{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:10:08Z","timestamp":1789053008422,"version":"build-2803163510"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Qujing Central Hospital of Yunnan Province","award":["2023YJKTF19"],"award-info":[{"award-number":["2023YJKTF19"]}]},{"name":"Yunnan Revitalization Talent Support Program","award":["XDYC-QNRC-2024-165"],"award-info":[{"award-number":["XDYC-QNRC-2024-165"]}]},{"name":"Yunnan Revitalization Talent Support Program","award":["YNWR-MY-2020-050"],"award-info":[{"award-number":["YNWR-MY-2020-050"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460114"],"award-info":[{"award-number":["82460114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Psychiatry Clin Neurosci"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00406-026-02367-y","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:09:22Z","timestamp":1787800162000},"page":"3975-3993","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated multi-omics and functional analyses reveal a GDCA-TGR5-mediated immunometabolic signature in anorexia nervosa"],"prefix":"10.1007","volume":"276","author":[{"given":"Yanbo","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengguo","family":"Zao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyue","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"issue":"3","key":"2367_CR1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nrendo.2016.175","volume":"13","author":"M Schorr","year":"2017","unstructured":"Schorr M, Miller KK (2017) The endocrine manifestations of anorexia nervosa: mechanisms and management. Nat Rev Endocrinol 13(3):174\u2013186","journal-title":"Nat Rev Endocrinol"},{"issue":"7599","key":"2367_CR2","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/bmj.39171.616840.BE","volume":"334","author":"J Morris","year":"2007","unstructured":"Morris J, Twaddle S (2007) Anorexia nervosa. BMJ 334(7599):894\u2013898","journal-title":"BMJ"},{"issue":"8","key":"2367_CR3","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1001\/jamapsychiatry.2025.0812","volume":"82","author":"A Phillipou","year":"2025","unstructured":"Phillipou A, Schmidt U, Neill E, Miles S, McGorry P, Eddy KT (2025) Anorexia Nervosa-Facts, Frustrations, and the Future. JAMA Psychiatry 82(8):844\u2013847","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"2367_CR4","first-page":"247","volume":"57","author":"U W\u00e4sserle","year":"2022","unstructured":"W\u00e4sserle U, Ermer U, Habisch B, Seeliger S (2022) [Anorexia nervosa: does the incidence increase during the coronavirus pandemic?]. Padiatr Padol 57(5):247\u201353","journal-title":"Padiatr Padol"},{"issue":"14","key":"2367_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/nu17142260","volume":"17","author":"J Rog","year":"2025","unstructured":"Rog J, Karaku\u0142a K, Rz\u0105d Z, Niedzia\u0142ek-Serafin K, Juchnowicz D, Rymuszka A et al (2025) The prognostic value of hematological, immune-inflammatory, metabolic, and hormonal biomarkers in the treatment response of hospitalized patients with anorexia nervosa. Nutrients 17(14):2260","journal-title":"Nutrients"},{"issue":"1","key":"2367_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41398-025-03425-0","volume":"15","author":"J Xu","year":"2025","unstructured":"Xu J, Zhang R, Millischer V, Stiernborg M, Tume CE, Mehdinia S et al (2025) Elevated plasma GDF15 combined with FGF21 suggests mitochondrial dysfunction in a subgroup of anorexia nervosa patients. Transl Psychiatry 15(1):215","journal-title":"Transl Psychiatry"},{"issue":"8","key":"2367_CR7","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/dev.20403","volume":"51","author":"SD Hancock","year":"2009","unstructured":"Hancock SD, Grant VL (2009) Sexually dimorphic effects of postnatal treatment on the development of activity-based anorexia in adolescent and adult rats. Dev Psychobiol 51(8):679\u2013695","journal-title":"Dev Psychobiol"},{"issue":"12","key":"2367_CR8","doi-asserted-by":"publisher","first-page":"E700","DOI":"10.1002\/oby.20581","volume":"21","author":"SK Janhunen","year":"2013","unstructured":"Janhunen SK, la Fleur SE, Adan RAH (2013) Blocking alpha2A adrenoceptors, but not dopamine receptors, augments bupropion-induced hypophagia in rats. Obes (Silver Spring) 21(12):E700\u2013708","journal-title":"Obes (Silver Spring)"},{"issue":"1","key":"2367_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2174\/1568007033338850","volume":"2","author":"JE Mitchell","year":"2003","unstructured":"Mitchell JE, de Zwaan M, Roerig JL (2003) Drug therapy for patients