{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:40:06Z","timestamp":1750034406220,"version":"3.41.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T00:00:00Z","timestamp":1488585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00408-017-9989-1","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T05:19:02Z","timestamp":1488604742000},"page":"323-332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome"],"prefix":"10.1007","volume":"195","author":[{"given":"Mir M. K.","family":"Abbas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Moorthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Puschett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,4]]},"reference":[{"issue":"16","key":"9989_CR1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1056\/NEJMoa050333","volume":"353","author":"GD Rubenfeld","year":"2005","unstructured":"Rubenfeld GD, Caldwell E, Peabody E et al (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353(16):1685\u20131693. doi: 10.1056\/NEJMoa050333","journal-title":"N Engl J Med"},{"issue":"4","key":"9989_CR2","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1165\/rcmb.F305","volume":"33","author":"MA Matthay","year":"2005","unstructured":"Matthay MA, Zimmerman GA (2005) Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 33(4):319\u2013327. doi: 10.1165\/rcmb.F305","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"9989_CR3","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1172\/JCI60331","volume":"122","author":"MA Matthay","year":"2012","unstructured":"Matthay MA, Ware LB, Zimmerman GA (2012) The acute respiratory distress syndrome. J Clin Invest 122(8):2731\u20132740. doi: 10.1172\/JCI60331","journal-title":"J Clin Invest"},{"key":"9989_CR4","doi-asserted-by":"publisher","first-page":"3501373","DOI":"10.1155\/2016\/3501373","volume":"2016","author":"R Blondonnet","year":"2016","unstructured":"Blondonnet R, Constantin JM, Sapin V et al (2016) A pathophysiologic approach to biomarkers in acute respiratory distress syndrome. Dis Markers 2016:3501373. doi: 10.1155\/2016\/3501373","journal-title":"Dis Markers"},{"key":"9989_CR5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.6.8520742","author":"RL Doyle","year":"1995","unstructured":"Doyle RL, Szaflarski N, Modin GW et al (1995) Identification of patients with acute lung injury. Predictors of mortality. Am J Respir Crit Care Med. doi: 10.1164\/ajrccm.152.6.8520742","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"9989_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1164\/ajrccm\/146.2.419","volume":"146","author":"PJ Sloane","year":"1992","unstructured":"Sloane PJ, Gee MH, Gottlieb JE et al (1992) A multicenter registry of patients with acute respiratory distress syndrome: physiology and outcome. Am Rev Respir Dis 146(2):419\u2013426. doi: 10.1164\/ajrccm\/146.2.419","journal-title":"Am Rev Respir Dis"},{"issue":"2","key":"9989_CR7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1378\/chest.97.2.447","volume":"97","author":"JE Heffner","year":"1990","unstructured":"Heffner JE, Zamora CA (1990) Clinical predictors of prolonged translaryngeal intubation in patients with the adult respiratory distress syndrome. Chest 97(2):447\u2013452","journal-title":"Chest"},{"issue":"5 Pt 1","key":"9989_CR8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-98-5-593","volume":"98","author":"AA Fowler","year":"1983","unstructured":"Fowler AA, Hamman RF, Good JT et al (1983) Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med 98(5 Pt 1):593\u2013597","journal-title":"Ann Intern Med"},{"key":"9989_CR9","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842182","author":"LD Hudson","year":"1995","unstructured":"Hudson LD, Milberg JA, Anardi D et al. (1995) Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med. doi: 10.1164\/ajrccm.151.2.7842182","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"9989_CR10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0002-9610(82)90612-2","volume":"144","author":"PE