{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:00:59Z","timestamp":1789790459375,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s00408-009-9197-8","type":"journal-article","created":{"date-parts":[[2009,11,23]],"date-time":"2009-11-23T14:41:15Z","timestamp":1258987275000},"page":"47-52","source":"Crossref","is-referenced-by-count":42,"title":["The Efficacy of a NOP1 Agonist (SCH486757) in Subacute Cough"],"prefix":"10.1007","volume":"188","author":[{"given":"Ashley","family":"Woodcock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbie L.","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Sadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"issue":"Suppl 1","key":"9197_CR1","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2006.065144","volume":"61","author":"AH Morice","year":"2006","unstructured":"Morice AH, McGarvey L, Pavord I (2006) Recommendations for the management of cough in adults. Thorax 61(Suppl 1):i1\u2013i24","journal-title":"Thorax"},{"issue":"159","key":"9197_CR2","first-page":"1","volume":"13","author":"SM Schappert","year":"2006","unstructured":"Schappert SM, Burt CW (2006) Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001\u201302. Vital Health Stat 13(159):1\u201366","journal-title":"Vital Health Stat"},{"issue":"3","key":"9197_CR3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2710.1992.tb01289.x","volume":"17","author":"R Eccles","year":"1992","unstructured":"Eccles R, Morris S, Jawad M (1992) Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. J Clin Pharm Ther 17(3):175\u2013180","journal-title":"J Clin Pharm Ther"},{"issue":"9","key":"9197_CR4","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1211\/0022357001774903","volume":"52","author":"PCL Lee","year":"2000","unstructured":"Lee PCL, Jawad MS, Eccles R (2000) Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. J Pharm Pharmacol 52(9):1137\u20131142","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"9197_CR5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/01.psy.0000155667.59662.92","volume":"67","author":"PC Lee","year":"2005","unstructured":"Lee PC, Jawad MS, Hull JD, West WH, Shaw K, Eccles R (2005) The antitussive effect of placebo treatment on cough associated with acute upper respiratory infection. Psychosom Med 67(2):314\u2013317","journal-title":"Psychosom Med"},{"issue":"6","key":"9197_CR6","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/sj.bjp.0703954","volume":"132","author":"RL McLeod","year":"2001","unstructured":"McLeod RL, Parra LE, Mutter JC, Erickson CH, Carey GJ, Tulshian DB, Fawzi AB, Smith-Torhan A, Egan RW, Cuss FM, Hey JA (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. Br J Pharmacol 132(6):1175\u20131178","journal-title":"Br J Pharmacol"},{"key":"9197_CR7","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1517\/13543776.13.10.1501","volume":"13","author":"RL McLeod","year":"2003","unstructured":"McLeod RL, Tulshian DB, Hey JA (2003) Novel pharmacological targets and potential progression of new antitussive drugs. Expert Opin Therapeut Pat 13:1501\u20131512","journal-title":"Expert Opin Therapeut Pat"},{"key":"9197_CR8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000235601","volume":"84","author":"RL McLeod","year":"2009","unstructured":"McLeod RL, Tulshian DB, Ho GD, Fernandez X, Bolser DC, Parra LE, Zimmer JC, Erickson CH, Fawzi AB, Jayappa H, Lehr C, Erskine J, Smith-Torhan A, Zhang H, Hey JA (2009) Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough. Pharmacology 84:153\u2013161","journal-title":"Pharmacology"},{"issue":"9","key":"9197_CR9","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/j.bmcl.2009.03.031","volume":"19","author":"GD Ho","year":"2009","unstructured":"Ho GD, Anthes J, Bercovici A, Caldwell JP, Cheng KC, Cui X, Fawzi A, Fernandez X, Greenlee WJ, Hey J, Korfmacher W, Lu SX, McLeod RL, Ng F, Torhan AS, Tan Z, Tulshian D, Varty GB, Xu X, Zhang H (2009) The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett 19(9):2519\u20132523","journal-title":"Bioorg Med Chem Lett"},{"issue":"17","key":"9197_CR10","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1021\/jm9008218","volume":"52","author":"SW Yang","year":"2009","unstructured":"Yang SW, Ho G, Tulshian D, Greenlee WJ, Anthes J, Fernandez X, McLeod RL, Hey JA, Xu X (2009) Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough. J Med Chem 52(17):5323\u20135329","journal-title":"J Med