{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:46:09Z","timestamp":1792107969361,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"european structural and investment funds","award":["P4410032038"],"award-info":[{"award-number":["P4410032038"]}]},{"DOI":"10.13039\/501100012320","name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012320","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Transport of secretory immunoglobulin A (SIgA) through the airway epithelial cell barrier into the mucosal lumen by the polymeric immunoglobulin receptor (pIgR) is an important mechanism of respiratory mucosal host defense. Identification of immunomodulating substances that regulate secretory immunity might have therapeutic implications with regard to an improved immune exclusion.<\/jats:p>\n                    <jats:p>Thus, we sought to analyze secretory immunity under homeostatic and immunomodulating conditions in different compartments of the murine upper and lower respiratory tract (URT&amp;LRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Pigr<\/jats:italic>\n                      gene expression in lung, trachea, and nasal-associated lymphoid tissue (NALT) of germ-free mice, specific pathogen-free mice, mice with an undefined microbiome, as well as LPS- and IFN-\u03b3-treated mice was determined by quantitative real-time PCR. IgA levels in bronchoalveolar lavage (BAL), nasal lavage (NAL), and serum were determined by ELISA. LPS- and IFN-\u03b3-treated mice were colonized with\n                      <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n                      and bacterial CFUs were determined in URT and LRT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Respiratory\n                      <jats:italic>Pigr<\/jats:italic>\n                      expression and IgA levels were dependent on the degree of exposure to environmental microbial stimuli. While immunostimulation with LPS and IFN-\u03b3 differentially impacts respiratory\n                      <jats:italic>Pigr<\/jats:italic>\n                      expression and IgA in URT\n                      <jats:italic>vs<\/jats:italic>\n                      . LRT, only prophylactic IFN-\u03b3 treatment reduces nasal colonization with\n                      <jats:italic>S. pneumoniae<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Airway-associated secretory immunity can be partly modulated by exposure to microbial ligands and proinflammatory stimuli. Prophylactic IFN-\u03b3-treatment modestly improves antibacterial immunity in the URT, but this does not appear to be mediated by SIgA or pIgR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00408-021-00498-8","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T08:02:35Z","timestamp":1637913755000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract"],"prefix":"10.1007","volume":"200","author":[{"given":"Alexander","family":"Pausder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fricke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-7523","authenticated-orcid":false,"given":"Klaus","family":"Schughart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-2282","authenticated-orcid":false,"given":"Jens","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0185-1459","authenticated-orcid":false,"given":"Till","family":"Strowig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-189X","authenticated-orcid":false,"given":"Dunja","family":"Bruder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-0952","authenticated-orcid":false,"given":"Julia D.","family":"Boehme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"issue":"6 Pt 1","key":"498_CR1","doi-asserted-by":"publisher","first-page":"C749","DOI":"10.1152\/ajpcell.1987.253.6.C749","volume":"253","author":"B Gumbiner","year":"1987","unstructured":"Gumbiner B (1987) Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol 253(6 Pt 1):C749\u2013C758. https:\/\/doi.org\/10.1152\/ajpcell.1987.253.6.C749","journal-title":"Am J Physiol"},{"issue":"7","key":"498_CR2","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/S0962-8924(99)01578-0","volume":"9","author":"S Tsukita","year":"1999","unstructured":"Tsukita S, Furuse M (1999) Occludin and claudins in tight-junction strands: leading or supporting players? Trends Cell Biol 