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Each HRCT finding was assessed in six distinct lung regions, resulting scores were graded as minimal (0\u20131 regions involved), medium (2\u20134) or extensive (5\u20136). Associations of routinely assessed PBL\/BAL biomarkers with these HRCT scores were evaluated using Spearman correlation coefficients and graphical presentation; significance was tested by applying Kruskal\u2013Wallis tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Blood neutrophil, lymphocyte and eosinophil fraction, neutrophil to lymphocyte ratio (NLR) and BAL lymphocyte fraction consistently showed opposite correlations with inflammatory versus non-inflammatory\/fibrotic HRCT finding scores. Blood lymphocyte fraction significantly differed by graded GGO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) and CON (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027) extent, eosinophil fraction by TBR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and NLR by CON (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). C-reactive protein was significantly related to GGO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) and CON (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), BAL lymphocyte fraction to GGO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) extent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Blood lymphocyte and eosinophil fraction, NLR, CRP and BAL lymphocyte fraction may aid to differentiate inflammatory from non-inflammatory\/fibrotic ILD patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>This evaluation was based on data from the ILD registry of Kepler University Hospital Linz, as approved by the ethics committee of the Federal State of Upper-Austria (EK Number. I-26-17).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00408-021-00434-w","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T09:02:59Z","timestamp":1616749379000},"page":"155-164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Computed Tomography Findings as Determinants of Local and Systemic Inflammation Biomarkers in Interstitial Lung Diseases: A Retrospective Registry-Based Descriptive Study"],"prefix":"10.1007","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-1554","authenticated-orcid":false,"given":"David","family":"Lang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaveh","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Horner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Hepp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herwig","family":"Pieringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Lamprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"434_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.rmed.2016.02.001","volume":"113","author":"L Richeldi","year":"2016","unstructured":"Richeldi L, Cottin V, du Bois RM et al (2016) Nintedanib in patients with idiopathic pulmonary fibrosis: combined evidence from the TOMORROW and INPULSIS\u00ae trials. 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