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Our objective was to assess the value of CCR for predicting in-hospital mortality of patients hospitalized with AECOPD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with AECOPD (<jats:italic>n<\/jats:italic>\u2009=\u2009597) were retrospectively enrolled. Patient\u2019s clinical characteristics and laboratory tests, including serum cystatin C and creatinine, were reviewed. The prediction value of CCR was evaluated using area under the receiver operating characteristic curve (AUC) values. Factors potentially impacting in-hospital mortality were investigated using univariate and multivariate logistic regression analyses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mortality rate during hospitalization was 10.05%. CCR was lower in non-surviving vs. survived patients (41.67 vs. 61.52, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). AUC value for CCR for in-hospital mortality prediction was 0.79 [95% confidence interval (CI) 0.73\u20130.85]. On multivariate logistic regression analysis, in-hospital mortality was strongly associated with CCR\u2009&lt;\u200952.27 [odds ratio (OR) 6.23, 95% CI (3.00\u201312.92), <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001], age\u2009\u2265\u200981\u00a0years [OR 2.97, 95% CI (1.20\u20137.37), <jats:italic>P<\/jats:italic>\u2009=\u20090.019], oxygenation index\u2009&lt;\u2009300 [OR 3.28, 95% CI (1.27\u20138.44), <jats:italic>P<\/jats:italic>\u2009=\u20090.014], CRP\u00a0&gt;\u00a08\u00a0mg\/L [OR 1.84, 95% CI (1.15\u20132.95), <jats:italic>P<\/jats:italic>\u2009=\u20090.012], and D-dimer\u2009&gt;\u2009500\u00a0ng\/L [OR 5.19, 95% CI (1.51\u201317.79), <jats:italic>P<\/jats:italic>\u2009=\u20090.009].<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>CCR was significantly lower, and is a potential prognostic indicator, in patients with AECOPD who died during hospitalization.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00408-022-00568-5","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T01:02:33Z","timestamp":1663203753000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serum Creatinine\/Cystatin C Ratio as a Predictor of In-hospital Mortality in Patients Hospitalized with Acute Exacerbation of Chronic Obstructive Pulmonary Disease"],"prefix":"10.1007","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-598X","authenticated-orcid":false,"given":"Zhixiang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-0703","authenticated-orcid":false,"given":"Lei","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"568_CR1","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1016\/j.mayocp.2018.05.026","volume":"93","author":"S Mirza","year":"2018","unstructured":"Mirza S, Clay RD, Koslow MA et al (2018) COPD guidelines: a review of the 2018 GOLD report. 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The present study was approved by the Medical Ethics Committee of Wuhu Hospital of Traditional Chinese Medicine (LW 2022-10; May 13, 2022).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}