{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:01Z","timestamp":1786980121200,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Spydspids Foundation"},{"name":"Fr\u00f6lich Foundation"},{"name":"Jens Ove Jacobsens Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00408-023-00602-0","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T06:06:25Z","timestamp":1676095585000},"page":"103-110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fatigue in Patients with Sarcoidosis in Denmark"],"prefix":"10.1007","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-3669","authenticated-orcid":false,"given":"Janne","family":"M\u00f8ller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-6963","authenticated-orcid":false,"given":"Ole","family":"Hilberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Bendstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,11]]},"reference":[{"key":"602_CR1","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1183\/13993003.00477-2016","volume":"48","author":"EV Arkema","year":"2016","unstructured":"Arkema EV, Grunewald J, Kullberg S et al (2016) Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden. European Respir J 48:1690\u20131699. https:\/\/doi.org\/10.1183\/13993003.00477-2016","journal-title":"European Respir J"},{"key":"602_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106548","author":"MG Sikj\u00e6r","year":"2021","unstructured":"Sikj\u00e6r MG, Hilberg O, Ibsen R, L\u00f8kke A (2021) Sarcoidosis: a nationwide registry-based study of incidence, prevalence and diagnostic work-up. Respir Med. https:\/\/doi.org\/10.1016\/j.rmed.2021.106548","journal-title":"Respir Med"},{"key":"602_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/TAN.12326","volume":"83","author":"P Darlington","year":"2014","unstructured":"Darlington P, Gabrielsen A, S\u00f6rensson P et al (2014) HLA-alleles associated with increased risk for extra-pulmonary involvement in sarcoidosis. Tissue Antigen 83:267\u2013272. https:\/\/doi.org\/10.1111\/TAN.12326","journal-title":"Tissue Antigen"},{"key":"602_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1465-9921-11-25","volume":"11","author":"J Grunewald","year":"2010","unstructured":"Grunewald J, Brynedal B, Darlington P et al (2010) Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients. Respir Res 11:1. https:\/\/doi.org\/10.1186\/1465-9921-11-25","journal-title":"Respir Res"},{"key":"602_CR5","doi-asserted-by":"publisher","first-page":"E26","DOI":"10.1164\/rccm.202002-0251ST","volume":"201","author":"ED Crouser","year":"2020","unstructured":"Crouser ED, Maier LA, Baughman RP et al (2020) Diagnosis and detection of sarcoidosis an official American thoracic society clinical practice guideline. Am J Respir Crit Care Med 201:E26\u2013E51","journal-title":"Am J Respir Crit Care Med"},{"key":"602_CR6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1378\/chest.130.4.989","volume":"130","author":"HJ Michielsen","year":"2006","unstructured":"Michielsen HJ, Drent M, Peros-Golubicic T, De Vries J (2006) Fatigue is associated with quality of life in sarcoidosis patients. Chest 130:989\u2013994. https:\/\/doi.org\/10.1378\/chest.130.4.989","journal-title":"Chest"},{"key":"602_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.rmed.2019.04.004","volume":"152","author":"M Gade Sikj\u00e6r","year":"2019","unstructured":"Gade Sikj\u00e6r M, Hilberg O, Ibsen R et al (2019) Direct and indirect economic and health consequences related to sarcoidosis in Denmark: a national register-based study. Respir Med 152:7\u201313. https:\/\/doi.org\/10.1016\/j.rmed.2019.04.004","journal-title":"Respir Med"},{"key":"602_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00408-019-00206-7","volume":"197","author":"M Voortman","year":"2019","unstructured":"Voortman M, Hendriks CMR, Elfferich MDP et al (2019) The burden of sarcoidosis symptoms from a patient perspective. Lung 197:155\u2013161. https:\/\/doi.org\/10.1007\/s00408-019-00206-7","journal-title":"Lung"},{"key":"602_CR9","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/MCP.0b013e32832d0403","volume":"15","author":"WPE De Kleijn","year":"2009","unstructured":"De Kleijn WPE, De Vries J, Lower EE et al (2009) Fatigue in sarcoidosis: a systematic review. Curr Opin Pulm Med 15:499\u2013506","journal-title":"Curr Opin Pulm Med"},{"key":"602_CR10","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1378\/CHEST.10-2629","volume":"140","author":"IHE Korenromp","year":"2011","unstructured":"Korenromp IHE, Heijnen CJ, Vogels OJM et al (2011) Characterization of chronic fatigue in patients with sarcoidosis in clinical remission. Chest 140:441\u2013447. https:\/\/doi.org\/10.1378\/CHEST.10-2629","journal-title":"Chest"},{"key":"602_CR11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.04079-2020","author":"RP Baughman","year":"2021","unstructured":"Baughman RP, Valeyre D, Korsten P et al (2021) ERS clinical practice guidelines on treatment of sarcoidosis. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.04079-2020","journal-title":"Eur Respir J"},{"key":"602_CR12","first-page":"46","volume":"20","author":"KE Byg","year":"2003","unstructured":"Byg KE, Milman NHS (2003) Sarcoidosis in Denmark 1980\u20131994. a registry-based incidence study comprising 5536 patients. Sarcoidosis Vasc Diffuse Lung Dis 20:46\u201352","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"3","key":"602_CR13","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1348\/1359107041557048","volume":"9","author":"J De Vries","year":"2004","unstructured":"De Vries J, Michielsen H, van Heck GL, Drent M (2004) Measuring fatigue in sarcoidosis: the Fatigue Assessment Scale (FAS). British J health Psychol 9(3):279\u2013291","journal-title":"British J health Psychol"},{"key":"602_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/MCP.0000000000000496","volume":"24","author":"C Hendriks","year":"2018","unstructured":"Hendriks C, Drent M, Elfferich M, De Vries J (2018) The Fatigue Assessment Scale: quality and availability in sarcoidosis and other diseases. Curr Opin Pulm Med 24:495\u2013503. https:\/\/doi.org\/10.1097\/MCP.0000000000000496","journal-title":"Curr Opin Pulm Med"},{"key":"602_CR15","first-page":"4","volume":"38","author":"J M\u00f8ller","year":"2022","unstructured":"M\u00f8ller J, Hilberg O, Bendstrup E (2022) Design and rationale of ProSar, the first Danish sarcoidosis registry. Sarcoidosis Vasc Diffuse Lung Dis 38:4","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"1","key":"602_CR16","first-page":"19","volume":"31","author":"MA Judson","year":"2014","unstructured":"Judson MA, Costabel U, Drent M et al (2014) The WASOG sarcoidosis organ assessment instrument: an update of a previous clinical tool WASOG sarcoidosis organ assessment instrument investigators. Sarcoidosis Vasc Diffuse Lung Dis 31(1):19\u201327","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"602_CR17","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1034\/J.1399-3003.1999.13D03.X","volume":"13","author":"M Drent","year":"1999","unstructured":"Drent M, Wirnsberger RM, De Vries J et al (1999) Association of fatigue with an acute phase response in sarcoidosis. Eur Respir J 13:718\u2013722. https:\/\/doi.org\/10.1034\/J.1399-3003.1999.13D03.X","journal-title":"Eur Respir J"},{"key":"602_CR18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/J.RMED.2016.05.010","volume":"116","author":"B Strookappe","year":"2016","unstructured":"Strookappe B, De Vries J, Elfferich M et al (2016) Predictors of fatigue in sarcoidosis: the value of exercise testing. Respir Med 116:49\u201354. https:\/\/doi.org\/10.1016\/J.RMED.2016.05.010","journal-title":"Respir Med"},{"key":"602_CR19","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4187\/RESPCARE.04312","volume":"61","author":"MN Karadall\u0131","year":"2016","unstructured":"Karadall\u0131 MN, Bo\u015fnak-G\u00fc\u00e7l\u00fc M, Camc\u0131o\u011flu B et al (2016) Effects of inspiratory muscle training in subjects with sarcoidosis: a randomized controlled clinical trial. Respir Care 61:483\u2013494. https:\/\/doi.org\/10.4187\/RESPCARE.04312","journal-title":"Respir Care"},{"key":"602_CR20","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.4187\/respcare.02080","volume":"59","author":"M Fleischer","year":"2014","unstructured":"Fleischer M, Hinz A, Br\u00e4hler E et al (2014) Factors associated with fatigue in sarcoidosis. Respir Care 59:1086\u20131094. https:\/\/doi.org\/10.4187\/respcare.02080","journal-title":"Respir Care"},{"key":"602_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106564","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Gerke AK, Lower EE et al (2021) The impact of demographic disparities in the presentation of sarcoidosis: a multicenter prospective study. Respir Med. https:\/\/doi.org\/10.1016\/j.rmed.2021.106564","journal-title":"Respir Med"},{"key":"602_CR22","first-page":"50","volume":"7","author":"N Milman","year":"1990","unstructured":"Milman N, Selroos O (1990) Pulmonary sarcoidosis in the Nordic Countries 1950\u20131082. Epidimiol Clin pict Sarcoidosis 7:50\u201357","journal-title":"Epidimiol Clin pict Sarcoidosis"},{"key":"602_CR23","first-page":"27","volume":"29","author":"F R\u00f8mer","year":"1992","unstructured":"R\u00f8mer F (1992) Presentation of sarcoidosis