with eating disorders. Curr Drug Targets CNS Neurol Disord 2(1):17\u201329","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"issue":"3","key":"2367_CR10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.9740\/mhc.2018.05.127","volume":"8","author":"M Marvanova","year":"2018","unstructured":"Marvanova M, Gramith K (2018) Role of antidepressants in the treatment of adults with anorexia nervosa. Ment Health Clin 8(3):127\u2013137","journal-title":"Ment Health Clin"},{"key":"2367_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.psyneuen.2014.09.031","volume":"51","author":"M Solmi","year":"2015","unstructured":"Solmi M, Veronese N, Favaro A, Santonastaso P, Manzato E, Sergi G et al (2015) Inflammatory cytokines and anorexia nervosa: A meta-analysis of cross-sectional and longitudinal studies. Psychoneuroendocrinology 51:237\u2013252","journal-title":"Psychoneuroendocrinology"},{"key":"2367_CR12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.65031\/vjcx5272","volume":"6","author":"M Vasey","year":"2024","unstructured":"Vasey M, Besag F, Bronowska Z, Cini E (2024) The NICE guideline for the recognition and treatment of eating disorders. Cutt Edge Psychiatry Pract 6:117\u2013127","journal-title":"Cutt Edge Psychiatry Pract"},{"issue":"4","key":"2367_CR13","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","volume":"21","author":"SL Collins","year":"2023","unstructured":"Collins SL, Stine JG, Bisanz JE, Okafor CD, Patterson AD (2023) Bile acids and the gut microbiota: metabolic interactions and impacts on disease. Nat Rev Microbiol 21(4):236\u2013247","journal-title":"Nat Rev Microbiol"},{"issue":"7834","key":"2367_CR14","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41586-020-2569-1","volume":"587","author":"F Yang","year":"2020","unstructured":"Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P et al (2020) Structural basis of GPBAR activation and bile acid recognition. Nature 587(7834):499\u2013504","journal-title":"Nature"},{"issue":"12","key":"2367_CR15","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.tips.2015.08.002","volume":"36","author":"A Perino","year":"2015","unstructured":"Perino A, Schoonjans K (2015) TGR5 and Immunometabolism: Insights from Physiology and Pharmacology. Trends Pharmacol Sci 36(12):847\u2013857","journal-title":"Trends Pharmacol Sci"},{"key":"2367_CR16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.bbi.2020.09.016","volume":"91","author":"X Hu","year":"2021","unstructured":"Hu X, Yan J, Huang L, Araujo C, Peng J, Gao L et al (2021) INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5\/cAMP\/PKA signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun 91:587\u2013600","journal-title":"Brain Behav Immun"},{"issue":"1","key":"2367_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41522-023-00374-8","volume":"9","author":"C Zhao","year":"2023","unstructured":"Zhao C, Wu K, Hao H, Zhao Y, Bao L, Qiu M et al (2023) Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-\u03baB\/NLRP3 pathways in mice. NPJ Biofilms Microbiomes 9(1):8","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"14","key":"2367_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/nu17142347","volume":"17","author":"A \u017d\u00e1k","year":"2025","unstructured":"\u017d\u00e1k A, Vecka M, Szitanyi P, Flori\u00e1nkov\u00e1 M, Sta\u0148kov\u00e1 B, Uhl\u00edkov\u00e1 P et al (2025) Dyslipidemia in anorexia nervosa is associated with decreased plasma tauroursodeoxycholic acid and a specific fatty acid pattern. Nutrients 17(14):2347","journal-title":"Nutrients"},{"issue":"5","key":"2367_CR19","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/s41564-023-01355-5","volume":"8","author":"Y Fan","year":"2023","unstructured":"Fan Y, St\u00f8ving RK, Berreira Ibraim S, Hy\u00f6tyl\u00e4inen T, Thirion F, Arora T et al (2023) The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice. Nat Microbiol 8(5):787\u2013802","journal-title":"Nat Microbiol"},{"key":"2367_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jpsychires.2018.06.002","volume":"103","author":"B Dalton","year":"2018","unstructured":"Dalton B, Bartholdy S, Robinson L, Solmi M, Ibrahim MAA, Breen G et al (2018) A meta-analysis of cytokine concentrations in eating disorders. J Psychiatr Res 103:252\u201364","journal-title":"J Psychiatr Res"},{"key":"2367_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2023.106390","volume":"158","author":"K Maunder","year":"2023","unstructured":"Maunder K, Molloy E, Jenkins E, Hayden J, Adamis D, McNicholas F (2023) Anorexia nervosa in vivo cytokine