{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:56:42Z","timestamp":1791280602912,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,14]],"date-time":"2013-12-14T00:00:00Z","timestamp":1386979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s00408-013-9543-8","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T09:29:41Z","timestamp":1386926981000},"page":"33-38","source":"Crossref","is-referenced-by-count":8,"title":["Cough in Asthma Is due to Eosinophilic Airway Inflammation: A Pro\/Con Debate"],"prefix":"10.1007","volume":"192","author":[{"given":"Akio","family":"Niimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Brightling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Dicpinigaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,14]]},"reference":[{"issue":"1 Suppl","key":"9543_CR1","doi-asserted-by":"crossref","first-page":"75S","DOI":"10.1378\/chest.129.1_suppl.75S","volume":"129","author":"PV Dicpinigaitis","year":"2006","unstructured":"Dicpinigaitis PV (2006) Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines. Chest 129(1 Suppl):75S\u201379S","journal-title":"Chest"},{"key":"9543_CR2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm.160.2.9810100","volume":"160","author":"CE Brightling","year":"1999","unstructured":"Brightling CE, Ward R, Goh KL et al (1999) Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 160:406\u2013410","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1056\/NEJM197903223001201","volume":"300","author":"WM Corrao","year":"1979","unstructured":"Corrao WM, Braman SS, Irwin RS (1979) Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med 300:633\u2013637","journal-title":"N Engl J Med"},{"key":"9543_CR4","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/S0140-6736(99)01813-9","volume":"353","author":"ID Pavord","year":"1999","unstructured":"Pavord ID, Brightling CE, Woltmann G et al (1999) Non-eosinophilic corticosteroid unresponsive asthma. Lancet 353:2213\u20132214","journal-title":"Lancet"},{"key":"9543_CR5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1164\/rccm.201109-1640OC","volume":"185","author":"KW McGrath","year":"2012","unstructured":"McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM et al (2012) Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. A large subgroup of mild-to-moderate asthma is persistently non-eosinophilic. Am J Respir Crit Care Med 185:612\u2013619","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR6","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0140-6736(89)92801-8","volume":"1","author":"PG Gibson","year":"1989","unstructured":"Gibson PG, Dolovich J, Denburg J et al (1989) Chronic cough: eosinophilic bronchitis without asthma. Lancet 1:1346\u20131348","journal-title":"Lancet"},{"key":"9543_CR7","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1136\/thx.53.9.738","volume":"53","author":"LP McGarvey","year":"1998","unstructured":"McGarvey LP, Heaney LG, Lawson JT et al (1998) Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol. Thorax 53:738\u2013743","journal-title":"Thorax"},{"key":"9543_CR8","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1183\/09031936.98.11051064","volume":"11","author":"A Niimi","year":"1998","unstructured":"Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F (1998) Eosinophilic inflammation in cough variant asthma. Eur Respir J 11:1064\u20131069","journal-title":"Eur Respir J"},{"key":"9543_CR9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1745-9974-5-3","volume":"5","author":"H Matsumoto","year":"2009","unstructured":"Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H et al (2009) Features of cough variant asthma and classic asthma during methacholine-induced bronchoconstriction: a cross-sectional study. Cough 5:3","journal-title":"Cough"},{"key":"9543_CR10","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1111\/j.1365-2222.2007.02848.x","volume":"37","author":"M Takemura","year":"2007","unstructured":"Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H et al (2007) Atopic features of cough variant asthma and classic asthma with wheezing. Clin Exp Allergy 37:1833\u20131839","journal-title":"Clin Exp Allergy"},{"key":"9543_CR11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000330419","volume":"82","author":"K Otsuka","year":"2011","unstructured":"Otsuka K, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H et al (2011) Plasma substance P levels in patients with persistent cough. Respiration 82:431\u2013438","journal-title":"Respiration"},{"key":"9543_CR12","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1034\/j.1399-3003.2000.15d10.x","volume":"15","author":"CE Brightling","year":"2000","unstructured":"Brightling CE, Ward R, Wardlaw AJ, Pavord ID (2000) Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis. Eur Respir J 15:682\u2013686","journal-title":"Eur Respir J"},{"key":"9543_CR13","doi-asserted-by":"crossref","first-page":"961","DOI":"10.4049\/jimmunol.141.3.961","volume":"141","author":"JV Weinstock","year":"1988","unstructured":"Weinstock