{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:54:02Z","timestamp":1789977242638,"version":"4.0.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T00:00:00Z","timestamp":1492819200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00P3_150531\/1"],"award-info":[{"award-number":["PP00P3_150531\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["3200BO-116177\/1"],"award-info":[{"award-number":["3200BO-116177\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sant\u00e9 Suisse"},{"name":"Research Council of the Kantonsspital Aarau","award":["1310.000.044"],"award-info":[{"award-number":["1310.000.044"]}]},{"DOI":"10.13039\/501100005688","name":"Gottfried und Julia Bangerter-Rhyner-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005688","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BRAHAMS Biomarkers"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00408-017-0004-7","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T09:19:12Z","timestamp":1492852752000},"page":"303-311","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study"],"prefix":"10.1007","volume":"195","author":[{"given":"Marc A.","family":"Meier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ottiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaadin","family":"V\u00f6geli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Steuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Thomann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Henzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Hoess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Zimmerli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schuetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,22]]},"reference":[{"key":"4_CR1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.foodchem.2015.02.108","volume":"193","author":"SA Cevikkalp","year":"2016","unstructured":"Cevikkalp SA, Loker GB, Yaman M et al (2016) A simplified HPLC method for determination of tryptophan in some cereals and legumes. Food Chem 193:26\u201329","journal-title":"Food Chem"},{"issue":"7","key":"4_CR2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/CS20140392","volume":"129","author":"AW Yeung","year":"2015","unstructured":"Yeung AW, Terentis AC, King NJ et al (2015) Role of indoleamine 2,3-dioxygenase in health and disease. Clin Sci 129(7):601\u2013672","journal-title":"Clin Sci"},{"key":"4_CR3","doi-asserted-by":"crossref","first-page":"22747","DOI":"10.1038\/srep22747","volume":"6","author":"Y Li","year":"2016","unstructured":"Li Y, Hadden C, Cooper A et al (2016) Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability. Sci Rep 6:22747","journal-title":"Sci Rep"},{"issue":"3","key":"4_CR4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00964611","volume":"5","author":"EM Gal","year":"1980","unstructured":"Gal EM, Sherman AD (1980) L-kynurenine: its synthesis and possible regulatory function in brain. Neurochem Res 5(3):223\u2013239","journal-title":"Neurochem Res"},{"issue":"7","key":"4_CR5","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.4049\/jimmunol.139.7.2414","volume":"139","author":"JM Carlin","year":"1987","unstructured":"Carlin JM, Borden EC, Sondel PM et al (1987) Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures. J Immunol 139(7):2414\u20132418","journal-title":"J Immunol"},{"issue":"4","key":"4_CR6","doi-asserted-by":"crossref","first-page":"13P","DOI":"10.1093\/oxfordjournals.jbchem.a131115","volume":"79","author":"O Hayaishi","year":"1976","unstructured":"Hayaishi O (1976) Properties and function of indoleamine 2,3-dioxygenase. J Biochem 79(4):13P\u201321P","journal-title":"J Biochem"},{"issue":"2","key":"4_CR7","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbrc.2004.11.033","volume":"326","author":"T Herraiz","year":"2005","unstructured":"Herraiz T, Chaparro C (2005) Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors. Biochem Biophys Res Commun 326(2):378\u2013386","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"4_CR8","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1016\/j.bmc.2005.12.057","volume":"14","author":"AA Khalil","year":"2006","unstructured":"Khalil AA, Davies B, Castagnoli N Jr (2006) Isolation and characterization of a monoamine oxidase B selective inhibitor from tobacco smoke. Bioorg Med Chem 14(10):3392\u20133398","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"4_CR9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1124\/jpet.104.081182","volume":"313","author":"I Morecroft","year":"2005","unstructured":"Morecroft I, Loughlin L, Nilsen M et al (2005) Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries. J Pharmacol Exp Ther 313(2):539\u2013548","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"4_CR10","doi-asserted-by":"crossref","first-page":"e31617","DOI":"10.1371\/journal.pone.0031617","volume":"7","author":"WK Lau","year":"2012","unstructured":"Lau WK, Chan-Yeung MM, Yip BH et al (2012) The role of circulating serotonin in the development of chronic obstructive pulmonary disease. PLoS One 7(2):e31617","journal-title":"PLoS One"},{"issue":"4","key":"4_CR11","first-page":"1","volume":"65","author":"KD Kochanek","year":"2016","unstructured":"Kochanek KD, Murphy SL, Xu J et al (2016) Deaths: final data for 2014. Natl Vital Stat Rep 65(4):1\u2013122","journal-title":"Natl Vital Stat Rep"},{"key":"4_CR12","doi-asserted-by":"publisher","unstructured":"Meier MA, Ottiger M, Voegeli