{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:38:08Z","timestamp":1791074288213,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T00:00:00Z","timestamp":1267142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1007\/s00408-010-9232-9","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T07:01:02Z","timestamp":1267081262000},"page":"191-197","source":"Crossref","is-referenced-by-count":31,"title":["CXC-Chemokine Ligand 10 in Idiopathic Pulmonary Arterial Hypertension: Marker of Improved Survival"],"prefix":"10.1007","volume":"188","author":[{"given":"Gustavo A.","family":"Heresi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Aytekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raed A.","family":"Dweik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,26]]},"reference":[{"key":"9232_CR1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1378\/chest.06-2453","volume":"131","author":"NF Voelkel","year":"2007","unstructured":"Voelkel NF, Douglas IS, Nicolls M (2007) Angiogenesis in chronic lung disease. Chest 131:874\u2013879","journal-title":"Chest"},{"key":"9232_CR2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1164\/rccm.200709-1369PP","volume":"178","author":"PR Rai","year":"2008","unstructured":"Rai PR, Cool CD, King JA, Stevens T, Burns N, Winn RA, Kasper M, Voelkel NF (2008) The cancer paradigm of severe pulmonary arterial hypertension. Am J Respir Crit Care Med 178:558\u2013564","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR3","first-page":"95","volume":"1","author":"Y Le","year":"2004","unstructured":"Le Y, Zhou Y, Iribarren P, Wang J (2004) Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol 1:95\u2013104","journal-title":"Cell Mol Immunol"},{"key":"9232_CR4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1146\/annurev.immunol.24.021605.090529","volume":"25","author":"SJ Allen","year":"2007","unstructured":"Allen SJ, Crown SE, Handel TM (2007) Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol 25:787\u2013820","journal-title":"Annu Rev Immunol"},{"key":"9232_CR5","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1089\/107999002760624305","volume":"22","author":"K Bacon","year":"2002","unstructured":"Bacon K, Baggiolini M, Broxmeyer H, Horuk R, Lindley I, Mantovani A, Maysushima K, Murphy P, Nomiyama H, Oppenheim J, Rot A, Schall T, Tsang M, Thorpe R, Van Damme J, Wadhwa M, Yoshie O, Zlotnik A, Zoon K (2002) Chemokine\/chemokine receptor nomenclature. J Interferon Cytokine Res 22:1067\u20131068","journal-title":"J Interferon Cytokine Res"},{"key":"9232_CR6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJM199802123380706","volume":"338","author":"AD Luster","year":"1998","unstructured":"Luster AD (1998) Chemokines\u2014chemotactic cytokines that mediate inflammation. N Engl J Med 338:436\u2013445","journal-title":"N Engl J Med"},{"key":"9232_CR7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1084\/jem.184.3.963","volume":"184","author":"M Loetscher","year":"1996","unstructured":"Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B (1996) Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med 184:963\u2013969","journal-title":"J Exp Med"},{"key":"9232_CR8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1084\/jem.182.1.155","volume":"182","author":"AL Angiolillo","year":"1995","unstructured":"Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G (1995) Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182:155\u2013162","journal-title":"J Exp Med"},{"key":"9232_CR9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/bbrc.1995.1626","volume":"210","author":"RM Strieter","year":"1995","unstructured":"Strieter RM, Kunkel SL, Arenberg DA, Burdick MD, Polverini PJ (1995) Interferon gamma-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. Biochem Biophys Res Commun 210:51\u201357","journal-title":"Biochem Biophys Res Commun"},{"key":"9232_CR10","doi-asserted-by":"crossref","first-page":"27348","DOI":"10.1074\/jbc.270.45.27348","volume":"270","author":"RM Strieter","year":"1995","unstructured":"Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J, Dzuiba J, Van Damme J, Walz A, Marriott D et al (1995) The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 270:27348\u201327357","journal-title":"J Biol Chem"},{"key":"9232_CR11","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jacc.2009.04.012","volume":"54","author":"G Simonneau","year":"2009","unstructured":"Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R (2009) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 54:S43\u2013S54","journal-title":"J Am Coll Cardiol"},{"key":"9232_CR12","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/eurheartj\/ehp297","volume":"30","author":"N Galie","year":"2009","unstructured":"Galie N, Hoeper MM, Humbert M, Torbicki A, Vachiery JL, Barbera JA, Beghetti M, Corris P, Gaine S, Gibbs JS, Gomez-Sanchez MA, Jondeau G, Klepetko W, Opitz C, Peacock