Pepe","year":"1982","unstructured":"Pepe PE, Potkin RT, Reus DH et al (1982) Clinical predictors of the adult respiratory distress syndrome. Am J Surg 144(1):124\u2013130","journal-title":"Am J Surg"},{"issue":"10","key":"9989_CR11","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1097\/01.CCM.0000280434.33451.87","volume":"35","author":"CS Calfee","year":"2007","unstructured":"Calfee CS, Eisner MD, Ware LB et al (2007) Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med 35(10):2243\u20132250","journal-title":"Crit Care Med"},{"issue":"4","key":"9989_CR12","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1183\/09031936.02.00401702","volume":"20","author":"P Pelosi","year":"2002","unstructured":"Pelosi P, Brazzi L, Gattinoni L (2002) Prone position in acute respiratory distress syndrome. Eur Respir J 20(4):1017\u20131028","journal-title":"Eur Respir J"},{"issue":"6","key":"9989_CR13","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1001\/jama.299.6.637","volume":"299","author":"MO Meade","year":"2008","unstructured":"Meade MO, Cook DJ, Guyatt GH et al (2008) Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299(6):637\u2013645. doi: 10.1001\/jama.299.6.637","journal-title":"JAMA"},{"issue":"4","key":"9989_CR14","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1055\/s-0033-1351118","volume":"34","author":"E Ortiz-Diaz","year":"2013","unstructured":"Ortiz-Diaz E, Festic E, Gajic O et al (2013) Emerging pharmacological therapies for prevention and early treatment of acute lung injury. Semin Respir Crit Care Med 34(4):448\u2013458. doi: 10.1055\/s-0033-1351118","journal-title":"Semin Respir Crit Care Med"},{"issue":"12 Pt 2","key":"9989_CR15","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1097\/00004872-199816121-00015","volume":"16","author":"AY Bagrov","year":"1998","unstructured":"Bagrov AY, Fedorova OV (1998) Effects of two putative endogenous digitalis-like factors, marinobufagenin and ouabain, on the Na+, K+-pump in human mesenteric arteries. J Hypertens 16(12 Pt 2):1953\u20131958","journal-title":"J Hypertens"},{"issue":"2 Pt 2","key":"9989_CR16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/01.HYP.37.2.462","volume":"37","author":"OV Fedorova","year":"2001","unstructured":"Fedorova OV, Kolodkin NI, Agalakova NI et al (2001) Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats. Hypertension 37(2 Pt 2):462\u2013466","journal-title":"Hypertension"},{"issue":"1 Suppl","key":"9989_CR17","doi-asserted-by":"crossref","first-page":"I106","DOI":"10.1161\/01.HYP.23.1_Suppl.I106","volume":"23","author":"MB Pamnani","year":"1994","unstructured":"Pamnani MB, Chen S, Yuan CM et al. (1994) Chronic blood pressure effects of bufalin, a sodium-potassium ATPase inhibitor, in rats. Hypertension 23 (1 Suppl):I106\u2013109**","journal-title":"Hypertension"},{"issue":"10","key":"9989_CR18","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1046\/j.1432-1033.2002.02911.x","volume":"269","author":"W Schoner","year":"2002","unstructured":"Schoner W (2002) Endogenous cardiac glycosides, a new class of steroid hormones. Eur J Biochem 269(10):2440\u20132448","journal-title":"Eur J Biochem"},{"issue":"6","key":"9989_CR19","doi-asserted-by":"publisher","first-page":"R1726","DOI":"10.1152\/ajpregu.90963.2008","volume":"296","author":"MN Uddin","year":"2009","unstructured":"Uddin MN, Horvat D, Childs EW et al (2009) Marinobufagenin causes endothelial cell monolayer hyperpermeability by altering apoptotic signaling. Am J Physiol Regul Integr Comp Physiol 296(6):R1726\u2013R1734. doi: 10.1152\/ajpregu.90963.2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"12","key":"9989_CR20","doi-asserted-by":"publisher","first-page":"R918","DOI":"10.1152\/ajpregu.00499.2013","volume":"306","author":"NH Ing","year":"2014","unstructured":"Ing NH, Berghman L, Abi-Ghanem D et al (2014) Marinobufagenin regulates permeability and gene expression