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Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Legal Med"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Alcohol intoxication is known to affect blood coagulation. The specific effects remain poorly understood. Here, we investigate the impact of severe alcohol intoxication on blood clotting by comprehensive coagulation testing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A prospective study included 21 patients admitted to the emergency department of University Hospital D\u00fcsseldorf with severe alcohol intoxication (target blood alcohol concentration\u2009&gt;\u20092\u00a0g\/l). Platelet function and coagulation was compared between states of alcohol intoxication and soberness using multiple platelet function analysis, thrombelastography and determination of single coagulation factors. The same test panel was used to study\u00a0in vitro-effects of ethanol\u00a0on coagulation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Blood alcohol was correlated with impaired platelet aggregation determined in vivo by functional testing employing ADP and ASPI stimulation. Blood alcohol-associated coagulation impairment was not detectable by thrombelastography or\u00a0clotting factor measurements. Blood alcohol was\u00a0negatively correlated\u00a0with von Willebrand factor ratio and clot strength. The association of elevated blood alcohol with impaired coagulation could not be replicated in vitro.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>Our findings suggest that alcohol impairs primary hemostasis by reducing platelet function, while secondary hemostasis remains largely unaffected. Reversion of effects upon sobering suggest a rather direct impact of alcohol on platelet function. That effect was, however, not replicated in vitro possibly implicating involvement of vascular factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Blood alcohol has a potentially negative impact on platelet function, which should be considered\u00a0in the clinical management of intoxicated patients, especially\u00a0in emergency settings. Potential bleeding risks due to increased blood alcohol are possibly detected by analysis of platelet function, while\u00a0not by thrombelastography or plasmatic coagulation tests.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00414-025-03449-7","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T09:19:03Z","timestamp":1740215943000},"page":"1797-1808","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of alcohol intoxication on primary and secondary haemostasis \u2013 results from comprehensive coagulation testing"],"prefix":"10.1007","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3087-7002","authenticated-orcid":false,"given":"Ronja Sabine","family":"Schm\u00f6lders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derik","family":"Hermsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bernhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Boege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benno","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"3449_CR1","doi-asserted-by":"crossref","unstructured":"Pape HC, Kurtz A, Silbernagl S (eds) (2019) \"Physiologie\", 9th edn. 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