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In forensic medicine, methods based on \u201cmolecular clocks\u201d in dental tissues and bone play an increasing role. The question, whether these methods are applicable also in cases with post-depositional intervals far beyond the forensically relevant period, was investigated for two \u201cprotein clocks\u201d, the accumulation of D-aspartic acid (D-Asp) and the accumulation of pentosidine (Pen) in dentine. Eight teeth of skeletons from different burial sites in Austria and with post-depositional intervals between c. 1216 and c. 8775 years were analysed. The results of age at death estimation based on D-Asp and Pen in dentine were compared to that derived from a classical morphological examination. Age at death estimation based on D-Asp resulted consistently in false high values. This finding can be explained by a post-mortem accumulation of D-Asp that may be enhanced by protein degradation. In contrast, the Pen-based age estimates fitted well with the morphological age diagnoses. The described effect of post-mortem protein degradation is negligible in forensically relevant time horizons, but not for post-depositional intervals of thousands of years. That means that the \u201cD-Asp clock\u201d loses its functionality with increasing post-depositional intervals, whereas Pen seems to be very stable. The \u201cPen-clock\u201d may have the potential to become an interesting supplement to the existing repertoire of methods even in cases with extremely long post-depositional intervals. 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