{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:21:24Z","timestamp":1774660884727,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T00:00:00Z","timestamp":1220400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T00:00:00Z","timestamp":1220400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00415-008-0008-6","type":"journal-article","created":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T15:49:09Z","timestamp":1220456949000},"page":"1726-1730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Bell\u2019s palsy"],"prefix":"10.1007","volume":"255","author":[{"given":"Martina","family":"Minnerop","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Herbst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Fimmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertfried","family":"Matz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Klockgether","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ullrich","family":"W\u00fcllner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,9,3]]},"reference":[{"key":"8_CR1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/000348949610500508","volume":"105","author":"Adour","year":"1996","unstructured":"Adour KK, Ruboyianes JM, Von\nDoersten PG, Byl FM, Trent CS,\nQuesenberry CP Jr, Hitchcock T (1996)\nBell\u2019s palsy treatment with acyclovir\nand prednisone compared with prednisone\nalone: a double-blind, randomized,\ncontrolled trial. Ann Otol Rhinol\nLaryngol 105:371\u2013378","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"8_CR2","doi-asserted-by":"crossref","unstructured":"Allen D, Dunn L (2004) Aciclovir or\nvalaciclovir for Bell\u2019s palsy (idiopathic\nfacial paralysis). Cochrane Database\nSyst Rev, Issue 2:CD001869","DOI":"10.1002\/14651858.CD001869.pub2"},{"key":"8_CR3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/000348940311200301","volume":"112","author":"Axelsson","year":"2003","unstructured":"Axelsson S, Lindberg S, Stjernquist-Desatnik A (2003) Outcome of treatment\nwith valacyclovir and prednisone\nin patients with Bell\u2019s palsy. Ann Otol\nRhinol Laryngol 112:197\u2013201","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"8_CR4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0030-6665(20)32842-5","volume":"7","author":"Brackmann","year":"1974","unstructured":"Brackmann DE (1974) Bell\u2019s palsy:\nincidence, etiology, and results of\nmedical treatment. Otolaryngol Clin\nNorth Am 7:357\u2013368","journal-title":"Otolaryngol Clin North Am"},{"key":"8_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1097\/00005537-199804000-00020","volume":"108","author":"De Diego","year":"1998","unstructured":"De Diego JI, Prim MP, De Sarria MJ,\nMadero R, Gavilan J (1998) Idiopathic\nfacial paralysis: a randomized, prospective,\nand controlled study using\nsingle-dose prednisone versus acyclovir\nthree times daily. Laryngoscope\n108:573\u2013575","journal-title":"Laryngoscope"},{"key":"8_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/jac\/12.suppl_B.29","volume":"12","author":"De Miranda","year":"1983","unstructured":"De Miranda P, Blum MR (1983) Pharmacokinetics\nof acyclovir after intravenous\nand oral administration. J Antimicrob\nChemother12(Suppl B):29\u201337","journal-title":"J Antimicrob Chemother"},{"key":"8_CR7","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1056\/NEJMe078188","volume":"357","author":"Gilden","year":"2007","unstructured":"Gilden DH, Tyler KL (2007) Bell\u2019s palsy\n\u2013 is glucocorticoid treatment enough?\nN Engl J Med 357:1653\u20131655","journal-title":"N Engl J Med"},{"key":"8_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ijpharm.2006.01.050","volume":"317","author":"Granero","year":"2006","unstructured":"Granero GE, Amidon GL (2006) Stability\nof valacyclovir: implications for its\noral bioavailability. Int J Pharm 317:14\u201318","journal-title":"Int J Pharm"},{"key":"8_CR9","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1212\/WNL.56.7.830","volume":"56","author":"Grogan","year":"2001","unstructured":"Grogan PM, Gronseth GS (2001) Practice\nparameter: Steroids, acyclovir, and\nsurgery for Bell\u2019s palsy (an evidence-based\nreview): report of the Quality\nStandards Subcommittee of the American\nAcademy of Neurology. Neurology\n56:830\u2013836","journal-title":"Neurology"},{"key":"8_CR10","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1097\/01.mao.0000265190.29969.12","volume":"28","author":"Hato","year":"2007","unstructured":"Hato N, Yamada H, Kohno H, Matsumoto\nS, Honda N, Gyo K, Fukuda S,\nFuruta Y, Ohtani F, Aizawa H, Aoyagi\nM, Inamura H, Nakashima T, Nakata S,\nMurakami S, Kiguchi J, Yamano K,\nTakeda T, Hamada M, Yamakawa