{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:32:42Z","timestamp":1789975962611,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["5232"],"award-info":[{"award-number":["5232"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00408-019-00301-9","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T13:02:47Z","timestamp":1575896567000},"page":"105-112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Impact of Interleukin (IL)-33 Gene Polymorphisms and Environmental Factors on Risk of Asthma in the Iranian Population"],"prefix":"10.1007","volume":"198","author":[{"given":"Mojdeh","family":"Matloubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maral","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-2862","authenticated-orcid":false,"given":"Mohammad-Ali","family":"Assarehzadegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Fallahpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Soleyman-Jahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Janani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"issue":"1","key":"301_CR1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/ppul.23498","volume":"52","author":"D de Benedictis","year":"2017","unstructured":"de Benedictis D, Bush A (2017) Asthma in adolescence: is there any news? Pediatr Pulmonol 52(1):129\u2013138. https:\/\/doi.org\/10.1002\/ppul.23498","journal-title":"Pediatr Pulmonol"},{"issue":"5","key":"301_CR2","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1111\/crj.12750","volume":"12","author":"MR Fazlollahi","year":"2018","unstructured":"Fazlollahi MR, Najmi M, Fallahnezhad M et al (2018) The prevalence of asthma in Iranian adults: the first national survey and the most recent updates. Clin Respir J 12(5):1872\u20131881. https:\/\/doi.org\/10.1111\/crj.12750","journal-title":"Clin Respir J"},{"issue":"5","key":"301_CR3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","volume":"59","author":"M Masoli","year":"2004","unstructured":"Masoli M, Fabian D, Holt S et al (2004) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59(5):469\u2013478. https:\/\/doi.org\/10.1111\/j.1398-9995.2004.00526.x","journal-title":"Allergy"},{"issue":"12","key":"301_CR4","first-page":"804","volume":"17","author":"M Varmaghani","year":"2014","unstructured":"Varmaghani M, Rashidian A, Kebriaeezadeh A et al (2017) National and sub-national prevalence, trend, and burden of asthma in Iran from 1990 to 2013; the study protocol. Arch Iran Med 17(12):804\u2013809.","journal-title":"Arch Iran Med"},{"issue":"11","key":"301_CR5","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nri.2016.95","volume":"16","author":"FY Liew","year":"2016","unstructured":"Liew FY, Girard JP, Turnquist HR (2016) Interleukin-33 in health and disease. Nat Rev Immunol 16(11):676\u2013689. https:\/\/doi.org\/10.1038\/nri.2016.95","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"301_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1134\/s0006297918010029","volume":"83","author":"MR Khaitov","year":"2018","unstructured":"Khaitov MR, Gaisina AR, Shilovskiy IP et al (2018) The role of interleukin-33 in pathogenesis of bronchial asthma. New experimental data. Biochemistry (Mosc) 83(1):13\u201325. https:\/\/doi.org\/10.1134\/s0006297918010029","journal-title":"Biochemistry (Mosc)"},{"issue":"13","key":"301_CR7","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","volume":"363","author":"MF Moffatt","year":"2010","unstructured":"Moffatt MF, Gut IG, Demenais F et al (2010) A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363(13):1211\u20131221. https:\/\/doi.org\/10.1056\/NEJMoa0906312","journal-title":"N Engl J Med"},{"issue":"3","key":"301_CR8","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/ng.323","volume":"41","author":"DF Gudbjartsson","year":"2009","unstructured":"Gudbjartsson DF, Bjornsdottir US, Halapi E et al (2009) Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 41(3):342\u2013347. https:\/\/doi.org\/10.1038\/ng.323","journal-title":"Nat Genet"},{"issue":"3","key":"301_CR9","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.jaci.2011.05.004","volume":"128","author":"F Belpinati","year":"2011","unstructured":"Belpinati