{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:38:19Z","timestamp":1785307099539,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Iran Nuclear Regulatory Authority"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Radiat Environ Biophys"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00411-015-0624-3","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T11:32:22Z","timestamp":1445945542000},"page":"41-51","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The cytokinesis-blocked micronucleus assay: dose\u2013response calibration curve, background frequency in the population and dose estimation"],"prefix":"10.1007","volume":"55","author":[{"given":"E.","family":"Rastkhah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zakeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ghoranneviss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Rajabpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Farshidpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mianji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,27]]},"reference":[{"key":"624_CR1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00411-008-0209-5","volume":"48","author":"S Acharya","year":"2009","unstructured":"Acharya S, Sanjeev G, Bhat NN, Siddappa K, Narayana Y (2009) The effect of electron and gamma irradiation on the induction of micronuclei in cytokinesis-blocked human blood lymphocytes. Radiat Environ Biophys 48:197\u2013203","journal-title":"Radiat Environ Biophys"},{"key":"624_CR2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/01.HP.0000346305.84577.b4","volume":"98","author":"EA Ainsbury","year":"2010","unstructured":"Ainsbury EA, Lloyd DC (2010) Dose estimation software for radiation biodosimetry. Health Phys 98:290\u2013295","journal-title":"Health Phys"},{"issue":"4","key":"624_CR3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/rpd\/ncq499","volume":"147","author":"EA Ainsbury","year":"2011","unstructured":"Ainsbury EA, Bakhanova E, Barquinero JF, Brai M, Chumak V et al (2011) Review of retrospective dosimetry techniques for external ionizing radiation exposures. Radiat Prot Dosimetry 147(4):573\u2013592","journal-title":"Radiat Prot Dosimetry"},{"key":"624_CR4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mrgentox.2013.09.012","volume":"760","author":"AC Antunes","year":"2014","unstructured":"Antunes AC, Martins V, Cardoso J, Santos L, Monteiro Gil O (2014) The cytokinesis-blocked micronucleus assay: dose estimation and inter-individual differences in the response to \u03b3-radiation. Mutat Res 760:17\u201322","journal-title":"Mutat Res"},{"key":"624_CR5","first-page":"249","volume":"6","author":"C Bolognesi","year":"1997","unstructured":"Bolognesi C, Abbondandolo A, Barale R, Casalone R, Dalpr\u00e0 L, De Fer-rari M et al (1997) Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes. Cancer Epidemiol Biomarkers Prev 6:249\u2013256","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"6","key":"624_CR6","first-page":"671","volume":"4","author":"S Bonassi","year":"1995","unstructured":"Bonassi S, Bolognesi C, Abbondandolo A, Barale R, Bigatti P, Camurri L et al (1995) Influence of sex on cytogenetic end points: evidence from a large human sample and review of the literature. Cancer Epidemiol Biomarkers Prev 4(6):671\u2013679","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"624_CR7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/1098-2280(2001)37:1<31::AID-EM1004>3.0.CO;2-P","volume":"37","author":"S Bonassi","year":"2001","unstructured":"Bonassi S, Fenech M, Lando C, Lin Y, Ceppi M, Chang WP et al (2001) HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ Mol Mutagen 37(1):31\u201345","journal-title":"Environ Mol Mutagen"},{"key":"624_CR8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.etap.2006.10.003","volume":"23","author":"FL Dias","year":"2007","unstructured":"Dias FL, Antunes LMG, Rezende PA et al (2007) Cytogenetic analysis in lymphocytes from workers occupationally exposed to low levels of ionising radiation. Environ Toxicol Pharmacol 23:228\u2013233","journal-title":"Environ Toxicol Pharmacol"},{"key":"624_CR9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF01323216","volume":"16","author":"AA Edwards","year":"1979","unstructured":"Edwards AA, Lloyd DC, Purrott RJ (1979) Radiation induced