix":"10.1007","volume":"276","author":[{"given":"Xiuwen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-4967","authenticated-orcid":false,"given":"Ciyong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"issue":"3","key":"2326_CR1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41573-021-00368-1","volume":"21","author":"WC Drevets","year":"2022","unstructured":"Drevets WC, Wittenberg GM, Bullmore ET, Manji HK (2022) Immune targets for therapeutic development in depression: towards precision medicine. Nat Rev Drug Discov 21(3):224\u2013244","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"2326_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","volume":"9","author":"R Dantzer","year":"2008","unstructured":"Dantzer R, O\u2019Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46\u201356","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2326_CR3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","volume":"25","author":"JP Konsman","year":"2002","unstructured":"Konsman JP, Parnet P, Dantzer R (2002) Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25(3):154\u2013159","journal-title":"Trends Neurosci"},{"issue":"3","key":"2326_CR4","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.jhep.2021.11.008","volume":"76","author":"VT Kronsten","year":"2021","unstructured":"Kronsten VT, Tranah TH, Pariante C, Shawcross DL (2021) Gut-derived systemic inflammation as a driver of depression in chronic liver disease. J Hepatol 76(3):665\u2013680","journal-title":"J Hepatol"},{"issue":"5","key":"2326_CR5","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/acps.12698","volume":"135","author":"CA K\u00f6hler","year":"2017","unstructured":"K\u00f6hler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, Stubbs B, Solmi M, Veronese N, Herrmann N et al (2017) Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand 135(5):373\u2013387","journal-title":"Acta Psychiatr Scand"},{"key":"2326_CR6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.bbi.2023.10.010","volume":"115","author":"ZW Sun","year":"2024","unstructured":"Sun ZW, Wang X, Zhao Y, Sun ZX, Wu YH, Hu H, Zhang L, Wang SD, Li F, Wei AJ et al (2024) Blood-brain barrier dysfunction mediated by the EZH2-Claudin-5 axis drives stress-induced TNF-alpha infiltration and depression-like behaviors. Brain Behav Immun 115:143\u2013156","journal-title":"Brain Behav Immun"},{"issue":"4","key":"2326_CR7","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/s41380-024-02751-x","volume":"30","author":"MT Treadway","year":"2025","unstructured":"Treadway MT, Etuk SM, Cooper JA, Hossein S, Hahn E, Betters SA, Liu S, Arulpragasam AR, DeVries BAM, Irfan N et al (2025) A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation. Mol Psychiatry 30(4):1407\u20131417","journal-title":"Mol Psychiatry"},{"issue":"2","key":"2326_CR8","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/mp.2016.167","volume":"23","author":"N Kappelmann","year":"2018","unstructured":"Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM (2018) Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry 23(2):335\u2013343","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2326_CR9","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41398-022-01883-4","volume":"12","author":"ET Luning Prak","year":"2022","unstructured":"Luning Prak ET, Brooks T, Makhoul W, Beer JC, Zhao L, Girelli T, Skarke C, Sheline YI (2022) No increase in inflammation in late-life major depression screened to exclude physical illness. Transl Psychiatry 12(1):118","journal-title":"Transl Psychiatry"},{"issue":"3","key":"2326_CR10","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1037\/a0035302","volume":"140","author":"GM Slavich","year":"2014","unstructured":"Slavich GM, Irwin MR (2014) From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychol Bull 140(3):774\u2013815","journal-title":"Psychol Bull"},{"issue":"11","key":"2326_CR11","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1038\/s41380-022-01737-x","volume":"27","author":"GM Kemp","year":"2022","unstructured":"Kemp GM, Altimimi HF, Nho Y, Heir R, Klyczek A, Stellwagen D (2022) Sustained TNF signaling is required for the synaptic and anxiety-like behavioral response to acute stress. Mol Psychiatry 27(11):4474\u20134484","journal-title":"Mol Psychiatry"},{"key":"2326_CR12","doi-asserted-by":"publisher","first-page":"105398","DOI":"10.1016\/j.psyneuen.2021.105398","volume":"133","author":"M Rengasamy","year":"2021","unstructured":"Rengasamy M, Marsland A, McClain L, Kovats T, Walko T, Pan L, Price RB (2021) Linking childhood trauma and cytokine levels in depressed adolescents. Psychoneuroendocrinology 133:105398","journal-title":"Psychoneuroendocrinology"},{"key":"2326_CR13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jad.2022.02.020","volume":"305","author":"Y Li","year":"2022","unstructured":"Li Y, Jinxiang T, Shu Y, Yadong P, Ying L, Meng Y, Ping Z, Xiao H, Yixiao F (2022) Childhood trauma and the plasma levels of IL-6, TNF-\u03b1 are risk factors for major depressive disorder and schizophrenia in adolescents: A cross-sectional and case-control study. J Affect Disord 305:227\u2013232","journal-title":"J Affect Disord"},{"key":"2326_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jpsychires.2015.02.010","volume":"63","author":"SA Hiles","year":"2015","unstructured":"Hiles SA, Baker AL, de Malmanche T, McEvoy M, Boyle M, Attia J (2015) Unhealthy lifestyle may increase later depression via inflammation in older women but not men. J Psychiatr Res 63:65\u201374","journal-title":"J Psychiatr Res"},{"key":"2326_CR15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neubiorev.2020.12.031","volume":"122","author":"MJ Rantala","year":"2021","unstructured":"Rantala MJ, Luoto S, Borr\u00e1z-Le\u00f3n JI, Krams I (2021) Bipolar disorder: An evolutionary psychoneuroimmunological approach. Neurosci Biobehav Rev 122:28\u201337","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"2326_CR16","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2337\/dc23-1503","volume":"47","author":"K Zhu","year":"2024","unstructured":"Zhu K, Qian F, Lu Q, Li R, Qiu Z, Li L, Li R, Yu H, Deng Y, Yang K et al (2024) Modifiable Lifestyle Factors, Genetic Risk, and Incident Peripheral Artery Disease Among Individuals With Type 2 Diabetes: A Prospective Study. Diabetes Care 47(3):435\u2013443","journal-title":"Diabetes Care"},{"key":"2326_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jad.2023.01.086","volume":"326","author":"LL da Cunha","year":"2023","unstructured":"da Cunha LL, Feter N, Alt R, Rombaldi AJ (2023) Effects of exercise training on inflammatory, neurotrophic and immunological markers and neurotransmitters in people with depression: A systematic review and meta-analysis. J Affect Disord 326:73\u201382","journal-title":"J Affect Disord"},{"issue":"2","key":"2326_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/da.22987","volume":"37","author":"GM Slavich","year":"2020","unstructured":"Slavich GM, Giletta M, Helms SW, Hastings PD, Rudolph KD, Nock MK, Prinstein MJ (2020) Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression. Depress Anxiety 37(2):179\u2013193","journal-title":"Depress Anxiety"},{"issue":"1","key":"2326_CR19","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/s41398-025-03547-5","volume":"15","author":"RR Jin","year":"2025","unstructured":"Jin RR, Wong NML, Ma J, Fang J-T, Lin C-M, Toh CH, Wu K-Y, Hsu JL, Huang C-M, Lee SH et al (2025) A psychoneuroimmunological underpinnings of the relationship between childhood trauma, loneliness, and depression in older adults. Translational Psychiatry 15(1):328","journal-title":"Translational Psychiatry"},{"key":"2326_CR20","doi-asserted-by":"crossref","unstructured":"Ross AJ, Russotti J, Cicchetti D, Handley ED (2025) The Effects of Childhood Abuse on Emerging Adulthood Inflammation: Investigating Protective Characteristics. Child Maltreat :10775595251358395","DOI":"10.1177\/10775595251358395"},{"issue":"5","key":"2326_CR21","doi-asserted-by":"publisher","first-page":"e30907","DOI":"10.2196\/30907","volume":"24","author":"H Zhang","year":"2022","unstructured":"Zhang H, Liao Y, Han X, Fan B, Liu Y, Lui LMW, Lee Y, Subramaniapillai M, Li L, Guo L et al (2022) Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App-Based Integrated Mental Health Care Model: Cohort Study. J Med Internet Res 24(5):e30907","journal-title":"J Med Internet Res"},{"key":"2326_CR22","doi-asserted-by":"publisher","first-page":"n2183","DOI":"10.1136\/bmj.n2183","volume":"375","author":"ZF Negeri","year":"2021","unstructured":"Negeri ZF, Levis B, Sun Y, He C, Krishnan A, Wu Y, Bhandari PM, Neupane D, Brehaut E, Benedetti A et al (2021) Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: updated systematic review and individual participant data meta-analysis. BMJ 