{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:59:41Z","timestamp":1768517981381,"version":"3.49.0"},"reference-count":5,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Legal Med"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Perioperative death is a catastrophic event for the family and the surgical team. It is in the interest of both that an autopsy is carried out to explain the death. We report a sudden perioperative death post aortic valve replacement in an undiagnosed hypertrophic cardiomyopathy (HCM) in an elderly female.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 73-year-old female underwent an elective aortic valve replacement (AVR) due to severe aortic valve stenosis (AS). The operation went smoothly. However, left ventricular function was poor despite maximal inotropic treatment. The left ventricular function never recovered and she died on the operating table. The heart weight was normal but the left ventricle shows septal hypertrophy (20\u00a0mm). Histology of the left ventricle showed florid myocyte disarray indicating hypertrophic cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>AS is the most common Valvular Heart Disease, and most patients undergo AVR. Nevertheless, sudden unexpected death remains a common cause of late mortality after successful valve replacement. Surprisingly this lady died just after the operative procedure. Histological examination confirmed HCM. HCM is an inherited cardiac condition and it is important for the family to be screened to prevent future sudden cardiac death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of autopsy in a post-operative death case. It can be of great value to the surgical team and family members.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00414-025-03544-9","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T02:08:18Z","timestamp":1759370898000},"page":"249-251","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sudden perioperative death post aortic valve replacement with autopsy showing hypertrophic cardiomyopathy in elderly female"],"prefix":"10.1007","volume":"140","author":[{"given":"Zubair Abdul","family":"Razak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Westaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-3881","authenticated-orcid":false,"given":"Mary N.","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"issue":"22","key":"3544_CR1","doi-asserted-by":"publisher","first-page":"e022627","DOI":"10.1161\/JAHA.121.022627","volume":"10","author":"N Glaser","year":"2021","unstructured":"Glaser N, Persson M, Franco-Cereceda A, Sartipy U (2021) Cause of death after surgical aortic valve replacement: SWEDEHEART observational study. J Am Heart Assoc 10(22):e022627 Epub 2021 Nov 8","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"3544_CR2","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/clc.4960120405","volume":"12","author":"M F\u00f6ppl","year":"1989","unstructured":"F\u00f6ppl M, Hoffmann A, Amann FW et al (1989) Sudden cardiac death after aortic valve surgery: incidence and concomitant factors. Clin Cardiol 12(4):202\u2013207","journal-title":"Clin Cardiol"},{"key":"3544_CR3","doi-asserted-by":"crossref","unstructured":"Finocchiaro G, Papadakis M, Tanzarella G et al (2019 Feb) Sudden death can be the first manifestation of hypertrophic cardiomyopathy: data from a united Kingdom pathology registry. J Am Coll Cardiol EP 5(2):252\u2013254","DOI":"10.1016\/j.jacep.2018.11.004"},{"issue":"7","key":"3544_CR4","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1093\/europace\/euaa348","volume":"23","author":"G Finocchiaro","year":"2021","unstructured":"Finocchiaro G, Sheikh N, Leone O, Westaby J et al (2021) Arrhythmogenic potential of myocardial disarray in hypertrophic cardiomyopathy: genetic basis, functional consequences and relation to sudden cardiac death. Europace 23(7):985\u2013995 Erratum in: Europace. 2021;23(9):1509","journal-title":"Europace"},{"issue":"4","key":"3544_CR5","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s00428-023-03523-8","volume":"482","author":"MN Sheppard","year":"2023","unstructured":"Sheppard MN, van der Wal AC, Banner J, d\u2019Amati G et al (2023) Association for European cardiovascular pathology (AECVP). Genetically determined cardiomyopathies at autopsy: the pivotal role of the pathologist in Establishing the diagnosis and guiding family screening. Virchows Arch 482(4):653\u2013669","journal-title":"Virchows Arch"}],"container-title":["International Journal of Legal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-025-03544-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00414-025-03544-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00414-025-03544-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:10:17Z","timestamp":1768464617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00414-025-03544-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["3544"],"URL":"https:\/\/doi.org\/10.1007\/s00414-025-03544-9","relation":{},"ISSN":["0937-9827","1437-1596"],"issn-type":[{"value":"0937-9827","type":"print"},{"value":"1437-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"assertion":[{"value":"14 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for this case report was obtained from Wales Research Ethics Committee 3 Cardiff (Reference number: 24\/WA\/0008).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"There are no relevant financial or non-financial competing interests to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Consent for research and teaching obtained from the next of kin.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent"}},{"value":"The authors declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"conflicts of interest"}},{"value":"This case report does not need a consent to publish because the case and photos are anonymous. Ethics approval and consent for research from the next of kin were obtained.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}