{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:46:21Z","timestamp":1766378781931,"version":"3.48.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"This research was supported by grants from the National Institutes of Health","award":["R01HL 141251"],"award-info":[{"award-number":["R01HL 141251"]}]},{"name":"This research was supported by grants from the National Institutes of Health","award":["R21 ES036349"],"award-info":[{"award-number":["R21 ES036349"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00408-025-00835-1","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T02:34:25Z","timestamp":1753324465000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence that Mast Cells Regulate the Cough Hypersensitivity Associated with Eosinophilic Bronchitis"],"prefix":"10.1007","volume":"203","author":[{"given":"Li","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan J.","family":"Canning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"issue":"8651","key":"835_CR1","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/s0140-6736(89)92801-8","volume":"1","author":"PG Gibson","year":"1989","unstructured":"Gibson PG, Dolovich J, Denburg J, Ramsdale EH, Hargreave FE (1989) Chronic cough: eosinophilic bronchitis without asthma. Lancet 1(8651):1346\u20131348. https:\/\/doi.org\/10.1016\/s0140-6736(89)92801-8","journal-title":"Lancet"},{"key":"835_CR2","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1365-2222.1995.tb01017.x","volume":"25","author":"PG Gibson","year":"1995","unstructured":"Gibson PG, Hargreave FE, Girgis-Gabardo A, Morris M, Denburg JA, Dolovich J (1995) Chronic cough with eosinophilic bronchitis: examination for variable airflow obstruction and response to corticosteroid. Clin Exp Allergy 25:127\u2013132. https:\/\/doi.org\/10.1111\/j.1365-2222.1995.tb01017.x","journal-title":"Clin Exp Allergy"},{"key":"835_CR3","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1164\/ajrccm.160.2.9810100","volume":"160","author":"CE Brightling","year":"1999","unstructured":"Brightling CE, Ward R, Goh KL, Wardlaw AJ, Pavord ID (1999) Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 160:406\u2013410. https:\/\/doi.org\/10.1164\/ajrccm.160.2.9810100","journal-title":"Am J Respir Crit Care Med"},{"key":"835_CR4","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1034\/j.1399-3003.2000.15d10.x","volume":"15","author":"CE Brightling","year":"2000","unstructured":"Brightling CE, Ward R, Wardlaw AJ, Pavord ID (2000) Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis. Eur Respir J 15:682\u2013686. https:\/\/doi.org\/10.1034\/j.1399-3003.2000.15d10.x","journal-title":"Eur Respir J"},{"key":"835_CR5","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.pupt.2008.12.001","volume":"22","author":"A Niimi","year":"2009","unstructured":"Niimi A, Matsumoto H, Mishima M (2009) Eosinophilic airway disorders associated with chronic cough. Pulm Pharmacol Ther 22:114\u2013120. https:\/\/doi.org\/10.1016\/j.pupt.2008.12.001","journal-title":"Pulm Pharmacol Ther"},{"key":"835_CR6","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1378\/chest.12-0441","volume":"143","author":"K Lai","year":"2013","unstructured":"Lai K et al (2013) A prospective, multicenter survey on causes of chronic cough in China. Chest 143:613\u2013620. https:\/\/doi.org\/10.1378\/chest.12-0441","journal-title":"Chest"},{"key":"835_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.chest.2019.12.021","volume":"158","author":"A C\u00f4t\u00e9","year":"2020","unstructured":"C\u00f4t\u00e9 A, Russell RJ, Boulet LP, Gibson PG, Lai K, Irwin RS, Brightling CE, CHEST Expert Cough Panel (2020) Managing chronic cough due to asthma and NAEB in adults and adolescents: CHEST guideline and expert panel report. Chest 158:68\u201396. https:\/\/doi.org\/10.1016\/j.chest.2019.12.021","journal-title":"Chest"},{"key":"835_CR8","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","volume":"557","author":"BJ Canning","year":"2004","unstructured":"Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004) Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557:543\u2013558. https:\/\/doi.org\/10.1113\/jphysiol.2003.057885","journal-title":"J Physiol"},{"key":"835_CR9","doi-asserted-by":"publisher","first-page":"13662","DOI":"10.1523\/JNEUROSCI.4354-08.2009","volume":"29","author":"SB Mazzone","year":"2009","unstructured":"Mazzone SB, Reynolds SM, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009) Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci 29:13662\u201313671. https:\/\/doi.org\/10.1523\/JNEUROSCI.4354-08.2009","journal-title":"J Neurosci"},{"key":"835_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1164\/rccm.201412-2293OC","volume":"192","author":"PW West","year":"2015","unstructured":"West PW, Canning BJ, Merlo-Pich E, Woodcock AA, Smith JA (2015) Morphologic characterization of nerves in whole-mount airway biopsies. Am J Respir Crit Care Med 