375:n2183","journal-title":"BMJ"},{"key":"2326_CR23","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jpsychires.2023.11.012","volume":"169","author":"GS Rodrigues","year":"2023","unstructured":"Rodrigues GS, Pellini GL, Rocha R, Lima AF, Pio de Almeida Fleck M, Panzenhagen AC, Shansis FM, Capp E (2023) Diagnosis of bipolar and major depressive disorders: The appropriateness of MINI compared to the clinical interview in a sample of patients with mood disorders in tertiary mental health care. J Psychiatr Res 169:341\u2013346","journal-title":"J Psychiatr Res"},{"key":"2326_CR24","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jad.2023.01.050","volume":"325","author":"J Shi","year":"2023","unstructured":"Shi J, Han X, Liao Y, Zhao H, Fan B, Zhang H, Teopiz KM, Song W, Li L, Guo L et al (2023) Associations of stressful life events with subthreshold depressive symptoms and major depressive disorder: The moderating role of gender. J Affect Disord 325:588\u2013595","journal-title":"J Affect Disord"},{"issue":"1","key":"2326_CR25","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1186\/s12888-021-03499-2","volume":"21","author":"S\u00d8 Lie","year":"2021","unstructured":"Lie S\u00d8, Bulik CM, Andreassen OA, R\u00f8 \u00d8, Bang L (2021) Stressful life events among individuals with a history of eating disorders: a case-control comparison. BMC Psychiatry 21(1):501","journal-title":"BMC Psychiatry"},{"issue":"4","key":"2326_CR26","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S2352-4642(20)30390-4","volume":"5","author":"C Ma","year":"2021","unstructured":"Ma C, Xi B, Li Z, Wu H, Zhao M, Liang Y, Bovet P (2021) Prevalence and trends in tobacco use among adolescents aged 13\u201315 years in 143 countries, 1999\u20132018: findings from the Global Youth Tobacco Surveys. Lancet Child Adolesc Health 5(4):245\u2013255","journal-title":"Lancet Child Adolesc Health"},{"issue":"10","key":"2326_CR27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.2188\/jea.JE20180125","volume":"29","author":"M Takakura","year":"2018","unstructured":"Takakura M, Miyagi M, Ueji M, Kobayashi M, Kurihara A, Kyan A (2018) The Relative Association of Collective Efficacy in School and Neighborhood Contexts With Adolescent Alcohol Use. J Epidemiol 29(10):384\u2013390","journal-title":"J Epidemiol"},{"key":"2326_CR28","doi-asserted-by":"crossref","unstructured":"Robert J, Grissom JJK (2012) Effect Sizes for Research: Univariate and Multivariate Applications, Second Edition (2nd ed.)","DOI":"10.4324\/9780203803233"},{"issue":"3","key":"2326_CR29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1080\/00031305.2000.10474549","volume":"54","author":"JS Long","year":"2000","unstructured":"Long JS, Ervin LH (2000) Using Heteroscedasticity Consistent Standard Errors in the Linear Regression Model. Am Stat 54(3):217\u2013224","journal-title":"Am Stat"},{"issue":"1","key":"2326_CR30","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12877-024-04857-x","volume":"24","author":"C Yang","year":"2024","unstructured":"Yang C, Mao Z, Wu S, Yin S, Sun Y, Cui D (2024) Influencing factors, gender differences and the decomposition of inequalities in cognitive function in Chinese older adults: a population-based cohort study. BMC Geriatr 24(1):371","journal-title":"BMC Geriatr"},{"issue":"13","key":"2326_CR31","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1002\/cncr.35265","volume":"130","author":"H Lee","year":"2024","unstructured":"Lee H, Baeker Bispo J, Pal Choudhury P, Wiese D, Jemal A, Islami F (2024) Factors contributing to differences in cervical cancer screening in rural and urban community health centers. Cancer 130(13):2315\u20132324","journal-title":"Cancer"},{"issue":"3","key":"2326_CR32","doi-asserted-by":"publisher","first-page":"J258","DOI":"10.1016\/j.jaut.2009.12.003","volume":"34","author":"Y Arnson","year":"2009","unstructured":"Arnson Y, Shoenfeld Y, Amital H (2009) Effects of tobacco smoke on immunity, inflammation and autoimmunity. J Autoimmun 34(3):J258\u2013J265","journal-title":"J Autoimmun"},{"issue":"5","key":"2326_CR33","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/ntr\/ntr247","volume":"14","author":"SOV Nunes","year":"2011","unstructured":"Nunes SOV, Vargas HO, Brum J, Prado E, Vargas MM, de Castro MRP, Dodd S, Berk M (2011) A comparison of inflammatory markers in depressed and nondepressed smokers. Nicotine Tob Res 14(5):540\u2013546","journal-title":"Nicotine