{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:33:42Z","timestamp":1757777622709,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U01 NS083457"],"award-info":[{"award-number":["U01 NS083457"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 NS083457-S1"],"award-info":[{"award-number":["U01 NS083457-S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00408-019-00227-2","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T09:02:37Z","timestamp":1555664557000},"page":"349-352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adherence to Long-Term Follow-Up of Patients with Life-Threatening, Inhaled Synthetic Cannabinoids-Associated Coagulopathy in Chicago"],"prefix":"10.1007","volume":"197","author":[{"given":"Mateo","family":"Tole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"LaBedz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas L.","family":"Feinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,19]]},"reference":[{"key":"227_CR1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.15585\/mmwr.mm6721a4","volume":"67","author":"E Moritz","year":"2018","unstructured":"Moritz E, Austin C, Wahl M et al (2018) Notes from the field: outbreak of severe illness linked to the vitamin K antagonist brodifacoum and use of synthetic cannabinoids\u2014Illinois. MMWR Morb Mortal Wkly Rep 67:607\u2013608","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"227_CR2","first-page":"923","volume":"56","author":"J Devguna","year":"2018","unstructured":"Devguna J, Rasina A, Kima T et al (2018) Outbreak of coagulopathy associated with synthetic cannabinoid use (abstract). Clin Toxicol (Phila) 56:923\u2013924","journal-title":"Clin Toxicol (Phila)"},{"key":"227_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/nyas.13085","volume":"1374","author":"DL Feinstein","year":"2016","unstructured":"Feinstein DL, Akpa BS, Ayee MA et al (2016) The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures. Ann N Y Acad Sci 1374:111\u20131122","journal-title":"Ann N Y Acad Sci"},{"key":"227_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15563650600795487","volume":"45","author":"EM Caravati","year":"2007","unstructured":"Caravati EM, Erdman AR, Scharman EJ et al (2007) Long-acting anticoagulant rodenticide poisoning: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 45:1\u201322","journal-title":"Clin Toxicol (Phila)"},{"key":"227_CR5","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1001\/jama.1984.03350210052030","volume":"252","author":"RA Lipton","year":"1984","unstructured":"Lipton RA, Klass EM (1984) Human ingestion of a \u2018superwarfarin\u2019 rodenticide resulting in a prolonged anticoagulant effect. JAMA 252:3004\u20133005","journal-title":"JAMA"},{"key":"227_CR6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.psym.2018.05.010","volume":"60","author":"W Micula-Gondek","year":"2019","unstructured":"Micula-Gondek W, Ruales V, Zorn C, Angelino A (2019) Synthetic cannabinoid-associated coagulopathy: case report. Psychosomatics 60:211\u2013215. \n                    https:\/\/doi.org\/10.1016\/j.psym.2018.05.010","journal-title":"Psychosomatics"},{"key":"227_CR7","doi-asserted-by":"publisher","first-page":"1922.e3","DOI":"10.1016\/j.ajem.2018.06.040","volume":"36","author":"RJ Doyle","year":"2018","unstructured":"Doyle RJ, Elfessi Z, Kolman K (2018) Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides. Am J Emerg Med 36:1922.e3\u20131922.e4","journal-title":"Am J Emerg Med"},{"key":"227_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/24734306.2018.1500152","volume":"2","author":"I Rubinstein","year":"2018","unstructured":"Rubinstein I, Weinberg W, van Breemen R et al (2018) Treatment for long acting anticoagulant rodenticide poisoning\u2014beyond INR monitoring? Toxicol Commun 2:59\u201361","journal-title":"Toxicol Commun"},{"unstructured":"http:\/\/www.dph.illinois.gov\/topics-services\/prevention-wellness\/medical-cannabis\/synthetic-cannabinoids\n                    \n                  . Accessed 15 Dec 2018","key":"227_CR9"},{"key":"227_CR10","first-page":"3","volume":"18","author":"L Wen","year":"2018","unstructured":"Wen L, Chen J, Duan L et al (2018) Vitamin K-dependent proteins involved in bone and cardiovascular health (Review). Mol Med Rep 18:3\u201315","journal-title":"Mol Med Rep"},{"key":"227_CR11","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.2147\/NDT.S142375","volume":"13","author":"M Wang","year":"2017","unstructured":"Wang M, Yang Y, Hou Y et al (2017) Effects of bromadiolone poisoning on the central nervous system. Neuropsychiatr Dis Treat 13:2297\u20132300","journal-title":"Neuropsychiatr Dis Treat"},{"key":"227_CR12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1093\/toxsci\/kfx134","volume":"159","author":"S