{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T11:51:57Z","timestamp":1777204317982,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T00:00:00Z","timestamp":1128988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiat Environ Biophys"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s00411-005-0017-0","type":"journal-article","created":{"date-parts":[[2005,10,10]],"date-time":"2005-10-10T05:14:37Z","timestamp":1128921277000},"page":"219-224","source":"Crossref","is-referenced-by-count":28,"title":["Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts\u2019 lymphocytes"],"prefix":"10.1007","volume":"44","author":[{"given":"M.","family":"Horstmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Durante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Johannes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pieper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Obe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,10,11]]},"reference":[{"key":"17_CR1","unstructured":"NCRP (2000) Radiation protection guidance for activities in low-Earth orbit. NCRP Report No. 132, Bethesda, Maryland"},{"key":"17_CR2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.asr.2003.10.053","volume":"34","author":"FA Cucinotta","year":"2004","unstructured":"Cucinotta FA, Schimmerling W, Wilson JW, Peterson LE, Saganti PB, Dicello JF (2004) Uncertainties in estimates of the risks of late effects from space radiation. Adv Space Res 34:1383\u20131389","journal-title":"Adv Space Res"},{"key":"17_CR3","unstructured":"NCRP (2002) Operational radiation safety program for astronauts in low Earth orbit: a Basic Framework. NCRP Report No. 142, Bethesda, Maryland"},{"key":"17_CR4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/095530096144879","volume":"70","author":"I Testard","year":"1996","unstructured":"Testard I, Ricoul M, Hoffschir F, Flury-Herard A, Dutrillaux B, Fedorenko B, Gerasimenko V, Sabatier L (1996) Radiation-induced chromosome damage in astronauts\u2019 lymphocytes. Int J Radiat Biol 70:403\u2013411","journal-title":"Int J Radiat Biol"},{"key":"17_CR5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/095530097142889","volume":"72","author":"G Obe","year":"1997","unstructured":"Obe G, Johannes I, Johannes C, Hallman K, Reitz G, Facius R (1997) Chromosomal aberrations in blood lymphocytes of astronauts after long-term space flights. Int J Radiat Biol 72:727\u2013734","journal-title":"Int J Radiat Biol"},{"key":"17_CR6","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2307\/3579712","volume":"148","author":"TC Yang","year":"1997","unstructured":"Yang TC, George K, Johnson AS, Durante M, Fedorenko BS (1997) Biodosimetry results from space flight Mir-18. Radiat Res 148:S17\u2013S23","journal-title":"Radiat Res"},{"key":"17_CR7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0027-5107(99)00144-X","volume":"430","author":"I Testard","year":"1999","unstructured":"Testard I, Sabatier L (1999) Biological dosimetry for astronauts: a real challenge. Mutat Res 430:315\u2013326","journal-title":"Mutat Res"},{"key":"17_CR8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0273-1177(01)00011-4","volume":"27","author":"B Fedorenko","year":"2001","unstructured":"Fedorenko B, Druzhinin S, Yudaeva L, Petrov V, Akatov Y, Snigiryova G, Novitskaya N, Shevchenko V, Rubanovich A (2001) Cytogenetic studies of blood lymphocytes from cosmonauts after long-term space flights on Mir station. Adv Space Res 27:355\u2013359","journal-title":"Adv Space Res"},{"key":"17_CR9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1667\/0033-7587(2001)156[0731:CAITBL]2.0.CO;2","volume":"156","author":"K George","year":"2001","unstructured":"George K, Durante M, Wu HL, Willingham V, Badhwar G, Cucinotta FA (2001) Chromosome aberrations in the blood lymphocytes of astronauts after space flight. Radiat Res 156:731\u2013738","journal-title":"Radiat Res"},{"key":"17_CR10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000077498","volume":"104","author":"K George","year":"2004","unstructured":"George K, Durante M, Willingham V, Cucinotta FA (2004) Chromosome aberrations of clonal origin are