Chem"},{"issue":"2\u20133","key":"9197_CR11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0014-5793(94)00561-3","volume":"347","author":"JR Bunzow","year":"1994","unstructured":"Bunzow JR, Saez C, Mortrud M, Bouvier C, Williams JT, Low M, Grandy DK (1994) Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. FEBS Lett 347(2\u20133):284\u2013288","journal-title":"FEBS Lett"},{"issue":"1","key":"9197_CR12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0014-5793(94)80235-1","volume":"341","author":"C Mollereau","year":"1994","unstructured":"Mollereau C, Parmentier M, Mailleux P, Butour JL, Moisand C, Chalon P, Caput D, Vassart G, Meunier JC (1994) ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization. FEBS Lett 341(1):33\u201338","journal-title":"FEBS Lett"},{"issue":"6549","key":"9197_CR13","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/377532a0","volume":"377","author":"JC Meunier","year":"1995","unstructured":"Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alvinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B et al (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377(6549):532\u2013535","journal-title":"Nature"},{"issue":"5237","key":"9197_CR14","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.270.5237.792","volume":"270","author":"RK Reinscheid","year":"1995","unstructured":"Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ Jr, Civelli O (1995) Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science 270(5237):792\u2013794","journal-title":"Science"},{"issue":"7","key":"9197_CR15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.bjp.0703219","volume":"129","author":"G Calo","year":"2000","unstructured":"Calo G, Guerrini R, Rizzi A, Salvadori S, Regoli D (2000) Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol 129(7):1261\u20131283","journal-title":"Br J Pharmacol"},{"key":"9197_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-9974-1-3","volume":"1","author":"MA Coyle","year":"2005","unstructured":"Coyle MA, Keenan DB, Henderson LS, Watkins ML, Haumann BK, Mayleben DW, Wilson MG (2005) Evaluation of an ambulatory system for the quantification of cough frequency in patients with chronic obstructive pulmonary disease. Cough 1:3","journal-title":"Cough"},{"issue":"4","key":"9197_CR17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1469-8986.1973.tb00801.x","volume":"10","author":"E Hoddes","year":"1973","unstructured":"Hoddes E, Zarcone V, Smythe H, Phillips R, Dement WC (1973) Quantification of sleepiness: a new approach. Psychophysiology 10(4):431\u2013436","journal-title":"Psychophysiology"},{"key":"9197_CR18","doi-asserted-by":"crossref","unstructured":"Nasra J, Belvisi MG (2009) Modulation of sensory nerve function and the cough reflex: understanding disease pathogenesis. Pharmacol Ther [Epub ahead of print]","DOI":"10.1016\/j.pharmthera.2009.09.006"},{"issue":"4","key":"9197_CR19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1136\/thx.2006.067413","volume":"62","author":"SC Decalmer","year":"2007","unstructured":"Decalmer SC, Webster D, Kelsall AA, McGuinness K, Woodcock AA, Smith JA (2007) Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring? Thorax 62(4):329\u2013334","journal-title":"Thorax"},{"issue":"1","key":"9197_CR20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0014-2999(01)01244-4","volume":"430","author":"DC Bolser","year":"2001","unstructured":"Bolser DC, McLeod RL, Tulshian DB, Hey JA (2001) Antitussive action of nociceptin in the cat. Eur J Pharmacol 430(1):107\u2013111","journal-title":"Eur J Pharmacol"},{"issue":"Pt 2","key":"9197_CR21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","volume":"569","author":"SB Mazzone","year":"2005","unstructured":"Mazzone SB, Mori N, Canning BJ (2005) Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. J Physiol 569(Pt 2):559\u2013573","journal-title":"J Physiol"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-009-9197-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-009-9197-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-009-9197-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:37:49Z","timestamp":1559054269000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-009-9197-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,24]]},"references-count":21,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["9197"],"URL":"https:\/\/doi.org\/10.1007\/s00408-009-9197-8","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,24]]}}}