{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:25:39Z","timestamp":1791847539140,"version":"4.3.4"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T00:00:00Z","timestamp":1487980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00408-017-9987-3","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T05:10:35Z","timestamp":1487999435000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Electronic Nose Technology in Respiratory Diseases"],"prefix":"10.1007","volume":"195","author":[{"given":"Silvano","family":"Dragonieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pennazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Carratu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onofrio","family":"Resta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,25]]},"reference":[{"key":"9987_CR1","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1073\/pnas.68.10.2374","volume":"68","author":"L Pauling","year":"1971","unstructured":"Pauling L, Robinson AB, Teranishi R, Cary P (1971) Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc Natl Acad Sci USA 68:2374\u20132376","journal-title":"Proc Natl Acad Sci USA"},{"key":"9987_CR2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.resp.2004.02.002","volume":"145","author":"B Moser","year":"2005","unstructured":"Moser B, Bodrogi F, Eibl G et al (2005) Mass spectrometric profile of exhaled breath. Field study by PTR-MS. Respir Physiol Neurobiol 145:295\u2013300","journal-title":"Respir Physiol Neurobiol"},{"key":"9987_CR3","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0140-6736(98)07552-7","volume":"353","author":"M Phillips","year":"1999","unstructured":"Phillips M, Gleeson K, Hughes JM et al (1999) Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353:1930\u20131933","journal-title":"Lancet"},{"key":"9987_CR4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/CBM-2007-3204","volume":"3","author":"M Phillips","year":"2007","unstructured":"Phillips M, Altorki N, Austin JHM et al (2007) Prediction of lung cancer using volatile biomarkers in breath. Cancer Biomark 3:95\u2013109","journal-title":"Cancer Biomark"},{"key":"9987_CR5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1465-9921-6-71","volume":"6","author":"D Poli","year":"2005","unstructured":"Poli D, Carbognani P, Corrdai M et al (2005) Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study. Respir Res 6:71","journal-title":"Respir Res"},{"key":"9987_CR6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.lungcan.2009.03.029","volume":"67","author":"G Song","year":"2010","unstructured":"Song G, Qin T, Liu H et al (2010) Quantitative breath analysis of volatile organic compounds of lung cancer patients. Lung Cancer 67:227\u2013231","journal-title":"Lung Cancer"},{"key":"9987_CR7","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jaci.2007.05.043","volume":"120","author":"S Dragonieri","year":"2007","unstructured":"Dragonieri S, Schot R, Mertens JA et al (2007) An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol 120:856\u2013862","journal-title":"J Allergy Clin Immunol"},{"key":"9987_CR8","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1378\/chest.09-1836","volume":"137","author":"P Montuschi","year":"2010","unstructured":"Montuschi P, Santonico M, Penazza G et al (2010) Diagnostic performance of an electronic nose, fractional exhaled nitric oxide and lung function testing in asthma. Chest 137:790\u2013796","journal-title":"Chest"},{"key":"9987_CR9","doi-asserted-by":"crossref","first-page":"046002","DOI":"10.1088\/1752-7155\/3\/4\/046002","volume":"3","author":"L Bennet","year":"2009","unstructured":"Bennet L, Ciaffoni L, Denzer W et al (2009) A chemometric study on human breath mass spectra for biomarker identification in cystic fibrosis. J Breath Res 3:046002","journal-title":"J Breath Res"},{"key":"9987_CR10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.rmed.2009.10.018","volume":"104","author":"JJ Berkel Van","year":"2010","unstructured":"Van Berkel JJ, Dallinga JW, Moller GM et al (2010) A profile of volatile organic compounds in breath discriminates COPD patients from controls. Respir Med 104:557\u2013563","journal-title":"Respir Med"},{"key":"9987_CR11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/299352a0","volume":"299","author":"K Persaud","year":"1982","unstructured":"Persaud