of brain endothelial cells. Am J Physiol Regul Integr Comp Physiol 306(12):R918\u2013R924. doi: 10.1152\/ajpregu.00499.2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5","key":"9989_CR21","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1159\/000088461","volume":"25","author":"HV Vu","year":"2005","unstructured":"Vu HV, Ianosi-Irimie MR, Pridjian CA et al (2005) Involvement of marinobufagenin in a rat model of human preeclampsia. Am J Nephrol 25(5):520\u2013528. doi: 10.1159\/000088461","journal-title":"Am J Nephrol"},{"issue":"2","key":"9989_CR22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00003246-199902000-00036","volume":"27","author":"J Pugin","year":"1999","unstructured":"Pugin J, Verghese G, Widmer MC et al (1999) The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 27(2):304\u2013312","journal-title":"Crit Care Med"},{"issue":"18","key":"9989_CR23","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","volume":"342","author":"LB Ware","year":"2000","unstructured":"Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342(18):1334\u20131349. doi: 10.1056\/NEJM200005043421806","journal-title":"N Engl J Med"},{"issue":"7","key":"9989_CR24","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1164\/rccm.200208-966WS","volume":"167","author":"MA Matthay","year":"2003","unstructured":"Matthay MA, Zimmerman GA, Esmon C et al (2003) Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 167(7):1027\u20131035. doi: 10.1164\/rccm.200208-966WS","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"9989_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/10641950802629709","volume":"29","author":"D Horvat","year":"2010","unstructured":"Horvat D, Severson J, Uddin MN et al (2010) Resibufogenin prevents the manifestations of preeclampsia in an animal model of the syndrome. Hypertens Pregnancy 29(1):1\u20139. doi: 10.3109\/10641950802629709","journal-title":"Hypertens Pregnancy"},{"issue":"10","key":"9989_CR26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1055\/s-0032-1316447","volume":"29","author":"JB Puschett","year":"2012","unstructured":"Puschett JB (2012) Marinobufagenin predicts and resibufogenin prevents preeclampsia: a review of the evidence. Am J Perinatol 29(10):777\u2013785. doi: 10.1055\/s-0032-1316447","journal-title":"Am J Perinatol"},{"issue":"1","key":"9989_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1165\/rcmb.2006-0080SF","volume":"35","author":"HG Folkesson","year":"2006","unstructured":"Folkesson HG, Matthay MA (2006) Alveolar epithelial ion and fluid transport: recent progress. Am J Respir Cell Mol Biol 35(1):10\u201319. doi: 10.1165\/rcmb.2006-0080SF","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"13","key":"9989_CR28","doi-asserted-by":"publisher","first-page":"4964","DOI":"10.1073\/pnas.0600855103","volume":"103","author":"MD Johnson","year":"2006","unstructured":"Johnson MD, Bao HF, Helms MN et al (2006) Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport. Proc Natl Acad Sci U S A 103(13):4964\u20134969. doi: 10.1073\/pnas.0600855103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"9989_CR29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1085\/jgp.119.2.199","volume":"119","author":"X Fang","year":"2002","unstructured":"Fang X, Fukuda N, Barbry P et al (2002) Novel role for CFTR in fluid absorption from the distal airspaces of the lung. J Gen Physiol 119(2):199\u2013207","journal-title":"J Gen Physiol"},{"issue":"23","key":"9989_CR30","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1001\/jama.2012.5669","volume":"307","author":"ADT Force","year":"2012","unstructured":"Force ADT, Ranieri VM, Rubenfeld GD et al (2012) Acute respiratory distress syndrome: the Berlin definition. JAMA 307(23):2526\u20132533. doi: 10.1001\/jama.2012.5669","journal-title":"JAMA"},{"issue":"1","key":"9989_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/15321819.2010.538107","volume":"32","author":"D