192:30\u201339. https:\/\/doi.org\/10.1164\/rccm.201412-2293OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"835_CR11","doi-asserted-by":"publisher","first-page":"2301619","DOI":"10.1183\/13993003.01619-2023","volume":"63","author":"G Varricchi","year":"2024","unstructured":"Varricchi G, Brightling CE, Grainge C, Lambrecht BN, Chanez P (2024) Airway remodelling in asthma and the epithelium: on the edge of a new era. Eur Respir J 63(4):2301619. https:\/\/doi.org\/10.1183\/13993003.01619-2023","journal-title":"Eur Respir J"},{"key":"835_CR12","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1152\/jappl.2001.91.3.1318","volume":"91","author":"LY Lee","year":"2001","unstructured":"Lee LY, Gu Q, Gleich GJ (2001) Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung. J Appl Physiol 91:1318\u20131326. https:\/\/doi.org\/10.1152\/jappl.2001.91.3.1318","journal-title":"J Appl Physiol"},{"key":"835_CR13","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.rmed.2012.06.009","volume":"106","author":"C Cai","year":"2012","unstructured":"Cai C, He MZ, Zhong SQ, Tang Y, Sun BQ, Chen QL, Zhong NS (2012) Add-on montelukast vs double-dose budesonide in nonasthmatic eosinophilic bronchitis: a pilot study. Respir Med 106:1369\u20131375. https:\/\/doi.org\/10.1016\/j.rmed.2012.06.009","journal-title":"Respir Med"},{"key":"835_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4103\/0366-6999.147805","volume":"128","author":"W Bao","year":"2015","unstructured":"Bao W, Liu P, Qiu Z, Yu L, Hang J, Gao X, Zhou X (2015) Efficacy of add-on montelukast in nonasthmatic eosinophilic bronchitis: the additive effect on airway inflammation, cough and life quality. Chin Med J (Engl) 128:39\u201345. https:\/\/doi.org\/10.4103\/0366-6999.147805","journal-title":"Chin Med J (Engl)"},{"key":"835_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2019.101804","volume":"57","author":"LY Lee","year":"2019","unstructured":"Lee LY, Gu Q, Lin AH, Khosravi M, Gleich G (2019) Airway hypersensitivity induced by eosinophil granule-derived cationic proteins. Pulm Pharmacol Ther 57:101804. https:\/\/doi.org\/10.1016\/j.pupt.2019.101804","journal-title":"Pulm Pharmacol Ther"},{"key":"835_CR16","doi-asserted-by":"publisher","first-page":"R93","DOI":"10.1152\/ajpregu.00081.2019","volume":"317","author":"AH Lin","year":"2019","unstructured":"Lin AH, Athukorala A, Gleich GJ, Lee LY (2019) Cough responses to inhaled irritants are enhanced by eosinophil major basic protein in awake mice. Am J Physiol Regul Integr Comp Physiol 317:R93\u2013R97. https:\/\/doi.org\/10.1152\/ajpregu.00081.2019","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"835_CR17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0014-2999(95)00076-w","volume":"277","author":"DC Bolser","year":"1995","unstructured":"Bolser DC, DeGennaro FC, O\u2019Reilly S, Hey JA, Chapman RW (1995) Pharmacological studies of allergic cough in the guinea pig. Eur J Pharmacol 277:159\u2013164. https:\/\/doi.org\/10.1016\/0014-2999(95)00076-w","journal-title":"Eur J Pharmacol"},{"key":"835_CR18","first-page":"74","volume":"25","author":"Z Qiu","year":"2002","unstructured":"Qiu Z, Liu Q, Guo D, Fu X (2002) The effect of bradykinin B(2) receptor antagonist on cough reactivity in a sensitized guinea pig model. Zhonghua Jie He He Hu Xi Za Zhi 25:74\u201377","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"835_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1745-9974-2-10","volume":"2","author":"RL McLeod","year":"2006","unstructured":"McLeod RL, Fernandez X, Correll CC, Phelps TP, Jia Y, Wang X, Hey JA (2006) TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs. Cough 2:10. https:\/\/doi.org\/10.1186\/1745-9974-2-10","journal-title":"Cough"},{"key":"835_CR20","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.4049\/jimmunol.129.4.1632","volume":"129","author":"RP Schleimer","year":"1982","unstructured":"Schleimer RP, MacGlashan DW Jr, Gillespie E, Lichtenstein LM (1982) Inhibition of basophil histamine release by anti-inflammatory steroids. II. Studies on the mechanism of action. J Immunol 129:1632\u20131636","journal-title":"J Immunol"},{"key":"835_CR21","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1172\/jci110938","volume":"71","author":"RP Schleimer","year":"1983","unstructured":"Schleimer RP, Schulman ES, MacGlashan DW Jr, Peters SP, Hayes EC, Adams GK 3rd, Lichtenstein LM, Adkinson NF Jr (1983) Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. J Clin Invest 71:1830\u20131835. https:\/\/doi.org\/10.1172\/jci110938","journal-title":"J Clin Invest"},{"key":"835_CR22","doi-asserted-by":"publisher","first-page":"7626","DOI":"10.1073\/pnas.80.24.7626","volume":"80","author":"PF Weller","year":"1983","unstructured":"Weller PF, Lee CW, Foster DW, Corey EJ, Austen KF, Lewis RA (1983) Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Proc Natl Acad Sci USA 80:7626\u20137630. https:\/\/doi.org\/10.1073\/pnas.80.24.7626","journal-title":"Proc Natl Acad Sci USA"},{"key":"835_CR23","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1164\/ajrccm\/140.4.951","volume":"140","author":"VL