{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:13:52Z","timestamp":1789596832972,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00408-014-9619-0","type":"journal-article","created":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T09:14:07Z","timestamp":1405242847000},"page":"849-855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Low-Dose Clarithromycin Therapy Modulates Th17 Response In Non-Cystic Fibrosis Bronchiectasis Patients"],"prefix":"10.1007","volume":"192","author":[{"given":"Evangelia","family":"Fouka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Lamprianidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Arvanitidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Filidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kolios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Miltiades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Paraskakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Antoniadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kotsianidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demosthenes","family":"Bouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"9619_CR1","first-page":"6","volume":"147","author":"PJ Cole","year":"1986","unstructured":"Cole PJ (1986) Inflammation: a two-edged sword\u2013the model of bronchiectasis. Eur J Respir Dis Suppl 147:6\u201315","journal-title":"Eur J Respir Dis Suppl"},{"issue":"18","key":"9619_CR2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMra012519","volume":"346","author":"AF Barker","year":"2002","unstructured":"Barker AF (2002) Bronchiectasis. N Engl J Med 346(18):1383\u20131393","journal-title":"N Engl J Med"},{"issue":"10","key":"9619_CR3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/01902140701756604","volume":"33","author":"SJ Aujla","year":"2007","unstructured":"Aujla SJ, Dubin PJ, Kolls JK (2007) Interleukin-17 in pulmonary host defense. Exp Lung Res 33(10):507\u2013518","journal-title":"Exp Lung Res"},{"key":"9619_CR4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","volume":"226","author":"Y Iwakura","year":"2008","unstructured":"Iwakura Y, Nakae S, Saijo S, Ishigame H (2008) The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 226:57\u201379","journal-title":"Immunol Rev"},{"issue":"7198","key":"9619_CR5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nature07036","volume":"453","author":"E Bettelli","year":"2008","unstructured":"Bettelli E, Korn T, Oukka M, Kuchroo VK (2008) Induction and effector functions of Th 17 cells. Nature 453(7198):1051\u20131057","journal-title":"Nature"},{"issue":"2","key":"9619_CR6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm1551","volume":"13","author":"L Steinman","year":"2007","unstructured":"Steinman L (2007) A brief history of Th 17, the first major revision in the Th 1\/Th 2 hypothesis of T cell-mediated tissue damage. Nat Med 13(2):139\u2013145","journal-title":"Nat Med"},{"issue":"8","key":"9619_CR7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1164\/rccm.201007-1196PP","volume":"183","author":"BM Vanaudenaerde","year":"2011","unstructured":"Vanaudenaerde BM, Verleden SE, Vos R et al (2011) Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders. Am J Respir Crit Care Med 183(8):977\u2013986","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"9619_CR8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00011-007-6187-2","volume":"56","author":"PJ Dubin","year":"2007","unstructured":"Dubin PJ, McAllister F, Kolls JK (2007) Is cystic fibrosis a TH17 disease? Inflamm Res 56(6):221\u2013227","journal-title":"Inflamm Res"},{"issue":"10","key":"9619_CR9","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1365-2362.2006.01710.x","volume":"36","author":"G Kolios","year":"2006","unstructured":"Kolios G, Manousou P, Bourikas L et al (2006) Ciprofloxacin inhibits cytokine-induced nitric oxide production in human colonic epithelium. Eur J Clin Invest 36(10):720\u2013729","journal-title":"Eur J Clin Invest"},{"issue":"2 Suppl","key":"9619_CR10","doi-asserted-by":"crossref","first-page":"70S","DOI":"10.1378\/chest.125.2_suppl.70S","volume":"125","author":"BK Rubin","year":"2004","unstructured":"Rubin BK, Henke MO (2004) Immunomodulatory activity and effectiveness of macrolides in chronic airway disease. Chest 125(2 Suppl):70S\u201378S","journal-title":"Chest"},{"issue":"5","key":"9619_CR11","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1128\/AAC.50.5.1738-1744.2006","volume":"50","author":"M Shinkai","year":"2006","unstructured":"Shinkai M, Tamaoki J, Kobayashi H et al (2006) Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppression. Antimicrob Agents Chemother 50(5):1738\u20131744","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"9619_CR12","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1440-1843.2009.01569.x","volume":"14","author":"WK Tsang","year":"2009","unstructured":"Tsang WK, Bilton D (2009) Clinical challenges in managing bronchiectasis. Respirology 14(5):637\u2013650","journal-title":"Respirology"},{"issue":"1","key":"9619_CR13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00151829-200403010-00007","volume":"3","author":"D