{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:26:15Z","timestamp":1779189975481,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T00:00:00Z","timestamp":1407456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s00408-014-9633-2","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T16:56:44Z","timestamp":1407430604000},"page":"811-817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["NS1619-Induced Vasodilation is Enhanced and Differentially Mediated in Chronically Hypoxic Lungs"],"prefix":"10.1007","volume":"192","author":[{"given":"Danielle J.","family":"McCullough","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Vang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,8]]},"reference":[{"issue":"1","key":"9633_CR1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cardiores.2006.07.025","volume":"72","author":"HA Ghofrani","year":"2006","unstructured":"Ghofrani HA, Voswinckel R, Reichenberger F, Weissmann N, Schermuly RT, Seeger W, Grimminger F (2006) Hypoxia- and non-hypoxia-related pulmonary hypertension\u2014established and new therapies. Cardiovasc Res 72(1):30\u201340. doi: 10.1016\/j.cardiores.2006.07.025","journal-title":"Cardiovasc Res"},{"issue":"2","key":"9633_CR2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/01.CIR.0000102381.57477.50","volume":"109","author":"R Budhiraja","year":"2004","unstructured":"Budhiraja R, Tuder RM, Hassoun PM (2004) Endothelial dysfunction in pulmonary hypertension. Circulation 109(2):159\u2013165. doi: 10.1161\/01.CIR.0000102381.57477.50","journal-title":"Circulation"},{"issue":"7","key":"9633_CR3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/01.RES.0000243584.45145.3f","volume":"99","author":"KR Stenmark","year":"2006","unstructured":"Stenmark KR, Fagan KA, Frid MG (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99(7):675\u2013691. doi: 10.1161\/01.RES.0000243584.45145.3f","journal-title":"Circ Res"},{"issue":"2","key":"9633_CR4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1183\/09031936.00128706","volume":"30","author":"O Pak","year":"2007","unstructured":"Pak O, Aldashev A, Welsh D, Peacock A (2007) The effects of hypoxia on the cells of the pulmonary vasculature. Eur Respir J 30(2):364\u2013372. doi: 10.1183\/09031936.00128706","journal-title":"Eur Respir J"},{"issue":"2","key":"9633_CR5","doi-asserted-by":"crossref","first-page":"L154","DOI":"10.1152\/ajplung.00313.2012","volume":"305","author":"J Wan","year":"2013","unstructured":"Wan J, Yamamura A, Zimnicka AM, Voiriot G, Smith KA, Tang H, Ayon RJ, Choudhury MS, Ko EA, Wang J, Wang C, Makino A, Yuan JX (2013) Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol 305(2):L154\u2013L164. doi: 10.1152\/ajplung.00313.2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"9633_CR6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2007.03.014","volume":"115","author":"S Bonnet","year":"2007","unstructured":"Bonnet S, Archer SL (2007) Potassium channel diversity in the pulmonary arteries and pulmonary veins: implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension. Pharmacol Ther 115(1):56\u201369. doi: 10.1016\/j.pharmthera.2007.03.014","journal-title":"Pharmacol Ther"},{"issue":"4\u20136","key":"9633_CR7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.vph.2008.07.006","volume":"49","author":"VI Peinado","year":"2008","unstructured":"Peinado VI, Par\u00eds R, Ram\u00edrez J, Roca J, Rodriguez-Roisin R, Barber\u00e0 JA (2008) Expression of BK(Ca) channels in human pulmonary arteries: relationship with remodeling and hypoxic pulmonary vasoconstriction. Vascul Pharmacol 49(4\u20136):178\u2013184. doi: 10.1016\/j.vph.2008.07.006","journal-title":"Vascul Pharmacol"},{"issue":"4","key":"9633_CR8","doi-asserted-by":"crossref","first-page":"L761","DOI":"10.1152\/ajplung.00283.2005","volume":"290","author":"E Resnik","year":"2006","unstructured":"Resnik E, Herron J, Fu R, Ivy DD, Cornfield DN (2006) Oxygen tension modulates the expression of pulmonary vascular BKCa channel alpha- and beta-subunits. Am J Physiol Lung Cell Mol Physiol 290(4):L761\u2013L768. doi: 10.1152\/ajplung.00283.2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9633_CR9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-60761-500-2_1","volume":"661","author":"EK Weir","year":"2010","unstructured":"Weir EK, Cabrera JA, Mahapatra S, Peterson DA, Hong Z (2010) The role of ion channels in hypoxic pulmonary vasoconstriction. Adv Exp Med Biol 661:3\u201314. doi: 10.1007\/978-1-60761-500-2_1","journal-title":"Adv Exp Med Biol"},{"issue":"3\u20134","key":"9633_CR10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.vph.2010.05.001","volume":"53","author":"A Vang","year":"2010","unstructured":"Vang A, Mazer J, Casserly B, Choudhary G (2010) Activation of endothelial BKCa channels causes pulmonary vasodilation. Vascul Pharmacol. 53(3\u20134):122\u2013129. doi: 10.1016\/j.vph.2010.05.001","journal-title":"Vascul Pharmacol."