K, Dodd G (1982) Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose. Nature 299:352","journal-title":"Nature"},{"key":"9987_CR12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0092-8674(91)90418-X","volume":"65","author":"L Buck","year":"1991","unstructured":"Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175\u2013187","journal-title":"Cell"},{"key":"9987_CR13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1021\/cr068121q","volume":"108","author":"F R\u00f6ck","year":"2008","unstructured":"R\u00f6ck F, Barsan N, Weimar U (2008) Electronic nose: current status and future trends. Chem Rev 108:705\u2013725","journal-title":"Chem Rev"},{"key":"9987_CR14","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3390\/s110101105","volume":"11","author":"AD Wilson","year":"2011","unstructured":"Wilson AD, Baietto M (2011). Advances in electronic-nose technologies developed for biomedical applications. Sensors 11:1105\u20131176.","journal-title":"Sensors"},{"key":"9987_CR15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11306-006-0037-z","volume":"2","author":"DI Broadhurst","year":"2006","unstructured":"Broadhurst DI, Kjell DB (2006) Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2:171\u2013196","journal-title":"Metabolomics"},{"key":"9987_CR16","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1164\/rccm.200906-0939OC","volume":"180","author":"N Fens","year":"2009","unstructured":"Fens N, Zwinderman AH, van der Schee MP et al (2009) Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med 180:1076\u20131082","journal-title":"Am J Respir Crit Care Med"},{"key":"9987_CR17","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1365-2222.2011.03800.x","volume":"41","author":"N Fens","year":"2011","unstructured":"Fens N, Roldaan AC, van der Schee MP et al (2011) External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease. Clin Exp Allergy 41:1371\u20131378","journal-title":"Clin Exp Allergy"},{"key":"9987_CR18","first-page":"A2392","volume":"187","author":"A Wagener","year":"2013","unstructured":"Wagener A, Brinkman P, Zwinderman A, et al (2013). Exhaled breath profiling and eosinophilic airway inflammation in asthma\u2014results of a pilot study. Am J Respir Crit Care Med. 187:A2392","journal-title":"Am J Respir Crit Care Med"},{"key":"9987_CR19","first-page":"431","volume":"25","author":"V Plaza","year":"2015","unstructured":"Plaza V, Crespo A, Giner J et al (2015) Inflammatory asthma phenotype discrimination using an electronic nose breath analyzer. J Investig Allergol Clin Immunol 25:431\u2013437","journal-title":"J Investig Allergol Clin Immunol"},{"key":"9987_CR20","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/cea.12147","volume":"43","author":"MP Schee van der","year":"2013","unstructured":"van der Schee MP, Palmay R, Cowan JO et al (2013) Predicting steroid responsiveness in patients with asthma using exhaled breath profiling. Clin Exp Allergy 43:1217\u20131225","journal-title":"Clin Exp Allergy"},{"key":"9987_CR21","doi-asserted-by":"crossref","first-page":"046001","DOI":"10.1088\/1752-7155\/9\/4\/046001","volume":"9","author":"R Vries de","year":"2015","unstructured":"de Vries R, Brinkman P, van der Schee MP et al (2015) Integration of electronic nose technology with spirometry: validation of a new approach for exhaled breath analysis. J Breath Res 9:046001","journal-title":"J Breath Res"},{"key":"9987_CR22","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1056\/NEJMra0804752","volume":"360","author":"MG Cosio","year":"2009","unstructured":"Cosio MG, Saetta M, Agusti A (2009) Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 360:2445\u20132454","journal-title":"N Engl J Med"},{"key":"9987_CR23","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.rmed.2014.09.008","volume":"108","author":"O Sibila","year":"2014","unstructured":"Sibila O, Garcia-Bellmunt L, Giner J et al (2014) Identification of airway bacterial colonization by an electronic nose in chronic obstructive pulmonary disease. Respir Med 108:1608\u20131614","journal-title":"Respir Med"},{"key":"9987_CR24","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1440-1843.2011.02047.x","volume":"16","author":"AD Hattesohl","year":"2011","unstructured":"Hattesohl AD, J\u00f6rres RA, Dressel H et al (2011) Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose. Respirology 16:1258\u20131264","journal-title":"Respirology"},{"key":"9987_CR25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.lungcan.2008.08.008","volume":"64","author":"S Dragonieri","year":"2009","unstructured":"Dragonieri S, Annema JT, Schot R et al (2009) An electronic nose in the discrimination of patients with lung cancer and COPD. Lung Cancer 64:166\u2013170","journal-title":"Lung Cancer"},{"key":"9987_CR26","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1183\/09031936.00032911","volume":"38","author":"N Fens","year":"2011","unstructured":"Fens N, de Nijs SB, Peters S et al (2011) Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD. Eur Respir J 38:1301\u20131309","journal-title":"Eur Respir J"},{"key":"9987_CR27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/15412555.2012.744388","volume":"10","author":"N Fens","year":"2013","unstructured":"Fens N, van Rossum AG, Zanen P et al (2013) Subphenotypes of mild-to-moderate COPD by factor and cluster analysis of pulmonary function, CT imaging and breathomics in a population-based survey. COPD 10:277\u2013285","journal-title":"COPD"},{"key":"9987_CR28","doi-asserted-by":"crossref","first-page":"e0135199","DOI":"10.1371\/journal.pone.0135199","volume":"10","author":"H Shafiek","year":"2015","unstructured":"Shafiek H, Fiorentino F, Merino JL et al (2015) Using the electronic nose to identify airway infection during COPD exacerbations. PLoS ONE 10:e0135199","journal-title":"PLoS ONE"},{"key":"9987_CR29","doi-asserted-by":"crossref","first-page":"036001","DOI":"10.1088\/1752-7155\/10\/3\/036001","volume":"10","author":"WH Geffen van","year":"2016","unstructured":"van Geffen WH, Bruins M, Kerstjens HA (2016) Diagnosing viral and bacterial respiratory infections in acute COPD exacerbations by an electronic nose: a pilot study. J Breath Res 10:036001","journal-title":"J Breath Res"},{"key":"9987_CR30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1155\/2012\/920918","volume":"19","author":"DD Marciniuk","year":"2012","unstructured":"Marciniuk DD, Hernandez P, Balter M et al (2012) Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline. Can Respir J 19:109\u2013116","journal-title":"Can Respir J"},{"key":"9987_CR31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1046\/j.1472-765X.2002.01197.x","volume":"35","author":"A Pavlou","year":"2002","unstructured":"Pavlou A, Turner AP, Magan N (2002) Recognition of anaerobic bacterial isolates in vitro using electronic nose technology. Lett Appl Microbiol 35:366\u2013369","journal-title":"Lett Appl Microbiol"},{"key":"9987_CR32","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bios.2004.03.002","volume":"20","author":"AK Pavlou","year":"2004","unstructured":"Pavlou AK, Magan N, Jones JM et al (2004) Detection of Mycobacterium tuberculosis (TB) in vitro and in situ using an electronic nose in combination with a neural network system. Biosens Bioelectron 20:538\u2013544","journal-title":"Biosens Bioelectron"},{"key":"9987_CR33","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1097\/00005537-200206000-00007","volume":"112","author":"SY Lai","year":"2002","unstructured":"Lai SY, Deffenderfer OF, Hanson W et al (2002) Identification of upper respiratory bacterial pathogens with the electronic nose. Laryngoscope 112:975\u2013979","journal-title":"Laryngoscope"},{"key":"9987_CR34","first-page":"1","volume":"16","author":"R Dutta","year":"2002","unstructured":"Dutta R, Hines EL, Gardner JW et al (2002) Bacteria classification using Cyranose 320 electronic nose. Biomed Eng Online 16:1\u20134","journal-title":"Biomed Eng Online"},{"key":"9987_CR35","first-page":"a6510","volume":"185","author":"MP Schee van der","year":"2012","unstructured":"van der Schee MP, Fens N, Buijze H et al (2012) Diagnostic value of exhaled breath analysis in tuberculosis. Am J Respir Crit Care Med 185:a6510","journal-title":"Am J Respir Crit Care Med"},{"key":"9987_CR36","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1183\/09031936.00019114","volume":"43","author":"MK Nakhleh","year":"2014","unstructured":"Nakhleh MK, Jeries R, Gharra A et al (2014) Detecting active pulmonary tuberculosis with a breath test using nanomaterial-based sensors. Eur Respir J 43:1522\u20131525","journal-title":"Eur Respir