Banerjee","year":"2004","unstructured":"Banerjee D, Honeybourne D, Khair OA (2004) The effect of oral clarithromycin on bronchial airway inflammation in moderate-to-severe stable COPD: a randomized controlled trial. Treat Respir Med 3(1):59\u201365","journal-title":"Treat Respir Med"},{"issue":"3","key":"9619_CR14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.05.00029705","volume":"26","author":"I Horv\u00e1th","year":"2005","unstructured":"Horv\u00e1th I, Hunt J, Barnes PJ et al (2005) ATS\/ERS task force on exhaled breath condensate. exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 26(3):523\u2013548","journal-title":"Eur Respir J"},{"issue":"1","key":"9619_CR15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1183\/09031936.05.00034505","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Crapo R, Hankinson J et al (2005) ATS\/ERS task force. General considerations for lung function testing. Eur Respir J 26(1):153\u2013161","journal-title":"Eur Respir J"},{"issue":"11","key":"9619_CR16","first-page":"953","volume":"118","author":"YC Sun","year":"2005","unstructured":"Sun YC, Zhou QT, Yao WZ (2005) Sputum interleukin-17 is increased and associated with airway neutrophilia in patients with severe asthma. Chin Med J (Engl) 118(11):953\u2013956","journal-title":"Chin Med J (Engl)"},{"key":"9619_CR17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-2249.2009.03965.x","volume":"157","author":"A Stefano Di","year":"2009","unstructured":"Di Stefano A, Caramori G, Gnemmi I et al (2009) T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol 157:316\u2013324","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"9619_CR18","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","volume":"175","author":"F McAllister","year":"2005","unstructured":"McAllister F, Henry A, Kreindler JL et al (2005) Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 175(1):404\u2013412","journal-title":"J Immunol"},{"issue":"2","key":"9619_CR19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1164\/rccm.201102-0236OC","volume":"184","author":"HL Tan","year":"2011","unstructured":"Tan HL, Regamey N, Brown S et al (2011) The Th17 pathway in cystic fibrosis lung disease. Am J Respir Crit Care Med 184(2):252\u2013258","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"9619_CR20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1440-1843.2012.02166.x","volume":"17","author":"FM Ding","year":"2012","unstructured":"Ding FM, Zhu SL, Shen C et al (2012) Low-dose clarithromycin therapy modulates CD4(+) T-cell responses in a mouse model of chronic Pseudomonas aeruginosa lung infection. Respirology 17(4):727\u2013734","journal-title":"Respirology"},{"issue":"6","key":"9619_CR21","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1164\/rccm.201206-1150OC","volume":"187","author":"K Tiringer","year":"2013","unstructured":"Tiringer K, Treis A, Fucik P et al (2013) A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am J Respir Crit Care Med 187(6):621\u2013629","journal-title":"Am J Respir Crit Care Med"},{"issue":"9842","key":"9619_CR22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","volume":"380","author":"C Wong","year":"2012","unstructured":"Wong C, Jayaram L, Karalus N et al (2012) Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. Lancet 380(9842):660\u2013667","journal-title":"Lancet"},{"issue":"12","key":"9619_CR23","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.2013.1937","volume":"309","author":"J Altenburg","year":"2013","unstructured":"Altenburg J, de Graaff CS, Stienstra Y et al (2013) Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial. JAMA 309(12):1251\u20131259","journal-title":"JAMA"},{"key":"9619_CR24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1465-9921-14-138","volume":"14","author":"R Kushwah","year":"2013","unstructured":"Kushwah R, Gagnon S, Sweezey NB (2013) Intrinsic predisposition of na\u00efve cystic fibrosis T cells to differentiate towards a Th17 phenotype. Respir Res 14:138","journal-title":"Respir Res"},{"issue":"3","key":"9619_CR25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijantimicag.2004.03.022","volume":"24","author":"Y Ishimatsu","year":"2004","unstructured":"Ishimatsu Y, Kadota J, Iwashita T et al (2004) Macrolide antibiotics induce apoptosis of human peripheral lymphocytes in vitro. Int J Antimicrob Agents 24(3):247\u2013253","journal-title":"Int J Antimicrob Agents"},{"issue":"3","key":"9619_CR26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijantimicag.2004.10.009","volume":"25","author":"J Kadota","year":"2005","unstructured":"Kadota J, Mizunoe S, Kishi K et al (2005) Antibiotic-induced apoptosis in human activated peripheral lymphocytes. Int J Antimicrob Agents 25(3):216\u2013220","journal-title":"Int J Antimicrob Agents"},{"issue":"10","key":"9619_CR27","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.2174\/092986711795328418","volume":"18","author":"S Loukides","year":"2011","unstructured":"Loukides S, Kontogianni K, Hillas G et al (2011) Exhaled