Cohan","year":"1989","unstructured":"Cohan VL, Undem BJ, Fox CC, Adkinson NF Jr, Lichtenstein LM, Schleimer RP (1989) Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin. Am Rev Respir Dis 140:951\u2013954. https:\/\/doi.org\/10.1164\/ajrccm\/140.4.951","journal-title":"Am Rev Respir Dis"},{"key":"835_CR24","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.4049\/jimmunol.144.9.3489","volume":"144","author":"MA Giembycz","year":"1990","unstructured":"Giembycz MA, Kroegel C, Barnes PJ (1990) Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins. J Immunol 144:3489\u20133497","journal-title":"J Immunol"},{"key":"835_CR25","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1172\/JCI117986","volume":"95","author":"M Kaneko","year":"1995","unstructured":"Kaneko M, Swanson MC, Gleich GJ, Kita H (1995) Allergen-specific IgG1 and IgG3 through Fc gamma RII induce eosinophil degranulation. J Clin Invest 95:2813\u20132821. https:\/\/doi.org\/10.1172\/JCI117986","journal-title":"J Clin Invest"},{"key":"835_CR26","doi-asserted-by":"publisher","first-page":"6901","DOI":"10.4049\/jimmunol.162.11.6901","volume":"162","author":"H Kita","year":"1999","unstructured":"Kita H, Kaneko M, Bartemes KR, Weiler DA, Schimming AW, Reed CE, Gleich GJ (1999) Does IgE bind to and activate eosinophils from patients with allergy? J Immunol 162:6901\u20136911","journal-title":"J Immunol"},{"key":"835_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1254\/jjp.83.261","volume":"83","author":"T Nabe","year":"2000","unstructured":"Nabe T, Miura M, Kamiki T, Kohno S (2000) Arachidonate 5-lipoxygenase and cyclooxygenase metabolites from guinea pig eosinophils and macrophages. Jpn J Pharmacol 83:261\u2013264. https:\/\/doi.org\/10.1254\/jjp.83.261","journal-title":"Jpn J Pharmacol"},{"key":"835_CR28","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jaci.2023.10.014","volume":"153","author":"KD Chhiba","year":"2024","unstructured":"Chhiba KD, Kuang FL, Berdnikovs S, Kato A, Bochner BS (2024) Little to no mRNA for the alpha- or beta-chains of FcepsilonRI in human eosinophils. J Allergy Clin Immunol 153:533\u2013534. https:\/\/doi.org\/10.1016\/j.jaci.2023.10.014","journal-title":"J Allergy Clin Immunol"},{"key":"835_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1081\/jas-120002285","volume":"39","author":"PV Dicpinigaitis","year":"2002","unstructured":"Dicpinigaitis PV, Dobkin JB, Reichel J (2002) Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma. J Asthma 39:291\u2013297. https:\/\/doi.org\/10.1081\/jas-120002285","journal-title":"J Asthma"},{"key":"835_CR30","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S1081-1206(10)61493-7","volume":"93","author":"SL Spector","year":"2004","unstructured":"Spector SL, Tan RA (2004) Effectiveness of montelukast in the treatment of cough variant asthma. Ann Allergy Asthma Immunol 93:232\u2013236. https:\/\/doi.org\/10.1016\/S1081-1206(10)61493-7","journal-title":"Ann Allergy Asthma Immunol"},{"key":"835_CR31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2332\/allergolint.09-OA-0112","volume":"59","author":"T Kita","year":"2010","unstructured":"Kita T, Fujimura M, Ogawa H, Nakatsumi Y, Nomura S, Ishiura Y, Myou S, Nakao S (2010) Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic cough. Allergol Int 59:185\u2013192. https:\/\/doi.org\/10.2332\/allergolint.09-OA-0112","journal-title":"Allergol Int"},{"key":"835_CR32","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1159\/000332835","volume":"83","author":"M Takemura","year":"2012","unstructured":"Takemura M et al (2012) Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough variant asthma. Respiration 83:308\u2013315. https:\/\/doi.org\/10.1159\/000332835","journal-title":"Respiration"},{"key":"835_CR33","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.pupt.2013.06.003","volume":"26","author":"A Niimi","year":"2013","unstructured":"Niimi A (2013) Cough, asthma, and cysteinyl-leukotrienes. Pulm Pharmacol Ther 26:514\u2013519. https:\/\/doi.org\/10.1016\/j.pupt.2013.06.003","journal-title":"Pulm Pharmacol Ther"},{"key":"835_CR34","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1164\/ajrccm.157.5.9609014","volume":"157","author":"WJ Calhoun","year":"1998","unstructured":"Calhoun WJ, Lavins BJ, Minkwitz MC, Evans R, Gleich GJ, Cohn J (1998) Effect of zafirlukast (Accolate) on cellular mediators of inflammation: bronchoalveolar lavage fluid findings after segmental antigen challenge. Am J Respir Crit Care Med 157:1381\u20131389. https:\/\/doi.org\/10.1164\/ajrccm.157.5.9609014","journal-title":"Am J Respir Crit Care Med"},{"key":"835_CR35","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1164\/ajrccm.162.3.9909064","volume":"162","author":"CE Brightling","year":"2000","unstructured":"Brightling CE, Ward R, Woltmann G, Bradding P, Sheller JR, Dworski R, Pavord ID (2000) Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med 