{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:18:09Z","timestamp":1775276289244,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Key R & D Program of China","award":["2018YFC0807403"],"award-info":[{"award-number":["2018YFC0807403"]}]},{"name":"National Key R & D Program of China","award":["2017YFC0803504"],"award-info":[{"award-number":["2017YFC0803504"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Legal Med"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00414-021-02532-z","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T17:03:10Z","timestamp":1620925390000},"page":"1437-1447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Application of Q-TOF\u2013MS based metabonomics techniques to analyze the plasma metabolic profile changes on rats following death due to acute intoxication of phorate"],"prefix":"10.1007","volume":"135","author":[{"given":"Zhiwen","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuxin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanlin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-4164","authenticated-orcid":false,"given":"Keming","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"2532_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s00128-008-9498-2","volume":"81","author":"L Wang","year":"2008","unstructured":"Wang L, Liang Y, Jiang X (2008) Analysis of eight organophosphorus pesticide residues in fresh vegetables retailed in agricultural product markets of Nanjing, China. Bull Environ Contam Toxicol 81:377\u2013382. https:\/\/doi.org\/10.1007\/s00128-008-9498-2","journal-title":"Bull Environ Contam Toxicol"},{"key":"2532_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jhazmat.2008.10.061","volume":"165","author":"PC Abhilash","year":"2009","unstructured":"Abhilash PC, Singh N (2009) Pesticide use and application: an Indian scenario. J Hazard Mater 165:1\u201312. https:\/\/doi.org\/10.1016\/j.jhazmat.2008.10.061","journal-title":"J Hazard Mater"},{"key":"2532_CR3","first-page":"49","volume":"52","author":"S Khatiwada","year":"2012","unstructured":"Khatiwada S, Tripathi M, Pokharel K, Acharya R, Subedi A (2012) Ambiguous phorate granules for sesame seeds linked to accidental organophosphate fatal poisoning. JNMA J Nepal Med Assoc 52:49\u201351","journal-title":"JNMA J Nepal Med Assoc"},{"key":"2532_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s10460-007-9067-z","volume":"24","author":"GJ Devine","year":"2007","unstructured":"Devine GJ, Furlong MJ (2007) Insecticide use: cContexts and ecological consequences. Agric Hum Values 24:281\u2013306. https:\/\/doi.org\/10.1007\/s10460-007-9067-z","journal-title":"Agric Hum Values"},{"key":"2532_CR5","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/jat.2848","volume":"34","author":"X Sun","year":"2014","unstructured":"Sun X, Xu W, Zeng Y et al (2014) Metabonomics evaluation of urine from rats administered with phorate under long-term and low-level exposure by ultra-performance liquid chromatography-mass spectrometry. J Appl Toxicol 34:176\u2013183. https:\/\/doi.org\/10.1002\/jat.2848","journal-title":"J Appl Toxicol"},{"key":"2532_CR6","first-page":"125","volume":"1","author":"W Zhang","year":"2011","unstructured":"Zhang W, Jiang F, Qu J (2011) Global pesticide consumption and pollution: with China as a focus. Proc Int Acad Ecol Environ Sci 1:125\u2013144","journal-title":"Proc Int Acad Ecol Environ Sci"},{"key":"2532_CR7","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/jat\/32.1.106","volume":"32","author":"G Weerasekera","year":"2008","unstructured":"Weerasekera G, Smith KD, Needham LL, Barr DB (2008) A Rapid, cost-effective method for analyzing organophosphorus pesticide metabolites in human urine for counter-terrorism response. J Anal Toxicol 32:106\u2013115","journal-title":"J Anal Toxicol"},{"key":"2532_CR8","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.envres.2008.07.014","volume":"108","author":"X Ye","year":"2008","unstructured":"Ye X, Pierik FH, Hauser R et al (2008) Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the generation R study. Environ Res 108:260\u2013267. https:\/\/doi.org\/10.1016\/j.envres.2008.07.014","journal-title":"Environ Res"},{"key":"2532_CR9","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1016\/j.jchromb.2010.04.027","volume":"878","author":"MS Odetokun","year":"2010","unstructured":"Odetokun MS, Montesano MA, Weerasekera G, Whitehead RD, Needham LL, Barr DB (2010) Quantification of dialkylphosphate metabolites of organophosphorus insecticides in human urine using 96-well plate sample preparation and high-performance liquid chromatography\u2013electrospray ionization-tandem mass spectrometry. J Chromatogr B 878:2567\u20132574. https:\/\/doi.org\/10.1016\/j.jchromb.2010.04.027","journal-title":"J Chromatogr B"},{"key":"2532_CR10","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.ijheh.2013.10.005","volume":"217","author":"T Prapamontol","year":"2014","unstructured":"Prapamontol T, Sutan K, Laoyang S et al (2014) Cross validation of gas chromatography-flame photometric detection and gas chromatography-mass spectrometry methods for measuring dialkylphosphate metabolites of organophosphate pesticides in human urine. Int J Hyg Environ Health 217:554\u2013566. https:\/\/doi.org\/10.1016\/j.ijheh.2013.10.005","journal-title":"Int J Hyg Environ Health"},{"key":"2532_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.forsciint.2011.10.019","volume":"218","author":"MP Kavvalakis","year":"2012","unstructured":"Kavvalakis MP, Tsatsakis AM (2012) The atlas of dialkylphosphates; assessment of cumulative human organophosphorus pesticides\" exposure. Forensic Sci Int 218:111\u2013122. https:\/\/doi.org\/10.1016\/j.forsciint.2011.10.019","journal-title":"Forensic Sci Int"},{"key":"2532_CR12","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.envres.2014.07.012","volume":"134","author":"A Kokkinaki","year":"2014","unstructured":"Kokkinaki A, Kokkinakis M, Kavvalakis MP et al (2014) Biomonitoring of dialkylphosphate metabolites (DAPs) in urine and hair samples of sprayers and rural residents of Crete, Greece. Environ Res 134:181\u2013187. https:\/\/doi.org\/10.1016\/j.envres.2014.07.012","journal-title":"Environ Res"},{"key":"2532_CR13","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/s00128-015-1617-2","volume":"95","author":"M Jariyal","year":"2015","unstructured":"Jariyal M, Gupta VK, Mandal K, Jindal V (2015) Brevibacterium frigoritolerans as a Novel Organism for the Bioremediation of Phorate. Bull Environ Contam Toxicol 95:680\u2013686. https:\/\/doi.org\/10.1007\/s00128-015-1617-2","journal-title":"Bull Environ Contam Toxicol"},{"key":"2532_CR14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/0048-3575(88)90028-4","volume":"31","author":"S Kinsler","year":"1988","unstructured":"Kinsler S, Levi PE, Hodgson E (1988) Hepatic and extrahepatic microsomal oxidation of phorate by the cytochrome P-450 and FAD-containing monooxygenase systems in the mouse. Pestic Biochem Physiol 31:54\u201360","journal-title":"Pestic Biochem Physiol"},{"key":"2532_CR15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jchromb.2005.12.030","volume":"832","author":"J Ueyama","year":"2006","unstructured":"Ueyama J, Saito I, Kamijima M et al (2006) Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 832:58\u201366. https:\/\/doi.org\/10.1016\/j.jchromb.2005.12.030","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"2532_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.chroma.2011.11.019","volume":"1219","author":"S Samadi","year":"2012","unstructured":"Samadi S, Sereshti H, Assadi Y (2012) Ultra-preconcentration and determination of thirteen organophosphorus pesticides in water samples using solid-phase extraction followed by dispersive liquid-liquid microextraction and gas chromatography with flame photometric detection. J Chromatogr A 1219:61\u201365. https:\/\/doi.org\/10.1016\/j.chroma.2011.11.019","journal-title":"J Chromatogr A"},{"key":"2532_CR17","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.jchromb.2010.02.021","volume":"878","author":"AM Tsatsakis","year":"2010","unstructured":"Tsatsakis AM, Barbounis MG, Kavalakis M, Kokkinakis M, Terzi I, Tzatzarakis MN (2010) Determination of dialkyl phosphates in human hair for the biomonitoring of exposure to organophosphate pesticides. J Chromatogr B Anal Technol Biomed Life Sci 