9(7):268\u2013273. https:\/\/doi.org\/10.1016\/S0962-8924(99)01578-0","journal-title":"Trends Cell Biol"},{"issue":"4","key":"498_CR3","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1165\/rcmb.2013-0456OC","volume":"51","author":"MJ LaFemina","year":"2014","unstructured":"LaFemina MJ, Sutherland KM, Bentley T et al (2014) Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice. Am J Respir Cell Mol Biol 51(4):550\u2013558. https:\/\/doi.org\/10.1165\/rcmb.2013-0456OC","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"498_CR4","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.chom.2011.04.012","volume":"9","author":"TB Clarke","year":"2011","unstructured":"Clarke TB, Francella N, Huegel A et al (2011) Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium. Cell Host Microbe 9(5):404\u2013414. https:\/\/doi.org\/10.1016\/j.chom.2011.04.012","journal-title":"Cell Host Microbe"},{"issue":"5 Pt 2","key":"498_CR5","doi-asserted-by":"publisher","first-page":"S38","DOI":"10.1164\/ajrccm.160.supplement_1.11","volume":"160","author":"PR Mills","year":"1999","unstructured":"Mills PR, Davies RJ, Devalia JL (1999) Airway epithelial cells, cytokines, and pollutants. Am J Respir Crit Care Med 160(5 Pt 2):S38-43. https:\/\/doi.org\/10.1164\/ajrccm.160.supplement_1.11","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"498_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/rr25","volume":"1","author":"R Bals","year":"2000","unstructured":"Bals R (2000) Epithelial antimicrobial peptides in host defense against infection. Respir Res 1(3):141\u2013150. https:\/\/doi.org\/10.1186\/rr25","journal-title":"Respir Res"},{"issue":"6","key":"498_CR7","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1165\/ajrcmb.15.6.8969267","volume":"15","author":"S Varsano","year":"1996","unstructured":"Varsano S, Frolkis I, Rashkovsky L et al (1996) Protection of human nasal respiratory epithelium from complement-mediated lysis by cell-membrane regulators of complement activation. Am J Respir Cell Mol Biol 15(6):731\u2013737. https:\/\/doi.org\/10.1165\/ajrcmb.15.6.8969267","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"498_CR8","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.jaci.2017.11.046","volume":"141","author":"HS Kulkarni","year":"2018","unstructured":"Kulkarni HS, Liszewski MK, Brody SL et al (2018) The complement system in the airway epithelium: an overlooked host defense mechanism and therapeutic target? J Allergy Clin Immunol 141(5):1582-1586.e1. https:\/\/doi.org\/10.1016\/j.jaci.2017.11.046","journal-title":"J Allergy Clin Immunol"},{"key":"498_CR9","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00276-16","author":"S Stegemann-Koniszewski","year":"2016","unstructured":"Stegemann-Koniszewski S, Jeron A, Gereke M et al (2016) Alveolar Type II epithelial cells contribute to the anti-influenza a virus response in the lung by integrating pathogen- and microenvironment-derived signals. mBio. https:\/\/doi.org\/10.1128\/mBio.00276-16","journal-title":"mBio"},{"issue":"2","key":"498_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S1471-4906(02)00031-5","volume":"24","author":"A Phalipon","year":"2003","unstructured":"Phalipon A, Corth\u00e9sy B (2003) Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins. Trends Immunol 24(2):55\u201358. https:\/\/doi.org\/10.1016\/S1471-4906(02)00031-5","journal-title":"Trends Immunol"},{"issue":"3","key":"498_CR11","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1183\/09031936.01.00228801","volume":"18","author":"C Pilette","year":"2001","unstructured":"Pilette C, Ouadrhiri Y, Godding V et al (2001) Lung mucosal immunity: immunoglobulin-A revisited. Eur Respir J 18(3):571\u2013588. https:\/\/doi.org\/10.1183\/09031936.01.00228801","journal-title":"Eur Respir J"},{"issue":"3","key":"498_CR12","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.4049\/jimmunol.1000831","volume":"185","author":"Y Fukuyama","year":"2010","unstructured":"Fukuyama Y, King JD, Kataoka K et al (2010) Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae. J Immunol (Baltimore, Md.\u201d 1950) 185(3):1755\u20131762. https:\/\/doi.org\/10.4049\/jimmunol.1000831","journal-title":"J Immunol (Baltimore, Md.