Tob Res"},{"issue":"1","key":"2326_CR34","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","volume":"80","author":"MR Irwin","year":"2015","unstructured":"Irwin MR, Olmstead R, Carroll JE (2015) Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation. Biol Psychiatry 80(1):40\u201352","journal-title":"Biol Psychiatry"},{"key":"2326_CR35","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.smrv.2017.10.005","volume":"40","author":"MD Rockstrom","year":"2017","unstructured":"Rockstrom MD, Chen L, Taishi P, Nguyen JT, Gibbons CM, Veasey SC, Krueger JM (2017) Tumor necrosis factor alpha in sleep regulation. Sleep Med Rev 40:69\u201378","journal-title":"Sleep Med Rev"},{"key":"2326_CR36","doi-asserted-by":"publisher","first-page":"100442","DOI":"10.1016\/j.mhpa.2022.100442","volume":"22","author":"BM Fernandes","year":"2022","unstructured":"Fernandes BM, Siqueira CC, Vieira RM, Moreno RA, Soeiro-de-Souza MG (2022) Physical activity as an adjuvant therapy for depression and influence on peripheral inflammatory markers: A randomized clinical trial. Ment Health Phys Act 22:100442","journal-title":"Ment Health Phys Act"},{"key":"2326_CR37","doi-asserted-by":"crossref","unstructured":"Imboden C, Gerber M, Beck J, Eckert A, Lejri I, P\u00fchse U, Holsboer-Trachsler E, Hatzinger M (2021) Aerobic Exercise and Stretching as Add-On to Inpatient Treatment for Depression Have No Differential Effects on Stress-Axis Activity, Serum-BDNF, TNF-Alpha and Objective Sleep Measures. Brain Sci 11(4)","DOI":"10.3390\/brainsci11040411"},{"issue":"1","key":"2326_CR38","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41380-021-01306-8","volume":"27","author":"YJ Toenders","year":"2021","unstructured":"Toenders YJ, Laskaris L, Davey CG, Berk M, Milaneschi Y, Lamers F, Penninx BWJH, Schmaal L (2021) Inflammation and depression in young people: a systematic review and proposed inflammatory pathways. Mol Psychiatry 27(1):315\u2013327","journal-title":"Mol Psychiatry"},{"key":"2326_CR39","doi-asserted-by":"publisher","first-page":"518837","DOI":"10.3389\/fpsyt.2020.518837","volume":"11","author":"L Yao","year":"2020","unstructured":"Yao L, Pan L, Qian M, Sun W, Gu C, Chen L, Tang X, Hu Y, Xu L, Wei Y et al (2020) Tumor Necrosis Factor-\u03b1 Variations in Patients With Major Depressive Disorder Before and After Antidepressant Treatment. Front Psychiatry 11:518837","journal-title":"Front Psychiatry"},{"issue":"9","key":"2326_CR40","doi-asserted-by":"publisher","first-page":"5150","DOI":"10.1038\/s41380-020-0790-9","volume":"26","author":"KA Davies","year":"2021","unstructured":"Davies KA, Cooper E, Voon V, Tibble J, Cercignani M, Harrison NA (2021) Interferon and anti-TNF therapies differentially modulate amygdala reactivity which predicts associated bidirectional changes in depressive symptoms. Mol Psychiatry 26(9):5150\u20135160","journal-title":"Mol Psychiatry"},{"issue":"6","key":"2326_CR41","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/j.cgh.2020.07.013","volume":"19","author":"C Dolovich","year":"2021","unstructured":"Dolovich C, Bernstein CN, Singh H, Nugent Z, Tennakoon A, Shafer LA, Marrie RA, Sareen J, Targownik LE (2021) Anxiety and Depression Leads to Anti-Tumor Necrosis Factor Discontinuation in Inflammatory Bowel Disease. Clin Gastroenterol Hepatol 19(6):1200\u20131208 e1201","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"2326_CR42","doi-asserted-by":"publisher","first-page":"5734","DOI":"10.1093\/rheumatology\/keab242","volume":"60","author":"SS Zhao","year":"2021","unstructured":"Zhao SS, Jones GT, Hughes DM, Moots RJ, Goodson NJ (2021) Depression and anxiety symptoms at TNF inhibitor initiation are associated with impaired treatment response in axial spondyloarthritis. Rheumatology (Oxford) 60(12):5734\u20135742","journal-title":"Rheumatology (Oxford)"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02326-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00406-026-02326-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02326-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:49:32Z","timestamp":1789051772000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00406-026-02326-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2326"],"URL":"https:\/\/doi.org\/10.1007\/s00406-026-02326-7","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"29 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}