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This study aimed to describe the cough response to mannitol among healthy adult subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>125 healthy subjects (aged 18\u201382 years, 52% females, 50% skin prick test positive) underwent a mannitol test. The coughs were recorded both simultaneously and afterwards from video recordings by two researchers. Three indices were evaluated: The cumulative number of coughs per cumulative dose of mannitol (CDR), cumulative provocative dose of mannitol to cause at least 5 coughs, and the maximal number of coughs provoked by any single mannitol dose. The test was repeated in 26 subjects after 3\u20137 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CDR showed the best repeatability with an intraclass correlation coefficient of 0.829. Gender was the only characteristics that associated with the cough response: The median CDR was 2.53 (interquartile range 0.45\u20137.01) coughs\/100\u2009mg among females and 0.787 (0.0\u20133.29) coughs\/100\u2009mg among males (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The interquartile range upper limits were defined as the cut-off limits for a normal response. The threshold for a statistically significant change in CDR was 6.26 coughs\/100\u2009mg. There was a close correlation between simultaneous- and video-assessed CDR (intraclass correlation coefficient 0.985).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Females cough more than males in response to mannitol. CDR is the most suitable index to describe the cough responsiveness. The repeatability of the response is good. Video recording of the coughs is not mandatory. The cut-off limits for a normal cough response to mannitol were provided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00408-024-00755-6","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T05:16:02Z","timestamp":1732770962000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Cough Response to Inhaled Mannitol in Healthy Subjects"],"prefix":"10.1007","volume":"203","clinical-trial-number":[{"clinical-trial-number":"nct05034367","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Hanna M.","family":"Nurmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-6021","authenticated-orcid":false,"given":"Anne M.","family":"L\u00e4tti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3386-3262","authenticated-orcid":false,"given":"Heikki O.","family":"Koskela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"755_CR1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.pupt.2011.01.012","volume":"24","author":"KF Chung","year":"2011","unstructured":"Chung KF (2011) Chronic cough hypersensitivity syndrome: a more precise label for chronic cough. 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Anne L\u00e4tti declares no competing interest. Heikki Koskela has received funding from Suomen Tuberkuloosin Vastustamisyhdistyksen s\u00e4\u00e4ti\u00f6 and Kuopion Seudun Hengityss\u00e4\u00e4ti\u00f6 and owns stocks of Orion Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the Ethics Committee of the Kuopio University Hospital (473\/2021) and registered at ClinicalTrials.gov database (\n                      \n                      , NCT05034367).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Written informed consent was gathered from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"5"}}