A et al (2017) Activation of the tryptophan\/serotonin pathway is associated with severity and predicts outcomes in pneumonia: results of a long-term cohort study. Clin Chem Lab Med 28076309. doi: 10.1515\/cclm-2016-0912","DOI":"10.1515\/cclm-2016-0912"},{"issue":"11","key":"4_CR13","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3109\/10715762.2012.721928","volume":"46","author":"WK Lau","year":"2012","unstructured":"Lau WK, Li X, Yeung DS et al (2012) The involvement of serotonin metabolism in cigarette smoke-induced oxidative stress in rat lung in vivo. Free Radic Res 46(11):1413\u20131419","journal-title":"Free Radic Res"},{"key":"4_CR14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1472-6963-7-102","volume":"7","author":"P Schuetz","year":"2007","unstructured":"Schuetz P, Christ-Crain M, Wolbers M et al (2007) Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial. BMC Health Serv Res 7:102","journal-title":"BMC Health Serv Res"},{"issue":"10","key":"4_CR15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jama.2009.1297","volume":"302","author":"P Schuetz","year":"2009","unstructured":"Schuetz P, Christ-Crain M, Thomann R et al (2009) Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA 302(10):1059\u20131066","journal-title":"JAMA"},{"issue":"3","key":"4_CR16","first-page":"295","volume":"12","author":"E Grolimund","year":"2015","unstructured":"Grolimund E, Kutz A, Marlowe RJ et al (2015) Long-term Prognosis in COPD Exacerbation: role of Biomarkers. Clin Var Exacerbation Type 12(3):295\u2013305","journal-title":"Clin Var Exacerbation Type"},{"issue":"9","key":"4_CR17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1024\/0040-5930.65.9.487","volume":"65","author":"KM Weinberger","year":"2008","unstructured":"Weinberger KM (2008) Metabolomics in diagnosing metabolic diseases. Ther Umsch 65(9):487\u2013491","journal-title":"Ther Umsch"},{"issue":"4","key":"4_CR18","doi-asserted-by":"crossref","first-page":"e0153672","DOI":"10.1371\/journal.pone.0153672","volume":"11","author":"I Yet","year":"2016","unstructured":"Yet I, Menni C, Shin SY et al (2016) Genetic influences on metabolite levels: a comparison across metabolomic platforms. PLoS One 11(4):e0153672","journal-title":"PLoS One"},{"issue":"2","key":"4_CR19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ng.507","volume":"42","author":"T Illig","year":"2010","unstructured":"Illig T, Gieger C, Zhai G et al (2010) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42(2):137\u2013141","journal-title":"Nat Genet"},{"issue":"12","key":"4_CR20","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1093\/clinchem\/43.12.2397","volume":"43","author":"N Lepage","year":"1997","unstructured":"Lepage N, McDonald N, Dallaire L et al (1997) Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population. Clin Chem 43(12):2397\u20132402","journal-title":"Clin Chem"},{"issue":"2","key":"4_CR21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/IAI.53.2.347-351.1986","volume":"53","author":"GI Byrne","year":"1986","unstructured":"Byrne GI, Lehmann LK, Landry GJ (1986) Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. Infect Immun 53(2):347\u2013351","journal-title":"Infect Immun"},{"issue":"5","key":"4_CR22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1515\/bchm3.1988.369.1.337","volume":"369","author":"ER Werner","year":"1988","unstructured":"Werner ER, Fuchs D, Hausen A et al (1988) Tryptophan degradation in patients infected by human immunodeficiency virus. Biol Chem Hoppe Seyler 369(5):337\u2013340","journal-title":"Biol Chem Hoppe Seyler"},{"issue":"12","key":"4_CR23","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1093\/clinchem\/43.12.2424","volume":"43","author":"B Widner","year":"1997","unstructured":"Widner B, Werner ER, Schennach H et al (1997) Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 43(12):2424\u20132426","journal-title":"Clin Chem"},{"issue":"2","key":"4_CR24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/joim.12341","volume":"278","author":"M Alan","year":"2014","unstructured":"Alan M, Grolimund E, Kutz A et al (2014) Clinical risk scores and blood biomarkers as predictors of long-term outcome in patients with community-acquired pneumonia: a 6-year prospective follow-up study. J Intern Med 278(2):174\u2013184","journal-title":"J Intern Med"},{"issue":"6","key":"4_CR25","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1183\/09031936.00121510","volume":"37","author":"C Guertler","year":"2011","unstructured":"Guertler C, Wirz B, Christ-Crain M et al (2011) Inflammatory responses predict long-term mortality risk in community-acquired pneumonia. Eur Respir J 37(6):1439\u20131446","journal-title":"Eur Respir J"},{"issue":"12","key":"4_CR26","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1097\/CCM.0b013e31822827f2","volume":"39","author":"D Changsirivathanathamrong","year":"2011","unstructured":"Changsirivathanathamrong D, Wang Y, Rajbhandari D et al (2011) Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Crit Care Med 39(12):2678\u20132683","journal-title":"Crit Care Med"},{"issue":"11","key":"4_CR27","doi-asserted-by":"crossref","first-page":"4487","DOI":"10.1128\/IAI.02113-14","volume":"82","author":"M Hoshi","year":"2014","unstructured":"Hoshi M, Osawa Y, Ito H et al (2014) Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells. Infect Immun 82(11):4487\u20134495","journal-title":"Infect