{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:41:09Z","timestamp":1792089669121,"version":"4.4.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1007\/s00415-006-0255-3","type":"journal-article","created":{"date-parts":[[2007,2,9]],"date-time":"2007-02-09T08:07:33Z","timestamp":1171008453000},"page":"146-153","source":"Crossref","is-referenced-by-count":34,"title":["Mitochondrial neurogastrointestinal encephalomyopathy in three siblings"],"prefix":"10.1007","volume":"254","author":[{"given":"W.M.M.","family":"Sch\u00fcpbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Madhavi","family":"Vadday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brekenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kappeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Nguyen-Thi","family":"Xuan-Huong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Burgunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Seibold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gallati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.P.","family":"Mattle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,2,9]]},"reference":[{"key":"255_CR1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0022-510X(76)90236-7","volume":"27","author":"K Okamura","year":"1976","unstructured":"Okamura K, Santa T, Nagae K, et al. (1976) Congenital okuloskeletal myopathy with abnormal muscle and liver mitochondria. J Neurol Sci 27:79\u201391","journal-title":"J Neurol Sci"},{"key":"255_CR2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ajmg.1320150114","volume":"15","author":"V Ionasescu","year":"1983","unstructured":"Ionasescu V (1983) Oculogastrointestinal muscular Dystrophy. Am J Med Genet 15:103\u2013112","journal-title":"Am J Med Genet"},{"key":"255_CR3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/gut.29.4.544","volume":"29","author":"R Cervera","year":"1988","unstructured":"Cervera R, Bruix J, Bayes A, et al. (1988) Chronic intestinal pseudoobstruction and ophthalmoplegia in a patient with mitochondrial myopathy. Gut 29:544\u2013547","journal-title":"Gut"},{"key":"255_CR4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0002-9394(14)71799-4","volume":"114","author":"AB Threlkeld","year":"1992","unstructured":"Threlkeld AB, Miller NR, Golnik KC, et al. (1992) Ophthalmic involvement in myo-neuro-gastrointestinal encephalopathy syndrome. Am J Ophthal 114:322\u2013328","journal-title":"Am J Ophthal"},{"key":"255_CR5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ana.410280308","volume":"28","author":"LT Simon","year":"1990","unstructured":"Simon LT, Horoupian DS, Dorfman LJ, et al. (1990) Polyneuropathy, ophthalmoplegia, leukoencephalopathy, and intestinal pseudo-obstruction: POLIP syndrome. Ann Neurol 28:349\u2013360","journal-title":"Ann Neurol"},{"key":"255_CR6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/0016-5085(87)90033-3","volume":"92","author":"J Faber","year":"1987","unstructured":"Faber J, Fich A, Steinberg A, et al. (1987) Familial intestinal pseudoobstruction dominated by progressive nbeurologic disease at a young age. Gastroenterology 92:786\u2013790","journal-title":"Gastroenterology"},{"key":"255_CR7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF00688189","volume":"74","author":"A Bardosi","year":"1987","unstructured":"Bardosi A, Creutzfeldt W, DiMauro S, et al. (1987) Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to a partial deficiency of cytochrome-c-oxidase. Acta Neuropathol (Berlin) 74:248\u2013258","journal-title":"Acta Neuropathol (Berlin)"},{"key":"255_CR8","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00005176-200209000-00029","volume":"35","author":"JE Teitelbaum","year":"2002","unstructured":"Teitelbaum JE, Berde CB, Nurko S, et al. (2002) Diagnosis and management of MNGIE syndrome in children: Case report and review of the literature. J Pediatr Gastroenterol Nutr 