K\n(2007) Valacyclovir and Prednisolone\nTreatment for Bell\u2019s Palsy: A Multicenter,\nRandomized, Placebo-Controlled\nStudy. Otol Otol Neurotol 28:408\u2013413","journal-title":"Otol Otol Neurotol"},{"key":"8_CR11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/019459988509300202","volume":"93","author":"House","year":"1985","unstructured":"House JW, Brackmann DE (1985)\nFacial nerve grading system. Otolaryngol\nHead Neck Surg 93:146\u2013147","journal-title":"Otolaryngol Head Neck Surg"},{"key":"8_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/01.mlg.0000248737.65607.9e","volume":"117","author":"Kawaguchi","year":"2007","unstructured":"Kawaguchi K, Inamura H, Abe Y, Koshu\nH, Takashita E, Muraki Y, Matsuzaki Y,\nNishimura H, Ishikawa H, Fukao A,\nHongo S, Aoyagi M (2007) Reactivation\nof herpes simplex virus type 1 and\nvaricella-zoster virus and therapeutic\neffects of combination therapy with\nprednisolone and valacyclovir in patients\nwith Bell\u2019s palsy. Laryngoscope\n117:147\u2013156","journal-title":"Laryngoscope"},{"key":"8_CR13","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0140-6736(72)91499-7","volume":"29","author":"McCormick","year":"1972","unstructured":"McCormick DP (1972) Herpes-simplex\nvirus as a cause of Bell\u2019s palsy. Lancet\n29:937\u2013939","journal-title":"Lancet"},{"key":"8_CR14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7326\/0003-4819-124-1_Part_1-199601010-00005","volume":"124","author":"Murakami","year":"1996","unstructured":"Murakami S, Mizobuchi M, Nakashiro\nY, Doi T, Hato N, Yanagihara N (1996)\nBell Palsy and Herpes Simplex Virus:\nIdentification of Viral DNA in Endoneurial\nFluid and Muscle. Ann Intern\nMed 124:27\u201330","journal-title":"Ann Intern Med"},{"key":"8_CR15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/000164802760370736","volume":"549","author":"Peitersen","year":"2002","unstructured":"Peitersen E (2002) Bell\u2019s palsy: the\nspontaneous course of 2,500 peripheral\nfacial nerve palsies of different\netiologies. Acta Otolaryngol Suppl\n549:4\u201330","journal-title":"Acta Otolaryngol Suppl"},{"key":"8_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/09563202930040S602","volume":"4","author":"Pue","year":"1993","unstructured":"Pue M, Benet LZ (1993) Pharmacokinetics\nof famciclovir in man. Antiviral\nChem Chemother 4(Suppl 1):47\u201355","journal-title":"Antiviral Chem Chemother"},{"key":"8_CR17","doi-asserted-by":"crossref","unstructured":"Salinas RA, Alvarez G, Ferreira J (2004)\nCorticosteroids for Bell\u2019s palsy (idiopathic\nfacial paralysis). Cochrane\nDatabase Syst Rev, Issue 2:CD001942","DOI":"10.1002\/14651858.CD001942.pub2"},{"key":"8_CR18","first-page":"96","volume":"23","author":"Standring-Cox","year":"1994","unstructured":"Standring-Cox R, Bacon TH, Howard\nB, Gilbart J, Boyd MR (1994) Prolonged\nactivity of penciclovir in cell culture\nagainst varicella-zoster virus. Antiviral\nRes 23(Suppl 1):96","journal-title":"Antiviral Res"},{"key":"8_CR19","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1056\/NEJMoa072006","volume":"357","author":"Sullivan","year":"2007","unstructured":"Sullivan FM, Swan IR, Donnan PT,\nMorrison JM, Smith BH, McKinstry B,\nDavenport RJ, Vale LD, Clarkson JE,\nHammersley V, Hayavi S, McAteer A,\nStewart K, Daly F (2007) Early treatment\nwith prednisolone or acyclovir\nin Bell\u2019s palsy. N Engl J Med 357:1598\u20131607","journal-title":"N Engl J Med"},{"key":"8_CR20","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3109\/00016489209137502","volume":"112","author":"Takasu","year":"1992","unstructured":"Takasu T, Furuta Y, Sato KC, Fukuda S,\nInuyama Y, Nagashima K (1992) Detection\nof latent herpes simplex virus\nDNA and RNA in human geniculate\nganglia by the polymerase chain reaction.\nActa Otolaryngol 112:1004\u20131011","journal-title":"Acta Otolaryngol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-008-0008-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-008-0008-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-008-0008-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-008-0008-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T15:49:00Z","timestamp":1659109740000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-008-0008-6"}},"subtitle":["Combined treatment of famciclovir and prednisone is superior to prednisone alone"],"short-title":[],"issued":{"date-parts":[[2008,9,3]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["8"],"URL":"https:\/\/doi.org\/10.1007\/s00415-008-0008-6","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,3]]},"assertion":[{"value":"18 December 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}