JV, Blum A, Walder J, Walder R (1988) Eosinophils from granulomas in murine Schistosomiasis mansoni produce substance P. J Immunol 141:961\u2013966","journal-title":"J Immunol"},{"key":"9543_CR14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000068413","volume":"70","author":"SY Lee","year":"2003","unstructured":"Lee SY, Kim MK, Shin C, Shim JJ, Kim HK, Kang KH et al (2003) Substance P-immmunoreactive nerves in endobronchial biopsies in cough-variant asthma and classsic asthma. Respiration 70:49\u201353","journal-title":"Respiration"},{"key":"9543_CR15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(00)02584-8","volume":"356","author":"A Niimi","year":"2000","unstructured":"Niimi A, Matsumoto H, Minakuchi M, Kitaichi M, Amitani R et al (2000) Airway remodelling in cough-variant asthma. Lancet 356:564\u2013565","journal-title":"Lancet"},{"key":"9543_CR16","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaci.2005.07.010","volume":"116","author":"A Niimi","year":"2005","unstructured":"Niimi A, Torrego A, Nicholson AG, Cosio BG, Oates TB, Chung KF (2005) Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol 116:565\u2013570","journal-title":"J Allergy Clin Immunol"},{"key":"9543_CR17","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1378\/chest.06-1025","volume":"131","author":"H Matsumoto","year":"2007","unstructured":"Matsumoto H, Niimi A, Tabuena RP, Takemura M, Ueda T, Yamaguchi M et al (2007) Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. Chest 131:1042\u20131049","journal-title":"Chest"},{"key":"9543_CR18","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1100283","volume":"305","author":"AA Humbles","year":"2004","unstructured":"Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE et al (2004) A critical role for eosinophils in allergic airways remodeling. Science 305:1776\u20131779","journal-title":"Science"},{"key":"9543_CR19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/ajrccm\/139.3.806","volume":"139","author":"R Beasley","year":"1989","unstructured":"Beasley R, Roche WR, Roberts JA, Holgate ST (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139:806\u2013817","journal-title":"Am Rev Respir Dis"},{"key":"9543_CR20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pupt.2011.01.011","volume":"24","author":"A Niimi","year":"2011","unstructured":"Niimi A (2011) Structural changes in the airways: cause or effect of chronic cough? Pulm Pharmacol Ther 24:328\u2013333","journal-title":"Pulm Pharmacol Ther"},{"key":"9543_CR21","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1378\/chest.10-0132","volume":"138","author":"H Matsuoka","year":"2010","unstructured":"Matsuoka H, Niimi A, Matsumoto H et al (2010) Inflammatory subtypes in cough variant asthma: association with maintenance doses of inhaled corticosteroids. Chest 138:1418\u20131425","journal-title":"Chest"},{"key":"9543_CR22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1843.2006.00784.x","volume":"11","author":"JL Simpson","year":"2006","unstructured":"Simpson JL, Scott R, Boyle MJ, Gibson PG (2006) Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 11:54\u201361","journal-title":"Respirology"},{"key":"9543_CR23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1165\/ajrcmb.21.2.3647","volume":"21","author":"SM Page","year":"1999","unstructured":"Page SM, Gleich GJ, Roebuck KA, Thomas LL (1999) Stimulation of neutrophil interleukin-8 production by eosinophil granule major basic protein. Am J Respir Cell Mol Biol 21:230\u2013237","journal-title":"Am J Respir Cell Mol Biol"},{"key":"9543_CR24","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1056\/NEJMoa012705","volume":"346","author":"CE Brightling","year":"2002","unstructured":"Brightling CE, Bradding P, Symon FA et al (2002) Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 346:1699\u20131705","journal-title":"N Engl J Med"},{"key":"9543_CR25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1183\/09031936.99.13105399","volume":"13","author":"LPA McGarvey","year":"1999","unstructured":"McGarvey LPA, Forsythe P, Heaney LG, MacMahon J, Ennis M (1999) Bronchoalveolar lavage findings in patients with chronic nonproductive cough. Eur Respir J 13:59\u201365","journal-title":"Eur Respir J"},{"key":"9543_CR26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1164\/rccm.200308-1092OC","volume":"169","author":"SS Birring","year":"2004","unstructured":"Birring SS, Parker D, Brightling CE, Bradding P, Wardlaw AJ, Pavord ID (2004) Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med 169:15\u201319","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1164\/rccm.2310009","volume":"169","author":"PG Gibson","year":"2004","unstructured":"Gibson PG (2004) Cough is an airway itch? Am J Respir Crit Care Med 169:1\u20132","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0169-328X(01)00314-X","volume":"97","author":"SD Skaper","year":"2001","unstructured":"Skaper SD, Pollock M, Facci L (2001) Mast cells differentially express and release