chromosome aberrations and the poison distribution. Radiat Environ Biophys 16:89\u2013100","journal-title":"Radiat Environ Biophys"},{"issue":"Suppl 3","key":"624_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1289\/ehp.93101s3101","volume":"101","author":"M Fenech","year":"1993","unstructured":"Fenech M (1993) The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ Health Perspect Suppl 101(Suppl 3):101\u2013107","journal-title":"Environ Health Perspect Suppl"},{"key":"624_CR11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mrfmmm.2006.05.028","volume":"600","author":"M Fenech","year":"2006","unstructured":"Fenech M (2006) Cytokinesis-block micronucleus assay evolves into a \u201ccytome\u201d assay of chromosomal instability, mitotic dysfunction and cell death. Mutat Res 600:58\u201366","journal-title":"Mutat Res"},{"key":"624_CR12","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nprot.2007.77","volume":"2","author":"M Fenech","year":"2007","unstructured":"Fenech M (2007) Cytokinesis-block micronucleus cytome assay. Nat Protoc 2:1084\u20131104","journal-title":"Nat Protoc"},{"key":"624_CR13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-1161(85)90015-9","volume":"147","author":"M Fenech","year":"1985","unstructured":"Fenech M, Morlay A (1985) Measurement of micronuclei in lymphocytes. Mutat Res 147:29\u201336","journal-title":"Mutat Res"},{"key":"624_CR14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1383-5718(02)00249-8","volume":"534","author":"M Fenech","year":"2003","unstructured":"Fenech M et al (2003) HUman MicronNucleus project. HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat Res 534:65\u201375","journal-title":"Mutat Res"},{"key":"624_CR15","unstructured":"International Atomic Energy Agency (2001) Cytogenetic analysis for radiation dose assessment. a manual technical reports series no. 405, Vienna, IAEA"},{"key":"624_CR16","volume-title":"cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies","author":"International Atomic Energy Agency","year":"2011","unstructured":"International Atomic Energy Agency (2011) cytogenetic dosimetry: applications in preparedness for and response to radiation emergencies. IAEA-EPR, Vienna"},{"issue":"2","key":"624_CR17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0165-1161(96)90261-7","volume":"359","author":"G K\u00f6ksal","year":"1996","unstructured":"K\u00f6ksal G, Dalc\u00ed DO, Pala FS (1996) Micronuclei in human lymphocytes: the Co-60 gamma-ray dose\u2013response. Mutat Res 359(2):151\u2013157","journal-title":"Mutat Res"},{"key":"624_CR18","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1259\/bjr\/62484075","volume":"82","author":"Q Liu","year":"2009","unstructured":"Liu Q, Cao J, Wang ZQ, Bai YS, Lu YM, Huang QL et al (2009) Dose estimation by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to 60Co radiation. Br J Radiol 82:1027\u20131032","journal-title":"Br J Radiol"},{"key":"624_CR19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1667\/RR13441.1","volume":"181","author":"OV Lyulko","year":"2014","unstructured":"Lyulko OV, Garty G, Randers-Pehrson G, Turner HC, Szolc B, Brenner DJ (2014) Fast image analysis for the micronucleus assay in a fully automated high-throughput biodosimetry system. Radiat Res 181:146\u2013161","journal-title":"Radiat Res"},{"issue":"5","key":"624_CR20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/mutage\/17.5.405","volume":"17","author":"F Maffei","year":"2002","unstructured":"Maffei F, Angelini S, Cantelli G, Forti Lodi V, Saverio Violante F, Mattioli S, Hrelia P (2002) Micronuclei frequencies in hospital workers occupationally exposed to low levels of ionizing radiation: influence of smoking status and other factors. Mutagenesis 17(5):405\u2013409","journal-title":"Mutagenesis"},{"key":"624_CR21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.31482\/mmsl.2011.004","volume":"80","author":"J Pejchal","year":"2011","unstructured":"Pejchal J, Vasilieva V, Hristozova M, Vilasova Z, Vavrova J et al (2011) Cytokinesis-block micronucleus (CBMN) cytome assay in human lymphocytes after in vitro irradiation and its use in biodosimetry. Mil Med Sci Lett (Voj Zdrav Listy) 80:28\u201337","journal-title":"Mil Med Sci Lett (Voj Zdrav Listy)"},{"issue":"1","key":"624_CR22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0027-5107(88)90228-X","volume":"199","author":"J