J"},{"key":"9987_CR37","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1586\/17434440.2.5.559","volume":"2","author":"ER Thaler","year":"2005","unstructured":"Thaler ER, Hanson CW (2005). Medical applications of electronic nose technology. Exert Rev Med Devices 2:559\u2013566","journal-title":"Exert Rev Med Devices"},{"key":"9987_CR38","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00000542-200501000-00013","volume":"102","author":"CW Hanson","year":"2005","unstructured":"Hanson CW, Thaler ER (2005) Electronic nose prediction of a clinical pneumonia score: biosensors and microbes. Anesthesiology 102:63\u201368","journal-title":"Anesthesiology"},{"key":"9987_CR39","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/00005537-200410000-00005","volume":"114","author":"NG Hockstein","year":"2004","unstructured":"Hockstein NG, Thaler ER, Torigian D et al (2004) Diagnosis of pneumonia with an electronic nose: correlation of vapor signature with chest computed tomography scan findings. Laryngoscope 114:1701\u20131705","journal-title":"Laryngoscope"},{"key":"9987_CR40","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00134-014-3260-5","volume":"40","author":"LD Bos","year":"2014","unstructured":"Bos LD, Martin-Loeches I, Kastelijn JB et al (2014) The volatile metabolic fingerprint of ventilator-associated pneumonia. Intensive Care Med 40:761\u2013762","journal-title":"Intensive Care Med"},{"key":"9987_CR41","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.rmed.2015.09.014","volume":"109","author":"RM Schnabel","year":"2015","unstructured":"Schnabel RM, Boumans ML, Smolinska A et al (2015) Electronic nose analysis of exhaled breath to diagnose ventilator-associated pneumonia. Respir Med 109:1454\u20131459","journal-title":"Respir Med"},{"key":"9987_CR42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/JCM.02214-15","volume":"54","author":"K Heer de","year":"2016","unstructured":"de Heer K, Kok MG, Fens N et al (2016) Detection of airway colonization by Aspergillus fumigatus by use of electronic nose technology in patients with cystic fibrosis. J Clin Microbiol 54:569\u2013575","journal-title":"J Clin Microbiol"},{"key":"9987_CR43","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1128\/JCM.02838-12","volume":"5","author":"K Heer de","year":"2013","unstructured":"de Heer K, van der Schee MP, Zwinderman K et al (2013) Electronic nose technology for detection of invasive pulmonary aspergillosis in prolonged chemotherapy-induced neutropenia: a proof-of-principle study. J Clin Microbiol 5:1490\u20131495","journal-title":"J Clin Microbiol"},{"key":"9987_CR44","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0956-5663(03)00086-1","volume":"18","author":"C Di Natale","year":"2003","unstructured":"Di Natale C, Macagnano A, Martinelli E et al (2003) Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors. Biosens Bioelectron 18:1209\u20131218","journal-title":"Biosens Bioelectron"},{"key":"9987_CR45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.lungcan.2011.12.010","volume":"77","author":"M Santonico","year":"2012","unstructured":"Santonico M, Lucantoni G, Pennazza G et al (2012) In situ detection of lung cancer volatile fingerprints using bronchoscopic air-sampling. Lung Cancer 77:46\u201350","journal-title":"Lung Cancer"},{"key":"9987_CR46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.lungcan.2009.11.003","volume":"68","author":"A D\u2019Amico","year":"2010","unstructured":"D\u2019Amico A, Pennazza G, Santonico M et al (2010) An investigation on electronic nose diagnosis of lung cancer. Lung Cancer 68:170\u2013176","journal-title":"Lung Cancer"},{"key":"9987_CR47","doi-asserted-by":"crossref","first-page":"016007","DOI":"10.1088\/1752-7155\/10\/1\/016007","volume":"10","author":"R Gasparri","year":"2016","unstructured":"Gasparri R, Santonico M, Valentini C et al (2016) Volatile signature for the early diagnosis of lung cancer. J Breath Res 10:016007","journal-title":"J Breath Res"},{"key":"9987_CR48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/thx.2006.072892","volume":"62","author":"PJ Mazzone","year":"2007","unstructured":"Mazzone PJ, Hammel J, Dweik R et al (2007) Diagnosis of lung cancer by the analysis of exhaled breath with a colorimetric sensor array. Thorax 