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We determined whether exposure to e-cigarette vapour (e-vapour) adversely affects ion transport using human airway epithelial cell lines 16HBE14o- and Calu-3 and well-differentiated primary human bronchial epithelial cells (HBEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We concurrently measured fluorescent signals and short-circuit current (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>SC<\/jats:italic>\n                      <\/jats:sub>\n                      ), an indicator of electrogenic ion transport, in polarised epithelia. The P2Y receptor-mediated signalling pathway was used to induce an increase in intracellular calcium concentration ([Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ]\n                      <jats:sub>i<\/jats:sub>\n                      ) and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>SC<\/jats:italic>\n                      <\/jats:sub>\n                      . We used a single-polypeptide fluorescence resonance energy transfer reporter based on\n                      <jats:underline>e<\/jats:underline>\n                      xchange\n                      <jats:underline>p<\/jats:underline>\n                      roteins directly\n                      <jats:underline>a<\/jats:underline>\n                      ctivated by\n                      <jats:underline>c<\/jats:underline>\n                      AMP (Epac) to measure forskolin-induced changes in cAMP and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>SC<\/jats:italic>\n                      <\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We compared the effects of e-vapour to those of traditional cigarette smoke (CS) on the human airway cell models. In all three cell types, e-vapour, similar to CS, significantly reduced agonist-induced increases in Ca\n                      <jats:sup>2+<\/jats:sup>\n                      or cAMP signalling and\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>SC<\/jats:italic>\n                      <\/jats:sub>\n                      . However, reductions in the epithelial electrolyte transport activities did not correlate with any changes in the protein levels of various ion channels and transporters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that e-vapour is not harmless and causes ion transport dysfunction similar to CS, thereby predisposing e-cigarette users to vaping-induced lung injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00408-025-00805-7","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T01:05:47Z","timestamp":1742259947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Electronic Cigarette Vapour Exposure on Ca2+- and cAMP-Dependent Ion Transport in Human Airway Epithelial Cells"],"prefix":"10.1007","volume":"203","author":[{"given":"Ya","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Yin","family":"Yip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-wu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith Choi-Wo","family":"Mak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-402X","authenticated-orcid":false,"given":"Wing-Hung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"issue":"10","key":"805_CR1","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1164\/rccm.200508-1330OC","volume":"173","author":"AM Cantin","year":"2006","unstructured":"Cantin AM et al (2006) Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. 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