Prosser","year":"1988","unstructured":"Prosser J, Moquet J, Lloyd D, Edwards AA (1988) Radiation induction of micronuclei in human lymphocytes. Mutat Res 199(1):37\u201345","journal-title":"Mutat Res"},{"issue":"1","key":"624_CR23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/mutage\/geq057","volume":"26","author":"A Rossnerova","year":"2011","unstructured":"Rossnerova A, Spatova M, Schunck Ch, Sram RJ (2011) Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. Mutagenesis 26(1):169\u2013175","journal-title":"Mutagenesis"},{"key":"624_CR24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mrgentox.2007.01.009","volume":"629","author":"I Sari-Minodier","year":"2007","unstructured":"Sari-Minodier I, Orsiere T, Auquier P et al (2007) Cytogenetic monitoring by use of the micronucleus assay among hospital workers exposed to low doses of ionising radiation. Mutat Res 629:111\u2013121","journal-title":"Mutat Res"},{"key":"624_CR25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/oxfordjournals.rpd.a082120","volume":"51","author":"B Sreedevi","year":"1994","unstructured":"Sreedevi B, Rao BS (1994) Assay of micronuclei in peripheral blood lymphocytes as a biological dosimeter of radiation dose. Radiat Prot Dosimetry 51:41\u201345","journal-title":"Radiat Prot Dosimetry"},{"issue":"3","key":"624_CR26","first-page":"260","volume":"45","author":"H Thierens","year":"2009","unstructured":"Thierens H, Vral A (2009) The micronucleus assay in radiation accidents. Ann Ist Super Sanit\u00e0 45(3):260\u2013264","journal-title":"Ann Ist Super Sanit\u00e0"},{"key":"624_CR27","unstructured":"United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 1982 report to the general assembly with annexes (1982) Ionizing radiation: sources and biological effects. United Nations Publication E.82.IX.8. New York"},{"issue":"1","key":"624_CR28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/mutage\/geq078","volume":"26","author":"A Vral","year":"2011","unstructured":"Vral A, Fenech M, Thierens H (2011) The micronucleus assay as a biological dosimeter of in vivo ionising radiation exposure. Mutagenesis 26(1):11\u201317","journal-title":"Mutagenesis"},{"key":"624_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2004.04.005","volume":"562","author":"F Zakeri","year":"2004","unstructured":"Zakeri F, Assaei RG (2004) Cytogenetic monitoring of personnel working in angiocardiography laboratories in Iran hospitals. Mutat Res 562:1\u20139","journal-title":"Mutat Res"},{"key":"624_CR30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejrad.2008.10.015","volume":"73","author":"F Zakeri","year":"2010","unstructured":"Zakeri F, Hirobe T (2010) A cytogenetic approach to the effects of low levels of ionizing radiations on occupationally exposed individuals. Eur J Radiol 73:191\u2013195","journal-title":"Eur J Radiol"},{"issue":"1","key":"624_CR31","first-page":"33","volume":"9","author":"F Zakeri","year":"2003","unstructured":"Zakeri F, Assaei R, Varzegar R (2003) Chromosomal aberrations in workers occupationally exposed to chronic low level ionizing radiation. Occup Environ Med 9(1):33\u201338","journal-title":"Occup Environ Med"},{"issue":"6","key":"624_CR32","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/occmed\/kqq062","volume":"60","author":"F Zakeri","year":"2010","unstructured":"Zakeri F, Hirobe T, Akbari Noghabi K (2010) Biological effects of low-dose ionizing radiation exposure on interventional cardiologists. Occup Med 60(6):464\u2013469","journal-title":"Occup Med"}],"container-title":["Radiation and Environmental Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00411-015-0624-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00411-015-0624-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00411-015-0624-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:53:04Z","timestamp":1567299184000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00411-015-0624-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,27]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["624"],"URL":"https:\/\/doi.org\/10.1007\/s00411-015-0624-3","relation":{},"ISSN":["0301-634X","1432-2099"],"issn-type":[{"value":"0301-634X","type":"print"},{"value":"1432-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,27]]}}}