162:878\u2013882. https:\/\/doi.org\/10.1164\/ajrccm.162.3.9909064","journal-title":"Am J Respir Crit Care Med"},{"key":"835_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1164\/rccm.200308-1092OC","volume":"169","author":"SS Birring","year":"2004","unstructured":"Birring SS, Parker D, Brightling CE, Bradding P, Wardlaw AJ, Pavord ID (2004) Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med 169:15\u201319. https:\/\/doi.org\/10.1164\/rccm.200308-1092OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"7542","key":"835_CR37","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature14022","volume":"519","author":"BD McNeil","year":"2015","unstructured":"McNeil BD, Pundir P, Meeker S, Han L, Undem BJ, Kulka M, Dong X (2015) Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. Nature 519(7542):237\u2013241. https:\/\/doi.org\/10.1038\/nature14022","journal-title":"Nature"},{"key":"835_CR38","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejphar.2017.11.017","volume":"822","author":"L Yu","year":"2018","unstructured":"Yu L, Liu Q, Canning BJ (2018) Evidence for autocrine and paracrine regulation of allergen-induced mast cell mediator release in the guinea pig airways. Eur J Pharmacol 822:108\u2013118. https:\/\/doi.org\/10.1016\/j.ejphar.2017.11.017","journal-title":"Eur J Pharmacol"},{"key":"835_CR39","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1183\/09031936.95.08091499","volume":"8","author":"M Fujimura","year":"1995","unstructured":"Fujimura M, Kamio Y, Kasahara K, Bando T, Hashimoto T, Matsuda T (1995) Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. Eur Respir J 8:1499\u20131505","journal-title":"Eur Respir J"},{"issue":"9070","key":"835_CR40","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0140-6736(96)12045-6","volume":"350","author":"PL Malini","year":"1997","unstructured":"Malini PL, Strocchi E, Zanardi M, Milani M, Ambrosioni E (1997) Thromboxane antagonism and cough induced by angiotensin-converting-enzyme inhibitor. Lancet 350(9070):15\u201318. https:\/\/doi.org\/10.1016\/S0140-6736(96)12045-6","journal-title":"Lancet"},{"key":"835_CR41","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/s0024-3205(97)00124-0","volume":"60","author":"K Umemura","year":"1997","unstructured":"Umemura K, Nakashima M, Saruta T (1997) Thromboxane A2 synthetase inhibition suppresses cough induced by angiotensin converting enzyme inhibitors. Life Sci 60:1583\u20131588. https:\/\/doi.org\/10.1016\/s0024-3205(97)00124-0","journal-title":"Life Sci"},{"key":"835_CR42","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/sj.bjp.0703553","volume":"131","author":"K Shinagawa","year":"2000","unstructured":"Shinagawa K, Kojima M, Ichikawa K, Hiratochi M, Aoyagi S, Akahane M (2000) Participation of thromboxane A(2) in the cough response in guinea-pigs: antitussive effect of ozagrel. Br J Pharmacol 131:266\u2013270. https:\/\/doi.org\/10.1038\/sj.bjp.0703553","journal-title":"Br J Pharmacol"},{"key":"835_CR43","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1046\/j.1365-2222.2001.00989.x","volume":"31","author":"Q Liu","year":"2001","unstructured":"Liu Q, Fujimura M, Tachibana H, Myou S, Kasahara K, Yasui M (2001) Characterization of increased cough sensitivity after antigen challenge in guinea pigs. Clin Exp Allergy 31:474\u2013484. https:\/\/doi.org\/10.1046\/j.1365-2222.2001.00989.x","journal-title":"Clin Exp Allergy"},{"key":"835_CR44","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1152\/jappl.2002.92.2.763","volume":"92","author":"A Xiang","year":"2002","unstructured":"Xiang A et al (2002) Involvement of thromboxane A(2) in airway mucous cells in asthma-related cough. J Appl Physiol 92:763\u2013770. https:\/\/doi.org\/10.1152\/jappl.2002.92.2.763","journal-title":"J Appl Physiol"},{"key":"835_CR45","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/07853890310010032","volume":"35","author":"Y Ishiura","year":"2003","unstructured":"Ishiura Y, Fujimura M, Yamamori C, Nobata K, Myou S, Kurashima K, Takegoshi T (2003) Thromboxane antagonism and cough in chronic bronchitis. Ann Med 35:135\u2013139. https:\/\/doi.org\/10.1080\/07853890310010032","journal-title":"Ann Med"},{"key":"835_CR46","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1164\/arrd.1987.135.3.562","volume":"135","author":"RP Schleimer","year":"1987","unstructured":"Schleimer RP, Undem BJ, Meeker S, Bollinger ME, Adkinson NF Jr, Lichtenstein LM, Adams GK 3rd (1987) Dexamethasone inhibits the antigen-induced contractile activity and release of inflammatory mediators in isolated guinea pig lung tissue. Am Rev Respir Dis 135:562\u2013566. https:\/\/doi.org\/10.1164\/arrd.1987.135.3.562","journal-title":"Am Rev Respir Dis"},{"key":"835_CR47","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0014-2999(89)90045-9","volume":"159","author":"RD Krell","year":"1989","unstructured":"Krell RD, Kusner EJ, Aharony D, Giles RE (1989) Biochemical and pharmacological characterization of ICI 198,615: a peptide leukotriene