{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:27:34Z","timestamp":1768739254019,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971793"],"award-info":[{"award-number":["81971793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772023"],"award-info":[{"award-number":["81772023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenyang Science and Technology Innovation Support Plan for Young and Middle-age Talent","award":["RC200412"],"award-info":[{"award-number":["RC200412"]}]},{"name":"Innovation and Entrepreneurship Training Program for College Students of China Medical University","award":["X202210159061"],"award-info":[{"award-number":["X202210159061"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Legal Med"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s00414-022-02897-9","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T16:07:26Z","timestamp":1664467646000},"page":"61-72","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Candidate biomarkers in brown adipose tissue for post-mortem diagnosis of fatal hypothermia"],"prefix":"10.1007","volume":"138","author":[{"given":"Miao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Shen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Wei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"2897_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1136\/oem.2006.029017","volume":"64","author":"S Hajat","year":"2007","unstructured":"Hajat S, Kovats RS, Lachowycz K (2007) Heat-related and cold-related deaths in England and Wales: who is at risk? Occup Environ Med 64:93\u2013100. https:\/\/doi.org\/10.1136\/oem.2006.029017","journal-title":"Occup Environ Med"},{"key":"2897_CR2","unstructured":"Berko J, Ingram DD, Saha S, Parker JD (2014) Deaths attributed to heat, cold, and other weather events in the United States, 2006-2010. Natl Health Stat Rep 1-15"},{"key":"2897_CR3","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/jech.45.1.19","volume":"45","author":"B Herity","year":"1991","unstructured":"Herity B, Daly L, Bourke GJ, Horgan JM (1991) Hypothermia and mortality and morbidity. An epidemiological analysis. J Epidemiol Community Health 45:19. https:\/\/doi.org\/10.1136\/jech.45.1.19","journal-title":"J Epidemiol Community Health"},{"key":"2897_CR4","doi-asserted-by":"publisher","unstructured":"Lin H, Deng K, Zhang J et al (2019) Biochemical detection of fatal hypothermia and hyperthermia in affected rat hypothalamus tissues by Fourier transform infrared spectroscopy. Biosci Rep 39. https:\/\/doi.org\/10.1042\/bsr20181633","DOI":"10.1042\/bsr20181633"},{"key":"2897_CR5","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00414-014-0977-1","volume":"128","author":"C Palmiere","year":"2014","unstructured":"Palmiere C, Teresinski G, Hejna P (2014) Postmortem diagnosis of hypothermia. Int J Legal Med 128:607\u2013614. https:\/\/doi.org\/10.1007\/s00414-014-0977-1","journal-title":"Int J Legal Med"},{"key":"2897_CR6","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1136\/emermed-2018-207804","volume":"35","author":"P Paal","year":"2018","unstructured":"Paal P, Rauch S (2018) Indoor accidental hypothermia in the elderly: an emerging lethal entity in the 21st century. Emerg Med J 35:667\u2013668. https:\/\/doi.org\/10.1136\/emermed-2018-207804","journal-title":"Emerg Med J"},{"key":"2897_CR7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.4065\/78.5.603","volume":"78","author":"N Charkoudian","year":"2003","unstructured":"Charkoudian N (2003) Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. Mayo Clin Proc 78:603\u2013612. https:\/\/doi.org\/10.4065\/78.5.603","journal-title":"Mayo Clin Proc"},{"key":"2897_CR8","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1172\/jci60433","volume":"122","author":"V Ouellet","year":"2012","unstructured":"Ouellet V, Labbe SM, Blondin DP et al (2012) Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest 122:545\u2013552. https:\/\/doi.org\/10.1172\/jci60433","journal-title":"J Clin Invest"},{"key":"2897_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1152\/physrev.00015.2003","volume":"84","author":"B Cannon","year":"2004","unstructured":"Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277\u2013359. https:\/\/doi.org\/10.1152\/physrev.00015.2003","journal-title":"Physiol Rev"},{"key":"2897_CR10","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.2741\/3786","volume":"16","author":"D Richard","year":"2011","unstructured":"Richard D, Picard F (2011) Brown fat biology and thermogenesis. Front Biosci (Landmark Ed) 16:1233\u20131260. https:\/\/doi.org\/10.2741\/3786","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2897_CR11","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1002\/cphy.c140013","volume":"4","author":"SF