},{"issue":"1","key":"9633_CR11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1476-5381.1996.tb15163.x","volume":"117","author":"M Holland","year":"1996","unstructured":"Holland M, Langton PD, Standen NB, Boyle JP (1996) Effects of the BKCa channel activator, NS1619, on rat cerebral artery smooth muscle. Br J Pharmacol 117(1):119\u2013129","journal-title":"Br J Pharmacol"},{"issue":"5","key":"9633_CR12","first-page":"1099","volume":"92","author":"CR Kuhlmann","year":"2004","unstructured":"Kuhlmann CR, Trumper JR, Abdallah Y, Wiebke Ludders D, Schaefer CA, Most AK, Backenkohler U, Neumann T, Walther S, Piper HM, Tillmanns H, Erdogan A (2004) The K+-channel opener NS1619 increases endothelial NO-synthesis involving p42\/p44 MAP-kinase. Thromb haemost 92(5):1099\u20131107. doi: 10.1267\/THRO04051099","journal-title":"Thromb haemost"},{"issue":"4","key":"9633_CR13","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/j.1476-5381.1994.tb17171.x","volume":"113","author":"G Edwards","year":"1994","unstructured":"Edwards G, Niederste-Hollenberg A, Schneider J, Noack T, Weston AH (1994) Ion channel modulation by NS 1619, the putative BKCa channel opener, in vascular smooth muscle. Br J Pharmacol 113(4):1538\u20131547","journal-title":"Br J Pharmacol"},{"issue":"7","key":"9633_CR14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.healun.2011.03.010","volume":"30","author":"G Choudhary","year":"2011","unstructured":"Choudhary G, Troncales F, Martin D, Harrington EO, Klinger J (2011) Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension. J Heart Lung Transplant 30(7):827\u2013833. doi: 10.1016\/j.healun.2011.03.010","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"9633_CR15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0022-2275(20)36900-5","volume":"14","author":"RI Godinez","year":"1973","unstructured":"Godinez RI, Longmore WJ (1973) Use of the isolated perfused rat lung in studies on lung lipid metabolism. J Lipid Res 14(2):138\u2013144","journal-title":"J Lipid Res"},{"issue":"2","key":"9633_CR16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/jappl.1979.47.2.325","volume":"47","author":"CA Watkins","year":"1979","unstructured":"Watkins CA, Rannels DE (1979) In situ perfusion of rat lungs: stability and effects of oxygen tension. J Appl Physiol 47(2):325\u2013329","journal-title":"J Appl Physiol"},{"issue":"1","key":"9633_CR17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1203\/00006450-200207000-00006","volume":"52","author":"B Thebaud","year":"2002","unstructured":"Thebaud B, Michelakis E, Wu XC, Harry G, Hashimoto K, Archer SL (2002) Sildenafil reverses O2 constriction of the rabbit ductus arteriosus by inhibiting type 5 phosphodiesterase and activating BK(Ca) channels. Pediatr Res 52(1):19\u201324. doi: 10.1203\/00006450-200207000-00006","journal-title":"Pediatr Res"},{"issue":"5","key":"9633_CR18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00424-008-0583-5","volume":"457","author":"BH Bentzen","year":"2009","unstructured":"Bentzen BH, Osadchii O, Jespersen T, Hansen RS, Olesen SP, Grunnet M (2009) Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury. Pflugers Arch 457(5):979\u2013988. doi: 10.1007\/s00424-008-0583-5","journal-title":"Pflugers Arch"},{"issue":"4","key":"9633_CR19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1476-5381.2008.00084.x","volume":"157","author":"C McKenzie","year":"2009","unstructured":"McKenzie C, MacDonald A, Shaw AM (2009) Mechanisms of U46619-induced contraction of rat pulmonary arteries in the presence and absence of the endothelium. Br J Pharmacol 157(4):581\u2013596. doi: 10.1111\/j.1476-5381.2008.00084.x","journal-title":"Br J Pharmacol"},{"issue":"3","key":"9633_CR20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00210-007-0193-3","volume":"376","author":"B Eichhorn","year":"2007","unstructured":"Eichhorn B, Dobrev D (2007) Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol 376(3):145\u2013155. doi: 10.1007\/s00210-007-0193-3","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"9633_CR21","doi-asserted-by":"crossref","first-page":"L248","DOI":"10.1152\/ajplung.90303.2008","volume":"296","author":"A Simon","year":"2009","unstructured":"Simon A, Harrington EO, Liu GX, Koren G, Choudhary G (2009) Mechanism of C-type natriuretic peptide-induced endothelial cell hyperpolarization. Am J Physiol Lung Cell Mol Physiol 296(2):L248\u2013L256","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"9633_CR22","doi-asserted-by":"crossref","first-page":"L665","DOI":"10.1152\/ajplung.00050.2003","volume":"287","author":"T Nagaoka","year":"2004","unstructured":"Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M (2004) Rho\/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287(4):L665\u2013L672. doi: 10.1152\/ajplung.00050.2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"9633_CR23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/01.RES.78.3.431","volume":"78","author":"S