878:1246\u20131252. https:\/\/doi.org\/10.1016\/j.jchromb.2010.02.021","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"2532_CR18","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.jchromb.2010.02.005","volume":"878","author":"J Ueyama","year":"2010","unstructured":"Ueyama J, Kamijima M, Kondo T et al (2010) Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 878:1257\u20131263. https:\/\/doi.org\/10.1016\/j.jchromb.2010.02.005","journal-title":"J Chromatogr B Anal Technol Biomed Life Sci"},{"key":"2532_CR19","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1021\/jf400269q","volume":"61","author":"X Wang","year":"2013","unstructured":"Wang X, Qiao X, Ma Y, Zhao T, Xu Z (2013) Simultaneous determination of nine trace organophosphorous pesticide residues in fruit samples using molecularly imprinted matrix solid-phase dispersion followed by gas chromatography. J Agric Food Chem 61:3821\u20133827. https:\/\/doi.org\/10.1021\/jf400269q","journal-title":"J Agric Food Chem"},{"key":"2532_CR20","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.snb.2013.11.096","volume":"193","author":"Z Li","year":"2014","unstructured":"Li Z, Wang Y, Ni Y, Kokot S (2014) Unmodified silver nanoparticles for rapid analysis of the organophosphorus pesticide, dipterex, often found in different waters. Sens Actuators B Chem 193:205\u2013211. https:\/\/doi.org\/10.1016\/j.snb.2013.11.096","journal-title":"Sens Actuators B Chem"},{"key":"2532_CR21","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1021\/ac300545p","volume":"84","author":"D Liu","year":"2012","unstructured":"Liu D, Chen W, Wei J, Li X, Wang Z, Jiang X (2012) A highly sensitive, dual-readout assay based on gold nanoparticles for organophosphorus and carbamate pesticides. Anal Chem 84:4185\u20134191. https:\/\/doi.org\/10.1021\/ac300545p","journal-title":"Anal Chem"},{"issue":"Pt 2","key":"2532_CR22","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.jhazmat.2013.10.048","volume":"263","author":"X Liu","year":"2013","unstructured":"Liu X, Li D, Li J, Rose G, Marriott PJ (2013) Organophosphorus pesticide and ester analysis by using comprehensive two-dimensional gas chromatography with flame photometric detection. J Hazard Mater 263(Pt 2):761\u2013767. https:\/\/doi.org\/10.1016\/j.jhazmat.2013.10.048","journal-title":"J Hazard Mater"},{"key":"2532_CR23","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jhazmat.2012.08.041","volume":"237\u2013238","author":"R Guo","year":"2012","unstructured":"Guo R, Ren X, Ren H (2012) A new method for analysis of the toxicity of organophosphorus pesticide, dimethoate on rotifer based on response surface methodology. J Hazard Mater 237\u2013238:270\u2013276. https:\/\/doi.org\/10.1016\/j.jhazmat.2012.08.041","journal-title":"J Hazard Mater"},{"key":"2532_CR24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3724\/SP.J.1123.2011.10012","volume":"30","author":"L Wang","year":"2012","unstructured":"Wang L, Zhou Y, Chen Y et al (2012) Evaluation of QuEchERS methods for the analysis of 66 organophosphorus pesticide residues in vegetables by liquid chromatography-tandem mass spectrometry. Chin J Chromatogr 30:146\u2013153","journal-title":"Chin J Chromatogr"},{"key":"2532_CR25","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.csbj.2014.08.004","volume":"11","author":"B Titz","year":"2014","unstructured":"Titz B, Elamin A, Martin F et al (2014) Proteomics for systems toxicology. Comput Struct Biotechnol J 11:73\u201390. https:\/\/doi.org\/10.1016\/j.csbj.2014.08.004","journal-title":"Comput Struct Biotechnol J"},{"key":"2532_CR26","doi-asserted-by":"publisher","first-page":"4815","DOI":"10.1016\/j.chroma.2010.05.043","volume":"1217","author":"SW Chung","year":"2010","unstructured":"Chung SW, Chan BT (2010) Validation and use of a fast sample preparation method and liquid chromatography-tandem mass spectrometry in analysis of ultra-trace levels of 98 organophosphorus pesticide and carbamate residues in a total diet study involving diversified food types. J Chromatogr A 1217:4815\u20134824. https:\/\/doi.org\/10.1016\/j.chroma.2010.05.043","journal-title":"J Chromatogr A"},{"key":"2532_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.jenvman.2012.12.031","volume":"117","author":"M