Morrison","year":"2014","unstructured":"Morrison SF, Madden CJ (2014) Central nervous system regulation of brown adipose tissue. Compr Physiol 4:1677\u20131713. https:\/\/doi.org\/10.1002\/cphy.c140013","journal-title":"Compr Physiol"},{"key":"2897_CR12","doi-asserted-by":"publisher","first-page":"16616","DOI":"10.1074\/jbc.M117.790451","volume":"292","author":"NC Bal","year":"2017","unstructured":"Bal NC, Singh S, Reis FCG et al (2017) Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem 292:16616\u201316625. https:\/\/doi.org\/10.1074\/jbc.M117.790451","journal-title":"J Biol Chem"},{"key":"2897_CR13","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nprot.2012.013","volume":"7","author":"S Lim","year":"2012","unstructured":"Lim S, Honek J, Xue Y et al (2012) Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nat Protoc 7:606\u2013615. https:\/\/doi.org\/10.1038\/nprot.2012.013","journal-title":"Nat Protoc"},{"key":"2897_CR14","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/ejcn.2016.223","volume":"71","author":"RJ Brychta","year":"2017","unstructured":"Brychta RJ, Chen KY (2017) Cold-induced thermogenesis in humans. Eur J Clin Nutr 71:345\u2013352. https:\/\/doi.org\/10.1038\/ejcn.2016.223","journal-title":"Eur J Clin Nutr"},{"key":"2897_CR15","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","volume":"360","author":"WD van Marken Lichtenbelt","year":"2009","unstructured":"van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360:1500\u20131508. https:\/\/doi.org\/10.1056\/NEJMoa0808718","journal-title":"N Engl J Med"},{"key":"2897_CR16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/s0005-2728(00)00247-4","volume":"1504","author":"J Nedergaard","year":"2001","unstructured":"Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B (2001) UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504:82\u2013106. https:\/\/doi.org\/10.1016\/s0005-2728(00)00247-4","journal-title":"Biochim Biophys Acta"},{"key":"2897_CR17","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1139\/y2012-013","volume":"90","author":"HJ Green","year":"2012","unstructured":"Green HJ, Burnett M, Kollias H, Ouyang J, Smith I, Tupling S (2012) Can increases in capillarization explain the early adaptations in metabolic regulation in human muscle to short-term training? Can J Physiol Pharmacol 90:557\u2013566. https:\/\/doi.org\/10.1139\/y2012-013","journal-title":"Can J Physiol Pharmacol"},{"key":"2897_CR18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/lipd.12148","volume":"54","author":"N Wang","year":"2019","unstructured":"Wang N, Lu HY, Li X et al (2019) ZW290 increases cold tolerance by inducing thermogenesis via the upregulation of uncoupling protein 1 in brown adipose tissue in vitro and in vivo. Lipids 54:265\u2013276. https:\/\/doi.org\/10.1002\/lipd.12148","journal-title":"Lipids"},{"key":"2897_CR19","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.jflm.2013.05.003","volume":"20","author":"F Bright","year":"2013","unstructured":"Bright F, Winskog C, Walker M, Byard RW (2013) Why are Wischnewski spots not always present in lethal hypothermia? The results of testing a stress-reduced animal model. J Forensic Legal Med 20:785\u2013787. https:\/\/doi.org\/10.1016\/j.jflm.2013.05.003","journal-title":"J Forensic Legal Med"},{"key":"2897_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/01.paf.0000202716.06378.91","volume":"27","author":"M Tsokos","year":"2006","unstructured":"Tsokos M, Rothschild MA, Madea B, Rie M, Sperhake JP (2006) Histological and immunohistochemical study of Wischnewsky spots in fatal hypothermia. Am J Forensic Med Pathol 27:70\u201374. https:\/\/doi.org\/10.1097\/01.paf.0000202716.06378.91","journal-title":"Am J Forensic Med Pathol"},{"key":"2897_CR21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s12024-019-00111-8","volume":"15","author":"H Lin","year":"2019","unstructured":"Lin H, Zou D, Luo Y et al (2019) Postmortem diagnosis of fatal hypothermia\/hyperthermia by spectrochemical analysis of plasma. Forensic Sci Med Pathol 15:332\u2013341. https:\/\/doi.org\/10.1007\/s12024-019-00111-8","journal-title":"Forensic Sci Med Pathol"},{"key":"2897_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.forsciint.2012.12.007","volume":"226","author":"C Palmiere","year":"2013","unstructured":"Palmiere C, Bardy D, Letovanec I et al (2013) Biochemical markers of fatal hypothermia. Forensic Sci Int 226:54\u201361. https:\/\/doi.org\/10.1016\/j.forsciint.2012.12.007","journal-title":"Forensic Sci Int"},{"key":"2897_CR23","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1111\/1556-4029.14260","volume":"65","author":"H Lin","year":"2020","unstructured":"Lin H, Guo X, Luo Y et al (2020) Postmortem diagnosis of fatal hypothermia by Fourier transform infrared spectroscopic analysis of edema