active high molecular weight neurotrophins. Brain Res Mol Brain Res 97:177\u2013185","journal-title":"Brain Res Mol Brain Res"},{"key":"9543_CR29","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1164\/ajrccm.152.6.8520777","volume":"152","author":"F O\u2019Connell","year":"1995","unstructured":"O\u2019Connell F, Springall DR, Moradoghli-Haftvani A, Krausz T, Price D, Fuller RW et al (1995) Abnormal intraepithelial airway nerves in persistent unexplained cough? Am J Respir Crit Care Med 152:2068\u20132075","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR30","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0022-3565(25)39238-4","volume":"243","author":"H Repke","year":"1987","unstructured":"Repke H, Piotrowski W, Bienert M, Foreman JC (1987) Histamine release induced by Arg-Pro-Lys-Pro(CH2)11CH3 from rat peritoneal mast cells. J Pharmacol Exp Ther 243:317\u2013321","journal-title":"J Pharmacol Exp Ther"},{"key":"9543_CR31","first-page":"L93","volume":"273","author":"RW Costello","year":"1997","unstructured":"Costello RW, Schofield BH, Kephart GM, Gleich GJ, Jacoby DB, Fryer AD (1997) Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. Am J Physiol 273:L93\u2013L103","journal-title":"Am J Physiol"},{"key":"9543_CR32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1094-5539(02)00093-7","volume":"16","author":"PJ Kingham","year":"2003","unstructured":"Kingham PJ, Costello RW, McLean WG (2003) Eosinophil and airway nerve interactions. Pulm Pharmacol Ther 16:9\u201313","journal-title":"Pulm Pharmacol Ther"},{"key":"9543_CR33","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1152\/jappl.2001.91.3.1318","volume":"91","author":"LY Lee","year":"2001","unstructured":"Lee LY, Gu Q, Gleich GJ (2001) Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung. J Appl Physiol 91:1318\u20131326","journal-title":"J Appl Physiol"},{"key":"9543_CR34","first-page":"L1096","volume":"273","author":"A Garland","year":"1997","unstructured":"Garland A, Necheles J, White SR, Neeley SP, Leff AR, Carson SS et al (1997) Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. Am J Physiol 273:L1096\u2013L1102","journal-title":"Am J Physiol"},{"key":"9543_CR35","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.4049\/jimmunol.149.10.3309","volume":"149","author":"T Numao","year":"1992","unstructured":"Numao T, Agrawal DK (1992) Neuropeptides modulate human eosinophil chemotaxis. J Immunol 149:3309\u20133315","journal-title":"J Immunol"},{"key":"9543_CR36","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1182\/blood-2002-05-1488","volume":"101","author":"AM Piliponsky","year":"2003","unstructured":"Piliponsky AM, Gleich GJ, Nagler A, Bar I, Levi-Schaffer F (2003) Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. Blood 101:1898\u20131904","journal-title":"Blood"},{"key":"9543_CR37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1164\/ajrccm\/142.1.91","volume":"142","author":"E Adelroth","year":"1990","unstructured":"Adelroth E, Rosenhall L, Johansson SA, Linden M, Venge P (1990) Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline. Am Rev Respir Dis 142:91\u201399","journal-title":"Am Rev Respir Dis"},{"key":"9543_CR38","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1164\/ajrccm\/145.3.669","volume":"145","author":"R Djukanovi\u0107","year":"1992","unstructured":"Djukanovi\u0107 R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR et al (1992) Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 145:669\u2013674","journal-title":"Am Rev Respir Dis"},{"key":"9543_CR39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1164\/ajrccm.163.1.9807061","volume":"163","author":"PG Gibson","year":"2001","unstructured":"Gibson PG, Saltos N, Fakes K (2001) Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial. Am J Respir Crit Care Med 163:32\u201336","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR40","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0091-6749(97)70286-0","volume":"100","author":"C Lemiere","year":"1997","unstructured":"Lemiere C, Efthimiadis A, Hargreave FE (1997) Occupational eosinophilic bronchitis without asthma: an unknown occupational airway disease. J Allergy Clin Immunol 100:852\u2013853","journal-title":"J Allergy Clin Immunol"},{"key":"9543_CR41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2222.1995.tb01017.x","volume":"25","author":"PG Gibson","year":"1995","unstructured":"Gibson PG, Hargreave FE, Girgis-Gabardo A et al (1995) Chronic cough with eosinophilic bronchitis: examination for variable airflow obstruction and response to corticosteroid. Clin Exp Allergy 25:127\u2013132","journal-title":"Clin Exp Allergy"},{"key":"9543_CR42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.156.1.9605044","volume":"156","author":"IK Carney","year":"1997","unstructured":"Carney IK, Gibson PG, Murree-Allen K et al (1997) A systematic evaluation of mechanisms in chronic cough. Am J Respir Crit Care Med 156:211\u2013216","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR43","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(00)02872-5","volume":"356","author":"CE