{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:42Z","timestamp":1787775882905,"version":"build-2784847793"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Catholic Medical Center Research Foundation made in the program year of 2024."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lung"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00408-025-00839-x","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T07:47:07Z","timestamp":1753343227000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Airway Mucus Plugs in Patients with Chronic Cough: A Single-Center Observational Study"],"prefix":"10.1007","volume":"203","author":[{"given":"Kyongmin Sarah","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hee","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Seob","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyoung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jung","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"issue":"21","key":"839_CR1","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1001\/jama.2023.2065","volume":"329","author":"AA Diaz","year":"2023","unstructured":"Diaz AA, Orejas JL, Grumley S et al (2023) Airway-occluding mucus plugs and mortality in patients with chronic obstructive pulmonary disease. JAMA 329(21):1832\u20131839","journal-title":"JAMA"},{"issue":"3","key":"839_CR2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.chest.2024.04.023","volume":"166","author":"HK Kooner","year":"2024","unstructured":"Kooner HK, Serajeddini H, Eddy RL, Yamashita C, Svenningsen S, Parraga G (2024) Airway mucus in older people without chronic respiratory illness. Chest 166(3):429\u2013432","journal-title":"Chest"},{"issue":"9","key":"839_CR3","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1164\/rccm.202110-2265OC","volume":"205","author":"M Tang","year":"2022","unstructured":"Tang M, Elicker BM, Henry T et al (2022) Mucus plugs persist in asthma, and changes in mucus plugs associate with changes in airflow over time. Am J Respir Crit Care Med 205(9):1036\u20131045","journal-title":"Am J Respir Crit Care Med"},{"key":"839_CR4","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.174124","author":"BK Huang","year":"2024","unstructured":"Huang BK, Elicker BM, Henry TS et al (2024) Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.174124","journal-title":"JCI Insight"},{"issue":"6","key":"839_CR5","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1007\/s00330-020-06664-5","volume":"30","author":"K Okumura","year":"2020","unstructured":"Okumura K, Ogawa H, Yoshie Y, Nadamura T, Igarashi T, Tone K, Kozaka K, Koda W, Kobayashi S, Gabata T (2020) Mucus plugs and bronchial wall thickening on three-dimensional computed tomography in patients with unexplained chronic cough whose sputum yielded filamentous Basidiomycetes. Eur Radiol 30(6):3268\u20133276","journal-title":"Eur Radiol"},{"issue":"9","key":"839_CR6","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.rmed.2015.05.020","volume":"109","author":"MJ Martin","year":"2015","unstructured":"Martin MJ, Harrison TW (2015) Causes of chronic productive cough: an approach to management. Respir Med 109(9):1105\u20131113","journal-title":"Respir Med"},{"issue":"Suppl 6","key":"839_CR7","doi-asserted-by":"publisher","first-page":"s3","DOI":"10.1136\/thorax-2023-220592","volume":"78","author":"SM Parker","year":"2023","unstructured":"Parker SM, Smith JA, Birring SS et al (2023) British Thoracic Society clinical statement on chronic cough in adults. Thorax 78(Suppl 6):s3\u2013s19","journal-title":"Thorax"},{"issue":"5","key":"839_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00408-023-00644-4","volume":"201","author":"EJ Jo","year":"2023","unstructured":"Jo EJ, Lee JH, Won HK et al (2023) Baseline cohort profile of the Korean chronic cough registry: a multicenter, prospective, observational study. Lung 201(5):477\u2013488","journal-title":"Lung"},{"issue":"6","key":"839_CR9","doi-asserted-by":"publisher","first-page":"00468","DOI":"10.1183\/23120541.00468-2024","volume":"10","author":"B Hirons","year":"2024","unstructured":"Hirons B, Cho PSP, Kr\u00e4geloh C, Siegert RJ, Turner R, Rhatigan K, Kesavan H, Mackay E, Won H-K, Kim J-Y, Song W-J, Birring SS (2024) The development of the cough hypersensitivity questionnaire (CHQ) for chronic cough. ERJ Open Res 10(6):00468\u201302024","journal-title":"ERJ Open Res"},{"issue":"3","key":"839_CR10","doi-asserted-by":"publisher","first-page":"230","DOI":"10.4168\/aair.2015.7.3.230","volume":"7","author":"JW