production: a systematic review. Psychoneuroendocrinology 158:106390","journal-title":"Psychoneuroendocrinology"},{"issue":"7944","key":"2367_CR22","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, Sipil\u00e4 TP, Kristiansson K, Donner KM et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613(7944):508\u2013518","journal-title":"Nature"},{"issue":"9","key":"2367_CR23","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/s41588-018-0184-y","volume":"50","author":"W Zhou","year":"2018","unstructured":"Zhou W, Nielsen JB, Fritsche LG, Dey R, Gabrielsen ME, Wolford BN et al (2018) Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nat Genet 50(9):1335\u201341","journal-title":"Nat Genet"},{"issue":"1","key":"2367_CR24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41588-022-01270-1","volume":"55","author":"Y Chen","year":"2023","unstructured":"Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T et al (2023) Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases. Nat Genet 55(1):44\u201353","journal-title":"Nat Genet"},{"issue":"10","key":"2367_CR25","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1038\/s41588-020-0684-4","volume":"52","author":"V Orr\u00f9","year":"2020","unstructured":"Orr\u00f9 V, Steri M, Sidore C, Marongiu M, Serra V, Olla S et al (2020) Complex genetic signatures in immune cells underlie autoimmunity and inform therapy. Nat Genet 52(10):1036\u201345","journal-title":"Nat Genet"},{"issue":"6","key":"2367_CR26","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032256","volume":"13","author":"E Alhathli","year":"2024","unstructured":"Alhathli E, Julian T, Girach ZUA, Thompson AAR, Rhodes C, Gr\u00e4f S et al (2024) Mendelian randomization study with clinical follow-up links metabolites to risk and severity of pulmonary arterial hypertension. J Am Heart Assoc 13(6):e032256","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"2367_CR27","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG, CRP CHD Genetics Collaboration (2011) Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 40(3):755\u201364","journal-title":"Int J Epidemiol"},{"issue":"2","key":"2367_CR28","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512\u2013525","journal-title":"Int J Epidemiol"},{"issue":"6","key":"2367_CR29","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1093\/ije\/dyx102","volume":"46","author":"FP Hartwig","year":"2017","unstructured":"Hartwig FP, Davey Smith G, Bowden J (2017) Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46(6):1985\u20131998","journal-title":"Int J Epidemiol"},{"issue":"1","key":"2367_CR30","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12916-024-03272-8","volume":"22","author":"Y Chen","year":"2024","unstructured":"Chen Y, Xie Y, Ci H, Cheng Z, Kuang Y, Li S et al (2024) Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants. BMC Med 22(1):90","journal-title":"BMC Med"},{"key":"2367_CR31","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife 7:e34408","journal-title":"Elife"},{"issue":"4","key":"2367_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.33018","volume":"198","author":"C Verebi","year":"2025","unstructured":"Verebi C, Lebrun N, Petit JV, Viltart O, Duriez P, Saint-Pierre B et al (2025) Potential new expression biomarkers for anorexia nervosa. Am J Med Genet B Neuropsychiatr Genet 198(4):e33018","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1","key":"2367_CR33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/pro.3307","volume":"27","author":"PJ Thul","year":"2018","unstructured":"Thul PJ, Lindskog C (2018) The human protein atlas: A spatial map of the human proteome. Protein Sci 27(1):233\u2013244","journal-title":"Protein Sci"},{"issue":"5","key":"2367_CR34","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41593-022-01071-z","volume":"25","author":"CM Bulik","year":"2022","unstructured":"Bulik CM, Coleman JRI, Hardaway JA, Breithaupt L, Watson HJ, Bryant CD et al (2022) Genetics and neurobiology of eating disorders. Nat Neurosci 25(5):543\u2013554","journal-title":"Nat Neurosci"},{"issue":"3","key":"2367_CR35","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.metabol.2014.10.025","volume":"64","author":"D Omodei","year":"2015","unstructured":"Omodei D, Pucino V, Labruna G, Procaccini C, Galgani M, Perna F et al (2015) Immune-metabolic profiling of anorexic patients reveals an anti-oxidant and anti-inflammatory phenotype. Metabolism 64(3):396\u2013405","journal-title":"Metabolism"},{"key":"2367_CR36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jad.2024.09.115","volume":"368","author":"Z