and outcome of pulmonary changes. Dan Med Bull 29:27\u201332","journal-title":"Dan Med Bull"},{"key":"602_CR24","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00550-2021","author":"S \u00d3l\u00edna Haraldsd\u00f3ttir","year":"2021","unstructured":"\u00d3l\u00edna Haraldsd\u00f3ttir S, Gunnlaugur Jonasson J, Bara Jorundsdottir K et al (2021) Sarcoidosis in Iceland: a nationwide study of epidemiology, clinical picture and environmental exposure. ERJ Open Res. https:\/\/doi.org\/10.1183\/23120541.00550-2021","journal-title":"ERJ Open Res"},{"key":"602_CR25","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.21037\/JTD-21-1760\/RC","volume":"14","author":"G Spyropoulos","year":"2022","unstructured":"Spyropoulos G, Domvri K, Manika K et al (2022) Clinical, imaging and functional determinants of sarcoidosis phenotypes in a Greek population. J Thorac Dis 14:1941\u20131949. https:\/\/doi.org\/10.21037\/JTD-21-1760\/RC","journal-title":"J Thorac Dis"},{"key":"602_CR26","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.rppnen.2017.05.004","volume":"23","author":"AV Cardoso","year":"2017","unstructured":"Cardoso AV, Mota PC, Melo N et al (2017) Analysis of sarcoidosis in the Oporto region (Portugal). Revista Portuguesa de Pneumologia (English Edition) 23:251\u2013258. https:\/\/doi.org\/10.1016\/j.rppnen.2017.05.004","journal-title":"Revista Portuguesa de Pneumologia (English Edition)"},{"key":"602_CR27","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ejim.2019.08.025","volume":"69","author":"R P\u00e9rez-Alvarez","year":"2019","unstructured":"P\u00e9rez-Alvarez R, Brito-Zer\u00f3n P, Kostov B et al (2019) Systemic phenotype of sarcoidosis associated with radiological stages. Analysis of 1230 patients. Eur J Intern Med 69:77\u201385. https:\/\/doi.org\/10.1016\/j.ejim.2019.08.025","journal-title":"Eur J Intern Med"},{"issue":"1","key":"602_CR28","doi-asserted-by":"publisher","first-page":"23700","DOI":"10.1038\/s41598-021-03175-1","volume":"11","author":"HJ Kim","year":"2021","unstructured":"Kim HJ, Kim HM, Song JW (2021) Clinical characteristics and outcomes of Korean patients with sarcoidosis. Sci Rep 11(1):23700. https:\/\/doi.org\/10.1038\/s41598-021-03175-1","journal-title":"Sci Rep"},{"key":"602_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8450-y","author":"MA Judson","year":"2014","unstructured":"Judson MA (2014) The clinical features of sarcoidosis: a comprehensive review. Clin Rev Allerg Immunol. https:\/\/doi.org\/10.1007\/s12016-014-8450-y","journal-title":"Clin Rev Allerg Immunol"},{"key":"602_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01191-x","author":"HS Te","year":"2020","unstructured":"Te HS, Perlman DM, Shenoy C et al (2020) Clinical characteristics and organ system involvement in sarcoidosis: comparison of the university of Minnesota cohort with other cohorts. BMC Pulm Med. https:\/\/doi.org\/10.1186\/s12890-020-01191-x","journal-title":"BMC Pulm Med"},{"key":"602_CR31","first-page":"181","volume":"53","author":"K Viskum","year":"1972","unstructured":"Viskum K, Thygesen K (1972) Vital prognosis in intrathorasic sarcoidosis. Scand J Respir Dis 53:181\u2013186","journal-title":"Scand J Respir Dis"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-023-00602-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00408-023-00602-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-023-00602-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T09:04:36Z","timestamp":1677315876000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00408-023-00602-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["602"],"URL":"https:\/\/doi.org\/10.1007\/s00408-023-00602-0","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"15 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Janne M\u00f8ller (JM) received honoraria for presentations from Hoffman la Roche and Novartis outside this work. Ole Hilberg (OH) received honoraria for presentations from Chiesi, GSK, and AstraZeneca, support for travel and attending meetings from Sanofi, and participated in Advisory Boards with ALK, MSD, and TEVA. Elisabeth Bendstrup (EB) received honoraria for presentations from Boehringer Ingelheim, Hoffman la Roche, and AstraZeneca and support for travel and attending meetings from Boehringer Ingelheim.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"This study protocol was reviewed and approved by Central Denmark Region Data Protection agency [case approval number: 1-16-02-90-19]. According to Danish legislation, permission from the Scientific Ethical Committee was not required. Written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}}]}}