Abi-Ghanem","year":"2011","unstructured":"Abi-Ghanem D, Lai X, Berghman LR et al (2011) A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. J Immunoass Immunochem 32(1):31\u201346. doi: 10.1080\/15321819.2010.538107","journal-title":"J Immunoass Immunochem"},{"issue":"2","key":"9989_CR32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0022-3565(24)35325-X","volume":"292","author":"B Moorthy","year":"2000","unstructured":"Moorthy B, Parker KM, Smith CV et al (2000) Potentiation of oxygen-induced lung injury in rats by the mechanism-based cytochrome P-450 inhibitor, 1-aminobenzotriazole. J Pharmacol Exp Ther 292(2):553\u2013560","journal-title":"J Pharmacol Exp Ther"},{"issue":"18","key":"9989_CR33","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","volume":"342","author":"The Acute Respiratory Distress Syndrome Network","year":"2000","unstructured":"The Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342(18):1301\u20131308. doi: 10.1056\/NEJM200005043421801","journal-title":"N Engl J Med"},{"issue":"2","key":"9989_CR34","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1164\/ajrccm.157.2.97-04023","volume":"157","author":"P Pelosi","year":"1998","unstructured":"Pelosi P, Tubiolo D, Mascheroni D et al (1998) Effects of the prone position on respiratory mechanics and gas exchange during acute lung injury. Am J Respir Crit Care Med 157(2):387\u2013393. doi: 10.1164\/ajrccm.157.2.97-04023","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"9989_CR35","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1097\/00003246-199709000-00022","volume":"25","author":"M Mure","year":"1997","unstructured":"Mure M, Martling CR, Lindahl SG (1997) Dramatic effect on oxygenation in patients with severe acute lung insufficiency treated in the prone position. Crit Care Med 25(9):1539\u20131544","journal-title":"Crit Care Med"},{"issue":"10","key":"9989_CR36","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s001340050453","volume":"23","author":"L Blanch","year":"1997","unstructured":"Blanch L, Mancebo J, Perez M et al (1997) Short-term effects of prone position in critically ill patients with acute respiratory distress syndrome. Intensive Care Med 23(10):1033\u20131039","journal-title":"Intensive Care Med"},{"issue":"6","key":"9989_CR37","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1001\/jama.299.6.646","volume":"299","author":"A Mercat","year":"2008","unstructured":"Mercat A, Richard JC, Vielle B et al (2008) Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 299(6):646\u2013655. doi: 10.1001\/jama.299.6.646","journal-title":"JAMA"},{"issue":"9","key":"9989_CR38","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1001\/jama.2010.218","volume":"303","author":"M Briel","year":"2010","unstructured":"Briel M, Meade M, Mercat A et al (2010) Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA 303(9):865\u2013873. doi: 10.1001\/jama.2010.218","journal-title":"JAMA"},{"issue":"9","key":"9989_CR39","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1215554","volume":"368","author":"ND Ferguson","year":"2013","unstructured":"Ferguson ND, Cook DJ, Guyatt GH et al (2013) High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med 368(9):795\u2013805. doi: 10.1056\/NEJMoa1215554","journal-title":"N Engl J Med"},{"issue":"9","key":"9989_CR40","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1056\/NEJMoa1215716","volume":"368","author":"D Young","year":"2013","unstructured":"Young D, Lamb SE, Shah S et al (2013) High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med 368(9):806\u2013813. doi: 10.1056\/NEJMoa1215716","journal-title":"N Engl J Med"},{"issue":"20","key":"9989_CR41","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1001\/jama.1979.03300200023016","volume":"242","author":"WM Zapol","year":"1979","unstructured":"Zapol WM, Snider MT, Hill JD et al (1979) Extracorporeal membrane oxygenation in severe acute respiratory failure: a randomized prospective study. JAMA 