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Among these, impairments in recognizing moral emotions may be especially relevant to social dysfunction, but their relationship with brain structure remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this cross-sectional case\u2013control study, 48 euthymic adults with BD (BD-I,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920; BD-II,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) and 45 sex- and age-matched healthy controls completed a computerized FER task and 3T T1-weighted MRI scan. FER efficiency (accuracy\/response time) for facial moral (anger and disgust) emotion expressions and gray-matter volume (GMV) from 9 bilateral a priori fronto\u2013limbic\/salience regions were compared between groups. Group-specific psychometric networks (regularized partial-correlation, i.e. Gaussian graphical models; LASSO\/EBIC) integrating FER and GMV nodes were estimated and compared using the Network Comparison Test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Relative to BD-II and controls, BD-I showed lower FER efficiency, with poorer decoding of moral but not neutral facial expressions. Network structure differed between BD-II and controls, whereas global network strength was comparable across all pairwise group comparisons. Exploratory centrality analyses suggested a more frontally weighted configuration in BD-I, with the superior frontal gyrus among the more central nodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In BD-I, persistently reduced ability to decode morally salient facial cues co-occurred with subtype-related differences in fronto\u2013limbic structural covariance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00406-026-02344-5","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:08:54Z","timestamp":1786158534000},"page":"3803-3814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Moral emotion processing in euthymic bipolar disorder: insights from network analysis"],"prefix":"10.1007","volume":"276","author":[{"given":"Marialaura","family":"Lussignoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Cattarinussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Miola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Valeggia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Manara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sambataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"2344_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/S12888-024-06462-Z","volume":"25","author":"B Zhang","year":"2025","unstructured":"Zhang B, Chen X, Qiu N (2025) Social cognition in bipolar I and II disorders: an updated systematic review and meta-analysis. 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