{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:31:51Z","timestamp":1773250311215,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VENI no. 09150162010003"],"award-info":[{"award-number":["VENI no. 09150162010003"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic obstructive pulmonary disease (COPD) is often associated with the co-occurrence of extra-pulmonary diseases, yet the underlying pathophysiology of comorbidities is poorly understood. In COPD patients, the bronchial epithelium often displays cellular damage and is chronically inflamed. The current study aimed to identify differentially expressed genes in bronchial epithelium of COPD patients with and without comorbidities. To this end, a genome-wide differential gene expression analysis was performed on bronchial epithelial samples of 123 severe COPD patients with and without the following comorbidities: anxiety, atherosclerosis, depression, hypercholesterolemia, hypertension, muscle wasting, osteoporosis, and low BMI. COPD patients with osteoporosis displayed higher expression of\n                    <jats:italic>COL6A3<\/jats:italic>\n                    and lower expression of\n                    <jats:italic>PHEX<\/jats:italic>\n                    . Furthermore, COPD patients with hypercholesterolemia displayed a distinct bronchial epithelial gene expression profile, with 162 differentially expressed genes. No differentially expressed genes were identified for the other comorbidities. This study identified differentially expressed bronchial epithelial genes associated with osteoporosis and hypercholesterolemia in COPD patients.\n                  <\/jats:p>","DOI":"10.1007\/s00408-025-00814-6","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T14:15:44Z","timestamp":1745676944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome-Wide Differential Airway Gene Expression Analysis Identifies Genes Associated with COPD Comorbidities"],"prefix":"10.1007","volume":"203","author":[{"given":"Alen","family":"Faiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else A. M. 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The study was approved by the Medical Ethical committee of the University Medical Center Groningen (UMCG), the Netherlands (ECnumber: 2014\/102).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors affirm that all individual participants included in the study provided informed consent for publication of pseudonymized data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"58"}}