35:377\u2013383","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"255_CR9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/mus.880170616","volume":"17","author":"A Uncini","year":"1994","unstructured":"Uncini A, Servidei S, Silvestri G, et al. (1994) Ophthalmoplegia, demyelinating neuropathy, leukoencephalopathy,myopathy, and gastrointestinal dysfunction with multiple deletions of mitochondrial DNA: A mitochondrial multisystem disorder in search of a name. Muscle Nerve 17:667\u2013674","journal-title":"Muscle Nerve"},{"issue":"suppl 1","key":"255_CR10","first-page":"294","volume":"40","author":"D Blake","year":"1990","unstructured":"Blake D, Lombes A, Minetti C, et al. (1990) MNGIE syndrome: Report of 2 new patients [abstract]. Neurology 40(suppl 1):294(643S)","journal-title":"Neurology"},{"key":"255_CR11","first-page":"547","volume":"153","author":"M Debouverie","year":"1997","unstructured":"Debouverie M, Wagner M, Ducrocq X, et al. (1997) Le MNGIE syndrome: deux cas dans une m\u00eame fratrie. Rev Neurol (Paris) 153:547\u2013553","journal-title":"Rev Neurol (Paris)"},{"key":"255_CR12","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1212\/WNL.37.6.1046","volume":"37","author":"I Steiner","year":"1987","unstructured":"Steiner I, Steinberg A, Argov Z, et al. (1987) Familial progressive neuronal disease and chronic idiopathic intestinal pseudo-obstruction. Neurology 37:1046\u20131050","journal-title":"Neurology"},{"key":"255_CR13","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1212\/WNL.51.4.1086","volume":"51","author":"A Papadimitriou","year":"1998","unstructured":"Papadimitriou A, Comi GP, Hadjigeorgiou GM, et al. (1998) Partial depletion and multiple deletions of muscle mtDNA in familial MNGIE syndrome. Neurology 51:1086\u20131092","journal-title":"Neurology"},{"key":"255_CR14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1212\/WNL.44.4.721","volume":"44","author":"M Hirano","year":"1994","unstructured":"Hirano M, Silvestri G, Blake DM, et al. (1994) Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): Clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder. Neurology 44:721\u2013727","journal-title":"Neurology"},{"issue":"suppl 3","key":"255_CR15","first-page":"418","volume":"42","author":"M Sabatelli","year":"1992","unstructured":"Sabatelli M, Servidei S, Ricci E, et al. (1992) Myo-neuro-gastro-intestinal disease and encephalopathy (MNGIE syndrome): a patient with multiple deletions of mitochondrial DNA [abstract]. Neurology 42(suppl 3):418","journal-title":"Neurology"},{"key":"255_CR16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1212\/WNL.50.1.99","volume":"50","author":"R Carrozzo","year":"1998","unstructured":"Carrozzo R, Hirano M, Fromenty B, et al. (1998) Multiple mtDNA deletions features in autosomal dominant and recessive diseases suggest distinct pathogeneses. Neurology 50:99\u2013106","journal-title":"Neurology"},{"key":"255_CR17","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJM199003223221208","volume":"322","author":"DR Cave","year":"1990","unstructured":"Cave DR (1990) Case records of the Massachusetts General Hospital, Case 12\u20131990. New Engl J Med 322:829\u2013841","journal-title":"New Engl J Med"},{"key":"255_CR18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0016-5085(99)70080-6","volume":"116","author":"LA Mueller","year":"1999","unstructured":"Mueller LA, Camilleri M, Emslie-Smith AM (1999) Mitochondrial neurogastrointestinal encephalomyopathy: Manometric and diagnostic features. Gastroenterology 116:959\u2013963","journal-title":"Gastroenterology"},{"key":"255_CR19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/gut.34.2.279","volume":"34","author":"R Lowsky","year":"1993","unstructured":"Lowsky R, Davidson G, Wolman S, et al. (1993) Familial visceral myopathy associated with a mitochondrial myopathy. Gut 