\u201d 1950)"},{"issue":"5","key":"498_CR13","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/intimm\/dxl017","volume":"18","author":"A Tj\u00e4rnlund","year":"2006","unstructured":"Tj\u00e4rnlund A, Rodr\u00edguez A, Cardona P et al (2006) Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice. Int Immunol 18(5):807\u2013816. https:\/\/doi.org\/10.1093\/intimm\/dxl017","journal-title":"Int Immunol"},{"key":"498_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11240","author":"BW Richmond","year":"2016","unstructured":"Richmond BW, Brucker RM, Han W et al (2016) Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms11240","journal-title":"Nat Commun"},{"issue":"8","key":"498_CR15","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1164\/rccm.201604-0759OC","volume":"195","author":"VV Polosukhin","year":"2017","unstructured":"Polosukhin VV, Richmond BW, Du R et al (2017) Secretory IgA deficiency in individual small airways is associated with persistent inflammation and remodeling. Am J Respir Crit Care Med 195(8):1010\u20131021. https:\/\/doi.org\/10.1164\/rccm.201604-0759OC","journal-title":"Am J Respir Crit Care Med"},{"key":"498_CR16","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-1971OC","author":"ST Gohy","year":"2014","unstructured":"Gohy ST, Detry BR, Lecocq M et al (2014) Polymeric immunoglobulin receptor down-regulation in chronic obstructive pulmonary disease. Persistence in the cultured epithelium and role of transforming growth factor-\u03b2. Am J Respir Crit Care Med. https:\/\/doi.org\/10.1164\/rccm.201311-1971OC","journal-title":"Am J Respir Crit Care Med"},{"key":"498_CR17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201703-0561OC","author":"MZ Ladjemi","year":"2018","unstructured":"Ladjemi MZ, Gras D, Dupasquier S et al (2018) Bronchial epithelial IgA secretion is impaired in asthma. Role of IL-4\/IL-13. Am J Respir Crit Care Med. https:\/\/doi.org\/10.1164\/rccm.201703-0561OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"498_CR18","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1086\/432513","volume":"192","author":"A Sandgren","year":"2005","unstructured":"Sandgren A, Albiger B, Orihuela CJ et al (2005) Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis 192(5):791\u2013800. https:\/\/doi.org\/10.1086\/432513","journal-title":"J Infect Dis"},{"issue":"1","key":"498_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000345112","volume":"5","author":"S Stegemann-Koniszewski","year":"2013","unstructured":"Stegemann-Koniszewski S, Gereke M, Orrskog S et al (2013) TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection. J Innate Immun 5(1):84\u201396. https:\/\/doi.org\/10.1159\/000345112","journal-title":"J Innate Immun"},{"issue":"5664","key":"498_CR20","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1091334","volume":"303","author":"AJ Macpherson","year":"2004","unstructured":"Macpherson AJ, Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science (New York, N.Y.) 303(5664):1662\u20131665. https:\/\/doi.org\/10.1126\/science.1091334","journal-title":"Science (New York, N.Y.)"},{"issue":"5505","key":"498_CR21","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1126\/science.291.5505.881","volume":"291","author":"LV Hooper","year":"2001","unstructured":"Hooper LV, Wong MH, Thelin A et al (2001) Molecular analysis of commensal host-microbial relationships in the intestine. Science (New York, N.Y.) 291(5505):881\u2013884. https:\/\/doi.org\/10.1126\/science.291.5505.881","journal-title":"Science (New York, N.Y.)"},{"issue":"4","key":"498_CR22","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/mi.2011.8","volume":"4","author":"MEC Bruno","year":"2011","unstructured":"Bruno MEC, Frantz AL, Rogier EW et al (2011) Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-\u03baB pathways in intestinal epithelial cells. Mucosal Immunol 4(4):468\u2013478. https:\/\/doi.org\/10.1038\/mi.2011.8","journal-title":"Mucosal Immunol"},{"issue":"4","key":"498_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0161-5890(93)90071-I","volume":"30","author":"JF Piskurich","year":"1993","unstructured":"Piskurich JF, France JA, Tamer CM et al (1993) Interferon-\u03b3 induces polymeric immunoglobulin receptor mrna in human intestinal epithelial cells by a protein synthesis dependent mechanism. Mol Immunol 30(4):413\u2013421. https:\/\/doi.org\/10.1016\/0161-5890(93)90071-I","journal-title":"Mol