62:565\u2013568","journal-title":"Thorax"},{"key":"9987_CR49","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1164\/rccm.200409-1184OC","volume":"171","author":"RF Machado","year":"2005","unstructured":"Machado RF, Laskowski O, Deffenderfer O et al (2005) Detection of lung cancer by sensor array analysis of exhaled breath. Am J Respir Crit Care Med 171:1286\u20131291","journal-title":"Am J Respir Crit Care Med"},{"key":"9987_CR50","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/1471-2466-14-202","volume":"14","author":"A Bikov","year":"2014","unstructured":"Bikov A, Hernadi M, Korosi BZ et al (2014) Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer. BMC Pulm Med 14:202","journal-title":"BMC Pulm Med"},{"key":"9987_CR51","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/jclinpath-2014-202414","volume":"67","author":"AJ Hubers","year":"2014","unstructured":"Hubers AJ, Brinkman P, Boksem RJ et al (2014) Combined sputum hypermethylation and eNose analysis for lung cancer diagnosis. J Clin Pathol 67:707\u2013711","journal-title":"J Clin Pathol"},{"key":"9987_CR52","first-page":"5873","volume":"6","author":"X Chen","year":"2005","unstructured":"Chen X, Cao M, Hao Y et al (2005) A Non-invasive detection of lung cancer combined virtual gas sensors array with imaging recognition technique. Conf Proc IEEE Eng Med Biol Soc 6:5873\u20135876","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"9987_CR53","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nnano.2009.235","volume":"4","author":"G Peng","year":"2009","unstructured":"Peng G, Tisch U, Adams O et al (2009) Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nat Nanotechnol 4:669\u2013673","journal-title":"Nat Nanotechnol"},{"key":"9987_CR54","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nano.2012.07.009","volume":"9","author":"YY Broza","year":"2013","unstructured":"Broza YY, Kremer R, Tisch U et al (2013) A nanomaterial-based breath test for short-term follow-up after lung tumor resection. Nanomedicine 9:15\u201321","journal-title":"Nanomedicine"},{"key":"9987_CR55","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.lungcan.2011.08.009","volume":"75","author":"S Dragonieri","year":"2012","unstructured":"Dragonieri S, van der Schee MP, Massaro T et al (2012) An electronic nose distinguishes exhaled breath of patients with malignant pleural mesothelioma from controls. Lung Cancer 75:326\u2013331","journal-title":"Lung Cancer"},{"key":"9987_CR56","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1183\/09031936.00040911","volume":"40","author":"EA Chapman","year":"2012","unstructured":"Chapman EA, Thomas PS, Stone E et al (2012) A breath test for malignant mesothelioma using an electronic nose. Eur Resp J 40:448\u2013454","journal-title":"Eur Resp J"},{"key":"9987_CR57","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1183\/09031936.00091712","volume":"42","author":"T Greulich","year":"2013","unstructured":"Greulich T, Hattesohl A, Grabisch A et al (2013) Detection of obstructive sleep apnoea by an electronic nose. Eur Respir J 42:145\u2013155","journal-title":"Eur Respir J"},{"key":"9987_CR58","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.ijporl.2013.04.025","volume":"77","author":"P Benedek","year":"2013","unstructured":"Benedek P, L\u00e1z\u00e1r Z, Bikov A et al (2013) Exhaled biomarker pattern is altered in children with obstructive sleep apnoea syndrome. Int J Pediatr Otorhinolaryngol 77:1244\u20131247","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"9987_CR59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11325-014-1003-z","volume":"19","author":"L Kunos","year":"2015","unstructured":"Kunos L, Bikov A, Lazar Z et al (2015) Evening and morning exhaled volatile compound patterns are different in obstructive sleep apnoea assessed with electronic nose. Sleep Breath 19:247\u2013253","journal-title":"Sleep Breath"},{"key":"9987_CR60","doi-asserted-by":"crossref","first-page":"026005","DOI":"10.1088\/1752-7155\/9\/2\/026005","volume":"9","author":"S Dragonieri","year":"2015","unstructured":"Dragonieri S, Porcelli F, Longobardi F et al (2015) An electronic nose in the discrimination of obese patients with and without obstructive sleep apnoea. J Breath Res 9:026005","journal-title":"J Breath Res"},{"issue":"10","key":"9987_CR61","doi-asserted-by":"crossref","first-page":"041001","DOI":"10.1088\/1752-7155\/10\/4\/041001","volume":"3","author":"S