A, Rubin L, Zellweger M, Simonneau G, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, McGregor K, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Al Attar N, Andreotti F, Aschermann M, Asteggiano R, Benza R, Berger R, Bonnet D, Delcroix M, Howard L, Kitsiou AN, Lang I, Maggioni A, Nielsen-Kudsk JE, Park M, Perrone-Filardi P, Price S, Domenech MT, Vonk-Noordegraaf A, Zamorano JL (2009) Guidelines for the diagnosis and treatment of pulmonary hypertension: the task force for the diagnosis and treatment of pulmonary hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). Eur Heart J 30:2493\u20132537","journal-title":"Eur Heart J"},{"key":"9232_CR13","unstructured":"R Development Core Team (2008) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna. ISBN 3-900051-07-0. http:\/\/www.R-project.org"},{"key":"9232_CR14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1440-1843.2006.00821.x","volume":"11","author":"T Itoh","year":"2006","unstructured":"Itoh T, Nagaya N, Ishibashi-Ueda H, Kyotani S, Oya H, Sakamaki F, Kimura H, Nakanishi N (2006) Increased plasma monocyte chemoattractant protein-1 level in idiopathic pulmonary arterial hypertension. Respirology 11:158\u2013163","journal-title":"Respirology"},{"key":"9232_CR15","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1164\/rccm.200610-1559OC","volume":"176","author":"O Sanchez","year":"2007","unstructured":"Sanchez O, Marcos E, Perros F, Fadel E, Tu L, Humbert M, Dartevelle P, Simonneau G, Adnot S, Eddahibi S (2007) Role of endothelium-derived CC chemokine ligand 2 in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 176:1041\u20131047","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1164\/ajrccm.165.4.2012112","volume":"165","author":"P Dorfmuller","year":"2002","unstructured":"Dorfmuller P, Zarka V, Durand-Gasselin I, Monti G, Balabanian K, Garcia G, Capron F, Coulomb-Lhermine A, Marfaing-Koka A, Simonneau G, Emilie D, Humbert M (2002) Chemokine RANTES in severe pulmonary arterial hypertension. Am J Respir Crit Care Med 165:534\u2013539","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR17","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1164\/rccm.2106007","volume":"165","author":"K Balabanian","year":"2002","unstructured":"Balabanian K, Foussat A, Dorfmuller P, Durand-Gasselin I, Capel F, Bouchet-Delbos L, Portier A, Marfaing-Koka A, Krzysiek R, Rimaniol AC, Simonneau G, Emilie D, Humbert M (2002) CX(3)C chemokine fractalkine in pulmonary arterial hypertension. Am J Respir Crit Care Med 165:1419\u20131425","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR18","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1084\/jem.166.4.1084","volume":"166","author":"AD Luster","year":"1987","unstructured":"Luster AD, Ravetch JV (1987) Biochemical characterization of a gamma interferon-inducible cytokine (IP-10). J Exp Med 166:1084\u20131097","journal-title":"J Exp Med"},{"key":"9232_CR19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jlb.61.3.246","volume":"61","author":"JM Farber","year":"1997","unstructured":"Farber JM (1997) Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol 61:246\u2013257","journal-title":"J Leukoc Biol"},{"key":"9232_CR20","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1161\/CIRCULATIONAHA.105.605121","volume":"113","author":"EA Heller","year":"2006","unstructured":"Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE (2006) Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation 113:2301\u20132312","journal-title":"Circulation"},{"key":"9232_CR21","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1161\/hc4601.098010","volume":"104","author":"M Melter","year":"2001","unstructured":"Melter M, Exeni A, Reinders ME, Fang JC, McMahon G, Ganz P, Hancock WW, Briscoe DM (2001) Expression of the chemokine receptor CXCR3 and its ligand IP-10 during human cardiac allograft rejection. Circulation 104:2558\u20132564","journal-title":"Circulation"},{"key":"9232_CR22","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.4049\/jimmunol.161.11.6413","volume":"161","author":"C Agostini","year":"1998","unstructured":"Agostini C, Cassatella M, Zambello R, Trentin L, Gasperini S, Perin A, Piazza F, Siviero M, Facco M, Dziejman M, Chilosi M, Qin S, Luster AD, Semenzato G (1998) Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. J Immunol 161:6413\u20136420","journal-title":"J Immunol"},{"key":"9232_CR23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1165\/rcmb.2004-0175OC","volume":"31","author":"AM Tager","year":"2004","unstructured":"Tager AM, Kradin RL, LaCamera P, Bercury SD, Campanella GS, Leary CP, Polosukhin V, Zhao LH, Sakamoto H, Blackwell TS, Luster AD (2004) Inhibition of pulmonary fibrosis by the chemokine IP-10\/CXCL10. Am J Respir Cell Mol Biol 31:395\u2013404","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9232_CR24","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1164\/rccm.2107139","volume":"165","author":"M