Cycon","year":"2013","unstructured":"Cycon M, Zmijowska A, Wojcik M, Piotrowska-Seget Z (2013) Biodegradation and bioremediation potential of diazinon-degrading Serratia marcescens to remove other organophosphorus pesticides from soils. J Environ Manage 117:7\u201316. https:\/\/doi.org\/10.1016\/j.jenvman.2012.12.031","journal-title":"J Environ Manage"},{"key":"2532_CR28","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.ibiod.2010.12.017","volume":"65","author":"M Kapoor","year":"2011","unstructured":"Kapoor M, Rajagopal R (2011) Enzymatic bioremediation of organophosphorus insecticides by recombinant organophosphorous hydrolase. Int Biodeterior Biodegradation 65:896\u2013901. https:\/\/doi.org\/10.1016\/j.ibiod.2010.12.017","journal-title":"Int Biodeterior Biodegradation"},{"key":"2532_CR29","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1007\/s00216-007-1267-2","volume":"388","author":"FT Peters","year":"2007","unstructured":"Peters FT (2007) Stability of analytes in biosamples - an important issue in clinical and forensic toxicology? Anal Bioanal Chem 388:1505\u20131519. https:\/\/doi.org\/10.1007\/s00216-007-1267-2","journal-title":"Anal Bioanal Chem"},{"key":"2532_CR30","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"JK Nicholson","year":"1999","unstructured":"Nicholson JK, Lindon JC, Holmes E (1999) \"Metabonomics\": understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29:1181\u20131189","journal-title":"Xenobiotica"},{"key":"2532_CR31","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1517\/14622416.5.7.879","volume":"5","author":"P Francois","year":"2004","unstructured":"Francois P (2004) Genomics, proteomics and metabonomics in toxicology hopefully not \"fashionomics\".pdf. Pharmacogenomics 5:879\u2013893","journal-title":"Pharmacogenomics"},{"key":"2532_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s0041-008x(02)00079-0","volume":"187","author":"JC Lindon","year":"2003","unstructured":"Lindon JC, Nicholson JK, Holmes E et al (2003) Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol 187:137\u2013146. https:\/\/doi.org\/10.1016\/s0041-008x(02)00079-0","journal-title":"Toxicol Appl Pharmacol"},{"key":"2532_CR33","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pharmthera.2005.06.008","volume":"109","author":"HC Keun","year":"2006","unstructured":"Keun HC (2006) Metabonomic modeling of drug toxicity. Pharmacol Ther 109:92\u2013106. https:\/\/doi.org\/10.1016\/j.pharmthera.2005.06.008","journal-title":"Pharmacol Ther"},{"key":"2532_CR34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrd728","volume":"1","author":"JK Nicholson","year":"2012","unstructured":"Nicholson JK, Connelly J, Lindon JC, Holmes E (2012) Metabonomics a platform for studying drug toxicity and gene function.pdf. Nat Rev Drug Discovery 1:153\u2013161","journal-title":"Nat Rev Drug Discovery"},{"key":"2532_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0027-5107(01)00292-5","volume":"499","author":"MJ Aardema","year":"2002","unstructured":"Aardema MJ, MacGregor JT (2002) Toxicology and genetic toxicology in the new era of \u201ctoxicogenomics \u201d impact of \u201c-omics\u201d technologies. Mutat Res Fundam Mol Mech Mutagen 499:13\u201325","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"key":"2532_CR36","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/jat.2874","volume":"33","author":"M Bouhifd","year":"2013","unstructured":"Bouhifd M, Hartung T, Hogberg HT, Kleensang A, Zhao L (2013) Review: toxicometabolomics. J Appl Toxicol 33:1365\u20131383. https:\/\/doi.org\/10.1002\/jat.2874","journal-title":"J Appl Toxicol"},{"key":"2532_CR37","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3389\/fchem.2019.00319","volume":"7","author":"AE Steuer","year":"2019","unstructured":"Steuer AE, Brockbals L, Kraemer T (2019) Metabolomic strategies in biomarker research\u2013new approach for indirect identification of drug consumption and sample manipulation in clinical and forensic toxicology? Front Chem 7:319. https:\/\/doi.org\/10.3389\/fchem.2019.00319","journal-title":"Front Chem"},{"key":"2532_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.tox.2011.05.012","volume":"287","author":"N