receptor antagonist. Eur J Pharmacol 159:73\u201381. https:\/\/doi.org\/10.1016\/0014-2999(89)90045-9","journal-title":"Eur J Pharmacol"},{"key":"835_CR48","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/S0022-3565(25)23130-5","volume":"255","author":"JB Cheng","year":"1990","unstructured":"Cheng JB, Pillar JS, Conklyn MJ, Breslow R, Shirley JT, Showell HJ (1990) Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs. J Pharmacol Exp Ther 255:664\u2013671","journal-title":"J Pharmacol Exp Ther"},{"key":"835_CR49","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1124\/jpet.115.230383","volume":"357","author":"MM Hewitt","year":"2016","unstructured":"Hewitt MM, Adams G Jr, Mazzone SB, Mori N, Yu L, Canning BJ (2016) Pharmacology of Bradykinin-Evoked coughing in guinea pigs. J Pharmacol Exp Ther 357:620\u2013628. https:\/\/doi.org\/10.1124\/jpet.115.230383","journal-title":"J Pharmacol Exp Ther"},{"key":"835_CR50","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1136\/thorax.56.5.351","volume":"56","author":"AE Redington","year":"2001","unstructured":"Redington AE et al (2001) Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax 56:351\u2013357. https:\/\/doi.org\/10.1136\/thorax.56.5.351","journal-title":"Thorax"},{"key":"835_CR51","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1164\/ajrccm.165.3.2103093","volume":"165","author":"T Oguma","year":"2002","unstructured":"Oguma T et al (2002) Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs. Am J Respir Crit Care Med 165:382\u2013386. https:\/\/doi.org\/10.1164\/ajrccm.165.3.2103093","journal-title":"Am J Respir Crit Care Med"},{"key":"835_CR52","doi-asserted-by":"publisher","first-page":"1701655","DOI":"10.1183\/13993003.01655-2017","volume":"50","author":"A Agust\u00ed","year":"2017","unstructured":"Agust\u00ed A et al (2017) Precision medicine in airway diseases: moving to clinical practice. Eur Respir J 50:1701655. https:\/\/doi.org\/10.1183\/13993003.01655-2017","journal-title":"Eur Respir J"},{"key":"835_CR53","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/all.15679","volume":"78","author":"J Bousquet","year":"2023","unstructured":"Bousquet J et al (2023) Rhinitis associated with asthma is distinct from rhinitis alone: the ARIA-MeDALL hypothesis. Allergy 78:1169\u20131203. https:\/\/doi.org\/10.1111\/all.15679","journal-title":"Allergy"},{"key":"835_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaip.2022.09.034","volume":"11","author":"ID Pavord","year":"2023","unstructured":"Pavord ID, Barnes PJ, Lemi\u00e8re C, Gibson PG (2023) Diagnosis and assessment of the asthmas. J Allergy Clin Immunol Pract 11:1\u20138. https:\/\/doi.org\/10.1016\/j.jaip.2022.09.034","journal-title":"J Allergy Clin Immunol Pract"},{"key":"835_CR55","doi-asserted-by":"publisher","first-page":"1939","DOI":"10.1046\/j.1365-2222.2001.01241.x","volume":"31","author":"S Myou","year":"2001","unstructured":"Myou S et al (2001) Effects of suplatast tosilate, a new type of anti-allergic agent, on airway cough hypersensitivity induced by airway allergy in guinea-pigs. Clin Exp Allergy 31:1939\u20131944. https:\/\/doi.org\/10.1046\/j.1365-2222.2001.01241.x","journal-title":"Clin Exp Allergy"},{"issue":"Supplement 3","key":"835_CR56","first-page":"23","volume":"55","author":"M Brozmanova","year":"2004","unstructured":"Brozmanova M, Calkovsky V, Plevkova J, Tatar M (2004) Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis\u2013the first experience. J Physiol Pharmacol 55(Supplement 3):23\u201330","journal-title":"J Physiol Pharmacol"},{"issue":"Supplement 4","key":"835_CR57","first-page":"21","volume":"56","author":"M Brozmanova","year":"2005","unstructured":"Brozmanova M, Plevkova J, Bartos V, Plank L, Tatar M (2005) Antileukotriene treatment and allergic rhinitis-related cough in guinea pigs. J Physiol Pharmacol 56(Supplement 4):21\u201330","journal-title":"J Physiol Pharmacol"},{"issue":"Supplement 6","key":"835_CR58","first-page":"153","volume":"59","author":"M Brozmanova","year":"2008","unstructured":"Brozmanova M, Plevkova J, Tatar M, Kollarik M (2008) Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. J Physiol Pharmacol 59(Supplement 6):153\u2013161","journal-title":"J Physiol Pharmacol"},{"key":"835_CR59","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.1365-2222.2005.02158.x","volume":"35","author":"Y Oribe","year":"2005","unstructured":"Oribe Y, Fujimura M, Kita T, Katayama N, Nishitsuji M, Hara J, Myou S, Nakao S (2005) Attenuating effect of H+K+ATPase inhibitors on airway cough hypersensitivity induced by allergic airway inflammation in guinea-pigs. Clin Exp Allergy 35:262\u2013267. https:\/\/doi.org\/10.1111\/j.1365-2222.2005.02158.x","journal-title":"Clin Exp Allergy"},{"key":"835_CR60","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.pupt.2007.01.005","volume":"21","author":"M Nishitsuji","year":"2008","unstructured":"Nishitsuji M, Fujimura M, Oribe Y, Nakao S (2008) Effect of montelukast in a guinea pig model of