F, Malerba G, Trabetti E et al (2011) Association of childhood allergic asthma with markers flanking the IL33 gene in Italian families. J Allergy Clin Immunol 128(3):667\u2013668. https:\/\/doi.org\/10.1016\/j.jaci.2011.05.004","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"301_CR10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jaci.2013.12.1080","volume":"134","author":"OE Savenije","year":"2014","unstructured":"Savenije OE, Mahachie John JM, Granell R et al (2014) Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. J Allergy Clin Immunol 134(1):170\u2013177. https:\/\/doi.org\/10.1016\/j.jaci.2013.12.1080","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"301_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.alit.2015.03.004","volume":"64","author":"H Kabata","year":"2015","unstructured":"Kabata H, Moro K, Koyasu S et al (2015) Group 2 innate lymphoid cells and asthma. Allergol Int 64(3):227\u2013234. https:\/\/doi.org\/10.1016\/j.alit.2015.03.004","journal-title":"Allergol Int"},{"issue":"3","key":"301_CR12","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.jaci.2013.04.012","volume":"132","author":"S Saglani","year":"2013","unstructured":"Saglani S, Lui S, Ullmann N et al (2013) IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. J Allergy Clin Immunol 132(3):676\u2013685.e13. https:\/\/doi.org\/10.1016\/j.jaci.2013.04.012","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"301_CR13","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.jaci.2012.04.041","volume":"130","author":"X Li","year":"2012","unstructured":"Li X, Ampleford EJ, Howard TD et al (2012) Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol 130(4):861\u20138.e7. https:\/\/doi.org\/10.1016\/j.jaci.2012.04.041","journal-title":"J Allergy Clin Immunol"},{"key":"301_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.030","author":"E Melen","year":"2010","unstructured":"Melen E, Himes BE, Brehm JM et al (2010) Analyses of shared genetic factors between asthma and obesity in children. J Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2010.06.030","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"301_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/j.1398-9995.2006.01305.x","volume":"62","author":"J Bousquet","year":"2007","unstructured":"Bousquet J, Clark TJ, Hurd S et al (2007) GINA guidelines on asthma and beyond. Allergy 62(2):102\u2013112. https:\/\/doi.org\/10.1111\/j.1398-9995.2006.01305.x","journal-title":"Allergy"},{"issue":"6 Pt 1","key":"301_CR16","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1164\/ajrccm.152.6.8520796","volume":"152","author":"American Thoracic Society","year":"1995","unstructured":"American Thoracic Society (1995) Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique\u20141995 update. Am J Respir Crit Care Med 152(6 Pt 1):2185\u20132198. https:\/\/doi.org\/10.1164\/ajrccm.152.6.8520796","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"301_CR17","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3923\/jms.2013.592.597","volume":"13","author":"MA Assarehzadegan","year":"2013","unstructured":"Assarehzadegan MA, Shakurnia AH, Amini A (2013) Sensitization to common aeroallergens among asthmatic patients in a tropical region affected by dust storm. J Med Sci 13(7):592\u2013597. https:\/\/doi.org\/10.3923\/jms.2013.592.597","journal-title":"J Med Sci"},{"key":"301_CR18","unstructured":"Lung function protocol, data sheets and questionnaire (2014). https:\/\/www.ecrhs.org\/quests.htm."},{"key":"301_CR19","unstructured":"Adult and child asthma call-back surveys questionnaires (2006). https:\/\/www.cdc.gov\/asthma\/pdfs\/surveyquestions06.pdf."