Saetta","year":"2002","unstructured":"Saetta M, Mariani M, Panina-Bordignon P, Turato G, Buonsanti C, Baraldo S, Bellettato CM, Papi A, Corbetta L, Zuin R, Sinigaglia F, Fabbri LM (2002) Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 165:1404\u20131409","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1183\/09031936.00160307","volume":"32","author":"G Warwick","year":"2008","unstructured":"Warwick G, Thomas PS, Yates DH (2008) Biomarkers in pulmonary hypertension. Eur Respir J 32:503\u2013512","journal-title":"Eur Respir J"},{"key":"9232_CR26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1164\/ajrccm.160.2.9812078","volume":"160","author":"N Nagaya","year":"1999","unstructured":"Nagaya N, Uematsu M, Satoh T, Kyotani S, Sakamaki F, Nakanishi N, Yamagishi M, Kunieda T, Miyatake K (1999) Serum uric acid levels correlate with the severity and the mortality of primary pulmonary hypertension. Am J Respir Crit Care Med 160:487\u2013492","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/rmed.2003.1440","volume":"97","author":"D Bendayan","year":"2003","unstructured":"Bendayan D, Shitrit D, Ygla M, Huerta M, Fink G, Kramer MR (2003) Hyperuricemia as a prognostic factor in pulmonary arterial hypertension. Respir Med 97:130\u2013133","journal-title":"Respir Med"},{"key":"9232_CR28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0002-9343(98)00138-7","volume":"105","author":"AA Lopes","year":"1998","unstructured":"Lopes AA, Maeda NY, Bydlowski SP (1998) Abnormalities in circulating von Willebrand factor and survival in pulmonary hypertension. Am J Med 105:21\u201326","journal-title":"Am J Med"},{"key":"9232_CR29","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1378\/chest.128.4.2355","volume":"128","author":"SM Kawut","year":"2005","unstructured":"Kawut SM, Horn EM, Berekashvili KK, Widlitz AC, Rosenzweig EB, Barst RJ (2005) von Willebrand factor independently predicts long-term survival in patients with pulmonary arterial hypertension. Chest 128:2355\u20132362","journal-title":"Chest"},{"key":"9232_CR30","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1161\/01.CIR.102.8.865","volume":"102","author":"N Nagaya","year":"2000","unstructured":"Nagaya N, Nishikimi T, Uematsu M, Satoh T, Kyotani S, Sakamaki F, Kakishita M, Fukushima K, Okano Y, Nakanishi N, Miyatake K, Kangawa K (2000) Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation 102:865\u2013870","journal-title":"Circulation"},{"key":"9232_CR31","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1378\/chest.128.4.2368","volume":"128","author":"HH Leuchte","year":"2005","unstructured":"Leuchte HH, Holzapfel M, Baumgartner RA, Neurohr C, Vogeser M, Behr J (2005) Characterization of brain natriuretic peptide in long-term follow-up of pulmonary arterial hypertension. Chest 128:2368\u20132374","journal-title":"Chest"},{"key":"9232_CR32","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1164\/rccm.200608-1189OC","volume":"175","author":"L Taraseviciene-Stewart","year":"2007","unstructured":"Taraseviciene-Stewart L, Nicolls MR, Kraskauskas D, Scerbavicius R, Burns N, Cool C, Wood K, Parr JE, Boackle SA, Voelkel NF (2007) Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am J Respir Crit Care Med 175:1280\u20131289","journal-title":"Am J Respir Crit Care Med"},{"key":"9232_CR33","first-page":"275","volume":"144","author":"RM Tuder","year":"1994","unstructured":"Tuder RM, Groves B, Badesch DB, Voelkel NF (1994) Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol 144:275\u2013285","journal-title":"Am J Pathol"},{"key":"9232_CR34","doi-asserted-by":"crossref","first-page":"571S","DOI":"10.1378\/chest.128.6_suppl.571S-a","volume":"128","author":"FA Masri","year":"2005","unstructured":"Masri FA, Anand-Apte B, Vasanji A, Xu W, Goggans T, Drazba J, Erzurum SC (2005) Definitive evidence of fundamental and inherent alteration in the phenotype of primary pulmonary hypertension endothelial cells in angiogenesis. Chest 128:571S","journal-title":"Chest"},{"key":"9232_CR35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/jpet.107.129312","volume":"324","author":"LM Ayer","year":"2008","unstructured":"Ayer LM, Wilson SM, Traves SL, Proud D, Giembycz MA (2008) 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. J Pharmacol Exp Ther 324:815\u2013826","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-010-9232-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-010-9232-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-010-9232-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T16:43:05Z","timestamp":1685464985000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-010-9232-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,26]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["9232"],"URL":"https:\/\/doi.org\/10.1007\/s00408-010-9232-9","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,26]]}}}