Immunol"},{"issue":"1","key":"498_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11373-004-8185-5","volume":"12","author":"NH Khattar","year":"2005","unstructured":"Khattar NH, Lele SM, Kaetzel CS (2005) Down-regulation of the polymeric immunoglobulin receptor in non-small cell lung carcinoma: correlation with dysregulated expression of the transcription factors USF and AP2. J Biomed Sci 12(1):65\u201377. https:\/\/doi.org\/10.1007\/s11373-004-8185-5","journal-title":"J Biomed Sci"},{"issue":"4","key":"498_CR25","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1046\/j.1365-2567.1999.00731.x","volume":"96","author":"S Loman","year":"1999","unstructured":"Loman S, Jansen HM, Out TA et al (1999) Interleukin-4 and interferon-gamma synergistically increase secretory component gene expression, but are additive in stimulating secretory immunoglobulin A release by Calu-3 airway epithelial cells. Immunology 96(4):537\u2013543. https:\/\/doi.org\/10.1046\/j.1365-2567.1999.00731.x","journal-title":"Immunology"},{"issue":"3","key":"498_CR26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1164\/rccm.201010-1629OC","volume":"184","author":"VV Polosukhin","year":"2011","unstructured":"Polosukhin VV, Cates JM, Lawson WE et al (2011) Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 184(3):317\u2013327. https:\/\/doi.org\/10.1164\/rccm.201010-1629OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"498_CR27","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1164\/ajrccm.163.1.9912137","volume":"163","author":"C Pilette","year":"2001","unstructured":"Pilette C, Godding V, Kiss R et al (2001) Reduced epithelial expression of secretory component in small airways correlates with airflow obstruction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 163(1):185\u2013194. https:\/\/doi.org\/10.1164\/ajrccm.163.1.9912137","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"498_CR28","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1111\/all.12274","volume":"68","author":"C Hupin","year":"2013","unstructured":"Hupin C, Rombaux P, Bowen H et al (2013) Downregulation of polymeric immunoglobulin receptor and secretory IgA antibodies in eosinophilic upper airway diseases. Allergy 68(12):1589\u20131597. https:\/\/doi.org\/10.1111\/all.12274","journal-title":"Allergy"},{"issue":"4","key":"498_CR29","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jaci.2009.01.003","volume":"123","author":"CC Lewis","year":"2009","unstructured":"Lewis CC, Aronow B, Hutton J et al (2009) Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung. J Allergy Clin Immunol 123(4):795-804.e8. https:\/\/doi.org\/10.1016\/j.jaci.2009.01.003","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"498_CR30","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.4049\/jimmunol.0900237","volume":"182","author":"Z Jaffar","year":"2009","unstructured":"Jaffar Z, Ferrini ME, Herritt LA et al (2009) Cutting edge: lung mucosal Th17-mediated responses induce polymeric Ig receptor expression by the airway epithelium and elevate secretory IgA levels. J Immunol (Baltimore, Md.: 1950) 182(8):4507\u20134511. https:\/\/doi.org\/10.4049\/jimmunol.0900237","journal-title":"J Immunol (Baltimore, Md.: 1950)"},{"issue":"Suppl","key":"498_CR31","doi-asserted-by":"publisher","first-page":"S84","DOI":"10.1016\/j.exppara.2014.04.002","volume":"145","author":"M Carrasco-Yepez","year":"2014","unstructured":"Carrasco-Yepez M, Campos-Rodriguez R, Lopez-Reyes I et al (2014) Intranasal coadministration of Cholera toxin with amoeba lysates modulates the secretion of IgA and IgG antibodies, production of cytokines and expression of pIgR in the nasal cavity of mice in the model of Naegleria fowleri meningoencephalitis. Exp Parasitol 145(Suppl):S84-92. https:\/\/doi.org\/10.1016\/j.exppara.2014.04.002","journal-title":"Exp Parasitol"},{"issue":"5","key":"498_CR32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nrmicro.2017.14","volume":"15","author":"WH Man","year":"2017","unstructured":"Man WH, de Steenhuijsen-Piters WAA, Bogaert D (2017) The microbiota of the respiratory tract: gatekeeper to respiratory health. Nat Rev Microbiol 15(5):259\u2013270. https:\/\/doi.org\/10.1038\/nrmicro.2017.14","journal-title":"Nat Rev