cough variant asthma. Pulm Pharmacol Ther 21:142\u2013145. https:\/\/doi.org\/10.1016\/j.pupt.2007.01.005","journal-title":"Pulm Pharmacol Ther"},{"key":"835_CR61","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4149\/gpb_2013018","volume":"32","author":"M Sutovsk\u00e1","year":"2013","unstructured":"Sutovsk\u00e1 M et al (2013) The long-term administration of Orai 1 antagonist possesses antitussive, bronchodilatory and anti-inflammatory effects in experimental asthma model. Gen Physiol Biophys 32:251\u2013259","journal-title":"Gen Physiol Biophys"},{"key":"835_CR62","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/5584_2016_217","volume":"905","author":"T Buday","year":"2016","unstructured":"Buday T, Gavliakova S, Mokry J, Medvedova I, Kavalcikova-Bogdanova N, Plevkova J (2016) The guinea pig sensitized by house dust mite: a model of experimental cough studies. Adv Exp Med Biol 905:87\u201395. https:\/\/doi.org\/10.1007\/5584_2016_217","journal-title":"Adv Exp Med Biol"},{"key":"835_CR63","doi-asserted-by":"publisher","first-page":"10557","DOI":"10.1038\/s41598-020-67475-8","volume":"10","author":"L Chen","year":"2020","unstructured":"Chen L, Li C, Peng M, Xie J, Lai K, Zhong N (2020) Establishment of a mouse model with all four clinical features of eosinophilic bronchitis. Sci Rep 10:10557. https:\/\/doi.org\/10.1038\/s41598-020-67475-8","journal-title":"Sci Rep"},{"key":"835_CR64","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.pupt.2010.11.001","volume":"24","author":"CE Brightling","year":"2011","unstructured":"Brightling CE (2011) Eosinophils, bronchitis and asthma: pathogenesis of cough and airflow obstruction. Pulm Pharmacol Ther 24:324\u2013327. https:\/\/doi.org\/10.1016\/j.pupt.2010.11.001","journal-title":"Pulm Pharmacol Ther"},{"key":"835_CR65","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1465","volume":"147","author":"WJ Calhoun","year":"1993","unstructured":"Calhoun WJ, Jarjour NN, Gleich GJ, Stevens CA, Busse WW (1993) Increased airway inflammation with segmental versus aerosol antigen challenge. Am Rev Respir Dis 147:1465\u20131471. https:\/\/doi.org\/10.1164\/ajrccm\/147.6_Pt_1.1465","journal-title":"Am Rev Respir Dis"},{"key":"835_CR66","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1164\/ajrccm.152.4.7551369","volume":"152","author":"JR Shaver","year":"1995","unstructured":"Shaver JR, O\u2019Connor JJ, Pollice M, Cho SK, Kane GC, Fish JE, Peters SP (1995) Pulmonary inflammation after segmental ragweed challenge in allergic asthmatic and nonasthmatic subjects. Am J Respir Crit Care Med 152:1189\u20131197. https:\/\/doi.org\/10.1164\/ajrccm.152.4.7551369","journal-title":"Am J Respir Crit Care Med"},{"key":"835_CR67","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1046\/j.1365-2745.2002.01508.x","volume":"32","author":"ME Boulay","year":"2002","unstructured":"Boulay ME, Boulet LP (2002) Lower airway inflammatory responses to repeated very-low-dose allergen challenge in allergic rhinitis and asthma. Clin Exp Allergy 32:1441\u20131447. https:\/\/doi.org\/10.1046\/j.1365-2745.2002.01508.x","journal-title":"Clin Exp Allergy"},{"key":"835_CR68","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000632","volume":"7","author":"R Nadif","year":"2020","unstructured":"Nadif R et al (2020) Endotypes identified by cluster analysis in asthmatics and non-asthmatics and their clinical characteristics at follow-up: the case-control EGEA study. BMJ Open Respir Res 7:e000632. https:\/\/doi.org\/10.1136\/bmjresp-2020-000632","journal-title":"BMJ Open Respir Res"},{"key":"835_CR69","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1136\/gut.2009.178558","volume":"59","author":"A Straumann","year":"2010","unstructured":"Straumann A et al (2010) Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut 59:21\u201330. https:\/\/doi.org\/10.1136\/gut.2009.178558","journal-title":"Gut"},{"key":"835_CR70","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/apt.13147","volume":"41","author":"T Sawas","year":"2015","unstructured":"Sawas T, Dhalla S, Sayyar M, Pasricha PJ, Hernaez R (2015) Systematic review with meta-analysis: pharmacological interventions for eosinophilic oesophagitis. Aliment Pharmacol Ther 41:797\u2013806. https:\/\/doi.org\/10.1111\/apt.13147","journal-title":"Aliment Pharmacol Ther"},{"key":"835_CR71","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1053\/j.gastro.2020.02.039","volume":"158","author":"MA Rank","year":"2020","unstructured":"Rank MA et al (2020) Technical review on the management of eosinophilic esophagitis: a report From the AGA institute and the joint task force on allergy-immunology practice parameters. Gastroenterology 158:1789\u20131810. https:\/\/doi.org\/10.1053\/j.gastro.2020.02.039","journal-title":"Gastroenterology"},{"key":"835_CR72","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1136\/gutjnl-2023-330337","volume":"72","author":"ES Dellon","year":"2023","unstructured":"Dellon ES et al (2023) Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Gut 72:1828\u20131837. https:\/\/doi.org\/10.1136\/gutjnl-2023-330337","journal-title":"Gut"},{"key":"835_CR73","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1056\/NEJMoa2313318","volume":"390","author":"ME Rothenberg","year":"2024","unstructured":"Rothenberg ME et al (2024) Eosinophil depletion with benralizumab for eosinophilic esophagitis. N Engl J Med 390:2252\u20132263. https:\/\/doi.org\/10.1056\/NEJMoa2313318","journal-title":"N Engl J Med"},{"key":"835_CR74","doi-asserted-by":"publisher","first-page":"11515","DOI":"10.1073\/pnas.1411032111","volume":"111","author":"D Tr\u00e4nkner","year":"2014","unstructured":"Tr\u00e4nkner D, Hahne N, Sugino K, Hoon MA, Zuker C (2014) Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways. Proc Natl Acad Sci USA 111:11515\u201311520. https:\/\/doi.org\/10.1073\/pnas.1411032111","journal-title":"Proc Natl Acad Sci USA"},{"key":"835_CR75","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1164\/rccm.201912-2347OC","volume":"203","author":"CO Shapiro","year":"2021","unstructured":"Shapiro CO et al (2021) Airway sensory nerve density is increased in chronic cough. Am J Respir Crit Care Med 203:348\u2013355. https:\/\/doi.org\/10.1164\/rccm.201912-2347OC","journal-title":"Am J Respir Crit Care Med"},{"key":"835_CR76","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.otc.2022.09.011","volume":"56","author":"AM Donaldson","year":"2023","unstructured":"Donaldson AM (2023) Upper airway cough syndrome. Otolaryngol Clin North Am 56:147\u2013155. https:\/\/doi.org\/10.1016\/j.otc.2022.09.011","journal-title":"Otolaryngol Clin North Am"},{"key":"835_CR77","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.anai.2023.04.022","volume":"131","author":"K Ito","year":"2023","unstructured":"Ito K et al (2023) Targeting the interleukin-5 pathway improves cough hypersensitivity in patients with severe uncontrolled asthma. Ann Allergy Asthma Immunol 131:203\u2013208. https:\/\/doi.org\/10.1016\/j.anai.2023.04.022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"835_CR78","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.ejphar.2004.03.053","volume":"492","author":"A House","year":"2004","unstructured":"House A, Celly C, Skeans S, Lamca J, Egan RW, Hey JA, Chapman RW (2004) Cough reflex in allergic dogs. Eur J Pharmacol 492:251\u2013258. https:\/\/doi.org\/10.1016\/j.ejphar.2004.03.053","journal-title":"Eur J Pharmacol"},{"key":"835_CR79","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ejphar.2006.07.034","volume":"547","author":"J Kamei","year":"2006","unstructured":"Kamei J, Takahashi Y (2006) Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. Eur J Pharmacol 547:160\u2013164. https:\/\/doi.org\/10.1016\/j.ejphar.2006.07.034","journal-title":"Eur J Pharmacol"},{"key":"835_CR80","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/0091-6749(88)90198-4","volume":"81","author":"R Bascom","year":"1988","unstructured":"Bascom R, Wachs M, Naclerio RM, Pipkorn U, Galli SJ, Lichtenstein LM (1988) Basophil influx occurs after nasal antigen challenge: effects of topical corticosteroid pretreatment. J Allergy Clin Immunol 81:580\u2013589","journal-title":"J Allergy Clin Immunol"},{"key":"835_CR81","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1165\/ajrcmb.10.4.7510984","volume":"10","author":"CB Guo","year":"1994","unstructured":"Guo CB, Liu MC, Galli SJ, Bochner BS, Kagey-Sobotka A, Lichtenstein LM (1994) Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils. Am J Respir Cell Mol Biol 10:384\u2013390. https:\/\/doi.org\/10.1165\/ajrcmb.10.4.7510984","journal-title":"Am J Respir Cell Mol Biol"},{"key":"835_CR82","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.jaci.2009.09.012","volume":"125","author":"JA Eckman","year":"2010","unstructured":"Eckman JA, Sterba PM, Kelly D, Alexander V, Liu MC, Bochner BS, Macglashan DW Jr, Saini SS (2010) Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge. J Allergy Clin Immunol 125:889\u2013895. https:\/\/doi.org\/10.1016\/j.jaci.2009.09.012","journal-title":"J Allergy Clin Immunol"},{"key":"835_CR83","doi-asserted-by":"publisher","unstructured":"Wang JC, Nikpoor AR, Crosson T, Kaufmann E, Rafei M, Talbot S (2024) Basophils activate pruriceptor-like vagal sensory neurons. Preprint at bioRxiv 2024.06.11.598517. https:\/\/doi.org\/10.1101\/2024.06.11.598517.","DOI":"10.1101\/2024.06.11.598517"},{"key":"835_CR84","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.cell.2020.12.033","volume":"184","author":"F Wang","year":"2021","unstructured":"Wang F et al (2021) A basophil-neuronal axis promotes itch. Cell 184:422\u2013440. https:\/\/doi.org\/10.1016\/j.cell.2020.12.033","journal-title":"Cell"},{"key":"835_CR85","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.1073\/pnas.1019418108","volume":"108","author":"G Krasteva","year":"2011","unstructured":"Krasteva G et al (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci USA 