fluid in formalin-fixed, paraffin-embedded lung tissues. J Forensic Sci 65:846\u2013854. https:\/\/doi.org\/10.1111\/1556-4029.14260","journal-title":"J Forensic Sci"},{"key":"2897_CR24","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1021\/acs.jproteome.0c00901","volume":"20","author":"G Rousseau","year":"2021","unstructured":"Rousseau G, Chao de la Barca JM, Roug\u00e9-Maillart C et al (2021) Preliminary metabolomic profiling of the vitreous humor from hypothermia fatalities. J Proteome Res 20:2390\u20132396. https:\/\/doi.org\/10.1021\/acs.jproteome.0c00901","journal-title":"J Proteome Res"},{"key":"2897_CR25","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s00414-018-1937-y","volume":"133","author":"G Rousseau","year":"2019","unstructured":"Rousseau G, Chao de la Barca JM, Roug\u00e9-Maillart C et al (2019) A serum metabolomics signature of hypothermia fatalities involving arginase activity, tryptophan content, and phosphatidylcholine saturation. Int J Legal Med 133:889\u2013898. https:\/\/doi.org\/10.1007\/s00414-018-1937-y","journal-title":"Int J Legal Med"},{"key":"2897_CR26","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0022-2275(20)39470-0","volume":"12","author":"L Sj\u00f6str\u00f6m","year":"1971","unstructured":"Sj\u00f6str\u00f6m L, Bj\u00f6rntorp P, Vr\u00e1na J (1971) Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium-fixed fat cells. J Lipid Res 12:521\u2013530","journal-title":"J Lipid Res"},{"key":"2897_CR27","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/nm.2297","volume":"17","author":"A Bartelt","year":"2011","unstructured":"Bartelt A, Bruns OT, Reimer R et al (2011) Brown adipose tissue activity controls triglyceride clearance. Nat Med 17:200\u2013205. https:\/\/doi.org\/10.1038\/nm.2297","journal-title":"Nat Med"},{"key":"2897_CR28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/biology8010009","volume":"8","author":"P Valgas","year":"2019","unstructured":"Valgas P, da Silva C, Hern\u00e1ndez-Saavedra D, White JD, Stanford KI (2019) Cold and exercise: therapeutic tools to activate brown adipose tissue and combat obesity. Biology (Basel) 8:9. https:\/\/doi.org\/10.3390\/biology8010009","journal-title":"Biology (Basel)"},{"key":"2897_CR29","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.2337\/db09-0530","volume":"58","author":"M Saito","year":"2009","unstructured":"Saito M, Okamatsu-Ogura Y, Matsushita M et al (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58:1526\u20131531. https:\/\/doi.org\/10.2337\/db09-0530","journal-title":"Diabetes"},{"key":"2897_CR30","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1023\/a:1005404708710","volume":"31","author":"RB McDonald","year":"1999","unstructured":"McDonald RB, Horwitz BA (1999) Brown adipose tissue thermogenesis during aging and senescence. J Bioenerg Biomembr 31:507\u2013516. https:\/\/doi.org\/10.1023\/a:1005404708710","journal-title":"J Bioenerg Biomembr"},{"key":"2897_CR31","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1194\/jlr.M079665","volume":"59","author":"P Kotzbeck","year":"2018","unstructured":"Kotzbeck P, Giordano A, Mondini E et al (2018) Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation. J Lipid Res 59:784\u2013794. https:\/\/doi.org\/10.1194\/jlr.M079665","journal-title":"J Lipid Res"},{"key":"2897_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ddtec.2021.06.006","volume":"39","author":"J Li","year":"2021","unstructured":"Li J, Smith LS, Zhu HJ (2021) Data-independent acquisition (DIA): an emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters. Drug Discov Today Technol 39:49\u201356. https:\/\/doi.org\/10.1016\/j.ddtec.2021.06.006","journal-title":"Drug Discov Today Technol"},{"key":"2897_CR33","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2165\/00007256-199316040-00005","volume":"16","author":"RJ Shephard","year":"1993","unstructured":"Shephard RJ (1993) Metabolic adaptations to exercise in the cold. An update. Sports Med 16:266\u2013289. https:\/\/doi.org\/10.2165\/00007256-199316040-00005","journal-title":"Sports Med"},{"key":"2897_CR34","doi-asserted-by":"publisher","first-page":"158557","DOI":"10.1016\/j.bbalip.2019.158557","volume":"1865","author":"JA Prieto","year":"2020","unstructured":"Prieto JA, Estruch F, C\u00f3rcoles-S\u00e1ez I et al (2020) Pho85 and PI(4,5)P(2) regulate different lipid metabolic pathways in response to cold. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158557. https:\/\/doi.org\/10.1016\/j.bbalip.2019.158557","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2897_CR35","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1152\/physrev.00059.2009","volume":"91","author":"AH Hutagalung","year":"2011","unstructured":"Hutagalung AH, Novick PJ (2011) Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91:119\u2013149. https:\/\/doi.org\/10.1152\/physrev.00059.2009","journal-title":"Physiol Rev"},{"key":"2897_CR36","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1091\/mbc.E12-07-0530","volume":"24","author":"N Romero","year":"2013","unstructured":"Romero N, Dumur CI, Martinez H et al (2013) Rab1b overexpression modifies Golgi size and gene expression in HeLa cells and modulates the thyrotrophin response in thyroid cells in culture. Mol Biol Cell 24:617\u2013632. https:\/\/doi.org\/10.1091\/mbc.E12-07-0530","journal-title":"Mol Biol Cell"},{"key":"2897_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molmet.2019.03.011","volume":"24","author":"S Gohlke","year":"2019","unstructured":"Gohlke S, Zagoriy V, Cuadros Inostroza A et al (2019) Identification of functional lipid metabolism biomarkers of brown adipose tissue aging. Mol Metab 24:1\u201317. https:\/\/doi.org\/10.1016\/j.molmet.2019.03.011","journal-title":"Mol Metab"},{"key":"2897_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(92)90971-b","volume":"591","author":"BR Wang","year":"1992","unstructured":"Wang BR, Zaheer A, Lim R (1992) Polyclonal antibody localizes glia maturation factor beta-like immunoreactivity in neurons and glia. Brain Res 591:1\u20137. https:\/\/doi.org\/10.1016\/0006-8993(92)90971-b","journal-title":"Brain Res"},{"key":"2897_CR39","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1111\/j.1471-4159.1993.tb03237.x","volume":"60","author":"A Zaheer","year":"1993","unstructured":"Zaheer A, Fink BD, Lim R (1993) Expression of glia maturation factor beta mRNA and protein in rat organs and cells. J Neurochem 60:914\u2013920. https:\/\/doi.org\/10.1111\/j.1471-4159.1993.tb03237.x","journal-title":"J Neurochem"},{"key":"2897_CR40","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/s0006-291x(02)00467-9","volume":"294","author":"A Zaheer","year":"2002","unstructured":"Zaheer A, Mathur SN, Lim R (2002) Overexpression of glia maturation factor in astrocytes leads to immune activation of microglia through secretion of granulocyte-macrophage-colony stimulating factor. Biochem Biophys Res Commun 294:238\u2013244. https:\/\/doi.org\/10.1016\/s0006-291x(02)00467-9","journal-title":"Biochem Biophys Res Commun"},{"key":"2897_CR41","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molbrainres.2004.09.027","volume":"133","author":"N Hotta","year":"2005","unstructured":"Hotta N, Aoyama M, Inagaki M et al (2005) Expression of glia maturation factor beta after cryogenic brain injury. Brain Res Mol Brain Res 133:71\u201377. https:\/\/doi.org\/10.1016\/j.molbrainres.2004.09.027","journal-title":"Brain Res Mol Brain Res"},{"key":"2897_CR42","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/j.1460-9568.2010.07128.x","volume":"31","author":"A Diestel","year":"2010","unstructured":"Diestel A, Troeller S, Billecke N, Sauer IM, Berger F, Schmitt KR (2010) Mechanisms of hypothermia-induced cell protection mediated by microglial cells in vitro. Eur J Neurosci 31:779\u2013787. https:\/\/doi.org\/10.1111\/j.1460-9568.2010.07128.x","journal-title":"Eur J Neurosci"},{"key":"2897_CR43","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.legalmed.2004.07.002","volume":"7","author":"G Teresi\u0144ski","year":"2005","unstructured":"Teresi\u0144ski G, Buszewicz G, Madro R (2005) Biochemical background of ethanol-induced cold susceptibility. Leg Med (Tokyo) 7:15\u201323. https:\/\/doi.org\/10.1016\/j.legalmed.2004.07.002","journal-title":"Leg Med (Tokyo)"},{"key":"2897_CR44","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.bbadis.2013.05.011","volume":"1842","author":"YH Lee","year":"2014","unstructured":"Lee YH, Mottillo EP, Granneman JG (2014) Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta 1842:358\u2013369. https:\/\/doi.org\/10.1016\/j.bbadis.2013.05.011","journal-title":"Biochim Biophys Acta"}],"container-title":["International Journal of Legal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-022-02897-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00414-022-02897-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-022-02897-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T12:03:40Z","timestamp":1704715420000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00414-022-02897-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["2897"],"URL":"https:\/\/doi.org\/10.1007\/s00414-022-02897-9","relation":{},"ISSN":["0937-9827","1437-1596"],"issn-type":[{"value":"0937-9827","type":"print"},{"value":"1437-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"assertion":[{"value":"30 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of China Medical University (Approval No. CMU2020315) and performed in accordance with the 1964 Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}