},{"issue":"3","key":"301_CR20","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16(3):1215.","journal-title":"Nucleic Acids Res"},{"key":"301_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cyto.2017.09.028","volume":"104","author":"R Charrad","year":"2018","unstructured":"Charrad R, Kaabachi W, Berraies A et al (2018) IL-33 gene variants and protein expression in pediatric Tunisian asthmatic patients. Cytokine 104:85\u201391. https:\/\/doi.org\/10.1016\/j.cyto.2017.09.028","journal-title":"Cytokine"},{"key":"301_CR22","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/1471-2350-14-100","volume":"14","author":"AS Tulah","year":"2013","unstructured":"Tulah AS, Holloway JW, Sayers I (2013) Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children. BMC Med Genet 14:100. https:\/\/doi.org\/10.1186\/1471-2350-14-100","journal-title":"BMC Med Genet"},{"issue":"1","key":"301_CR23","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/imr.12619","volume":"281","author":"C Cayrol","year":"2018","unstructured":"Cayrol C, Girard JP (2018) Interleukin-33 (IL-33): a nuclear cytokine from the IL-1 family. Immunol Rev 281(1): 154\u2013168. https:\/\/doi.org\/10.1111\/imr.12619","journal-title":"Immunol Rev"},{"key":"301_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.coi.2014.09.004","volume":"31","author":"C Cayrol","year":"2014","unstructured":"Cayrol C, Girard JP (2014) IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol 31:31\u201337. https:\/\/doi.org\/10.1016\/j.coi.2014.09.004","journal-title":"Curr Opin Immunol"},{"issue":"7","key":"301_CR25","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.4049\/jimmunol.1701455","volume":"200","author":"Y Li","year":"2018","unstructured":"Li Y, Wang W, Lv Z et al (2018) Elevated expression of IL-33 and TSLP in the airways of human asthmatics in vivo: a potential biomarker of severe refractory disease. J Immunol 200(7):2253\u20132262. https:\/\/doi.org\/10.4049\/jimmunol.1701455","journal-title":"J Immunol"},{"issue":"1","key":"301_CR26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11882-015-0581-6","volume":"16","author":"MR Karta","year":"2016","unstructured":"Karta MR, Broide DH, Doherty TA (2016) Insights into group 2 innate lymphoid cells in human airway disease. Curr Allergy Asthma Rep 16(1):8. https:\/\/doi.org\/10.1007\/s11882-015-0581-6","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"301_CR27","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1586\/17476348.2015.1000311","volume":"9","author":"DJ Tan","year":"2015","unstructured":"Tan DJ, Walters EH, Perret JL et al (2015) Age-of-asthma onset as a determinant of different asthma phenotypes in adults: a systematic review and meta-analysis of the literature. Expert Rev Respir Med 9(1):109\u2013123. https:\/\/doi.org\/10.1586\/17476348.2015.1000311","journal-title":"Expert Rev Respir Med"},{"issue":"6","key":"301_CR28","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.jaip.2014.09.006","volume":"2","author":"SP Peters","year":"2014","unstructured":"Peters SP (2014) Asthma phenotypes: nonallergic (intrinsic) asthma. J Allergy Clin Immunol Pract 2(6):650\u2013652. https:\/\/doi.org\/10.1016\/j.jaip.2014.09.006","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"6","key":"301_CR29","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jaip.2014.09.004","volume":"2","author":"M Schatz","year":"2014","unstructured":"Schatz M, Rosenwasser L (2014) The allergic asthma phenotype. J Allergy Clin Immunol Pract 2(6):645\u2013648. https:\/\/doi.org\/10.1016\/j.jaip.2014.09.004","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"7","key":"301_CR30","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1136\/oemed-2017-104866","volume":"75","author":"N Le Moual","year":"2018","unstructured":"Le Moual N, Zock JP, Dumas O et al (2018) Update of an occupational asthma-specific job exposure matrix to assess exposure to 30 specific agents. Occup Environ Med 75(7):507\u2013514. https:\/\/doi.org\/10.1136\/oemed-2017-104866","journal-title":"Occup Environ Med"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-019-00301-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00408-019-00301-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-019-00301-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T19:16:44Z","timestamp":1607368604000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00408-019-00301-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["301"],"URL":"https:\/\/doi.org\/10.1007\/s00408-019-00301-9","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]},"assertion":[{"value":"29 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}