Shima","year":"2011","unstructured":"Shima N, Miyawaki I, Bando K et al (2011) Influences of methamphetamine-induced acute intoxication on urinary and plasma metabolic profiles in the rat. Toxicology 287:29\u201337. https:\/\/doi.org\/10.1016\/j.tox.2011.05.012","journal-title":"Toxicology"},{"key":"2532_CR39","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1039\/c4mb00158c","volume":"10","author":"T Zheng","year":"2014","unstructured":"Zheng T, Liu L, Shi J et al (2014) The metabolic impact of methamphetamine on the systemic metabolism of rats and potential markers of methamphetamine abuse. Mol Bio Syst 10:1968\u20131977. https:\/\/doi.org\/10.1039\/c4mb00158c","journal-title":"Mol Bio Syst"},{"key":"2532_CR40","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.chroma.2012.02.053","volume":"1259","author":"HG Gika","year":"2012","unstructured":"Gika HG, Ji C, Theodoridis GA, Michopoulos F, Kaplowitz N, Wilson ID (2012) Investigation of chronic alcohol consumption in rodents via ultra-high-performance liquid chromatography\u2013mass spectrometry based metabolite profiling. J Chromatogr A 1259:128\u2013137. https:\/\/doi.org\/10.1016\/j.chroma.2012.02.053","journal-title":"J Chromatogr A"},{"key":"2532_CR41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jflm.2015.02.014","volume":"32","author":"M Deng","year":"2015","unstructured":"Deng M, Zhang M, Huang X et al (2015) A gas chromatography\u2013mass spectrometry based study on serum metabolomics in rats chronically poisoned with hydrogen sulfide. J Forensic Leg Med 32:59\u201363. https:\/\/doi.org\/10.1016\/j.jflm.2015.02.014","journal-title":"J Forensic Leg Med"},{"key":"2532_CR42","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1080\/1354750X.2016.1201530","volume":"21","author":"L Wang","year":"2016","unstructured":"Wang L, Wu N, Zhao TY, Li J (2016) The potential biomarkers of drug addiction: proteomic and metabolomics challenges. Biomarkers 21:678\u2013685. https:\/\/doi.org\/10.1080\/1354750X.2016.1201530","journal-title":"Biomarkers"},{"key":"2532_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.aca.2016.04.040","volume":"925","author":"LS Castillo-Peinado","year":"2016","unstructured":"Castillo-Peinado LS, Luque de Castro MD (2016) Present and foreseeable future of metabolomics in forensic analysis. Anal Chim Acta 925:1\u201315. https:\/\/doi.org\/10.1016\/j.aca.2016.04.040","journal-title":"Anal Chim Acta"},{"key":"2532_CR44","doi-asserted-by":"publisher","unstructured":"Wood PL, Shirley NR (2013) Lipidomics analysis of postmortem interval: preliminary evaluation of human skeletal muscle. Metabolomics 3. https:\/\/doi.org\/10.3138\/9781442618145_2","DOI":"10.3138\/9781442618145_2"},{"key":"2532_CR45","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.forsciint.2011.07.031","volume":"213","author":"C Reichel","year":"2011","unstructured":"Reichel C (2011) OMICS-strategies and methods in the fight against doping. Forensic Sci Int 213:20\u201334. https:\/\/doi.org\/10.1016\/j.forsciint.2011.07.031","journal-title":"Forensic Sci Int"},{"key":"2532_CR46","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.forsciint.2011.07.024","volume":"213","author":"F Badoud","year":"2011","unstructured":"Badoud F, Guillarme D, Boccard J et al (2011) Analytical aspects in doping control: challenges and perspectives. Forensic Sci Int 213:49\u201361. https:\/\/doi.org\/10.1016\/j.forsciint.2011.07.024","journal-title":"Forensic Sci Int"},{"key":"2532_CR47","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1016\/j.fct.2011.04.028","volume":"49","author":"Q Saquib","year":"2011","unstructured":"Saquib Q, Al-Khedhairy AA, Siddiqui MA, Roy AS, Dasgupta S, Musarrat J (2011) Preferential binding of insecticide phorate with sub-domain IIA of human serum albumin induces protein damage and its toxicological significance. Food Chem Toxicol 49:1787\u20131795. https:\/\/doi.org\/10.1016\/j.fct.2011.04.028","journal-title":"Food Chem Toxicol"},{"key":"2532_CR48","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.taap.2011.12.006","volume":"259","author":"Q Saquib","year":"2012","unstructured":"Saquib Q, Attia SM, Siddiqui MA