34:279\u2013283","journal-title":"Gut"},{"key":"255_CR20","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/1531-8249(200006)47:6<792::AID-ANA12>3.0.CO;2-Y","volume":"47","author":"I Nishino","year":"2000","unstructured":"Nishino I, Spinazzola A, Papadimitriou A, et al. (2000) Mitochondrial Neurograstrointestinal Encephalomyopathy: An Autosomal Recessive Disorder due to Thymidine Phosphorylase Mutations. Ann Neurol 47:792\u2013800","journal-title":"Ann Neurol"},{"key":"255_CR21","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1212\/WNL.58.12.1862","volume":"58","author":"P Labague","year":"2002","unstructured":"Labague P, Durant R, Castelnuovo G, et al. (2002) MNGIE: Diarrhea and leukoencephalopathy. Neurology 58:1862","journal-title":"Neurology"},{"key":"255_CR22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1212\/WNL.59.3.455","volume":"59","author":"J Gamez","year":"2002","unstructured":"Gamez J, Ferreiro C, Accarino ML, et al. (2002) Phenotypic variability in a Spanish family with MNGIE. Neurology 59:455\u2013457","journal-title":"Neurology"},{"key":"255_CR23","first-page":"917","volume":"37","author":"H Hamano","year":"1997","unstructured":"Hamano H, Ohta T, Takekawa Y, et al. (1997) Mitochondrial neurogasrtointestinal encephalomyopathy presenting with protein-losing gastroenteropathy and serum copper deficiency: a case report. Rinsho Shinkeigaku 37:917\u2013922","journal-title":"Rinsho Shinkeigaku"},{"key":"255_CR24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/sj.ejhg.5200908","volume":"11","author":"YC Kocaefe","year":"2003","unstructured":"Kocaefe YC, Erdem S, \u00d6zg\u00fc\u00e7 M, et al. (2003) Four novel thymidine phosphorylase gene mutations in mitochondrial neurogastrointestinal encephalomyopathy syndrome (MNGIE) patients. Eur J Hum Genet 11:102\u2013104","journal-title":"Eur J Hum Genet"},{"key":"255_CR25","first-page":"111","volume":"158","author":"F Chaury","year":"2002","unstructured":"Chaury F, Fleury M, Tranchant C (2002) Cas clinique. Troubles digestifs r\u00e9v\u00e9lateurs d\u2019une cytopathie mitochondriale: le syndrome MNGIE. Rev Neurol (Paris) 158:111\u2013113","journal-title":"Rev Neurol (Paris)"},{"issue":"Spl.3","key":"255_CR26","first-page":"3S117","volume":"160","author":"MA Rafai","year":"2004","unstructured":"Rafai MA, Laforet P, El Moutawakil B, et al. (2004) Mitochondriopathie type MNGIE \u00abmitochondrial neuro-gastro-intestinal encephalopathy\u00bb [abstract]. Rev Neurol (Paris) 160(Spl.3):3S117","journal-title":"Rev Neurol (Paris)"},{"key":"255_CR27","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1212\/01.WNL.0000141857.37073.97","volume":"63","author":"MA Martin","year":"2004","unstructured":"Martin MA, Blazquez A, Marti R, et al. (2004) Lack of gastrointestinal symptoms in a 60-year-old patient with MNGIE. Neurology 63:1536\u20137","journal-title":"Neurology"},{"key":"255_CR28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/jmg.2003.013789","volume":"41","author":"K Szigeti","year":"2004","unstructured":"Szigeti K, Wong LJ, Perng CL, et al. (2004) MNGIE with lack of skeletal muscle involvement and a novel TP splice site mutation. J Med Genet 41:125\u20139","journal-title":"J Med Genet"},{"key":"255_CR29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jocn.2004.02.009","volume":"12","author":"S Peker","year":"2005","unstructured":"Peker S, Pamir MN (2005) Trigeminal nevralgia in a patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). J Clin Neurosci 12:172\u2013174","journal-title":"J Clin Neurosci"},{"key":"255_CR30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jns.2004.09.034","volume":"228","author":"J Gamez","year":"2005","unstructured":"Gamez J, Lara MC, Mearin F, et al. (2005) A novel thymidine phosphorylase mutation in a Spanish MNGIE patient. J Neurol Sci 228:35\u201339","journal-title":"J Neurol Sci"},{"key":"255_CR31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ymgme.2004.12.004","volume":"84","author":"A