{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:06:47Z","timestamp":1782832007287,"version":"3.54.5"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T00:00:00Z","timestamp":1527292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00408-018-0124-8","type":"journal-article","created":{"date-parts":[[2018,5,26]],"date-time":"2018-05-26T08:17:41Z","timestamp":1527322661000},"page":"447-454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SERPINA1 Hepatocyte-Specific Promoter Polymorphism Associate with Chronic Obstructive Pulmonary Disease in a Study of Kashmiri Ancestry Individuals"],"prefix":"10.1007","volume":"196","author":[{"given":"Arif","family":"Bashir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younis M.","family":"Hazari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samirul","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Hilal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Banday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Khurshid","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq Rashid","family":"Jan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Suraiya","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed Nazir","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Majid","family":"Fazili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,26]]},"reference":[{"issue":"6","key":"124_CR1","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1183\/09031936.04.00014304","volume":"23","author":"BR Celli","year":"2004","unstructured":"Celli BR, MacNee W (2004) Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS\/ERS position paper. Eur Respir J 23(6):932\u2013946","journal-title":"Eur Respir J"},{"issue":"5","key":"124_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3109\/15412555.2012.696159","volume":"9","author":"J Thornton Snider","year":"2012","unstructured":"Thornton Snider J, Romley JA, Wong KS, Zhang J, Eber M, Goldman DP (2012) The disability burden of COPD. Copd 9(5):513\u2013521. \n                    https:\/\/doi.org\/10.3109\/15412555.2012.696159","journal-title":"Copd"},{"issue":"2","key":"124_CR3","first-page":"1","volume":"59","author":"AM Minino","year":"2010","unstructured":"Minino AM, Xu J, Kochanek KD (2010) Deaths: preliminary data for 2008. Natl Vital Stat Rep 59(2):1\u201352","journal-title":"Natl Vital Stat Rep"},{"issue":"5","key":"124_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1136\/thoraxjnl-2013-204460","volume":"69","author":"P Burney","year":"2014","unstructured":"Burney P, Jithoo A, Kato B, Janson C, Mannino D, Nizankowska-Mogilnicka E et al. (2014) Chronic obstructive pulmonary disease mortality and prevalence: the associations with smoking and poverty\u2013a BOLD analysis. Thorax 69(5):465\u2013473. \n                    https:\/\/doi.org\/10.1136\/thoraxjnl-2013-204460","journal-title":"Thorax"},{"issue":"11","key":"124_CR5","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1172\/JCI0216782","volume":"110","author":"DA Lomas","year":"2002","unstructured":"Lomas DA, Mahadeva R (2002) Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy. J Clin Invest 110(11):1585\u20131590","journal-title":"J Clin Invest"},{"issue":"6","key":"124_CR6","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.rmed.2010.01.016","volume":"104","author":"E Kelly","year":"2010","unstructured":"Kelly E, Greene CM, Carroll TP, McElvaney NG, O\u2019Neill SJ (2010) Alpha-1 antitrypsin deficiency. Respir Med 104(6):763\u2013772. \n                    https:\/\/doi.org\/10.1016\/j.rmed.2010.01.016","journal-title":"Respir Med"},{"key":"124_CR7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.rmed.2016.06.005","volume":"117","author":"A Bashir","year":"2016","unstructured":"Bashir A, Shah NN, Hazari YM, Habib M, Bashir S, Hilal N et al. (2016) Novel variants of SERPIN1A gene: interplay between alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease. Respir Med 117:139\u2013149. \n                    https:\/\/doi.org\/10.1016\/j.rmed.2016.06.005","journal-title":"Respir Med"},{"issue":"5","key":"124_CR8","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/JCI114578","volume":"85","author":"RG Crystal","year":"1990","unstructured":"Crystal RG (1990) Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy. J Clin Invest 85(5):1343\u20131352","journal-title":"J Clin Invest"},{"key":"124_CR9","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mrrev.2017.03.001","volume":"773","author":"YM Hazari","year":"2017","unstructured":"Hazari YM, Bashir A, Habib M, Bashir S, Habib H, Qasim MA et al. (2017) Alpha-1-antitrypsin deficiency: Genetic variations, clinical manifestations and therapeutic interventions. Mutat Res2017 Jul;773:14\u201325. \n                    https:\/\/doi.org\/10.1016\/j.mrrev.2017.03.001","journal-title":"Mutat Res2017 Jul"},{"issue":"9478","key":"124_CR10","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1016\/S0140-6736(05)66781-5","volume":"365","author":"JK Stoller","year":"2005","unstructured":"Stoller JK, Aboussouan LS (2005) Alpha1-antitrypsin deficiency. Lancet 365(9478):2225\u20132236","journal-title":"Lancet"},{"key":"124_CR11","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.lfs.2016.01.002","volume":"146","author":"Y Hazari","year":"2016","unstructured":"Hazari Y, Habib M, Bashir S, Bashir A, Hilal N, Irfan S et al. (2016) Natural osmolytes alleviate GRP78 and ATF-4 levels: corroboration for potential modulators of unfolded protein response. Life Sci 146:148\u201353","journal-title":"Life Sci"},{"issue":"5","key":"124_CR12","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.clinbiochem.2005.01.016","volume":"38","author":"J Gupta","year":"2005","unstructured":"Gupta J, Bhadoria DP, Lal MK, Kukreti R, Chattopadhaya D, Gupta VK et al (2005) Association of the PIM3 allele of the alpha-1-antitrypsin gene with chronic obstructive pulmonary disease. Clin Biochem 38(5):489\u2013491","journal-title":"Clin Biochem"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-018-0124-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-018-0124-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-018-0124-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T23:34:15Z","timestamp":1558827255000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-018-0124-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,26]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["124"],"URL":"https:\/\/doi.org\/10.1007\/s00408-018-0124-8","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,26]]},"assertion":[{"value":"13 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declared that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study is approved by the Ethics Committee of the Government Medical College Srinagar-India.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}