{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T20:33:32Z","timestamp":1781728412579,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1007\/s00415-005-0591-8","type":"journal-article","created":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T15:48:08Z","timestamp":1105717688000},"page":"14-20","source":"Crossref","is-referenced-by-count":20,"title":["Secondary prevention after ischemic stroke"],"prefix":"10.1007","volume":"252","author":[{"given":"Marie","family":"Girot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Mackowiak-Cordoliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Deplanque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"H\ufffdnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Leys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"CR1","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0140-6736(96)07495-8","volume":"349","author":"Murray","year":"1997","unstructured":"Murray CJ, Lopez AD (1997) Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 349:1436?1442","journal-title":"Lancet"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0140-6736(99)04407-4","volume":"354","author":"Hankey","year":"1999","unstructured":"Hankey GJ, Warlow CP (1999) Treatment and secondary prevention of stroke: evidence, costs, and effects on individuals and populations. Lancet 354:1457?1463","journal-title":"Lancet"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1212\/WNL.59.1.26","volume":"59","author":"Leys","year":"2002","unstructured":"Leys D, Bandu L, H\u00e9non H, Lucas C, Mounier-Vehier F, Rondepierre P, Godefroy O (2002) Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke. Neurology 59:26?33","journal-title":"Neurology"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1001\/jama.1983.03340210040022","volume":"250","author":"Kannel","year":"1983","unstructured":"Kannel WB, Wolf PA, Verter J (1983) Manifestations of coronary disease predisposing to stroke. The Framingham study. JAMA 250:2942?2946","journal-title":"JAMA"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/hs0102.101630","volume":"33","author":"Tanne","year":"2002","unstructured":"Tanne D, Shotan A, Goldbourt U, Haim M, Boyko V, Adler Y, Mandelzweig L, Behar S (2002) Severity of angina pectoris and risk of ischemic stroke. Stroke 33:245?250","journal-title":"Stroke"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s004150200057","volume":"249","author":"Leys","year":"2002","unstructured":"Leys D, Deplanque D, Mounier-Vehier C, Mackowiak-Cordoliani M-A, Lucas C, Bordet R (2002) Stroke prevention: management of modifiable risk factors. J Neurol 249:507?517","journal-title":"J Neurol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","volume":"335","author":"Collins","year":"1990","unstructured":"Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO, Hennekens CH (1990) Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335:827?838","journal-title":"Lancet"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0140-6736(02)09327-3","volume":"360","author":"Heart","year":"2002","unstructured":"Heart Protection Study Collaborative Group (2002) MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360:7?22","journal-title":"Lancet"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","volume":"359","author":"Dahlof","year":"2002","unstructured":"Dahlof B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, Faire U, Fyhrquist F, Ibsen H, Kristiansson K, Lederballe-Pedersen O, Lindholm LH, Nieminen MS, Omvik P, Oparil S, Wedel H and the LIFE Study Group (2002) Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359:995?1003","journal-title":"Lancet"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(01)06178-5","volume":"358","author":"Progress","year":"2001","unstructured":"Progress Collaborative group (2001) Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 358:1033?1041","journal-title":"Lancet"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1001\/archinte.1997.00440320055006","volume":"157","author":"Grundy","year":"1997","unstructured":"Grundy SM (1997) Cholesterol and coronary heart disease. The 21st century. Arch Intern Med 157:1177?1184","journal-title":"Arch Intern Med"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000016035","volume":"10","author":"Di Mascio","year":"2000","unstructured":"Di Mascio R, Marchioli R, Tognoni G (2000) Cholesterol reduction and stroke occurrence: an overview of randomized clinical trials. Cerebrovasc Dis 10:85?92","journal-title":"Cerebrovasc Dis"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(99)12323-7","volume":"355","author":"Heart","year":"2000","unstructured":"Heart Outcomes Prevention Evaluation Study Investigators (2000) Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Lancet 355:253?259","journal-title":"Lancet"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/hrt.82.5.563","volume":"82","author":"Deplanque","year":"1999","unstructured":"Deplanque D, Corea F, Arquizan C, Parnetti L, Mas JL, Gallai V, Leys D (1999) Stroke and atrial fibrillation: is stroke prevention treatment appropriate beforehand? SAFE I Study Investigators. Heart 82:563?569","journal-title":"Heart"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1161\/01.STR.31.8.1877","volume":"31","author":"Redfern","year":"2000","unstructured":"Redfern J, McKevitt C, Dundas R, Rudd AG, Wolfe CD (2000) Behavioral risk factor prevalence and lifestyle change after stroke: a prospective study. Stroke 31:1877?1881","journal-title":"Stroke"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1001\/archinte.161.13.1621","volume":"161","author":"Qureshi","year":"2001","unstructured":"Qureshi AI, Suri MF, Guterman LR, Hopkins LN (2001) Ineffective secondary prevention in survivors of cardiovascular events in the US population: report from the Third National Health and Nutrition Examination Survey. Arch Intern Med 161:1621?1628","journal-title":"Arch Intern Med"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1212\/WNL.60.1.64","volume":"60","author":"Ruland","year":"2003","unstructured":"Ruland S, Raman R, Chaturvedi S, Leurgans S, Gorelick PB (2003) Awareness, treatment, and control of vascular risk factors in African Americans with stroke. Neurology 60:64?68","journal-title":"Neurology"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/oxfordjournals.eurheartj.a015136","volume":"18","author":"EUROASPIRE","year":"1997","unstructured":"EUROASPIRE