Slama","year":"2005","unstructured":"Slama A, Lacroix C, Plante-Bordeneuve V, et al. (2005) Thymidine phosphorylase gene mutations in patients with mitochondrial neurogastrointestinal encephalomyopathy syndrome. Mol Genet Metab 84:326\u201331","journal-title":"Mol Genet Metab"},{"key":"255_CR32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ana.20615","volume":"58","author":"R Mart\u00ed","year":"2005","unstructured":"Mart\u00ed R, Verschuuren JJ, Buchman A, et al. (2005) Late-onset MNGIE due to partial loss of thymidine phosphorylase activity. Ann Neurol 58:649\u2013652","journal-title":"Ann Neurol"},{"key":"255_CR33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.nmd.2005.07.008","volume":"15","author":"A Blazquez","year":"2005","unstructured":"Blazquez A, Mart\u00edn MA, Lara MC, et al. (2005) Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE. Neuromuscul Disord 15:775\u2013778","journal-title":"Neuromuscul Disord"},{"key":"255_CR34","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1086\/301979","volume":"63","author":"M Hirano","year":"1998","unstructured":"Hirano M, Garcia-de-Yebenes J, Jones AC, et al. (1998) Mitochondrial Neurogastrointestinal Encephalomyopathy Syndrome Maps to Chromosome 22q13.32-qter. Am J Hum Genet 63:526\u2013533","journal-title":"Am J Hum Genet"},{"key":"255_CR35","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1126\/science.283.5402.689","volume":"283","author":"I Nishino","year":"1999","unstructured":"Nishino I, Spinazzola A, Hirano M (1999) Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder. Science 283:689\u2013692","journal-title":"Science"},{"key":"255_CR35a","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1212\/01.wnl.0000240853.97716.24","volume":"67","author":"M Hirano","year":"2006","unstructured":"Hirano M, Mart\u00ed R, Casali C, et al. (2006) Allogenic stem cell transplantation corrects biochemical derangements in MNGIE. Neurology 67:1458\u20131460","journal-title":"Neurology"},{"key":"255_CR36","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/mus.10546","volume":"29","author":"RS Bedlack","year":"2004","unstructured":"Bedlack RS, Vu T, Hammans S, et al. (2004) MNGIE neuropathy: Five cases mimicking chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 29:364\u2013368","journal-title":"Muscle Nerve"},{"key":"255_CR37","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/mrm.1910390607","volume":"39","author":"J Slotboom","year":"1998","unstructured":"Slotboom J, Boesch C, Kreis R (1998) Versatile Frequency Domain Fitting using Time Domain Models and Prior Knowledge. Magn Reson Med 39:899\u2013911","journal-title":"Magn Reson Med"},{"key":"255_CR38","first-page":"Hommes","volume":"In","author":"Simmonds","year":"1990","unstructured":"Simmonds HA, Duley JA, Davies PM (1990) Analysis of purines and pyrimidines in blood, urine, and other physiological fluids. Chapter 25 In: Hommes FA, (Eds.), Techniques in diagnostic human biochemical genetics. A laboratory manual. John Wiley & Sons, 397\u2013424","journal-title":"Chapter 25"},{"key":"255_CR39","first-page":"287","volume-title":"Handbook of clinical neurology","author":"LP Rowland","year":"1992","unstructured":"Rowland LP (1992) Progressive external ophthalmoplegia. In: Vinkens PJ, Bruyn GW, Klawans HL, (eds.) Handbook of clinical neurology. Elsevier, Amsterdam 287\u2013329"},{"key":"255_CR40","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1074\/jbc.M111028200","volume":"277","author":"A Spinazzola","year":"2002","unstructured":"Spinazzola A, Mart\u00ed R, Nishino I, et al. (2002) Altered thymidine metabolism due to defects of thymidine phosphorylase. J Biol Chem 277:4128\u20134133","journal-title":"J Biol Chem"},{"key":"255_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0006-291X(03)00294-8","volume":"303","author":"R Mart\u00ed","year":"2003","unstructured":"Mart\u00ed R, Nishigaki