108:9478\u20139483. https:\/\/doi.org\/10.1073\/pnas.1019418108","journal-title":"Proc Natl Acad Sci USA"},{"key":"835_CR86","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1096\/fj.201901314RR","volume":"34","author":"MI Hollenhorst","year":"2020","unstructured":"Hollenhorst MI et al (2020) Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling. FASEB J 34:316\u2013332. https:\/\/doi.org\/10.1096\/fj.201901314RR","journal-title":"FASEB J"},{"issue":"43","key":"835_CR87","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax7224","volume":"5","author":"S Ualiyeva","year":"2020","unstructured":"Ualiyeva S et al (2020) Airway\u00a0brush\u00a0cells\u00a0generate cysteinyl\u00a0leukotrienes\u00a0through the ATP sensor P2Y2. Sci Immunol 5(43):eaax7224. https:\/\/doi.org\/10.1126\/sciimmunol.aax7224","journal-title":"Sci Immunol"},{"issue":"66","key":"835_CR88","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abj0474","volume":"6","author":"S Ualiyeva","year":"2021","unstructured":"Ualiyeva S et al (2021) Tuft\u00a0cell-produced cysteinyl\u00a0leukotrienes\u00a0and IL-25 synergistically initiate lung type 2 inflammation. Sci Immunol 6(66):eabj0474. https:\/\/doi.org\/10.1126\/sciimmunol.abj0474","journal-title":"Sci Immunol"},{"issue":"1","key":"835_CR89","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41467-025-55936-5","volume":"16","author":"N Abdel Wadood","year":"2025","unstructured":"Abdel Wadood N et al (2025) Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia. Nat Commun 16(1):584. https:\/\/doi.org\/10.1038\/s41467-025-55936-5","journal-title":"Nat Commun"},{"issue":"7","key":"835_CR90","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1136\/thx.39.7.500","volume":"39","author":"NC Barnes","year":"1997","unstructured":"Barnes NC, Piper PJ, Costello JF (1997) Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. Thorax 39(7):500\u2013504. https:\/\/doi.org\/10.1136\/thx.39.7.500","journal-title":"Thorax"},{"issue":"11","key":"835_CR91","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13391","volume":"30","author":"RT Filippone","year":"2018","unstructured":"Filippone RT, Robinson AM, Jovanovska V et al (2018) Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs. Neurogastroenterol Motil 30(11):e13391. https:\/\/doi.org\/10.1111\/nmo.13391","journal-title":"Neurogastroenterol Motil"},{"issue":"1","key":"835_CR92","doi-asserted-by":"publisher","first-page":"18924","DOI":"10.1038\/s41598-022-23486-1","volume":"12","author":"J Liu","year":"2022","unstructured":"Liu J, Nie M, Dong C, S\u00e4fholm J, Pejler G, Nilsson G, Adner M (2022) Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models. Sci Rep 12(1):18924. https:\/\/doi.org\/10.1038\/s41598-022-23486-1","journal-title":"Sci Rep"},{"key":"835_CR93","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1006\/pupt.2000.0274","volume":"14","author":"PV Dicpinigaitis","year":"2001","unstructured":"Dicpinigaitis PV (2001) Effect of the cyclooxygenase-2 inhibitor celecoxib on bronchial responsiveness and cough reflex sensitivity in asthmatics. Pulm Pharmacol Ther 14:93\u201397. https:\/\/doi.org\/10.1006\/pupt.2000.0274","journal-title":"Pulm Pharmacol Ther"},{"key":"835_CR94","first-page":"370","volume":"19","author":"Y Ishiura","year":"2009","unstructured":"Ishiura Y, Fujimura M, Yamamoto H, Ishiguro T, Ohkura N, Myou S (2009) COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. J Investig Allergol Clin Immunol 19:370\u2013374","journal-title":"J Investig Allergol Clin Immunol"},{"key":"835_CR95","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1745-9974-6-7","volume":"6","author":"Y Ishiura","year":"2010","unstructured":"Ishiura Y, Fujimura M, Yamamoto H, Ohkura N, Myou S (2010) Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome. Cough 6:7. https:\/\/doi.org\/10.1186\/1745-9974-6-7","journal-title":"Cough"},{"key":"835_CR96","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1517\/13543784.11.2.275","volume":"11","author":"JM Dogn\u00e9","year":"2002","unstructured":"Dogn\u00e9 JM, de Leval X, Benoit P, Rolin S, Pirotte B, Masereel B (2002) Therapeutic potential of thromboxane inhibitors in asthma. Expert Opin Investig Drugs 11:275\u2013281. https:\/\/doi.org\/10.1517\/13543784.11.2.275","journal-title":"Expert Opin Investig Drugs"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-025-00835-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00408-025-00835-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-025-00835-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:42:37Z","timestamp":1766378557000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00408-025-00835-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["835"],"URL":"https:\/\/doi.org\/10.1007\/s00408-025-00835-1","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"type":"print","value":"0341-2040"},{"type":"electronic","value":"1432-1750"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"17 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"82"}}