present in astronauts\u2019 blood lymphocytes. Cytogenet Genome Res 104:245\u2013251","journal-title":"Cytogenet Genome Res"},{"key":"17_CR11","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0273-1177(03)00087-5","volume":"31","author":"O Greco","year":"2003","unstructured":"Greco O, Durante M, Gialanella G, Grossi G, Pugliese M, Scampoli P, Snigiryova G, Obe G (2003) Biological dosimetry in Russian and Italian astronauts. Adv Space Res 31:1495\u20131503","journal-title":"Adv Space Res"},{"key":"17_CR12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000076288","volume":"103","author":"M Durante","year":"2003","unstructured":"Durante M, Snigiryova G, Akaeva E, Bogomazova A, Druzhinin S, Fedorenko B, Greco O, Novitskaya N, Rubanovich A, Shevchenko V, Von Recklinghausen U, Obe G (2003) Chromosome aberration dosimetry in cosmonauts after single or multiple space flights. Cytogenet Genome Res 103:40\u201346","journal-title":"Cytogenet Genome Res"},{"key":"17_CR13","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1667\/0033-7587(2001)156[0662:REBOCA]2.0.CO;2","volume":"156","author":"M Durante","year":"2001","unstructured":"Durante M, Bonassi S, George K, Cucinotta FA (2001) Risk estimation based on chromosomal aberrations induced by radiation. Radiat Res 156:662\u2013667","journal-title":"Radiat Res"},{"key":"17_CR14","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/375041","volume":"72","author":"MP Hande","year":"2003","unstructured":"Hande MP, Azizova TV, Geard CR, Burak LE, Mitchell CR, Khokhryakov VF, Vasilenko EK, Brenner DJ (2003) Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am J Hum Genet 72:1162\u20131170","journal-title":"Am J Hum Genet"},{"key":"17_CR15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1667\/RR3231","volume":"162","author":"CR Mitchell","year":"2004","unstructured":"Mitchell CR, Azizova TV, Hande MP, Burak LE, Tsakok JM, Khokhryakov VF, Geard CR, Brenner DJ (2004) Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiat Res 162:257\u2013263","journal-title":"Radiat Res"},{"key":"17_CR16","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S1350-4487(96)00070-4","volume":"26","author":"FA Cucinotta","year":"1996","unstructured":"Cucinotta FA, Wilson JW, Shinn JL, Badavi FF, Badhwar GD (1996) Effects of target fragmentation on evaluation of LET spectra from space radiations: implications for space radiation protection studies. Radiat Meas 26:923\u2013934","journal-title":"Radiat Meas"},{"key":"17_CR17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1350-4487(99)00273-5","volume":"32","author":"FA Cucinotta","year":"2000","unstructured":"Cucinotta FA, Wilson JW, Williams JR, Dicello JF (2000) Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO. Radiat Meas 32:181\u2013191","journal-title":"Radiat Meas"},{"key":"17_CR18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/095530099140348","volume":"75","author":"G Obe","year":"1999","unstructured":"Obe G, Facius R, Reitz G, Johannes I, Johannes C (1999) Manned missions to Mars and chromosome damage. Int J Radiat Biol 75:429\u2013433","journal-title":"Int J Radiat Biol"},{"key":"17_CR19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000077521","volume":"104","author":"I Chudoba","year":"2004","unstructured":"Chudoba I, Hickmann G, Friedrich T, Jauch A, Kozlowski P, Senger G (2004) mBAND: a high resolution multicolor banding technique for the detection of complex intrachromosomal aberrations. Cytogenet Genome Res 104:390\u2013393","journal-title":"Cytogenet Genome Res"},{"key":"17_CR20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S1350-4487(02)00072-0","volume":"35","author":"GD Badhwar","year":"2002","unstructured":"Badhwar GD, Atwell W, Reitz G, Beaujean R, Heinrich W (2002) Radiation measurements on the Mir Orbital Station. Radiat Meas 35:393\u2013422","journal-title":"Radiat Meas"},{"key":"17_CR21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1667\/RR3157","volume":"161","author":"C Johannes","year":"2004","unstructured":"Johannes C, Horstmann M, Durante M, Chudoba I, Obe G (2004) Chromosome intrachanges and interchanges detected by multicolor banding in