242(20):2193\u20132196","journal-title":"JAMA"},{"issue":"2","key":"9989_CR42","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00000542-199708000-00017","volume":"87","author":"C Manktelow","year":"1997","unstructured":"Manktelow C, Bigatello LM, Hess D et al (1997) Physiologic determinants of the response to inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 87(2):297\u2013307","journal-title":"Anesthesiology"},{"issue":"11","key":"9989_CR43","first-page":"1441","volume":"53","author":"MO Meade","year":"2008","unstructured":"Meade MO, Cook DJ, Griffith LE et al (2008) A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome. Respir Care 53(11):1441\u20131449","journal-title":"Respir Care"},{"issue":"3","key":"9989_CR44","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11626-997-0141-z","volume":"33","author":"GS Filippatos","year":"1997","unstructured":"Filippatos GS, Hughes WF, Qiao R et al (1997) Mechanisms of liquid flux across pulmonary alveolar epithelial cell monolayers. In Vitro Cell Dev Biol Anim 33(3):195\u2013200. doi: 10.1007\/s11626-997-0141-z","journal-title":"In Vitro Cell Dev Biol Anim"},{"issue":"1","key":"9989_CR45","doi-asserted-by":"crossref","first-page":"C78","DOI":"10.1152\/ajpcell.1983.245.1.C78","volume":"245","author":"BE Goodman","year":"1983","unstructured":"Goodman BE, Fleischer RS, Crandall ED (1983) Evidence for active Na+ transport by cultured monolayers of pulmonary alveolar epithelial cells. Am J Physiol 245(1):C78\u2013C83","journal-title":"Am J Physiol"},{"issue":"19","key":"9989_CR46","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.79.19.6033","volume":"79","author":"RJ Mason","year":"1982","unstructured":"Mason RJ, Williams MC, Widdicombe JH et al (1982) Transepithelial transport by pulmonary alveolar type II cells in primary culture. Proc Natl Acad Sci U S A 79(19):6033\u20136037","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1 Pt 1","key":"9989_CR47","first-page":"L1","volume":"271","author":"S Matalon","year":"1996","unstructured":"Matalon S, Benos DJ, Jackson RM (1996) Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells. Am J Physiol 271(1 Pt 1):L1\u2013L22","journal-title":"Am J Physiol"},{"issue":"4 Pt 1","key":"9989_CR48","first-page":"L487","volume":"270","author":"MA Matthay","year":"1996","unstructured":"Matthay MA, Folkesson HG, Verkman AS (1996) Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol 270(4 Pt 1):L487\u2013L503","journal-title":"Am J Physiol"},{"issue":"4","key":"9989_CR49","doi-asserted-by":"publisher","first-page":"L599","DOI":"10.1152\/ajplung.00130.2000","volume":"282","author":"Z Borok","year":"2002","unstructured":"Borok Z, Liebler JM, Lubman RL et al (2002) Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 282(4):L599\u2013L608. doi: 10.1152\/ajplung.00130.2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"9989_CR50","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1073\/pnas.042689399","volume":"99","author":"MD Johnson","year":"2002","unstructured":"Johnson MD, Widdicombe JH, Allen L et al (2002) Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis. Proc Natl Acad Sci U S A 99(4):1966\u20131971. doi: 10.1073\/pnas.042689399","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1 Pt 1","key":"9989_CR51","first-page":"L246","volume":"273","author":"KM Ridge","year":"1997","unstructured":"Ridge KM, Rutschman DH, Factor P et al (1997) Differential expression of Na-K-ATPase isoforms in rat alveolar epithelial cells. Am J Physiol 273(1 Pt 1):L246\u2013L255","journal-title":"Am J Physiol"},{"issue":"1","key":"9989_CR52","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000108756","volume":"28","author":"S Danchuk","year":"2008","unstructured":"Danchuk S, Sukhanov S, Horvat D et al (2008) Effects of resibufogenin in experimental hypertension. Am J Nephrol 28(1):8\u201313. doi: 10.1159\/000108756","journal-title":"Am J