Kwon","year":"2015","unstructured":"Kwon JW, Moon JY, Kim SH et al (2015) Reliability and validity of a Korean version of the Leicester cough questionnaire. Allergy Asthma Immunol Res 7(3):230\u2013233","journal-title":"Allergy Asthma Immunol Res"},{"issue":"1","key":"839_CR11","doi-asserted-by":"publisher","first-page":"1901136","DOI":"10.1183\/13993003.01136-2019","volume":"55","author":"AH Morice","year":"2020","unstructured":"Morice AH, Millqvist E, Bieksiene K et al (2020) ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J 55(1):1901136","journal-title":"Eur Respir J"},{"issue":"6","key":"839_CR12","doi-asserted-by":"publisher","first-page":"591","DOI":"10.4168\/aair.2018.10.6.591","volume":"10","author":"DJ Song","year":"2018","unstructured":"Song DJ, Song W-J, Kwon J-W et al (2018) KAAACI evidence-based clinical practice guidelines for chronic cough in adults and children in Korea. Allergy Asthma Immunol Res 10(6):591\u2013613","journal-title":"Allergy Asthma Immunol Res"},{"key":"839_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.08.046","author":"K Rhatigan","year":"2023","unstructured":"Rhatigan K, Hirons B, Kesavan H, Turner RD, Ebelthite C, Hull JH, Jolley CJ, Birring SS, Cho PSP (2023) Patient global impression of severity scale in chronic cough: validation and formulation of symptom severity categories. J Allergy Clin Immunol Pract. https:\/\/doi.org\/10.1016\/j.jaip.2023.08.046","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"2","key":"839_CR14","doi-asserted-by":"publisher","first-page":"196","DOI":"10.4168\/aair.2022.14.2.196","volume":"14","author":"K Tamura","year":"2022","unstructured":"Tamura K, Shirai T, Hirai K, Nakayasu H, Takahashi S, Kishimoto Y, Akamatsu T, Asada K, Kato S (2022) Mucus plugs and small airway dysfunction in asthma, COPD, and asthma-COPD overlap. Allergy Asthma Immunol Res 14(2):196\u2013209","journal-title":"Allergy Asthma Immunol Res"},{"issue":"3","key":"839_CR15","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1172\/JCI95693","volume":"128","author":"EM Dunican","year":"2018","unstructured":"Dunican EM, Elicker BM, Gierada DS et al (2018) Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction. J Clin Invest 128(3):997\u20131009","journal-title":"J Clin Invest"},{"key":"839_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2022.106982","volume":"202","author":"C Tran","year":"2022","unstructured":"Tran C, Singh GV, Haider E, Boylan C, Venegas C, Riaz S, Al Duwaiki S, Yehia M, Ho T, Nair P, Svenningsen S, Kirby M (2022) Luminal mucus plugs are spatially associated with airway wall thickening in severe COPD and asthma: a single-centered, retrospective, observational study. Respir Med 202:106982","journal-title":"Respir Med"},{"issue":"10","key":"839_CR17","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2300135","volume":"2","author":"LH Nordenmark","year":"2023","unstructured":"Nordenmark LH, Hellqvist A, Emson C et al (2023) Tezepelumab and mucus plugs in patients with moderate-to-severe asthma. NEJM Evid 2(10):EVIDoa2300135","journal-title":"NEJM Evid"},{"issue":"3","key":"839_CR18","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1183\/09031936.93.05030296","volume":"5","author":"NB Choudry","year":"1992","unstructured":"Choudry NB, Fuller RW (1992) Sensitivity of the cough reflex in patients with chronic cough. Eur Respir J 5(3):296\u2013300","journal-title":"Eur Respir J"}],"container-title":["Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-025-00839-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00408-025-00839-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00408-025-00839-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T04:43:23Z","timestamp":1766378603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00408-025-00839-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["839"],"URL":"https:\/\/doi.org\/10.1007\/s00408-025-00839-x","relation":{},"ISSN":["0341-2040","1432-1750"],"issn-type":[{"value":"0341-2040","type":"print"},{"value":"1432-1750","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"5 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"WJ Song declares grants from Merck Sharp & Dohme Corp. and AstraZeneca, consulting fees from Merck, Bellus, AstraZeneca, Shionogi, and GSK, and lecture fees from Merck, AstraZeneca, GSK, Sanofi, and Novartis. Other authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"83"}}