Brightling","year":"2000","unstructured":"Brightling CE, Monteiro W, Ward R et al (2000) Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 356:1480\u20131485","journal-title":"Lancet"},{"key":"9543_CR44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1155\/1999\/434901","volume":"6","author":"MM Pizzichini","year":"1999","unstructured":"Pizzichini MM, Pizzichini E, Parameswaran K et al (1999) Nonasthmatic chronic cough: no effect of treatment with an inhaled corticosteroid in patients without sputum eosinophilia. Can Respir J 6:323\u2013330","journal-title":"Can Respir J"},{"key":"9543_CR45","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0091-6749(99)70069-2","volume":"104","author":"AJ Wardlaw","year":"1999","unstructured":"Wardlaw AJ (1999) Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm. J Allergy Clin Immunol 104:917\u2013926","journal-title":"J Allergy Clin Immunol"},{"key":"9543_CR46","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/S0140-6736(00)03496-6","volume":"356","author":"MJ Leckie","year":"2000","unstructured":"Leckie MJ, ten Brinke A, Khan J, Diamant Z, O\u2019Connor BJ, Walls CM et al (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356:2144\u20132148","journal-title":"Lancet"},{"key":"9543_CR47","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/rccm.200208-789OC","volume":"167","author":"PT Flood-Page","year":"2003","unstructured":"Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS (2003) Eosinophil\u2019s role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 167:199\u2013204","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR48","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","volume":"360","author":"P Haldar","year":"2009","unstructured":"Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A et al (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360:973\u2013984","journal-title":"N Engl J Med"},{"key":"9543_CR49","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/thorax.58.6.528","volume":"58","author":"CE Brightling","year":"2003","unstructured":"Brightling CE, Symon FA, Birring SS et al (2003) Comparison of the immunopathology of eosinophilic bronchitis and asthma. Thorax 58:528\u2013532","journal-title":"Thorax"},{"key":"9543_CR50","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1164\/ajrccm.162.3.9909064","volume":"162","author":"CE Brightling","year":"2000","unstructured":"Brightling CE, Ward R, Woltmann G et al (2000) Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med 162:878\u2013882","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR51","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0091-6749(98)70242-8","volume":"101","author":"PG Gibson","year":"1998","unstructured":"Gibson PG, Zlatic K, Scott J et al (1998) Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. J Allergy Clin Immunol 101:320\u2013326","journal-title":"J Allergy Clin Immunol"},{"key":"9543_CR52","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","volume":"3","author":"O Hermine","year":"2008","unstructured":"Hermine O, Lortholary O, Leventhal PS, Catteau A, Soppelsa F, Baude C et al (2008) Case-controlled cohort study of patients\u2019 perceptions of disability in mastocytosis. PLoS One 3:e2266","journal-title":"PLoS One"},{"key":"9543_CR53","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1164\/ajrccm.155.3.9117012","volume":"155","author":"R Djukanovi\u0107","year":"1997","unstructured":"Djukanovi\u0107 R, Homeyard S, Gratziou C, Madden J, Walls A, Montefort S et al (1997) The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation. Am J Respir Crit Care Med 155:826\u2013832","journal-title":"Am J Respir Crit Care Med"},{"key":"9543_CR54","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1183\/09031936.06.00089405","volume":"27","author":"KF Chung","year":"2006","unstructured":"Chung KF, Hew M, Score J, Jones AV, Reiter A, Cross NC et al (2006) Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity. Eur Respir J 27:230\u2013232","journal-title":"Eur Respir J"},{"key":"9543_CR55","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/thx.2010.135251","volume":"65","author":"B Barker","year":"2010","unstructured":"Barker B, Moudgil H, Slocombe G, Srinivasan K (2010) Persistent cough: an unusual cause. Idiopathic hypereosinophilic syndrome (HES). Thorax 65:1009","journal-title":"Thorax"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-013-9543-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-013-9543-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-013-9543-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T04:47:50Z","timestamp":1746074870000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-013-9543-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,14]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["9543"],"URL":"https:\/\/doi.org\/10.1007\/s00408-013-9543-8","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,14]]}}}