Nephrol"},{"issue":"12","key":"9989_CR53","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1097\/HJH.0b013e328312c86a","volume":"26","author":"OV Fedorova","year":"2008","unstructured":"Fedorova OV, Simbirtsev AS, Kolodkin NI et al (2008) Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na\/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. J Hypertens 26(12):2414\u20132425. doi: 10.1097\/HJH.0b013e328312c86a","journal-title":"J Hypertens"},{"issue":"6","key":"9989_CR54","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1097\/00004872-200206000-00032","volume":"20","author":"AI Fridman","year":"2002","unstructured":"Fridman AI, Matveev SA, Agalakova NI et al (2002) Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. J Hypertens 20(6):1189\u20131194","journal-title":"J Hypertens"},{"issue":"5","key":"9989_CR55","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/01.HYP.31.5.1097","volume":"31","author":"AY Bagrov","year":"1998","unstructured":"Bagrov AY, Fedorova OV, Dmitrieva RI et al (1998) Characterization of a urinary bufodienolide Na+, K+-ATPase inhibitor in patients after acute myocardial infarction. Hypertension 31(5):1097\u20131103","journal-title":"Hypertension"},{"issue":"6","key":"9989_CR56","doi-asserted-by":"publisher","first-page":"e1552","DOI":"10.1542\/peds.2011-3093","volume":"129","author":"EF Davis","year":"2012","unstructured":"Davis EF, Lazdam M, Lewandowski AJ et al (2012) Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review. Pediatrics 129(6):e1552\u2013e1561. doi: 10.1542\/peds.2011-3093","journal-title":"Pediatrics"},{"issue":"5","key":"9989_CR57","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1161\/HYPERTENSIONAHA.110.155564","volume":"56","author":"J Tian","year":"2010","unstructured":"Tian J, Haller S, Periyasamy S et al (2010) Renal ischemia regulates marinobufagenin release in humans. Hypertension 56(5):914\u2013919. doi: 10.1161\/HYPERTENSIONAHA.110.155564","journal-title":"Hypertension"},{"issue":"1","key":"9989_CR58","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000193220","volume":"30","author":"MN Uddin","year":"2009","unstructured":"Uddin MN, McLean LB, Hunter FA et al (2009) Vascular leak in a rat model of preeclampsia. Am J Nephrol 30(1):26\u201333. doi: 10.1159\/000193220","journal-title":"Am J Nephrol"},{"issue":"6","key":"9989_CR59","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1042\/cs0770599","volume":"77","author":"MA Brown","year":"1989","unstructured":"Brown MA, Zammit VC, Lowe SA (1989) Capillary permeability and extracellular fluid volumes in pregnancy-induced hypertension. Clin Sci 77(6):599\u2013604","journal-title":"Clin Sci"},{"issue":"9\u201310","key":"9989_CR60","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.placenta.2005.12.004","volume":"27","author":"HL LaMarca","year":"2006","unstructured":"LaMarca HL, Morris CA, Pettit GR et al (2006) Marinobufagenin impairs first trimester cytotrophoblast differentiation. Placenta 27(9\u201310):984\u2013988. doi: 10.1016\/j.placenta.2005.12.004","journal-title":"Placenta"},{"issue":"5","key":"9989_CR61","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1161\/01.HYP.26.5.781","volume":"26","author":"AY Bagrov","year":"1995","unstructured":"Bagrov AY, Fedorova OV, Austin-Lane JL et al (1995) Endogenous marinobufagenin-like immunoreactive factor and Na+, K + ATPase inhibition during voluntary hypoventilation. Hypertension 26(5):781\u2013788","journal-title":"Hypertension"},{"issue":"2","key":"9989_CR62","doi-asserted-by":"publisher","first-page":"C509","DOI":"10.1152\/ajpcell.00098.2007","volume":"293","author":"W Schoner","year":"2007","unstructured":"Schoner W, Scheiner-Bobis G (2007) Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. Am J Physiol Cell Physiol 293(2):C509\u2013C536. doi: 10.1152\/ajpcell.00098.2007","journal-title":"Am J Physiol Cell Physiol"},{"issue":"7","key":"9989_CR63","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s00134-007-0661-8","volume":"33","author":"I