Microbiol"},{"issue":"8","key":"498_CR33","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1177\/000348949110000807","volume":"100","author":"I Ichimiya","year":"1991","unstructured":"Ichimiya I, Kawauchi H, Tanaka T et al (1991) Distribution of immunocompetent cells in normal nasal mucosa: comparisons among germ-free, specific pathogen-free, and conventional mice. Ann Otol Rhinol Laryngol 100(8):638\u2013642. https:\/\/doi.org\/10.1177\/000348949110000807","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"12","key":"498_CR34","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1271\/bbb.60164","volume":"70","author":"Y Ohashi","year":"2006","unstructured":"Ohashi Y, Hiraguchi M, Ushida K (2006) The composition of intestinal bacteria affects the level of luminal IgA. Biosci Biotechnol Biochem 70(12):3031\u20133035. https:\/\/doi.org\/10.1271\/bbb.60164","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"498_CR35","doi-asserted-by":"publisher","first-page":"376","DOI":"10.4049\/jimmunol.175.1.376","volume":"175","author":"TA Schneeman","year":"2005","unstructured":"Schneeman TA, Bruno MEC, Schjerven H et al (2005) Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol (Baltimore, Md.: 1950) 175(1):376\u2013384. https:\/\/doi.org\/10.4049\/jimmunol.175.1.376","journal-title":"J Immunol (Baltimore, Md.: 1950)"},{"issue":"4","key":"498_CR36","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/mi.2013.98","volume":"7","author":"C Moon","year":"2014","unstructured":"Moon C, VanDussen KL, Miyoshi H et al (2014) Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol 7(4):818\u2013828. https:\/\/doi.org\/10.1038\/mi.2013.98","journal-title":"Mucosal Immunol"},{"issue":"27","key":"498_CR37","doi-asserted-by":"publisher","first-page":"16300","DOI":"10.1074\/jbc.271.27.16300","volume":"271","author":"E L\u00fcllau","year":"1996","unstructured":"L\u00fcllau E, Heyse S, Vogel H et al (1996) Antigen binding properties of purified immunoglobulin A and reconstituted secretory immunoglobulin A antibodies. J Biol Chem 271(27):16300\u201316309. https:\/\/doi.org\/10.1074\/jbc.271.27.16300","journal-title":"J Biol Chem"},{"issue":"3","key":"498_CR38","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/0923-1811(95)00444-0","volume":"11","author":"Y Nihei","year":"1996","unstructured":"Nihei Y, Maruyama K, Endo Y et al (1996) Secretory component (polymeric immunoglobulin receptor) expression on human keratinocytes by stimulation with interferon-\u03b3 and differences in response. J Dermatol Sci 11(3):214\u2013222. https:\/\/doi.org\/10.1016\/0923-1811(95)00444-0","journal-title":"J Dermatol Sci"},{"issue":"5 Pt 1","key":"498_CR39","doi-asserted-by":"publisher","first-page":"L951","DOI":"10.1152\/ajplung.1997.272.5.L951","volume":"272","author":"S Loman","year":"1997","unstructured":"Loman S, Radl J, Jansen HM et al (1997) Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: upregulation by IFN-gamma. Am J Physiol 272(5 Pt 1):L951\u2013L958. https:\/\/doi.org\/10.1152\/ajplung.1997.272.5.L951","journal-title":"Am J Physiol"},{"issue":"9","key":"498_CR40","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.4049\/jimmunol.140.9.2989","volume":"140","author":"TB Issekutz","year":"1988","unstructured":"Issekutz TB, Stoltz JM, vd Meide P (1988) Lymphocyte recruitment in delayed-type hypersensitivity. The role of IFN-gamma. J Immunol (Baltimore, Md.: 1950) 140(9):2989\u20132993","journal-title":"J Immunol (Baltimore, Md.: 1950)"},{"issue":"5","key":"498_CR41","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1023\/A:1012241117984","volume":"21","author":"C Cunningham-Rundles","year":"2001","unstructured":"Cunningham-Rundles C (2001) Physiology of IgA and IgA deficiency. J Clin Immunol 21(5):303\u2013309. https:\/\/doi.org\/10.1023\/A:1012241117984","journal-title":"J Clin Immunol"},{"issue":"1","key":"498_CR42","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.clim.2003.12.005","volume":"111","author":"E Edwards","year":"2004","unstructured":"Edwards E, Razvi S, Cunningham-Rundles C (2004) IgA deficiency: clinical correlates and responses to pneumococcal vaccine. Clin Immunol (Orlando, Fla.) 111(1):93\u201397. https:\/\/doi.org\/10.1016\/j.clim.2003.12.005","journal-title":"Clin Immunol (Orlando, Fla.)"