Kalinin","year":"2017","unstructured":"Kalinin S, Marangoni N, Kowal K et al (2017) The long-lasting rodenticide brodifacoum induces neuropathology in adult male rats. Toxicol Sci 159:224\u2013237","journal-title":"Toxicol Sci"},{"issue":"Pt 2","key":"227_CR13","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/S0029-7844(97)00408-0","volume":"90","author":"JM Zurawski","year":"1997","unstructured":"Zurawski JM, Kelly EA (1997) Pregnancy outcome after maternal poisoning with brodifacoum, a long-acting warfarin-like rodenticide. Obstet Gynecol 90(Pt 2):672\u2013674","journal-title":"Obstet Gynecol"},{"issue":"45","key":"227_CR14","doi-asserted-by":"publisher","first-page":"e8506","DOI":"10.1097\/MD.0000000000008506","volume":"96","author":"M Ma","year":"2017","unstructured":"Ma M, Zhang M, Tang X et al (2017) Massive neonatal intracranial hemorrhage caused by bromadiolone. A case report. Medicine 96(45):e8506","journal-title":"Medicine"},{"key":"227_CR15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ijgo.2013.03.008","volume":"122","author":"J Yan","year":"2013","unstructured":"Yan J, Shi Y, Sun C et al (2013) Vitamin K treatment of brodifacoum poisoning in a pregnant woman. Int J Gynaecol Obstet 122:162\u2013163","journal-title":"Int J Gynaecol Obstet"},{"key":"227_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00404-010-1369-5","volume":"282","author":"S Mehndiratta","year":"2010","unstructured":"Mehndiratta S, Suneja A, Gupta B et al (2010) Fetotoxicity of warfarin anticoagulation. Arch Gynecol Obstet 282:335\u2013337","journal-title":"Arch Gynecol Obstet"},{"issue":"75","key":"227_CR17","first-page":"334","volume":"1990","author":"NJ Kazzi","year":"1990","unstructured":"Kazzi NJ, Ilagan NB, Liang K-C et al (1990) Placental transfer of vitamin K1 in preterm pregnancy. Obstet Gynecol 1990(75):334\u2013337","journal-title":"Obstet Gynecol"},{"key":"227_CR18","doi-asserted-by":"publisher","first-page":"11459","DOI":"10.1038\/s41598-018-29616-y","volume":"8","author":"S Shahrook","year":"2018","unstructured":"Shahrook S, Erika Ota E, Hanada N et al (2018) Vitamin K supplementation during pregnancy for improving outcomes: a systematic review and meta-analysis. Sci Rep 8:11459","journal-title":"Sci Rep"},{"unstructured":"https:\/\/www.bauschhealth.com\/Portals\/25\/Pdf\/PI\/Mephyton-PI.pdf\n                    \n                  . Accessed 10 Dec 2018","key":"227_CR19"},{"key":"227_CR20","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1079\/BJN20051630","volume":"95","author":"HHW Thijssen","year":"2006","unstructured":"Thijssen HHW, Vervoort LMT, Schurgers LJ et al (2006) Menadione is a metabolite of oral vitamin K. Br J Nutr 95:260\u2013266","journal-title":"Br J Nutr"},{"key":"227_CR21","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.freeradbiomed.2010.09.021","volume":"49","author":"G Loor","year":"2010","unstructured":"Loor G, Kondapalli J, Schriewer JM et al (2010) Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis. Free Radic Biol Med 49:1925\u20131936","journal-title":"Free Radic Biol Med"},{"key":"227_CR22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1056\/NEJM197802022980504","volume":"298","author":"WJ Cohn","year":"1978","unstructured":"Cohn WJ, Boylan JJ, Blanker RV et al (1978) Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial. N Engl J Med 298:243\u2013248","journal-title":"N Engl J Med"},{"key":"227_CR23","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1093\/toxsci\/kfy147","volume":"165","author":"M Lindeblad","year":"2019","unstructured":"Lindeblad M, Lyubimov A, van Breemen R et al (2019) The bile sequestrant cholestyramine increases survival in a rabbit model of brodifacoum poisoning. Toxicol Sci 165:389\u2013395","journal-title":"Toxicol Sci"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-019-00227-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-019-00227-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-019-00227-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T06:25:43Z","timestamp":1589696743000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-019-00227-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,19]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["227"],"URL":"https:\/\/doi.org\/10.1007\/s00408-019-00227-2","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"type":"print","value":"0341-2040"},{"type":"electronic","value":"1432-1750"}],"subject":[],"published":{"date-parts":[[2019,4,19]]},"assertion":[{"value":"9 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Drs. Rubinstein and Feinstein are co-founders of EnSol Therapeutics, LLC.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Rights"}}]}}