Study Group. EUROASPIRE (1997) A European Society of Cardiology survey of secondary prevention of coronary heart disease: principal results. European Action on Secondary Prevention through Intervention to Reduce Events. Eur Heart 18:1569?1582","journal-title":"Eur Heart"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(00)04235-5","volume":"357","author":"EUROASPIRE","year":"2001","unstructured":"EUROASPIRE I and II Group (2001) Clinical reality of coronary prevention guidelines: a comparison of EUROASPIRE I and II in nine countries. European Action on Secondary Prevention by Intervention to Reduce Events. Lancet 357:995?1001","journal-title":"Lancet"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3109\/10641969909061028","volume":"21","author":"Chalmers","year":"1999","unstructured":"Chalmers J, MacMahon S, Mancia G, Whitworth J, Beilin L, Hansson L, Neal B, Rodgers A, Ni Mhurchu C, Clark T (1999) 1999 World Health Organization ? International Society of Hypertension Guidelines for the management of hypertension.Guidelines sub-committee of the World Health Organization. Clin Exp Hypertens 21:1009?1060","journal-title":"Clin Exp Hypertens"},{"key":"CR21","first-page":"1383","volume":"344","author":"Scandinavian","year":"1994","unstructured":"Scandinavian Simvastatin Survival Study Group (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344:1383?1389","journal-title":"Lancet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diacare.20.1.1","volume":"20","author":"American","year":"1997","unstructured":"American Diabetes Association (1997) clinical practice recommendations 1997. Diabetes Care 20:1?70","journal-title":"Diabetes Care"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/bmj.308.6921.81","volume":"308","author":"Antiplatelet","year":"1994","unstructured":"Antiplatelet Trialists? Collaboration (1994) Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death,myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308:81?106","journal-title":"BMJ"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(96)09457-3","volume":"348","author":"CAPRIE","year":"1996","unstructured":"CAPRIE Steering Committee (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348:1329?1339","journal-title":"Lancet"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0140-6736(89)92327-1","volume":"1","author":"Gent","year":"1989","unstructured":"Gent M, Blakely JA, Easton JD, Ellis DJ, Hachinski VC, Harbison JW, Panak E, Roberts RS, Sicurella J, Turpie AG (1989) The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1:1215?1220","journal-title":"Lancet"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM198908243210804","volume":"321","author":"Hass","year":"1989","unstructured":"Hass WK, Easton JD, Adams HP Jr, Pryse-Phillips W, Molony BA, Anderson S, Kamm B (1989) A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. N Engl J Med 321:501?507","journal-title":"N Engl J Med"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(96)00308-5","volume":"143","author":"Diener","year":"1996","unstructured":"Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A (1996) European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143:1?13","journal-title":"J Neurol Sci"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000047577","volume":"103","author":"Bogousslavsky","year":"2000","unstructured":"Bogousslavsky J, Kaste M, Skyhoj Olsen T, Hacke W, Orgogozo JM (2000) Risk factors and stroke prevention. European Stroke Initiative (EUSI). Cerebrovasc Dis 103:12?21","journal-title":"Cerebrovasc Dis"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/01.STR.25.6.1320","volume":"25","author":"Guidelines","year":"1994","unstructured":"Guidelines for the management of transient ischemic attacks (1994) From the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks of the Stroke Council of the American Heart Association. Stroke 25:1320?1335","journal-title":"Stroke"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1161\/01.STR.30.11.2502","volume":"30","author":"Albers","year":"1999","unstructured":"Albers GW, Hart RG, Lutsep HL, Newell DW, Sacco RL (1999) AHA Scientific Statement. Supplement to the guidelines for the management of transient ischemic attacks: A statement from the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks, Stroke Council, American Heart Association. Stroke 30:2502?2011","journal-title":"Stroke"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1001\/jama.1993.03500230097036","volume":"269","author":"Summary","year":"1993","unstructured":"Summary of the second report of the National Cholesterol Education Program (NCEP) (1993) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in adults (Adult treatment panel II). JAMA 269:3015?3023","journal-title":"JAMA"},{"key":"CR32","unstructured":"Diabetes mellitus. Report of a WHO study group. World health Organization, 1985"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/bmj.304.6827.597","volume":"304","author":"Wannamethee","year":"1992","unstructured":"Wannamethee G, Shaper AG (1992) Physical activity and stroke in British middle aged men. Br Med J 304:597?601","journal-title":"Br Med J"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1161\/01.CIR.96.12.4424","volume":"16","author":"Gotto","year":"1997","unstructured":"Gotto AM Jr (1997) Cholesterol management in theory and practice. Circulation 16:4424?4430","journal-title":"Circulation"},{"key":"CR35","first-page":"16","volume":"30","author":"Joseph","year":"1999","unstructured":"Joseph LN, Babikian VL, Allen NC, Winter MR (1999) Risk factor modification in stroke prevention: the experience of a stroke clinic. Stroke 30:16?20","journal-title":"Joseph"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-005-0591-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-005-0591-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-005-0591-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:03:56Z","timestamp":1559055836000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-005-0591-8"}},"subtitle":["Evolution over time in practice"],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["591"],"URL":"https:\/\/doi.org\/10.1007\/s00415-005-0591-8","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}