et al (2012) Phorate-induced oxidative stress, DNA damage and transcriptional activation of p53 and caspase genes in male Wistar rats. Toxicol Appl Pharmacol 259:54\u201365. https:\/\/doi.org\/10.1016\/j.taap.2011.12.006","journal-title":"Toxicol Appl Pharmacol"},{"key":"2532_CR49","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.mrgentox.2012.01.001","volume":"744","author":"Q Saquib","year":"2012","unstructured":"Saquib Q, Musarrat J, Siddiqui MA et al (2012) Cytotoxic and necrotic responses in human amniotic epithelial (WISH) cells exposed to organophosphate insecticide phorate. Mutat Res 744:125\u2013134. https:\/\/doi.org\/10.1016\/j.mrgentox.2012.01.001","journal-title":"Mutat Res"},{"key":"2532_CR50","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s10529-012-0850-6","volume":"34","author":"L Wang","year":"2012","unstructured":"Wang L, Liu X, Zhang Q et al (2012) Selection of DNA aptamers that bind to four organophosphorus pesticides. Biotech Lett 34:869\u2013874. https:\/\/doi.org\/10.1007\/s10529-012-0850-6","journal-title":"Biotech Lett"},{"key":"2532_CR51","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0021-9673(00)90100-6","volume":"369","author":"AK Singh","year":"1986","unstructured":"Singh AK, Hewetson DW, Jordon KC, Ashraf M (1986) Analysis of organophosphorus insecticides in biological samples by selective ion monitoring gas chromatography-mass spectrometry. J Chromatogr 369:83\u201396","journal-title":"J Chromatogr"},{"key":"2532_CR52","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/es5002105","volume":"48","author":"EL Schymanski","year":"2014","unstructured":"Schymanski EL, Jeon J, Gulde R et al (2014) Identifying small molecules via high resolution mass spectrometry: communicating confidence. Environ Sci Technol 48:2097\u20132098. https:\/\/doi.org\/10.1021\/es5002105","journal-title":"Environ Sci Technol"},{"key":"2532_CR53","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1289\/ehp.7894","volume":"113","author":"A Bradman","year":"2005","unstructured":"Bradman A, Eskenazi B, Barr DB et al (2005) Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community. Environ Health Perspect 113:1802\u20131807","journal-title":"Environ Health Perspect"},{"key":"2532_CR54","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.toxlet.2005.02.010","volume":"158","author":"A Lima","year":"2005","unstructured":"Lima A, Vega L (2005) Methyl-parathion and organophosphorous pesticide metabolites modify the activation status and interleukin-2 secretion of human peripheral blood mononuclear cells. Toxicol Lett 158:30\u201338. https:\/\/doi.org\/10.1016\/j.toxlet.2005.02.010","journal-title":"Toxicol Lett"},{"key":"2532_CR55","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.mrgentox.2009.07.009","volume":"679","author":"L Vega","year":"2009","unstructured":"Vega L, Valverde M, Elizondo G, Leyva JF, Rojas E (2009) Diethylthiophosphate and diethyldithiophosphate induce genotoxicity in hepatic cell lines when activated by further biotransformation via Cytochrome P450. Mutat Res 679:39\u201343. https:\/\/doi.org\/10.1016\/j.mrgentox.2009.07.009","journal-title":"Mutat Res"},{"key":"2532_CR56","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1126\/science.1218530","volume":"337","author":"S Herzig","year":"2012","unstructured":"Herzig S, Raemy E, Montessuit S et al (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337:93\u201396","journal-title":"Science"},{"key":"2532_CR57","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1126\/science.1218099","volume":"339","author":"D Bricker","year":"2012","unstructured":"Bricker D, Taylor E, Schell J et al (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, drosophila, and humans. Science 339:96\u2013100","journal-title":"Science"},{"key":"2532_CR58","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1161\/CIRCGENETICS.114.000220","volume":"7","author":"G Czibik","year":"2014","unstructured":"Czibik G, Steeples V, Yavari A, Ashrafian H (2014) Citric acid cycle intermediates in cardioprotection. Circ Cardiovasc Genet 7:711\u2013719. https:\/\/doi.org\/10.1161\/CIRCGENETICS.114.000220","journal-title":"Circ Cardiovasc