{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:16:54Z","timestamp":1773937014844,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1007\/s00415-007-0539-2","type":"journal-article","created":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T15:52:17Z","timestamp":1194364337000},"page":"1504-1508","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Somatostatin genetic variants modify the risk for Alzheimer's disease among Finnish patients"],"prefix":"10.1007","volume":"254","author":[{"given":"S.","family":"Veps\u00e4l\u00e4inen*","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Helisalmi*","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Koivisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tapaninen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Soininen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,11,9]]},"reference":[{"key":"539_CR1","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/0024-3205(92)90534-V","volume":"51","author":"Bissette","year":"1992","unstructured":"Bissette G, Myers B (1992) Somatostatin in Alzheimer's disease and depression. Life Sci 51:1389\u20131410","journal-title":"Life Sci"},{"key":"539_CR2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1093\/hmg\/3.4.569","volume":"3","author":"Chartier-Harlin","year":"1994","unstructured":"Chartier-Harlin MC, Parfitt M, Legrain S, Perez-Tur J, Brousseau T, Evans A, Berr C, Vidal O, Roques P, Gourlet V (1994) Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13. 2 chromosomal region. Hum Mol Genet 3:569\u2013574","journal-title":"Hum Mol Genet"},{"key":"539_CR3","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"Corder","year":"1993","unstructured":"Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak- Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921\u2013923","journal-title":"Science"},{"key":"539_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0301-0082(86)90012-2","volume":"27","author":"Epelbaum","year":"1986","unstructured":"Epelbaum J (1986) Somatostatin in the central nervous system: physiology and pathological modifications. Prog Neurobiol 27:63\u2013100","journal-title":"Prog Neurobiol"},{"key":"539_CR5","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1001\/jama.278.16.1349","volume":"278","author":"Farrer","year":"1997","unstructured":"Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. Jama 278:1349\u20131356","journal-title":"Jama"},{"key":"539_CR6","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1126\/science.1069424","volume":"296","author":"Gabriel","year":"2002","unstructured":"Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296:2225\u20132229","journal-title":"Science"},{"key":"539_CR7","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1001\/archneur.55.7.937","volume":"55","author":"Galasko","year":"1998","unstructured":"Galasko D, Chang L, Motter R, Clark CM, Kaye J, Knopman D, Thomas R, Kholodenko D, Schenk D, Lieberburg I, Miller B, Green R, Basherad R, Kertiles L, Boss MA, Seubert P (1998) High cerebrospinal fluid tau and low amyloid beta42 levels in the clinical diagnosis of Alzheimer disease and relation to apolipoprotein E genotype. Arch Neurol 55:937\u2013945","journal-title":"Arch Neurol"},{"key":"539_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0304-3940(98)00698-3","volume":"255","author":"Grouselle","year":"1998","unstructured":"Grouselle D, Winsky-Sommerer R, David JP, Delacourte A, Dournaud P, Epelbaum J (1998) Loss of somatostatin- like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele. Neurosci Lett 255:21\u201324","journal-title":"Neurosci Lett"},{"key":"539_CR9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ajmg.b.30257","volume":"141","author":"Hahs","year":"2006","unstructured":"Hahs DW, McCauley JL, Crunk AE, McFarland LL, Gaskell PC, Jiang L, Slifer SH, Vance JM, Scott WK, Welsh- Bohmer KA, Johnson SR, Jackson CE, Pericak-Vance MA, Haines JL (2006) A genome-wide linkage analysis of dementia in the Amish. Am J Med Genet B Neuropsychiatr Genet 141:160\u2013166","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"539_CR10","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353\u2013356","journal-title":"Science"},{"key":"539_CR11","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1212\/WNL.57.9.1663","volume":"57","author":"Hiltunen","year":"2001","unstructured":"Hiltunen M, Mannermaa A, Thompson D, Easton D, Pirskanen M, Helisalmi S, Koivisto AM, Lehtovirta M, Ryynanen M, Soininen H (2001) Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland. Neurology 57:1663\u20131668","journal-title":"Neurology"},{"key":"539_CR12","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1001\/archneur.63.11.1591","volume":"63","author":"Lee","year":"2006","unstructured":"Lee JH, Cheng R, Santana V, Williamson J, Lantigua R, Medrano M, Arriaga A, Stern Y, Tycko B, Rogaeva E, Wakutani Y, Kawarai T, St George- Hyslop P, Mayeux R (2006) Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease. Arch Neurol 63:1591\u20131598","journal-title":"Arch Neurol"},{"key":"539_CR13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.46.2.413","volume":"46","author":"Lehtovirta","year":"1996","unstructured":"Lehtovirta M, Soininen H, Helisalmi S, Mannermaa A, Helkala EL, Hartikainen P, Hanninen T, Ryynanen M, Riekkinen PJ (1996) Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism. Neurology 46:413\u2013419","journal-title":"Neurology"},{"key":"539_CR14","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939\u2013944","journal-title":"Neurology"},{"key":"539_CR15","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1212\/01.WNL.0000128088.08695.05","volume":"62","author":"Prince","year":"2004","unstructured":"Prince JA, Zetterberg H, Andreasen N, Marcusson J, Blennow K (2004) APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42. Neurology 62:2116\u20132118","journal-title":"Neurology"},{"key":"539_CR16","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1056\/NEJM198312153092406","volume":"309","author":"Reichlin","year":"1983","unstructured":"Reichlin S (1983) Somatostatin. N Engl J Med 309:1495\u20131501","journal-title":"N Engl J Med"},{"key":"539_CR17","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nm1206","volume":"11","author":"Saito","year":"2005","unstructured":"Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC (2005) Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat Med 11:434\u2013439","journal-title":"Nat Med"},{"key":"539_CR18","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","volume":"43","author":"Saunders","year":"1993","unstructured":"Saunders AM, Strittmatter WJ, Schmechel D, St George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ et al. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467\u20131472","journal-title":"Neurology"},{"key":"539_CR19","doi-asserted-by":"publisher","first-page":"9649","DOI":"10.1073\/pnas.90.20.9649","volume":"90","author":"Schmechel","year":"1993","unstructured":"Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD (1993) Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 90:9649\u20139653","journal-title":"Proc Natl Acad Sci USA"},{"key":"539_CR20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0022-510X(84)90193-X","volume":"63","author":"Soininen","year":"1984","unstructured":"Soininen HS, Jolkkonen JT, Reinikainen KJ, Halonen TO, Riekkinen PJ (1984) Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type. J Neurol Sci 63:167\u2013172","journal-title":"J Neurol Sci"},{"key":"539_CR21","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.biopsych.2004.07.021","volume":"56","author":"Sunderland","year":"2004","unstructured":"Sunderland T, Mirza N, Putnam KT, Linker G, Bhupali D, Durham R, Soares H, Kimmel L, Friedman D, Bergeson J, Csako G, Levy JA, Bartko JJ, Cohen RM (2004) Cerebrospinal fluid beta-amyloid1\u2013 42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele. Biol Psychiatry 56:670\u2013676","journal-title":"Biol Psychiatry"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-007-0539-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-007-0539-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-007-0539-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-007-0539-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T23:22:17Z","timestamp":1652656937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-007-0539-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["539"],"URL":"https:\/\/doi.org\/10.1007\/s00415-007-0539-2","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]},"assertion":[{"value":"21 November 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}