Dragonieri","year":"2016","unstructured":"Dragonieri S, Quaranta V, Carratu P et al (2016) Exhaled breath profiling in patients with COPD and OSA overlap syndrome: a pilot study. J Breath Res 3(10):041001","journal-title":"J Breath Res"},{"key":"9987_CR62","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s11325-014-1065-y","volume":"19","author":"R Antonelli Incalzi","year":"2015","unstructured":"Antonelli Incalzi R, Pennazza G, Scarlata S et al (2015) Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients. Sleep Breath 19:623\u2013630","journal-title":"Sleep Breath"},{"key":"9987_CR63","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jcf.2012.12.010","volume":"12","author":"T Paff","year":"2013","unstructured":"Paff T, van der Schee MP, Daniels JM et al (2013) Exhaled molecular profiles in the assessment of cystic fibrosis and primary ciliary dyskinesia. J Cyst Fibros 12:454\u2013460","journal-title":"J Cyst Fibros"},{"key":"9987_CR64","doi-asserted-by":"crossref","first-page":"e115584","DOI":"10.1371\/journal.pone.0115584","volume":"9","author":"O Joensen","year":"2014","unstructured":"Joensen O, Paff T, Haarman EG et al (2014) Exhaled breath analysis using electronic nose in cystic fibrosis and primary ciliary dyskinesia patients with chronic pulmonary infections. PLoS ONE 9:e115584","journal-title":"PLoS ONE"},{"key":"9987_CR65","doi-asserted-by":"crossref","first-page":"017117","DOI":"10.1088\/1752-7155\/7\/1\/017117","volume":"7","author":"D Kovacs","year":"2013","unstructured":"Kovacs D, Bikov A, Losonczy G et al (2013) Follow up of lung transplant recipients using an electronic nose. J Breath Res 7:017117","journal-title":"J Breath Res"},{"key":"9987_CR66","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1111\/j.1538-7836.2010.04064.x","volume":"8","author":"N Fens","year":"2010","unstructured":"Fens N, Douma RA, Sterk PJ et al (2010) Breathomics as a diagnostic tool for pulmonary embolism. J Thromb Haemost 8:2831\u20132833","journal-title":"J Thromb Haemost"},{"key":"9987_CR67","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1164\/rccm.201303-0467LE","volume":"188","author":"S Cohen-Kaminsky","year":"2013","unstructured":"Cohen-Kaminsky S, Nakhleh M, Perros F et al (2013) A proof of concept for the detection and classification of pulmonary arterial hypertension through breath analysis with a sensor array. Am J Respir Crit Care Med 188:756\u2013759","journal-title":"Am J Respir Crit Care Med"},{"key":"9987_CR68","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.rmed.2013.03.011","volume":"107","author":"S Dragonieri","year":"2013","unstructured":"Dragonieri S, Brinkman P, Mouw E et al (2013) An electronic nose discriminates exhaled breath of patients with untreated pulmonary sarcoidosis from controls. Respir Med 107:1073\u20131078","journal-title":"Respir Med"},{"key":"9987_CR69","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2466-14-72","volume":"14","author":"LD Bos","year":"2014","unstructured":"Bos LD, Schultz MJ, Sterk PJ (2014) Exhaled breath profiling for diagnosing acute respiratory distress syndrome. BMC Pulm Med 14:72","journal-title":"BMC Pulm Med"},{"key":"9987_CR70","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1378\/chest.14-0781","volume":"147","author":"MP Schee van der","year":"2015","unstructured":"van der Schee MP, Paff T, Brinkman P et al (2015) Breathomics in lung disease. Chest 147:224\u2013231","journal-title":"Chest"},{"key":"9987_CR71","doi-asserted-by":"crossref","first-page":"034001","DOI":"10.1088\/1752-7155\/9\/3\/034001","volume":"9","author":"A Bikov","year":"2015","unstructured":"Bikov A, L\u00e1z\u00e1r Z, Horvath I (2015) Established methodological issues in electronic nose research: how far are we from using these instruments in clinical settings of breath analysis? J Breath Res 9:034001","journal-title":"J Breath Res"},{"key":"9987_CR72","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1586\/14737159.2015.1043895","volume":"15","author":"S Scarlata","year":"2015","unstructured":"Scarlata S, Pennazza G, Santonico M et al (2015) Exhaled breath analysis by electronic nose in respiratory diseases. Expert Rev Mol Diagn 15:933\u2013956","journal-title":"Expert Rev Mol