Genet"},{"key":"2532_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-011-8189-x","volume":"44","author":"G Traina","year":"2011","unstructured":"Traina G, Federighi G, Macchi M, Bernardi R, Durante M, Brunelli M (2011) Modulation of myelin basic protein gene expression by acetyl-L-carnitine. Mol Neurobiol 44:1\u20136. https:\/\/doi.org\/10.1007\/s12035-011-8189-x","journal-title":"Mol Neurobiol"},{"key":"2532_CR60","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.plipres.2009.08.004","volume":"49","author":"LL Jones","year":"2010","unstructured":"Jones LL, McDonald DA, Borum PR (2010) Acylcarnitines: role in brain. Prog Lipid Res 49:61\u201375. https:\/\/doi.org\/10.1016\/j.plipres.2009.08.004","journal-title":"Prog Lipid Res"},{"key":"2532_CR61","unstructured":"(2010) Acetyl-L-carnitine monograph. Altern Med Rev 15: 76\u201383"},{"key":"2532_CR62","volume-title":"Biochemistry of glucuronic acid","author":"NE Artz","year":"1950","unstructured":"Artz NE, Osman EM (1950) Biochemistry of glucuronic acid. Academic Press Inc., NewYork"},{"key":"2532_CR63","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.pestbp.2011.09.011","volume":"101","author":"H-P Wang","year":"2011","unstructured":"Wang H-P, Liang Y-J, Zhang Q et al (2011) Changes in metabolic profiles of urine from rats following chronic exposure to anticholinesterase pesticides. Pestic Biochem Physiol 101:232\u2013239. https:\/\/doi.org\/10.1016\/j.pestbp.2011.09.011","journal-title":"Pestic Biochem Physiol"},{"key":"2532_CR64","first-page":"242","volume":"35","author":"K Gartland","year":"1989","unstructured":"Gartland K, Bonner F, Nicholson J (1989) Investigations into the biochemical effects of region-specific nephrotoxins. Mol Pharmacol 35:242\u2013250","journal-title":"Mol Pharmacol"},{"key":"2532_CR65","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/1523-1747.ep12543516","volume":"70","author":"PA Bowser","year":"1978","unstructured":"Bowser PA, Gray GM (1978) Sphingomyelinase in pig and human epidermis. J Investig Dermatol 70:331","journal-title":"J Investig Dermatol"},{"key":"2532_CR66","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1042\/bj20031733","volume":"380","author":"K-Y Tserng","year":"2004","unstructured":"Tserng K-Y, Griffin RL (2004) Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. Biochem J 380:715\u2013722","journal-title":"Biochem J"},{"key":"2532_CR67","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1016\/S0022-2275(20)34898-7","volume":"40","author":"LS Golfman","year":"1999","unstructured":"Golfman LS, Haughey NJ, Wong JT et al (1999) Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells. J Lipid Res 40:1818\u20131826","journal-title":"J Lipid Res"},{"key":"2532_CR68","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0005-2760(97)00114-8","volume":"1348","author":"PC Choy","year":"1997","unstructured":"Choy PC, Skrzypczak M, Lee D, Jay FT (1997) Acyl-GPC and alkenyl\/alkyl-GPC:acyl-CoA acyltransferases1. Biochim Biophys Acta (BBA) Lipids Lipid Metab 1348:124\u2013133","journal-title":"Biochim Biophys Acta (BBA) Lipids Lipid Metab"}],"container-title":["International Journal of Legal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-021-02532-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00414-021-02532-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-021-02532-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T09:13:31Z","timestamp":1623748411000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00414-021-02532-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,13]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2532"],"URL":"https:\/\/doi.org\/10.1007\/s00414-021-02532-z","relation":{},"ISSN":["0937-9827","1437-1596"],"issn-type":[{"value":"0937-9827","type":"print"},{"value":"1437-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,13]]},"assertion":[{"value":"25 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants performed by any of the authors. Animal experiments were performed in accordance with the current China legislation and approved by the Institute of Zoology Animal and Medical Ethics Committee, Shanxi Medical University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}