Immun"},{"issue":"3","key":"4_CR28","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.2092","volume":"16","author":"Y Wang","year":"2010","unstructured":"Wang Y, Liu H, McKenzie G et al (2010) Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med 16(3):279\u2013285","journal-title":"Nat Med"},{"issue":"3","key":"4_CR29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jinf.2011.07.003","volume":"63","author":"Y Suzuki","year":"2011","unstructured":"Suzuki Y, Suda T, Yokomura K et al (2011) Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia. J Infect 63(3):215\u2013222","journal-title":"J Infect"},{"issue":"2","key":"4_CR30","first-page":"175","volume":"54","author":"D Pawlak","year":"2003","unstructured":"Pawlak D, Tankiewicz A, Matys T et al (2003) Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. J Physiol Pharmacol 54(2):175\u2013189","journal-title":"J Physiol Pharmacol"},{"issue":"3","key":"4_CR31","doi-asserted-by":"crossref","first-page":"F565","DOI":"10.1152\/ajprenal.2000.279.3.F565","volume":"279","author":"K Saito","year":"2000","unstructured":"Saito K, Fujigaki S, Heyes MP et al (2000) Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Am J Physiol Ren Physiol 279(3):F565\u2013F572","journal-title":"Am J Physiol Ren Physiol"},{"issue":"6","key":"4_CR32","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1093\/ndt\/gfn739","volume":"24","author":"JC Schefold","year":"2009","unstructured":"Schefold JC, Zeden JP, Fotopoulou C et al (2009) Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms. Nephrol Dial Transpl 24(6):1901\u20131908","journal-title":"Nephrol Dial Transpl"},{"issue":"2","key":"4_CR33","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0003-2697(88)90478-2","volume":"172","author":"EW Holmes","year":"1988","unstructured":"Holmes EW (1988) Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography. Anal Biochem 172(2):518\u2013525","journal-title":"Anal Biochem"},{"issue":"10","key":"4_CR34","first-page":"1435","volume":"9","author":"I Nakanishi","year":"1994","unstructured":"Nakanishi I, Moutabarrik A, Okada N et al (1994) Interleukin-8 in chronic renal failure and dialysis patients. Nephrol Dial Transpl 9(10):1435\u20131442","journal-title":"Nephrol Dial Transpl"},{"issue":"2","key":"4_CR35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.numecd.2014.11.004","volume":"25","author":"A Zinellu","year":"2015","unstructured":"Zinellu A, Sotgia S, Mangoni AA et al (2015) Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. Nutr Metab Cardiovasc Dis 25(2):153\u2013159","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"5","key":"4_CR36","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/jnc.13496","volume":"136","author":"J Bie de","year":"2016","unstructured":"de Bie J, Guest J, Guillemin GJ et al (2016) Central kynurenine pathway shift with age in women. J Neurochem 136(5):995\u20131003","journal-title":"J Neurochem"},{"issue":"1","key":"4_CR37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/oby.20491","volume":"22","author":"H Mangge","year":"2014","unstructured":"Mangge H, Summers KL, Meinitzer A et al (2014) Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. Obesity 22(1):195\u2013201 (Silver Spring)","journal-title":"Obesity"},{"key":"4_CR38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.atherosclerosis.2016.01.015","volume":"246","author":"T Sugiura","year":"2016","unstructured":"Sugiura T, Dohi Y, Yamashita S et al (2016) Serotonin in peripheral blood reflects oxidative stress and plays a crucial role in atherosclerosis: novel insights toward holistic anti-atherothrombotic strategy. Atherosclerosis 246:157\u2013160","journal-title":"Atherosclerosis"},{"issue":"5","key":"4_CR39","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.CIR.100.5.483","volume":"100","author":"K Vikenes","year":"1999","unstructured":"Vikenes K, Farstad M, Nordrehaug JE (1999) Serotonin is associated with coronary artery disease and cardiac events. Circulation 100(5):483\u2013489","journal-title":"Circulation"},{"issue":"1","key":"4_CR40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1161\/01.CIR.79.1.154","volume":"79","author":"P Golino","year":"1989","unstructured":"Golino P, Ashton JH, Buja LM et al (1989) Local platelet activation causes vasoconstriction of large epicardial canine coronary arteries in vivo. Thromboxane A2 and serotonin are possible mediators. Circulation 79(1):154\u2013166","journal-title":"Circulation"},{"issue":"4","key":"4_CR41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/da.20041","volume":"20","author":"G Perna","year":"2004","unstructured":"Perna G, Cogo R, Bellodi L (2004) Selective serotonin re-uptake inhibitors beyond psychiatry: are they useful in the treatment of severe, chronic, obstructive pulmonary disease? Depress Anxiety 20(4):203\u2013204","journal-title":"Depress Anxiety"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-017-0004-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-017-0004-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-017-0004-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T07:08:03Z","timestamp":1692774483000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-017-0004-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,22]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["4"],"URL":"https:\/\/doi.org\/10.1007\/s00408-017-0004-7","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,22]]}}}