Archer","year":"1996","unstructured":"Archer S, Huang J, Reeve H, Hampl V, Tolarova S, Michelakis E, Weir E (1996) Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ Res 78(3):431","journal-title":"Circ Res"},{"key":"9633_CR24","author":"M F\u00e9l\u00e9tou","year":"2009","unstructured":"F\u00e9l\u00e9tou M (2009) Calcium-activated potassium channels and endothelial dysfunction: therapeutic options? Br J Pharmacol. doi: 10.1111\/j.1476-5381.2009.00052.x","journal-title":"Br J Pharmacol"},{"issue":"4","key":"9633_CR25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-201X.1998.00462.x","volume":"164","author":"JH Jaggar","year":"1998","unstructured":"Jaggar JH, Wellman GC, Heppner TJ, Porter VA, Perez GJ, Gollasch M, Kleppisch T, Rubart M, Stevenson AS, Lederer WJ, Knot HJ, Bonev AD, Nelson MT (1998) Ca2+ channels, ryanodine receptors and Ca(2+)-activated K+ channels: a functional unit for regulating arterial tone. Acta Physiol Scand 164(4):577\u2013587. doi: 10.1046\/j.1365-201X.1998.00462.x","journal-title":"Acta Physiol Scand"},{"issue":"3","key":"9633_CR26","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.cardiores.2004.11.007","volume":"65","author":"E Dubuis","year":"2005","unstructured":"Dubuis E, Potier M, Wang R, Vandier C (2005) Continuous inhalation of carbon monoxide attenuates hypoxic pulmonary hypertension development presumably through activation of BKCa channels. Cardiovasc Res 65(3):751\u2013761. doi: 10.1016\/j.cardiores.2004.11.007","journal-title":"Cardiovasc Res"},{"issue":"16","key":"9633_CR27","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1073\/pnas.1633724100","volume":"100","author":"S Bonnet","year":"2003","unstructured":"Bonnet S, Dumas-de-La-Roque E, B\u00e9gueret H, Marthan R, Fayon M, Dos Santos P, Savineau J-P, Baulieu E-E (2003) Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension. Proc Natl Acad Sci USA 100(16):9488\u20139493. doi: 10.1073\/pnas.1633724100","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9633_CR28","doi-asserted-by":"crossref","first-page":"L352","DOI":"10.1152\/ajplung.00302.2011","volume":"302","author":"YT Ahn","year":"2012","unstructured":"Ahn YT, Kim YM, Adams E, Lyu SC, Alvira CM, Cornfield DN (2012) Hypoxia-inducible factor-1alpha regulates KCNMB1 expression in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 302(3):L352\u2013L359. doi: 10.1152\/ajplung.00302.2011","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"12 Suppl S","key":"9633_CR29","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/j.jacc.2004.02.029","volume":"43","author":"M Humbert","year":"2004","unstructured":"Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M (2004) Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 43(12 Suppl S):13S\u201324S. doi: 10.1016\/j.jacc.2004.02.029","journal-title":"J Am Coll Cardiol"},{"issue":"3 Pt 2","key":"9633_CR30","first-page":"H888","volume":"270","author":"TC Resta","year":"1996","unstructured":"Resta TC, Walker BR (1996) Chronic hypoxia selectively augments endothelium-dependent pulmonary arterial vasodilation. Am J Physiol 270(3 Pt 2):H888\u2013H896","journal-title":"Am J Physiol"},{"issue":"4","key":"9633_CR31","doi-asserted-by":"crossref","first-page":"L801","DOI":"10.1152\/ajplung.00443.2003","volume":"287","author":"NL Jernigan","year":"2004","unstructured":"Jernigan NL, Walker BR, Resta TC (2004) Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 287(4):L801\u2013L808. doi: 10.1152\/ajplung.00443.2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"9633_CR32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb11293.x","volume":"868","author":"WA Coetzee","year":"1999","unstructured":"Coetzee WA, Amarillo Y, Chiu J, Chow A, Lau D, McCormack T, Moreno H, Nadal MS, Ozaita A, Pountney D, Saganich M, Vega-Saenz de Miera E, Rudy B (1999) Molecular diversity of K+ channels. Ann NY Acad Sci 868:233\u2013285","journal-title":"Ann NY Acad Sci"},{"issue":"6","key":"9633_CR33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/01.RES.85.6.489","volume":"85","author":"JT Hulme","year":"1999","unstructured":"Hulme JT, Coppock EA, Felipe A, Martens JR, Tamkun MM (1999) Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Circ Res 85(6):489\u2013497","journal-title":"Circ Res"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-014-9633-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-014-9633-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-014-9633-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T22:14:43Z","timestamp":1649888083000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-014-9633-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,8]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["9633"],"URL":"https:\/\/doi.org\/10.1007\/s00408-014-9633-2","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,8]]}}}