Li","year":"2025","unstructured":"Li Z, Bi T (2025) Causal effects of gut microbiota, metabolites, immune cells, liposomes, and inflammatory proteins on anorexia nervosa: A mediation joint multi-omics Mendelian randomization analysis. J Affect Disord 368:343\u2013358","journal-title":"J Affect Disord"},{"key":"2367_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.euroneuro.2021.02.015","volume":"49","author":"MA Salehi","year":"2021","unstructured":"Salehi MA, Nilsson IA, Figueira J, Thornton LM, Abdulkarim I, P\u00e5lsson E et al (2021) Serum profiling of anorexia nervosa: A 1H NMR-based metabolomics study. Eur Neuropsychopharmacol 49:1\u201310","journal-title":"Eur Neuropsychopharmacol"},{"issue":"11","key":"2367_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/nu16111596","volume":"16","author":"L K\u00e4ver","year":"2024","unstructured":"K\u00e4ver L, Voelz C, Specht HE, Thelen AC, Keller L, Dahmen B et al (2024) Cytokine and microbiome changes in adolescents with anorexia nervosa at admission, discharge, and one-year follow-up. Nutrients 16(11):1596","journal-title":"Nutrients"},{"issue":"2","key":"2367_CR39","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/bjd.15907","volume":"178","author":"EJ Kim","year":"2018","unstructured":"Kim EJ, Kim YK, Kim S, Kim JE, Tian YD, Doh EJ et al (2018) Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat cells. Br J Dermatol 178(2):492\u2013501","journal-title":"Br J Dermatol"},{"issue":"10","key":"2367_CR40","doi-asserted-by":"publisher","first-page":"12894","DOI":"10.1007\/s12035-025-05105-y","volume":"62","author":"X Xiao","year":"2025","unstructured":"Xiao X, Luo X, Wang Y, Pan X, Gao L, Liu S et al (2025) Interactive Effect of Plasma Lipidome on Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study. Mol Neurobiol 62(10):12894\u201312906","journal-title":"Mol Neurobiol"},{"issue":"4","key":"2367_CR41","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1007\/s00335-025-10150-y","volume":"36","author":"DM Adams","year":"2025","unstructured":"Adams DM, Cairns MJ (2025) Utilising genomic association data for causal inference in anorexia nervosa. Mamm Genome 36(4):1042\u20131062","journal-title":"Mamm Genome"},{"issue":"6","key":"2367_CR42","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.jhep.2010.12.004","volume":"54","author":"TWH Pols","year":"2011","unstructured":"Pols TWH, Noriega LG, Nomura M, Auwerx J, Schoonjans K (2011) The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol 54(6):1263\u20131272","journal-title":"J Hepatol"},{"issue":"6","key":"2367_CR43","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1021\/jm7015864","volume":"51","author":"H Sato","year":"2008","unstructured":"Sato H, Macchiarulo A, Thomas C, Gioiello A, Une M, Hofmann AF et al (2008) Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem 51(6):1831\u20131841","journal-title":"J Med Chem"},{"issue":"11","key":"2367_CR44","doi-asserted-by":"publisher","first-page":"3961","DOI":"10.1210\/en.2015-1321","volume":"156","author":"CA Brighton","year":"2015","unstructured":"Brighton CA, Rievaj J, Kuhre RE, Glass LL, Schoonjans K, Holst JJ et al (2015) Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors. Endocrinology 156(11):3961\u20133970","journal-title":"Endocrinology"},{"issue":"1","key":"2367_CR45","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2172671","volume":"15","author":"AB Larabi","year":"2023","unstructured":"Larabi AB, Masson HLP, B\u00e4umler AJ (2023) Bile acids as modulators of gut microbiota composition and function. Gut Microbes 15(1):2172671","journal-title":"Gut Microbes"},{"issue":"4","key":"2367_CR46","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/BF02256091","volume":"11","author":"Y Xu","year":"2004","unstructured":"Xu Y, Song G (2004) The role of CD40-CD154 interaction in cell immunoregulation. J Biomed Sci 11(4):426\u2013438","journal-title":"J Biomed Sci"},{"issue":"11","key":"2367_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11112730","volume":"11","author":"Y Kiriyama","year":"2023","unstructured":"Kiriyama Y, Nochi H (2023) The role of gut microbiota-derived lithocholic acid, deoxycholic acid and their derivatives on the function and differentiation of immune cells. Microorganisms 11(11):2730","journal-title":"Microorganisms"},{"issue":"3\u20134","key":"2367_CR48","first-page":"69","volume":"73","author":"T Kawabe","year":"2011","unstructured":"Kawabe T, Matsushima M, Hashimoto N, Imaizumi K, Hasegawa Y (2011) CD40\/CD40 ligand interactions in immune responses and