breath condensate in asthma: from bench to bedside. Curr Med Chem 18(10):1432\u20131443","journal-title":"Curr Med Chem"},{"issue":"2","key":"9619_CR28","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1183\/09031936.00116107","volume":"32","author":"ZL Borrill","year":"2008","unstructured":"Borrill ZL, Roy K, Singh D (2008) Exhaled breath condensate biomarkers in COPD. Eur Respir J 32(2):472\u2013486","journal-title":"Eur Respir J"},{"issue":"3","key":"9619_CR29","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1399-3038.2009.00872.x","volume":"21","author":"CM Robroeks","year":"2010","unstructured":"Robroeks CM, Roozeboom MH, de Jong PA et al (2010) Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosis. Pediatr Allergy Immunol 21(3):493\u2013500","journal-title":"Pediatr Allergy Immunol"},{"issue":"10","key":"9619_CR30","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/ppul.21096","volume":"44","author":"GB Karakoc","year":"2009","unstructured":"Karakoc GB, Inal A, Yilmaz M et al (2009) Exhaled breath condensate MMP-9 levels in children with bronchiectasis. Pediatr Pulmonol 44(10):1010\u20131016","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"9619_CR31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ppul.20344","volume":"41","author":"N Zihlif","year":"2006","unstructured":"Zihlif N, Paraskakis E, Tripoli C et al (2006) Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensate. Pediatr Pulmonol 41(6):509\u2013514","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"9619_CR32","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1183\/09031936.00067110","volume":"37","author":"M Brodlie","year":"2011","unstructured":"Brodlie M, McKean MC, Johnson GE et al (2011) Raised interleukin-17 is immunolocalised to neutrophils in cystic fibrosis lung disease. Eur Respir J 37(6):1378\u20131385","journal-title":"Eur Respir J"},{"issue":"5","key":"9619_CR33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1378\/chest.10-0779","volume":"139","author":"A Eustace","year":"2011","unstructured":"Eustace A, Smyth LJ, Mitchell L et al (2011) Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD. Chest 139(5):1089\u20131100","journal-title":"Chest"},{"issue":"1","key":"9619_CR34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1378\/chest.121.1.81","volume":"121","author":"S Loukides","year":"2002","unstructured":"Loukides S, Bouros D, Papatheodorou G et al (2002) Exhaled H2O2 in steady-state bronchiectasis: relationship with cellular composition in induced sputum, spirometry, and extent and severity of disease. Chest 121(1):81\u201388","journal-title":"Chest"},{"issue":"2","key":"9619_CR35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1183\/09031936.99.13236199","volume":"13","author":"KW Tsang","year":"1999","unstructured":"Tsang KW, Ho PI, Chan KN et al (1999) A pilot study of low-dose erythromycin in bronchiectasis. Eur Respir J 13(2):361\u2013364","journal-title":"Eur Respir J"},{"issue":"6","key":"9619_CR36","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1023\/A:1027342424205","volume":"21","author":"C Feldman","year":"1997","unstructured":"Feldman C, Anderson R, Theron AJ et al (1997) Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. Inflammation 21(6):655\u2013665","journal-title":"Inflammation"},{"issue":"2","key":"9619_CR37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/09629350410001688495","volume":"13","author":"AL Pukhalsky","year":"2004","unstructured":"Pukhalsky AL, Shmarina GV, Kapranov NI et al (2004) Anti-inflammatory and immunomodulating effects of clarithromycin in patients with cystic fibrosis lung disease. Mediat Inflamm 13(2):111\u2013117","journal-title":"Mediat Inflamm"},{"issue":"1","key":"9619_CR38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2710.2006.00708.x","volume":"31","author":"E Yal\u00e7in","year":"2006","unstructured":"Yal\u00e7in E, Kiper N, Oz\u00e7elik U et al (2006) Effects of claritromycin on inflammatory parameters and clinical conditions in children with bronchiectasis. J Clin Pharm Ther 31(1):49\u201355","journal-title":"J Clin Pharm Ther"},{"issue":"1","key":"9619_CR39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000320320","volume":"81","author":"J Altenburg","year":"2011","unstructured":"Altenburg J, de Graaff CS, van der Werf TS et al (2011) Immunomodulatory effects of macrolide antibiotics\u2014part 2: advantages and disadvantages of long-term, low-dose macrolide therapy. Respiration 81(1):75\u201387","journal-title":"Respiration"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-014-9619-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-014-9619-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-014-9619-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:37:59Z","timestamp":1559054279000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-014-9619-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,14]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["9619"],"URL":"https:\/\/doi.org\/10.1007\/s00408-014-9619-0","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,14]]}}}