{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:20:05Z","timestamp":1791667205651,"version":"4.3.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Legal Med"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Synthetic cathinones are a class of psychoactive drugs that have become, in recent years, of quite common observation in medical and toxicological forensic field. MDPHP (3,4-methylenedioxy-\u03b1-pyrrolidinohexanophenone) belongs to this class of substances but lethal acute intoxication caused by this specific substance without other co-ingestions has never been described in literature. We are presenting the unique case of a fatal acute intoxication caused by MDPHP in a 48-year-old man carried to the A&amp;E department of a big Milanese hospital where he suddenly deceased after brief time. Clinical records, autopsy examination, histological findings, and toxicological analysis, assessed via a Q-Exactive Orbitrap with a HPLC system and LC\/MS\u2013MS system, are discussed. This case report may represent the first case of this type of intoxication and might help in improving recognition and treatment of these particular cases.<\/jats:p>","DOI":"10.1007\/s00414-022-02799-w","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T22:02:20Z","timestamp":1644962540000},"page":"1291-1296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A unique case of death by MDPHP with no other co-ingestion: a forensic toxicology case"],"prefix":"10.1007","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-6815","authenticated-orcid":false,"given":"Domenico","family":"Di Candia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-4121","authenticated-orcid":false,"given":"Michele","family":"Boracchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ciprandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6081-0596","authenticated-orcid":false,"given":"Gaia","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-2541","authenticated-orcid":false,"given":"Riccardo","family":"Zoja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"2799_CR1","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1016\/S0140-6736(19)32231-7","volume":"394","author":"A Peacock","year":"2019","unstructured":"Peacock A, Bruno R, Gisev N et al (2019) New psychoactive substances: challenges for drug surveillance, control, and public health responses. Lancet 394:1668\u20131684. https:\/\/doi.org\/10.1016\/S0140-6736(19)32231-7","journal-title":"Lancet"},{"key":"2799_CR2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1080\/15563650.2017.1370097","volume":"56","author":"O Beck","year":"2018","unstructured":"Beck O, B\u00e4ckberg M, Signell P, Helander A (2018) Intoxications in the STRIDA project involving a panorama of psychostimulant pyrovalerone derivatives, MDPV copycats. Clin Toxicol 56:256\u2013263. https:\/\/doi.org\/10.1080\/15563650.2017.1370097","journal-title":"Clin Toxicol"},{"key":"2799_CR3","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1002\/dta.2869","volume":"12","author":"M Grapp","year":"2020","unstructured":"Grapp M, Kaufmann C, Schwelm HM et al (2020) Intoxication cases associated with the novel designer drug 3\u2032,4\u2032-methylenedioxy-\u03b1-pyrrolidinohexanophenone and studies on its human metabolism using high-resolution mass spectrometry. Drug Test Anal 12:1320\u20131335. https:\/\/doi.org\/10.1002\/dta.2869","journal-title":"Drug Test Anal"},{"key":"2799_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.4274\/tjps.galenos.2018.40820","volume":"17","author":"B Altun","year":"2020","unstructured":"Altun B, \u00c7ok \u0130 (2020) Psychoactive bath salts and neurotoxicity risk. Turk J Pharm Sci 17:235\u2013241. https:\/\/doi.org\/10.4274\/tjps.galenos.2018.40820","journal-title":"Turk J Pharm Sci"},{"key":"2799_CR5","doi-asserted-by":"publisher","first-page":"268","DOI":"10.26355\/eurrev-201801-14129","volume":"22","author":"S Zaami","year":"2018","unstructured":"Zaami S, Giorgetti R, Pichini S et al (2018) Synthetic cathinones related fatalities: an update. Eur Rev Med Pharmacol Sci 22:268\u2013274. https:\/\/doi.org\/10.26355\/eurrev-201801-14129","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2799_CR6","doi-asserted-by":"publisher","unstructured":"Di Candia D, Boracchi M, Muccino E, et al (2021) The lethal cutting: an unexpected cause of death\u2014a methomyl acute intoxication. J Anal Toxicol 46:e28\u2013e31.\u00a0https:\/\/doi.org\/10.1093\/jat\/bkab006","DOI":"10.1093\/jat\/bkab006"},{"key":"2799_CR7","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/jat\/bkt054","volume":"37","author":"F Toxicology","year":"2013","unstructured":"Group SW, Toxicology F, Methods V et al (2013) Scientific working group for forensic toxicology (SWGTOX) standard practices for method validation in forensic toxicology. J Anal Toxicol 37:452\u2013474. https:\/\/doi.org\/10.1093\/jat\/bkt054","journal-title":"J Anal Toxicol"},{"key":"2799_CR8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.talanta.2017.11.020","volume":"179","author":"KL Fowble","year":"2018","unstructured":"Fowble KL, Shepard JRE, Musah RA (2018) Identification and classification of cathinone unknowns by statistical analysis processing of direct analysis in real time-high resolution mass spectrometry-derived \u201cneutral loss\u201d spectra. Talanta 179:546\u2013553. https:\/\/doi.org\/10.1016\/j.talanta.2017.11.020","journal-title":"Talanta"},{"key":"2799_CR9","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/dta.2891","volume":"12","author":"P Kavanagh","year":"2020","unstructured":"Kavanagh P, Gofenberg M, Shevyrin V et al (2020) Tentative identification of the phase I and II metabolites of two synthetic cathinones, MDPHP and \u03b1-PBP, in human urine. Drug Test Anal 12:1442\u20131451. https:\/\/doi.org\/10.1002\/dta.2891","journal-title":"Drug Test Anal"},{"key":"2799_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/15563650.2018.1502443","volume":"57","author":"P Adamowicz","year":"2019","unstructured":"Adamowicz P, Hydzik P (2019) Fetal death associated with the use of 3,4-MDPHP and \u03b1-PHP. Clin Toxicol 57:112\u2013116. https:\/\/doi.org\/10.1080\/15563650.2018.1502443","journal-title":"Clin Toxicol"}],"container-title":["International Journal of Legal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-022-02799-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00414-022-02799-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-022-02799-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T05:25:31Z","timestamp":1660368331000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00414-022-02799-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2799"],"URL":"https:\/\/doi.org\/10.1007\/s00414-022-02799-w","relation":{},"ISSN":["0937-9827","1437-1596"],"issn-type":[{"value":"0937-9827","type":"print"},{"value":"1437-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,15]]},"assertion":[{"value":"23 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the work covered in this manuscript has been conducted under ethical approval. We confirm that there are no impediments to publication due to intellectual property and that we have followed the regulations of our institutions concerning intellectual property.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained when required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the work covered in this manuscript has been conducted under ethical approval.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}}]}}