Vadasz","year":"2007","unstructured":"Vadasz I, Raviv S, Sznajder JI (2007) Alveolar epithelium and Na, K-ATPase in acute lung injury. Intensive Care Med 33(7):1243\u20131251. doi: 10.1007\/s00134-007-0661-8","journal-title":"Intensive Care Med"},{"issue":"5","key":"9989_CR64","doi-asserted-by":"publisher","first-page":"L685","DOI":"10.1152\/ajplung.00247.2005","volume":"289","author":"GM Mutlu","year":"2005","unstructured":"Mutlu GM, Sznajder JI (2005) Mechanisms of pulmonary edema clearance. Am J Physiol Lung Cell Mol Physiol 289(5):L685\u2013L695. doi: 10.1152\/ajplung.00247.2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5\u20136","key":"9989_CR65","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10863-007-9102-1","volume":"39","author":"E Lecuona","year":"2007","unstructured":"Lecuona E, Trejo HE, Sznajder JI (2007) Regulation of Na, K-ATPase during acute lung injury. J Bioenerg Biomembr 39(5\u20136):391\u2013395. doi: 10.1007\/s10863-007-9102-1","journal-title":"J Bioenerg Biomembr"},{"issue":"1","key":"9989_CR66","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0272-5231(21)00143-X","volume":"3","author":"M Bachofen","year":"1982","unstructured":"Bachofen M, Weibel ER (1982) Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med 3(1):35\u201356","journal-title":"Clin Chest Med"},{"issue":"4","key":"9989_CR67","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1164\/arrd.1977.116.4.589","volume":"116","author":"M Bachofen","year":"1977","unstructured":"Bachofen M, Weibel ER (1977) Alterations of the gas exchange apparatus in adult respiratory insufficiency associated with septicemia. Am Rev Respir Dis 116(4):589\u2013615. doi: 10.1164\/arrd.1977.116.4.589","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"9989_CR68","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nm0397-320","volume":"3","author":"SC Donnelly","year":"1997","unstructured":"Donnelly SC, Haslett C, Reid PT et al (1997) Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat Med 3(3):320\u2013323","journal-title":"Nat Med"},{"issue":"1","key":"9989_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15287399309531772","volume":"40","author":"HV Dedhia","year":"1993","unstructured":"Dedhia HV, Ma JY, Vallyathan V et al (1993) Exposure of rats to hyperoxia: alteration of lavagate parameters and macrophage function. J Toxicol Environ Health 40(1):1\u201313. doi: 10.1080\/15287399309531772","journal-title":"J Toxicol Environ Health"},{"issue":"4","key":"9989_CR70","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s001340050571","volume":"24","author":"G Nakos","year":"1998","unstructured":"Nakos G, Kitsiouli EI, Tsangaris I et al (1998) Bronchoalveolar lavage fluid characteristics of early intermediate and late phases of ARDS. Alterations in leukocytes, proteins, PAF and surfactant components. Intensive Care Med 24(4):296\u2013303","journal-title":"Intensive Care Med"},{"key":"9989_CR71","doi-asserted-by":"crossref","first-page":"17946","DOI":"10.1074\/jbc.M800958200","volume":"283","author":"MN Uddin","year":"2008","unstructured":"Uddin MN, Horvat D, Glaser SS, Mitchell BM, Puschett JB (2008) Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblasts function. J Biol Chem 283:17946\u201317953","journal-title":"J Biol Chem"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-017-9989-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-017-9989-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-017-9989-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:16:59Z","timestamp":1750033019000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-017-9989-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,4]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["9989"],"URL":"https:\/\/doi.org\/10.1007\/s00408-017-9989-1","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"type":"print","value":"0341-2040"},{"type":"electronic","value":"1432-1750"}],"subject":[],"published":{"date-parts":[[2017,3,4]]}}}