pulmonary immunity. Nagoya J Med Sci 73(3\u20134):69\u201378","journal-title":"Nagoya J Med Sci"},{"key":"2367_CR49","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1146\/annurev.immunol.18.1.393","volume":"18","author":"DT Fearon","year":"2000","unstructured":"Fearon DT, Carroll MC (2000) Regulation of B lymphocyte responses to foreign and self-antigens by the CD19\/CD21 complex. Annu Rev Immunol 18:393\u2013422","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"2367_CR50","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/erv.2934","volume":"31","author":"T Gabriel","year":"2023","unstructured":"Gabriel T, Massoubre C, Hanachi M, Dor\u00e9 J, Lambert C, Germain N et al (2023) Association of gut-specific non-inflammatory T lymphocytes with chronic anorexia nervosa and constitutional thinness. Eur Eat Disord Rev 31(1):76\u201386","journal-title":"Eur Eat Disord Rev"},{"issue":"12","key":"2367_CR51","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3390\/ph7121028","volume":"7","author":"Y Nakagawa","year":"2014","unstructured":"Nakagawa Y, Chiba K (2014) Role of microglial m1\/m2 polarization in relapse and remission of psychiatric disorders and diseases. Pharmaceuticals (Basel) 7(12):1028\u20131048","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"2367_CR52","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s40425-018-0452-5","volume":"6","author":"ZF Wen","year":"2018","unstructured":"Wen ZF, Liu H, Gao R, Zhou M, Ma J, Zhang Y et al (2018) Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1. J Immunother Cancer 6(1):151","journal-title":"J Immunother Cancer"},{"issue":"2","key":"2367_CR53","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/nrgastro.2017.119","volume":"15","author":"W Jia","year":"2018","unstructured":"Jia W, Xie G, Jia W (2018) Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat Rev Gastroenterol Hepatol 15(2):111\u2013128","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"2367_CR54","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12876-023-02693-8","volume":"23","author":"X Gao","year":"2023","unstructured":"Gao X, Duan S, Cao Y, Zhang Y (2023) Change of monocytes\/macrophages in ulcerative colitis patients with symptoms of anxiety and depression. BMC Gastroenterol 23(1):67","journal-title":"BMC Gastroenterol"},{"key":"2367_CR55","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neuroscience.2022.02.028","volume":"490","author":"R Huang","year":"2022","unstructured":"Huang R, Gao Y, Chen J, Duan Q, He P, Zhang J et al (2022) TGR5 Agonist INT-777 Alleviates Inflammatory Neurodegeneration in Parkinson\u2019s Disease Mouse Model by Modulating Mitochondrial Dynamics in Microglia. Neuroscience 490:100\u2013119","journal-title":"Neuroscience"},{"issue":"5","key":"2367_CR56","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s42255-021-00398-4","volume":"3","author":"A Perino","year":"2021","unstructured":"Perino A, Vel\u00e1zquez-Villegas LA, Bresciani N, Sun Y, Huang Q, F\u00e9nelon VS et al (2021) Central anorexigenic actions of bile acids are mediated by TGR5. Nat Metab 3(5):595\u2013603","journal-title":"Nat Metab"},{"issue":"7","key":"2367_CR57","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.cmet.2021.04.009","volume":"33","author":"A Castellanos-Jankiewicz","year":"2021","unstructured":"Castellanos-Jankiewicz A, Guzm\u00e1n-Quevedo O, F\u00e9nelon VS, Zizzari P, Quarta C, Bellocchio L et al (2021) Hypothalamic bile acid-TGR5 signaling protects from obesity. Cell Metab 33(7):1483-1492e.e10","journal-title":"Cell Metab"}],"container-title":["European Archives of Psychiatry and Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02367-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00406-026-02367-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00406-026-02367-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:49:02Z","timestamp":1789051742000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00406-026-02367-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2367"],"URL":"https:\/\/doi.org\/10.1007\/s00406-026-02367-y","relation":{},"ISSN":["0940-1334","1433-8491"],"issn-type":[{"value":"0940-1334","type":"print"},{"value":"1433-8491","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"21 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were reviewed and approved by the institutional ethics committee (Approval No. kyfey2025029).","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have read and approved the manuscript for publication.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}