Y, Hirano M (2003) Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency. Biochem Biophys Res Comm 303:14\u201318","journal-title":"Biochem Biophys Res Comm"},{"key":"255_CR42","doi-asserted-by":"crossref","first-page":"24472","DOI":"10.1074\/jbc.M502869200","volume":"280","author":"P Ferraro","year":"2005","unstructured":"Ferraro P, Pontarin G, Crocco L, et al. (2005) Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). J Biol Chem 280:24472\u201380","journal-title":"J Biol Chem"},{"key":"255_CR43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.nrl.0000106919.06469.04","volume":"10","author":"M Hirano","year":"2004","unstructured":"Hirano M, Nishigaki Y, Mart\u00ed R (2004) Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): A disease of two genomes. Neurologist 10:8\u201317","journal-title":"Neurologist"},{"key":"255_CR44","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.gene.2005.04.041","volume":"354","author":"M Hirano","year":"2005","unstructured":"Hirano M, Lagier-Tourenne C, Valentino ML, et al. (2005) Thymidine phosphorylase mutations cause instability of mitochondrial DNA. Gene 354:152\u20136","journal-title":"Gene"},{"key":"255_CR45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1373\/clinchem.2003.026179","volume":"50","author":"R Mart\u00ed","year":"2004","unstructured":"Mart\u00ed R, Spinazzola A, Tadesse S, et al. (2004) Definitive diagnosis of mitochondrial neurogastrointestinal encephalomyopathy by biochemical assays. Clin Chem 50:120\u2013124","journal-title":"Clin Chem"},{"key":"255_CR46","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1023\/A:1022007827133","volume":"25","author":"LD Fairbanks","year":"2002","unstructured":"Fairbanks LD, Marinaki AM, Carrey EA, et al. (2002) Deoxyuridine accumulation in urine in thymidine phosphorylase deficiency (MNGIE). J Inherit Metab Dis 25:603\u2013604","journal-title":"J Inherit Metab Dis"},{"key":"255_CR47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/(SICI)1522-2594(199902)41:2<276::AID-MRM10>3.0.CO;2-8","volume":"41","author":"A Pfefferbaum","year":"1999","unstructured":"Pfefferbaum A, Adalsteinsson E, Spielman D, et al. (1999) In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain grey and white matter: Effects of normal aging. Magn Reson Med 41:276\u2013284","journal-title":"Magn Reson Med"},{"key":"255_CR48","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/(SICI)1522-2594(199904)41:4<841::AID-MRM25>3.0.CO;2-T","volume":"41","author":"N Lundbom","year":"1999","unstructured":"Lundbom N, Barnett A, Bonavita S, et al. (1999) MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain. Magn Reson Med 41:841\u2013845","journal-title":"Magn Reson Med"},{"key":"255_CR49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0306-4522(91)90101-S","volume":"45","author":"ML Simmons","year":"1991","unstructured":"Simmons ML, Frondoza CG, Coyle JT (1991) Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 45:37\u201345","journal-title":"Neuroscience"},{"key":"255_CR50","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/0024-3205(96)00182-8","volume":"58","author":"BL Miller","year":"1996","unstructured":"Miller BL, Chang L, Booth R, et al. (1996) In Vivo 1H MRS choline: correlation with in vitro chemistry\/histology. Life Sci 58:1929\u20131935","journal-title":"Life Sci"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-006-0255-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-006-0255-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-006-0255-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:04:10Z","timestamp":1559055850000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-006-0255-3"}},"subtitle":["Clinical, genetic and neuroradiological features"],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["255"],"URL":"https:\/\/doi.org\/10.1007\/s00415-006-0255-3","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}