lymphocytes: searching for clastogen signatures in the human genome. Radiat Res 161:540\u2013548","journal-title":"Radiat Res"},{"key":"17_CR22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/09553000410001702337","volume":"80","author":"M Horstmann","year":"2004","unstructured":"Horstmann M, Durante M, Obe G (2004) Distribution of breakpoints and fragment sizes in human chromosome 5 after heavy-ion bombardment. Int J Radiat Biol 80:437\u2013443","journal-title":"Int J Radiat Biol"},{"key":"17_CR23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1667\/0033-7587(2001)155[0643:ARICCR]2.0.CO;2","volume":"155","author":"MN Cornforth","year":"2001","unstructured":"Cornforth MN (2001) Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat Res 155:643\u2013659","journal-title":"Radiat Res"},{"key":"17_CR24","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000076283","volume":"103","author":"M Horstmann","year":"2003","unstructured":"Horstmann M, Obe G (2003) CABAND: Classification of aberrations in multicolor banded chromosomes. Cytogenet Genome Res 103:24\u201327","journal-title":"Cytogenet Genome Res"},{"key":"17_CR25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1667\/RR3286","volume":"163","author":"RM Anderson","year":"2005","unstructured":"Anderson RM, Tsepenko VV, Gasteva GN, Molokanov AA, Sevan\u2019kaev AV, Goodhead DT (2005) mFISH analysis reveals complexity of chromosome aberrations in individuals occupationally exposed to internal plutonium: a pilot study to assess the relevance of complex aberrations as biomarkers of exposure to high-LET alpha particles. Radiat Res 163:26\u201335","journal-title":"Radiat Res"},{"key":"17_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gcc.20217","volume":"44","author":"MP Hande","year":"2005","unstructured":"Hande MP, Azizova TV, Burak LE, Khokhryakov VF, Geard CR, Brenner DJ (2005) Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: an mFISH study. Genes Chromosomes Cancer 44:1\u20139","journal-title":"Genes Chromosomes Cancer"},{"key":"17_CR27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.asr.2004.12.031","volume":"35","author":"M Horstmann","year":"2005","unstructured":"Horstmann M, Durante M, Johannes C, Obe G (2005) Chromosomal intrachanges induced by swift iron ions. Adv Space Res 35:276\u2013279","journal-title":"Adv Space Res"},{"key":"17_CR28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1667\/0033-7587(2002)158[0581:KOHLET]2.0.CO;2","volume":"158","author":"M Durante","year":"2002","unstructured":"Durante M, George K, Wu HL, Cucinotta FA (2002) Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat Res 158:581\u2013590","journal-title":"Radiat Res"},{"key":"17_CR29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000077497","volume":"104","author":"M Durante","year":"2004","unstructured":"Durante M, Ando K, Furusawa Y, Obe G, George K, Cucinotta FA (2004) Complex chromosomal rearrangements induced in vivo by heavy ions. Cytogenet Genome Res 104:240\u2013244","journal-title":"Cytogenet Genome Res"},{"key":"17_CR30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1088\/0952-4746\/25\/1\/005","volume":"25","author":"EJ Tawn","year":"2005","unstructured":"Tawn EJ, Whitehouse CA (2005) Chromosome intra- and inter-changes determined by G-banding in radiation workers with in vivo exposure to plutonium. J Radiol Prot 25:83\u201388","journal-title":"J Radiol Prot"}],"container-title":["Radiation and Environmental Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00411-005-0017-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00411-005-0017-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00411-005-0017-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T14:46:57Z","timestamp":1559054817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00411-005-0017-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,11]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["17"],"URL":"https:\/\/doi.org\/10.1007\/s00411-005-0017-0","relation":{},"ISSN":["0301-634X","1432-2099"],"issn-type":[{"value":"0301-634X","type":"print"},{"value":"1432-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,11]]}}}