},{"issue":"1","key":"498_CR43","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.clim.2009.05.014","volume":"133","author":"M Janzi","year":"2009","unstructured":"Janzi M, Kull I, Sj\u00f6berg R et al (2009) Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clin Immunol (Orlando, Fla.) 133(1):78\u201385. https:\/\/doi.org\/10.1016\/j.clim.2009.05.014","journal-title":"Clin Immunol (Orlando, Fla.)"},{"issue":"10","key":"498_CR44","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1136\/thx.54.10.929","volume":"54","author":"JR Catterall","year":"1999","unstructured":"Catterall JR (1999) Streptococcus pneumoniae. Thorax 54(10):929\u2013937. https:\/\/doi.org\/10.1136\/thx.54.10.929","journal-title":"Thorax"},{"issue":"7","key":"498_CR45","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.4049\/jimmunol.173.7.4576","volume":"173","author":"K Sun","year":"2004","unstructured":"Sun K, Johansen F, Eckmann L et al (2004) An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriage. J Immunol (Baltimore, Md.: 1950) 173(7):4576\u20134581. https:\/\/doi.org\/10.4049\/jimmunol.173.7.4576","journal-title":"J Immunol (Baltimore, Md.: 1950)"},{"issue":"1","key":"498_CR46","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1164\/ajrccm\/137.1.138","volume":"137","author":"P Sestini","year":"1988","unstructured":"Sestini P, Nencioni L, Villa L et al (1988) IgA-driven antibacterial activity against Streptococcus pneumoniae by mouse lung lymphocytes. Am Rev Respir Dis 137(1):138\u2013143. https:\/\/doi.org\/10.1164\/ajrccm\/137.1.138","journal-title":"Am Rev Respir Dis"},{"issue":"4","key":"498_CR47","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1128\/IAI.01758-06","volume":"75","author":"CE Fasching","year":"2007","unstructured":"Fasching CE, Grossman T, Corth\u00e9sy B et al (2007) Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae. Infect Immun 75(4):1801\u20131810. https:\/\/doi.org\/10.1128\/IAI.01758-06","journal-title":"Infect Immun"},{"issue":"2","key":"498_CR48","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0008-8749(88)90126-8","volume":"117","author":"WA Jensen","year":"1988","unstructured":"Jensen WA, Rose RM, Burke RH Jr et al (1988) Cytokine activation of antibacterial activity in human pulmonary macrophages: comparison of recombinant interferon-\u03b3 and granulocyte-macrophage colony-stimulating factor. Cell Immunol 117(2):369\u2013377. https:\/\/doi.org\/10.1016\/0008-8749(88)90126-8","journal-title":"Cell Immunol"},{"issue":"4 Pt 1","key":"498_CR49","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1164\/ajrccm.156.4.97-03017","volume":"156","author":"PL Heritage","year":"1997","unstructured":"Heritage PL, Underdown BJ, Arsenault AL et al (1997) Comparison of murine nasal-associated lymphoid tissue and Peyer\u2019s patches. Am J Respir Crit Care Med 156(4 Pt 1):1256\u20131262. https:\/\/doi.org\/10.1164\/ajrccm.156.4.97-03017","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"498_CR50","doi-asserted-by":"publisher","first-page":"984","DOI":"10.4049\/jimmunol.179.2.984","volume":"179","author":"C Albanesi","year":"2007","unstructured":"Albanesi C, Fairchild HR, Madonna S et al (2007) IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3. J Immunol (Baltimore, Md.: 1950) 179(2):984\u2013992. https:\/\/doi.org\/10.4049\/jimmunol.179.2.984","journal-title":"J Immunol (Baltimore, Md.: 1950)"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-021-00498-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00408-021-00498-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-021-00498-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T06:30:48Z","timestamp":1673850648000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00408-021-00498-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["498"],"URL":"https:\/\/doi.org\/10.1007\/s00408-021-00498-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-759484\/v1","asserted-by":"object"}]},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]},"assertion":[{"value":"27 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experiments were approved by the federal ethical bodies and were carried out in accordance with the guidelines of the Saxony-Anhalt State Administration Office and the guidelines of the Lower Saxony State Office for Consumer Protection and Food Safety.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}