Diagn"},{"key":"9987_CR73","doi-asserted-by":"crossref","first-page":"016002","DOI":"10.1088\/1752-7155\/7\/1\/016002","volume":"7","author":"MP Schee van der","year":"2013","unstructured":"van der Schee MP, Fens N, Brinkman P et al (2013) Effect of transportation and storage using sorbent tubes of exhaled breath samples on diagnostic accuracy of electronic nose analysis. J Breath Res 7:016002","journal-title":"J Breath Res"},{"key":"9987_CR74","doi-asserted-by":"crossref","first-page":"e45396","DOI":"10.1371\/journal.pone.0045396","volume":"7","author":"RA Incalzi","year":"2012","unstructured":"Incalzi RA, Pennazza G, Scarlata S et al (2012) Reproducibility and respiratory function correlates of exhaled breath fingerprint in chronic obstructive pulmonary disease. PLoS ONE 7:e45396","journal-title":"PLoS ONE"},{"key":"9987_CR75","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.snb.2004.05.034","volume":"106","author":"A Nake","year":"2005","unstructured":"Nake A, Dubreuil B, Raynaud C, et al (2005). Outdoor in situ monitoring of volatile emissions from wastewater treatment plants with two portable technologies of electronic noses. Sens Actuators 106:36\u201339","journal-title":"Sens Actuators"},{"key":"9987_CR76","doi-asserted-by":"crossref","first-page":"026006","DOI":"10.1088\/1752-7155\/1\/2\/026006","volume":"1","author":"VV Meka","year":"2007","unstructured":"Meka VV, Lutz BJ, Melker RJ et al (2007) Prototype of a breath-based analysis system for medication compliance monitoring. J Breath Res 1:026006","journal-title":"J Breath Res"},{"key":"9987_CR77","doi-asserted-by":"crossref","first-page":"9127","DOI":"10.3390\/s101009127","volume":"10","author":"Z Lazar","year":"2010","unstructured":"Lazar Z, Fens N, van der Maten J et al (2010) Electronic nose breathprints are independent of acute changes in airway caliber in asthma. Sensors (Basel) 10:9127\u20139138","journal-title":"Sensors (Basel)"},{"key":"9987_CR78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/S1806-37562015000000195","volume":"42","author":"S Dragonieri","year":"2016","unstructured":"Dragonieri S, Quaranta VN, Carratu P et al (2016) Influence of age and gender on the profile of exhaled volatile organic compounds analyzed by an electronic nose. J Bras Pneumol 42:143\u2013145","journal-title":"J Bras Pneumol"},{"key":"9987_CR79","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1556\/APhysiol.98.2011.3.9","volume":"98","author":"A Bikov","year":"2011","unstructured":"Bikov A, Lazar Z, Schandl K et al (2011) Exercise changes volatiles in exhaled breath assessed by an electronic nose. Acta Physiol Hung 98:321\u2013328","journal-title":"Acta Physiol Hung"},{"key":"9987_CR80","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3109\/1354750X.2011.598562","volume":"16","author":"A Bikov","year":"2011","unstructured":"Bikov A, Pako J, Kovacs D et al (2011) Exhaled breath volatile alterations in pregnancy assessed with electronic nose. Biomarkers 16:476\u2013484","journal-title":"Biomarkers"},{"key":"9987_CR81","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.cca.2010.06.005","volume":"411","author":"S Kischkel","year":"2010","unstructured":"Kischkel S, Miekisch W, Sawacki A et al (2010) Breath biomarkers for lung cancer detection and assessment of smoking related effects-confounding variables, influence of normalization and statistical algorithms. Clin Chim Acta 411:1637\u20131644","journal-title":"Clin Chim Acta"},{"key":"9987_CR82","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1258\/000456303766476986","volume":"40","author":"PM Bossuyt","year":"2003","unstructured":"Bossuyt PM, Reitsma JB, Bruns DE et al (2003) Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Ann Clin Biochem 40:357\u2013363","journal-title":"Ann Clin Biochem"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-017-9987-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-017-9987-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-017-9987-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T11:23:23Z","timestamp":1498389803000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-017-9987-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,25]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["9987"],"URL":"https:\/\/doi.org\/10.1007\/s00408-017-9987-3","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,25]]}}}